Rosiglitazone (BRL 49653)

Catalog No.S2556

For research use only.

Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.

Rosiglitazone (BRL 49653) Chemical Structure

CAS No. 122320-73-4

Selleck's Rosiglitazone (BRL 49653) has been cited by 46 publications

Purity & Quality Control

Choose Selective PPAR Inhibitors

Other PPAR Products

Biological Activity

Description Rosiglitazone (BRL 49653) is a potent antihyperglycemic agent and a potent thiazolidinedione insulin sensitizer with IC50 of 12, 4 and 9 nM for rat, 3T3-L1 and human adipocytes, respectively. Rosiglitazone is a pure ligand of PPAR-gamma, and has no PPAR-alpha-binding action. Rosiglitazone modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.
Targets
PPAR [1]
(Cell-free assay)
TRPC [5]
()
Ferroptosis [6]
()
In vitro

Rosiglitazone markedly increase phosphorylation of threonine 172 within the α subunit of AMPK, with increased AMP:ATP ratio. Rosiglitazone has been reported to decrease cholesterol synthesis in a number of cell lines in a peroxisome proliferator-activated receptor γ-independent manner. Rosiglitazone activates both α1- and α2-containing AMPK complexes, and this leads to a marked increase in the phosphorylation of acetyl-CoA carboxylase. [1] Rosiglitazone activates PPAR-gamma2 which acts as a dominant inhibitor of osteoblastogenesis in murine bone marrow in vitro.[2] Rosiglitazone increases adiponectin secretion from omental cells up to 2.3-fold higher, whereas secretion from subcutaneous adipose cells is unaffected. [3] Rosiglitazone changes the morphological features and protein profiles of mitochondria in 3T3-L1 adipocytes. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 M4jLSWZ2dmO2aX;uJIF{e2G7 MoPPSYZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFjldGczKGOnbHzzMEBGSzVyPUCuNFIh|ryP MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPThyMUixO{c,OTV6MEG4NVc9N2F-
CV-1 MWrGeY5kfGmxbjDhd5NigQ>? NInlfHdKdiC4aYTyc{B1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBw\iCSZYLvfIl{d22nIIDyc4xq\mW{YYTvdkBi[3SrdnH0[YQhemWlZYD0c5Ih\2GvbXGgLHBRSVJrIHX4dJJme3OnZDDpckBEXi1zIHPlcIx{NCCHQ{WwJF0hOC5yNjFOwG0v M4e0T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzh3N{[5NFcoRjh3N{[5NFc9N2F-
CV-1 MXTGeY5kfGmxbjDhd5NigQ>? NGmzfWhC[3SrdnH0bY9vKG:oIIDldo95cXOxbXWgdJJwdGmoZYLheI9zKGGldHn2ZZRm\CC{ZXPldJRweiCpYX3tZUBu\WG|dYLl[EBjgSCrbnT1Z5Rqd25ib3[gOVAmKG:oIH3hfIlufW1iYXzrZYxqdmVicHjvd5Bp[XSjc3WgZYN1cX[rdImsJJRz[W6|ZnXjeIlwdiCjc4PhfUBqdiCFVj2xJINmdGy|LDDFR|UxKD1iMD6wPFkyOyEQvF2u MlfSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh|Nk[yNEc,QTh|Nk[yNFww[T5?
3T3-L1 MlLuSpVv[3Srb36gZZN{[Xl? NWG3[3dnW3SrbYXsZZRqd25ib3[gZYRqeG:pZX7ld4l{KGmwIEPUN{1NOSClZXzsd{BqeyCneIDy[ZN{\WRiYYOgZ49v[2WwdILheIlwdiCncYXpeoFt\W62IITvJJRp\SCdIEGtNVREZSC3cIThb4Uh[2:3boTzJIFnfGW{IITy[YF1dWWwdDD3bZRpKDBwMjD1[{9uVCC2cn;ncIl1[XqxbnWsJGVEKD1iMD6wPUDPxE1w MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODl3NkKxN{c,OTB7NU[yNVM9N2F-
CV-1 NYG0S4xwTnWwY4Tpc44h[XO|YYm= M3HyN21igGmvYXygdoVxd3K2ZYKgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSZYLvfIl{d22nIIDyc4xq\mW{YYTvdkBi[3SrdnH0[YQhemWlZYD0c5Ih\2GvbXGgS4FtPCClaHnt[ZJq[yCrbjD0doFve2mnboTsfUB1emGwc3\lZ5Rm\CCFVj2xJINmdGy|IHL5JIZ2dmO2aX;uZYwh[XO|YYmuMEBGSzVyIE2gNE4xPDNizszNMi=> Mo\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTF5MkC4OVQoRjFzN{KwPFU1RC:jPh?=
COS1 MYDGeY5kfGmxbjDhd5NigQ>? Ml23RYdwdmm|dHnjJIFkfGm4aYT5JJdieyCmZYTldo1qdmWmIHnuJGNQWzFiY3XscJMhfHKjboPm[YN1\WRid3n0bEBISUxiND3QVGFTKGejbX3hJJJm[2WydH;yMEBGSzVyIE2gNE4xOjFizszNMi=> M{fqXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{NkG3PVI1Lz5zMk[xO|kzPDxxYU6=
COS1 MmOzSpVv[3Srb36gZZN{[Xl? NV\PZ3d6UW5idnn0do8h[WexbnnzeEBi[3Srdnn0fUB1\XO2ZXSg[o9zKHS{YX7zZYN1cX[jdHnvckBqdiCqdX3hckBRWEGUIHfhcY1iNUejbESgZ4hqdWW{aXOgR29UNTFiY3XscJMtKEWFNUCgQUAxNjB{IN88UU4> M3LnZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF{N{K5OlY5Lz5zMkeyPVY3QDxxYU6=
COS1 NV:wOGhITnWwY4Tpc44h[XO|YYm= NWDkdVBqUW5idnn0do8hfHKjboPhZ5RqfmG2aX;uJI9nKGi3bXHuJJBmem:6aYPvcYUheHKxbHnm[ZJifG:{IHHjeIl3[XSnZDDy[YNmeHSxcjDnZY1u[SCvZXHzeZJm\CCrbjDQVGFTNUeDTESgZ4hqdWW{aXOgR29UNTFiY3XscJMtKEWFNUCgQUAxNjB{IN88UU4> NGPj[lk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMki3N|UyPyd-MUK4O|M2OTd:L3G+
CV-1 Mon5SpVv[3Srb36gZZN{[Xl? NGe2dplKdiC4aYTyc{BmfmGudXH0bY9vKGGpYXnud5QhWliULXHsdIhiN1CSQWKt[4FudWFiaX6gR3YuOSClZXzsd{BjgSClb4TyZY5{\mWldHnvckBie3OjeTD3ZZMh\GW2ZYLtbY5m\CxiRVO1NEA:KDBwM{K1JO69VS5? MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjl3NEC2NUc,OTJ7NUSwOlE9N2F-
3T3-L1 MUXGeY5kfGmxbjDhd5NigQ>? M33NT2Vn\mWldHn2[UBkd26lZX70doF1cW:wIH\vdkBmdmijbnPlcYVvfCCxZjDpcpN2dGmwLXnu[JVk\WRidILp[4x6[2W{aXTlJIFk[3WvdXzheIlwdiCrbjCzWFMuVDFiY3XscJMtKEWFM{CgQUAxNjB{IN88UU4> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPDVyNU[0OEc,OTR3MEW2OFQ9N2F-
HepG2 M4HpdGZ2dmO2aX;uJIF{e2G7 MWTF[oZm[3SrdnWgZ49v[2WwdILheIlwdiCjZ3HpcpN1KGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSHXwS|Ih[2WubIOsJGVEPTBiPTCwMlA{QSEQvF2u NHO3U3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkGwO|E2OCd-MU[xNFcyPTB:L3G+
U2OS NXiwc5hITnWwY4Tpc44h[XO|YYm= MVvF[oZm[3Rib36gVHBCWmejbX3hJJRz[W6|YXP0bZZifGmxbjDhZ5Rqfmm2eTDpckBWOk:VIHPlcIx{NCCHQ{WwJF0hOC5yMzFOwG0v NVPX[oh{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[zNFA6PDRpPkG2N|AxQTR2PD;hQi=>
Huh7 NGjITIZHfW6ldHnvckBie3OjeR?= M2jROGZ2dmO2aX;uZYwh[WO2aY\peJkh[XRiaIXtZY4hWFCDUjDnZY1u[SCrbjDIeYg4KGOnbHzzJIJ6KHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OCB;IECuNlIh|ryPLh?= NGXveXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNkO2OlYxOSd-MU[zOlY3ODF:L3G+
Huh7 MX\GeY5kfGmxbjDhd5NigQ>? NVn1OmJETW[oZXP0JI9vKFCSQWKg[4FudWFidILhcpNi[3SrdnH0bY9vKGGldHn2bZR6KGmwIFj1bFch[2WubIOsJGVEPTBiPTCwMlIzKM7:TT6= M3vjZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4NEWxNFg4Lz5zNkS1NVA5PzxxYU6=
HEK293 MY\GeY5kfGmxbjDhd5NigQ>? MkS3RYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{Bie3Onc4Pl[EBieyCrbnT1Z5Rqd25ib3[gdoVk\XC2b4KgbY51\XKjY4Tpc44hf2m2aDDzeIVzd2mmIILlZ4VxfG:{IHPvZYN1cX[jdH;yMVEh[nliRWnGVEBj[XOnZDDy[ZBwenSncjDn[Y5mKGG|c3H5 MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjZ6MEG1PUc,OTZ4OECxOVk9N2F-
HEK293 MUPGeY5kfGmxbjDhd5NigQ>? NYrO[pNVSWexbnnzeEBi[3Srdnn0fUBifCCSUFHS[4FudWFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhemWlZYD0c5IhcW62ZYLhZ5Rqd25id3n0bEBz\XSrbn;p[EBZNXKnY3XweI9zKGGucHjhJIJ6KEW\RmCgZoF{\WRicnXwc5J1\XJiZ3Xu[UBie3OjeR?= Moe2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTZ4OECxOVkoRjF4NkiwNVU6RC:jPh?=
CV1 MoO0SpVv[3Srb36gZZN{[Xl? MYfUdoFve2GldHn2ZZRqd25ib3[gVHBCWmejbX3hJIlvKEOYMTDj[YxteyxiRVO1NEA:KDBwMEe2JO69VS5? M1PXTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OEKxO|Y6Lz5zNkiyNVc3QTxxYU6=
NIH3T3 MlflSpVv[3Srb36gZZN{[Xl? MWjBZ5Rqfmm2eTDheEBpfW2jbjDQVGFTKGejbX3hJJRz[W6|ZnXjeIVlKGmwIF7JTFNVOyClZXzsd{BjgSCudXPp[oVz[XOnIHHjeIl3cXS7IHHzd4F6NCCHQ{WwJF0hOC5|MjFOwG0v MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjh3NEC4OUc,OTZ6NUSwPFU9N2F-
CV1 MX3GeY5kfGmxbjDhd5NigQ>? MknmWJJidnOjY4TpeoF1cW:wIH;mJIh2dWGwIGDQRXJo[W2vYTDpckBEXjFiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNE4{ODhizszNMi=> M{DwVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUewN|kyLz5zNkm3NFM6OTxxYU6=
HepG2 NYHJZ|RRTnWwY4Tpc44h[XO|YYm= MVrB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXIh\2GvbXGgbY4h[SCKZYDHNkBk\WyuczDifUBRWEGULVfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxKD1iMD6xOVgh|ryPLh?= M37sVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4OUezN|U5Lz5zNkm3N|M2QDxxYU6=
HepG2 M4C5bGZ2dmO2aX;uJIF{e2G7 M4S0Z2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWiCpYX3tZUBqdiCKZYDHNkBk\WyuczDifUBRWEGULVfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxKD1iMD6xOVgh|ryPLh?= NX65PW1RRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[5O|k{PDFpPkG2PVc6OzRzPD;hQi=>
CV1 M1HGU2Z2dmO2aX;uJIF{e2G7 NF[yVJlC[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEhcW5iQ2[xJINmdGy|LDDFR|UxKD1iMD6zNFgh|ryPLh?= M1\STlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MEC1N|k1Lz5zN{CwOVM6PDxxYU6=
Huh7 NHyw[JpHfW6ldHnvckBie3OjeR?= MUTBZ5Rqfmm2eTDheEBpfW2jbjDQVGFTKGejbX3hJIlvKEi3aEegZ4VtdHNiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5{MjFOwG0v NVW1NHhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewN|QyPDlpPkG3NFM1OTR7PD;hQi=>
CV1 NF[wS25HfW6ldHnvckBie3OjeR?= MXHB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVKpYX3tZUBqdiCFVkGgZ4VtdHNiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5|MEig{txONg>? NITPeIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{GyPVczPSd-MUexNlk4OjV:L3G+
HepG2 NXL0Z4hbTnWwY4Tpc44h[XO|YYm= M1OwTGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJIlvKEincFeyJINmdGy|IHL5JHBRSVJvR1HMOEB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVAhRSByLkC4NkDPxE1w MorZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzNUewNVkoRjF5MUW3NFE6RC:jPh?=
HEK293 Mkn3SpVv[3Srb36gZZN{[Xl? MmfjRYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIFjFT|I6OyClZXzsd{BjgSCJQVy0JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEO1JO69VS5? NHG0ZnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K5NlYxPid-MUeyPVI3ODZ:L3G+
HEK293 NWDKUGpFTnWwY4Tpc44h[XO|YYm= MUHBZ5Rqfmm2eTDheEBpfW2jbjDh[Ilxd3OnIITpd5N2\SCSUFHSJIdidW2jIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYomgVHBCWi2JQVy0JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwM{Gg{txONg>? MlG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd|NEOzO|EoRjF5M{SzN|cyRC:jPh?=
L6 MWnGeY5kfGmxbjDhd5NigQ>? MXrF[oZm[3Rib36g[oF1fHliYXPp[EBwgGmmYYTpc44hcW5icnH0JGw3KGOnbHzzMEBGSzVyIE2gOUDPxE1w NIT5U3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{O0N|M4OSd-MUezOFM{PzF:L3G+
HepG2/C3A NE[xNpdHfW6ldHnvckBie3OjeR?= NGeyNIVC[3SrdnH0bY9vKG:oIHj1cYFvKFCSQWLnZY1u[SCuaXfhcoQh[mmwZHnu[{Bld22jaX6tcYVlcWG2ZXSgeJJidnOlcnnweIlwdmGuIHHjeIl3cXS7IHnuJIh2dWGwIFjldGczN0N|QTDj[YxteyClbz30doFve2[nY4Tl[EB4cXSqIH\1d4VlKEejbEStUGJFKGK7IHPveJJidnOoZXP0bY9vKGG|c3H5MEBGSzVyIE2gNE4xODN6IN88UU4> MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzRyM{[4PEc,OTd2MEO2PFg9N2F-
CV1 NYLpXGY{TnWwY4Tpc44h[XO|YYm= NVuwPJM{OjRiaILz MlzhRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGgbY4hS1ZzIHPlcIx{KGK7IFfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7IHHmeIVzKDJ2IHjyd{whTUN3MDC9JFAvODNizszNMi=> NXTZWXpvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe1NFczOjVpPkG3OVA4OjJ3PD;hQi=>
CV1 NGTCWXZHfW6ldHnvckBie3OjeR?= NUnNRohNOjRiaILz NELrN2tC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKjbIDoZUBqdiCFVkGgZ4VtdHNiYomgS2FNPCC2cnHud4FkfGm4YYTpc44h[XO|YYmgZYZ1\XJiMkSgbJJ{NCCHQ{WwJF0hOy52NjFOwG0v NHTBcoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{WwO|IzPSd-MUe1NFczOjV:L3G+
NIH3T3 NW\jOIllTnWwY4Tpc44h[XO|YYm= NWfQPZRpSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIF7JTFNVOyClZXzsd{BjgSCJQVy0JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwM{Kg{txONg>? MmLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4MkS3O|coRjF5NkK0O|c4RC:jPh?=
HEK293 NU\ybFQ5TnWwY4Tpc44h[XO|YYm= NGr5c3dC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IHHQNkBo\W6nIHnu[JVkfGmxbjygSWM2OCB;IECuNVIh|ryPLh?= NWPIRWk5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUiwNlkyPzZpPkG4NFI6OTd4PD;hQi=>
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HEK293 NFu2O4xHfW6ldHnvckBie3OjeR?= MXnB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVKpYX3tZUBqdiCKRVuyPVMh[2WubIOgZpkhT0GONDD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUCgQUAxNjB2NTFOwG0v M1m4T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6MkmxOlQ2Lz5zOEK5NVY1PTxxYU6=
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HepG2 NHnKN2dHfW6ldHnvckBie3OjeR?= NYj5eoxrSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFjldGczKGOnbHzzJIJ6KEeDTESgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5{MkOg{txONg>? NXPJe|dIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizPVQ6ODdpPkG4N|k1QTB5PD;hQi=>
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HepG2 MUDGeY5kfGmxbjDhd5NigQ>? NXPnOGlqSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFjldGczKGOnbHzzJIJ6KEeDTESgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5{MkOg{txONg>? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd6M{S0OEc,OTl5OEO0OFQ9N2F-
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HepG2 MY\GeY5kfGmxbjDhd5NigQ>? NGnDT2cyOCC3bX;sM2w> NVfCPYN[OjRiaILz NHnmZ5ZKdmO{ZXHz[UBqdiCpbIXjc5NmKGOxboP1cZB1cW:wIHnuJIh2dWGwIFjldGczKGOnbHzzJIF1KDFyIIXtc4wwVCCjZoTldkAzPCCqcoOgdoVt[XSrdnWgeI8h[2:wdILvcC=> NWPsWXo{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyOVY4PDhpPkKxNlU3PzR6PD;hQi=>
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HepG2 NV3qSZpDTnWwY4Tpc44h[XO|YYm= Mm\4RYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhemWlZYD0c5Ih\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHL5JHBRWkVvbIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyIE2gNE4xOSEQvF2u M3\3VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNEiyOFQ3Lz5{MUS4NlQ1PjxxYU6=
CV1 M2rN[2Z2dmO2aX;uJIF{e2G7 MYq0NEBpenN? NFrGN|NC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZU1NSkRiZYjwdoV{e2WmIHnuJGNXOSClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbESgZYZ1\XJiNECgbJJ{KGK7IHz1Z4ln\XKjc3WgZoF{\WRidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyIE2gNE4yKM7:TT6= M1m2UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUG1NFY{Lz5{MUWxOVA3OzxxYU6=
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Sf21 NGDaOnFHfW6ldHnvckBie3OjeR?= Ml:wTY5pcWKrdHnvckBw\iCqdX3hckBDW0WSIHX4dJJme3OnZDDpckBxdGG|bXGgcYVu[nKjbnWgeoV{cWOuZYOgc4YhW2Z{MTDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGWUD3k[ZBmdmSnboSgX|NJZXSjdYLvZ4hwdGG2ZTD1dJRic2VuIFnDOVAhRSB4LkSg{txONg>? M4qyelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOU[1OlI{Lz5{MUm2OVYzOzxxYU6=
Sf21 M2G1OmZ2dmO2aX;uJIF{e2G7 NUTtPIRpUW6qaXLpeIlwdiCxZjDTdJJi\3WnLVThe4xmgSC{YYSgRpNmeCCneIDy[ZN{\WRiaX6gdIxie22jIH3lcYJz[W6nII\ld4lkdGW|IH;mJHNnOjFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCXFBvZHXw[Y5l\W62IGuzTH11[XW{b3Poc4xifGVidYD0ZYtmNCCLQ{WwJF0hPDBizszNMi=> NFLUfnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm2OVYzOyd-MkG5OlU3OjN:L3G+
COS-1 MnTvSpVv[3Srb36gZZN{[Xl? NYOwRmZiOjRiaILz NEPMPVFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJGNQWy1zIHPlcIx{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWtZoF{\WRibIXtbY5wdWW2cnnjJIFv[Wy7c3nzMEBGSzVyIE2gNE4xPDhizszNMi=> MoGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyNUGwOVQoRjJ{MEWxNFU1RC:jPh?=
COS1 MWTGeY5kfGmxbjDhd5NigQ>? MX;CbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIIfpcIQhfHmyZTDQVGFT\2GvbXGgUGJFKGW6cILld5Nm\CCrbjDDU3MyKGOnbHzzJINwNWW6cILld5NqdmdiR1HMOEBjgSC|Y3nueIltdGG2aX;uJJBzd3irbXn0fUBie3OjeR?= M1XTTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEewOlA1Lz5{MkC3NFYxPDxxYU6=
HepG2 NHjwO4xHfW6ldHnvckBie3OjeR?= MVWyNEBpenN? M4H6UmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gS2FNPC2odYPl[EBRWEGUZ3HtcYEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBJ\XCJMjDj[YxteyCjZoTldkAzOCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEKg{txONg>? NIrXc4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC4NVk{Oid-MkKwPFE6OzJ:L3G+
BL21 DE3 MoTtSpVv[3Srb36gZZN{[Xl? MnvBSIl{eGyjY3Xt[Y51KG:oIGuzTH1zd3OrZ3zpeIF7d26nIH\yc40hVi22ZYLtbY5idCCKaYOteIFo\2WmIHj1cYFvKFCSQWLnZY1u[SCuaXfhcoQh[mmwZHnu[{Bld22jaX6g[ZhxemW|c3XkJIlvKEW|Y3jldolkcGmjIHPvcIkhSkx{MTDESVMh[2WubIOgZpkhe2OrboTpcIxifGmxbjDwdo95cW2rdImgZZN{[XluIFvpJF0hOC5yN{Sg{txONg>? NILyXVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC4NVk{Oid-MkKwPFE6OzJ:L3G+
COS1 NG\FWolHfW6ldHnvckBie3OjeR?= MYeyOEBpenN? M3vqbXRz[W6|YXP0bZZifGmxbjDv[kBpfW2jbjDmeYxtKGynbnf0bEBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFPPV|Eh[2WubIOgZ48ufHKjboPm[YN1\WRid3n0bEBTYFKjbIDoZUBi\nSncjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5zMjFOwG0v NUDwe|lGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxPVc{QTZpPkKyNVk4Ozl4PD;hQi=>
MG-63 NWrDUotpTnWwY4Tpc44h[XO|YYm= MV\B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJo[W2vYTDlfJBz\XO|ZXSgbY4hVUdvNkOgZ4VtdHNiYomgdoVxd3K2ZYKg[4Vv\S2kYYPl[EB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVAhRSByLkCxNUDPxE1w NHH0[Gc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKyOVY1OSd-MkKyNlU3PDF:L3G+
293H DA NHHFNppHfW6ldHnvckBie3OjeR?= NULtcYZpOTZiaILz MWnB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVKpYX3tZUBNSkRiaX6gbJVu[W5iMkmzTEBFSSClZXzsd{Bi\nSncjCxOkBpenNiYomgWHIuTlKHVDDhZ5RqfmG2aX;uJJJmeG:{dHXyJIF{e2G7LDDFR|UxKD1iMD6wNFI1KM7:TT6= NF7MSoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkW4Nlk4Oyd-MkK1PFI6PzN:L3G+
MG-63 MmrKSpVv[3Srb36gZZN{[Xl? NXvNeopnOjRiaILz M13hZm1w\HWuYYTpc44hd2ZiZoXscE1t\W6pdHigbJVu[W5icGPHOU1nfXOnZDDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKE2JLU[zJINmdGy|IHPvMYV5eHKnc4PpcocheEeYLWCyMXBRWkViYX\0[ZIhOjRiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBj[XOnZDD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUCgQUAxNjBzMTFOwG0v NGS0cIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyO|Q1QCd-MkK3Nlc1PDh:L3G+
Ac2F MWfGeY5kfGmxbjDhd5NigQ>? NITVS5IxNjFidH:gNVAhfU1? MUe2JIhzew>? NHnZS5FC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SCrbjDyZZQhSWN{RjDj[YxteyCjc4Pld5Nm\CCjczDseYNq\mW{YYPlJIFkfGm4aYT5JIF1KDBwMTD0c{AyOCC3TTDh[pRmeiB4IHjyd{BjgSC{ZYDvdpRmeiCpZX7lJIF{e2G7 NIrQdFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkixPVE6OCd-MkK4NVkyQTB:L3G+
HepG2 M4nOd2Z2dmO2aX;uJIF{e2G7 M4\ydXRz[W6|YXP0bZZifGmxbjDv[kBISUx2LX\1d4VlKFCSQWLnZY1u[SCuaXfhcoQh[mmwZHnu[{Bld22jaX6geJJidnOoZXP0[YQhcW5iaIXtZY4hUGWyR{KgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5zIN88UU4> M1vYNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUO0OVM4Lz5{MkmzOFU{PzxxYU6=
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THP1 NYf1[IN5TnWwY4Tpc44h[XO|YYm= NUXjeVdWOTByIIXN MYWzJIhzew>? MVPUdoFve2GldHn2ZZRqd25ib3[gVHBCWmejbX3hJIlvKGi3bXHuJHRJWDFiY3XscJMh[XO|ZYPz[YQh[XNiZHXjdoVie2ViaX6gUHBUNWmwZIXj[YQhUUx4IH3SUmEh\XiycnXzd4lwdiCjdDCxNFAhfU1icILlbY5kfWKjdHXkJIZweiB|IHjyd{BxemmxcjD0c{BNWFNiY3jhcIxmdmenIH3lZZN2emWmIHHmeIVzKDF6IHjyd{BjgSCUVD3QR3Ih[W6jbInzbZMhemWuYYTpeoUhfG9idX70doVifGWmIHPvcpRzd2x? NFXCNJY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzOFU{Pyd-MkK5N|Q2Ozd:L3G+
HepG2 NUPQU4pHTnWwY4Tpc44h[XO|YYm= Mn\UNVAhfU1? NUjWeXlbOjRiaILz NUe4cpM6WmWmdXP0bY9vKG:oIHfseYNwe2ViY3;ud5VueHSrb36gbY4hcW6|dXzpck1z\XOrc4ThcpQhcHWvYX6gTIVxTzJiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JIdtfWOxc3Wgc5hq\GG|ZTDt[ZRpd2RiaX6gdJJme2WwY3Wgc4YhOC5zIIXNJI9nKGmwc4XsbY4> NWi0NINlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNlUzPDRpPkKzNFI2OjR2PD;hQi=>
HepG2 M3HsZmZ2dmO2aX;uJIF{e2G7 M3rNN|ExKHWP M1fjRlI1KGi{cx?= NX:zRlY4WmWmdXP0bY9vKG:oIHfseYNwe2ViY3;ud5VueHSrb36gbY4hcW6|dXzpck1z\XOrc4ThcpQhcHWvYX6gTIVxTzJiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JIdtfWOxc3Wgc5hq\GG|ZTDt[ZRpd2RiaX6gdJJme2WwY3Wgc4YhOjJwMjDtUUBw\iCpbIXjc5Nm M{XOU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEK1NlQ1Lz5{M{CyOVI1PDxxYU6=
HepG2 MmTWSpVv[3Srb36gZZN{[Xl? MkfaNlAhcHK| MnPwWJJidnOjY4TpeoF1cW:wIH;mJGdCVDRvZoXz[YQhcHWvYX6gVHBCWmejbX3hJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCneIDy[ZN{\WRiaX6gTIVxTzJiY3XscJMh[W[2ZYKgNlAhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwMEO5JO69VS5? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF5MUC0OUc,OjNzN{GwOFU9N2F-
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3T3L1 NUPhSWJrTnWwY4Tpc44h[XO|YYm= MmCwO{Bl[Xm| MkDGWZBz\We3bHH0bY9vKG:oIHHQNkBxem:2ZXnuJIV5eHKnc4Ppc44hcW5iZHnm[oVz\W62aXH0[YQhdW:3c3WgN3Q{VDFiY3XscJMh[W[2ZYKgO{Bl[Xm|IHL5JJdme3Sncn6gZoxwfCCjbnHsfZNqew>? M3vMUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOS9pPlPoSW1DVDxxYU6=
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3T3L1 MoPWSpVv[3Srb36gZZN{[Xl? MUWxNEB2VQ>? NGDLVWgzPCCqcoO= NVPkbXg2UW6mdXP0bY9vKG:oIHnud5VtcW5vc4TpcZVt[XSnZDCyMYRmd3i7LVStX|NJZS2pbIXjc5NmKHWydHHr[UBqdiCmaX\m[ZJmdnSrYYTl[EBud3W|ZTCzWFNNOSClZXzsd{BifCBzMDD1UUBi\nSncjCyOEBpenNiYomgd4NqdnSrbHzheIlwdiClb4XueIlv\yCjbnHsfZNqew>? Mn;DQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMNVIyNyd-Q3jFUWJNRC:jPh?=
3T3L1 MkTGSpVv[3Srb36gZZN{[Xl? MmDUNkB2VQ>? NGXxXZUyPCCmYYnz MXTB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVJiaX6gcY92e2ViM2SzUFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdiCjdDCyJJVOKGGodHXyJFE1KGSjeYOgZpkhV2muIGLl[EBQKHO2YXnubY5oKG2ndHjv[C=> M3fuTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOS9pPlPoSW1DVDxxYU6=
U2OS M1nLU2Z2dmO2aX;uJIF{e2G7 NH:yTFQyOCC3TR?= NXzoWnRoOjRiaILz MUjBZ5RqfmG2aX;uJI9nKFCSQWLHJEh2dmuwb4fuJI9zcWerbjmg[ZhxemW|c3XkJIlvKGi3bXHuJHUzV1NiY3XscJMh[XRiMUCgeW0hcW6ldXLheIVlKG[xcjCyOEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6 M{DhcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFEzOS9pPlPoSW1DVDxxYU6=
Assay
Methods Test Index PMID
Western blot Cyclin D1 / CDK2 / CDK4 / Bax / Bcl-2 29725405
Immunofluorescence PPARγ / E-cadherin 27145370
Growth inhibition assay Cell viability 29725405
In vivo

Rosiglitazone administration results in significant bone loss, including a decrease in bone volume, trabecular width, and trabecular number and an increase in trabecular spacing. Rosiglitazone also leads to a decrease in bone formation rate, with a simultaneous increase in fat content in the bone marrow. Rosiglitazone decreases the expression of the osteoblast-specific genes Runx2/Cbfa1, Dlx5, and alpha1(I)collagen, whereas the expression of the adipocyte-specific fatty acid binding protein aP2 is increased. [2] Rosiglitazone upregulates gene transcripts encoding mitochondrial proteins in white adipocytes from ob/ob mice accompanied by an increase in mitochondrial mass and changes in mitochondrial structure. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 71 mg/mL
(198.64 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
4% DMSO+30% PEG 300+5% Tween 80+ddH2O
For best results, use promptly after mixing.

5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 357.43
Formula

C18H19N3O3S

CAS No. 122320-73-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02737709 Terminated Drug: Paclitaxel and Carboplatin regimen Non-small Cell Lung Cancer Sun Yat-sen University March 2016 Phase 2
NCT01402076 Completed Drug: Tasimelteon|Drug: Rosiglitazone|Drug: Midazolam Healthy Volunteers Vanda Pharmaceuticals August 2011 Phase 1
NCT01100619 Completed Drug: rosiglitazone|Drug: XL184 Papillary Thyroid Cancer|Follicular Thyroid Cancer|Huerthle Cell Thyroid Cancer|Renal Cell Carcinoma Exelixis April 2010 Phase 1
NCT01415128 Completed Drug: Omeprazole|Drug: Rosiglitazone|Drug: Desipramine Erectile Dysfunction VIVUS LLC April 2010 Phase 1
NCT01376063 Completed Drug: FG-4592 Healthy Adult Subjects FibroGen March 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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