CHIR-99021 (CT99021) HCl

Catalog No.S2924

Molecular Weight(MW): 501.8

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.

Cited by 74 Publications

Nature, 2015, 10.1038/nature14413

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Cell, 2018, 174(2):406-421

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Nature, 2013, 500(7461):222-6

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Cell, 2018, 174(2):391-405

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Nat Protoc, 2012, 8(1):162-75

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Nat Commun, 2015, 6:7413

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Nat Commun, 2013, 4:2628

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Dev Cell, 2015, 32(6):667-77

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Proc Natl Acad Sci USA, 2012, 109(27):E1848-57

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Biomaterials, 2014, 35(5):1367-77

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Stem Cell Res, 2015, 10.1016/j.scr.2015.05.004

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Antioxid Redox Sign, 2013, 20(18):2907-22

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Acta Biomater, 2014, 10(2):604-12

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Protein Cell, 2014, 5(1):59-68

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Biomater Sci, 2017, 5(8):1567-1578

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Stem Cells, 2015, 33(3):686-98

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Stem Cells, 2012, 30(9):1863-74

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Exp Mol Med, 2015, 47:e143

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Exp Mol Med, 2015, 47:e143

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Mol Cancer Ther, 2014, 13(4):812-22

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Mol Cell Proteomics, 2014, 13(4):990-1007

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Mol Neurobiol, 2015, 10.1007/s12035-014-9084-z

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Carcinogenesis, 2012, 33(3):529-37

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J Thromb Haemost, 2015, 10.1111/jth.12954

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Biochim Biophys Acta, 2013, 1830(8):4102-16

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J Biol Chem, 2015, 290(9):5592-605

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J Biol Chem, 2014, 289(47):32628-38

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Am J Cancer Res, 2014, 6(6):724-735

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Mol Pharmacol, 2014, 83(5):1020-9

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Stem Cells Dev, 2015, 10.1089/scd.2014.0422

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Exp Cell Res, 2014, 328(2):351-60

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PLoS One, 2016, 11(8):e0161508

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PLoS One, 2014, 9(12):e115854

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PLoS One, 2012, 7(10):e47312

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BMC Dev Biol, 2012, 12:21

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Exp Biol Med, 2014, 239(10):1390-402

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Leuk Res, 2013, 37(10):1329-40

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Biol Open, 2015, 4(1):48-61

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Theriogenology, 2014, 82(2):283-93

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Mol Med Rep, 2019, 19(6):5440-5452

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Cell Reprogram, 2014, 10.1089/cell.2014.0028

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Exp Ther Med, 2016, 12(6):3851-3858

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J Huazhong Univ Sci Technolog Med Sci, 2014, 34(2):151-6

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Methods Mol Biol, 2016, 1353:181-90

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University of GOTHENBURG, 2014, 5495

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Bachelor of Science, 2012, East China Normal University

PubMed: ( click the link to review the publication )

9 Customer Reviews

Differentiation induced by treatment with the Gsk3 inhibitor in hPSCs is β-catenin dependent. H9-7TGP cells were treated with 12 uM CH in mTeSR1 for 4 d. Immunofluorescent staining for Oct4, Isl1, and Nkx2.5 was compared with GFP expression. (Scale bars, 50 uM.)

Proc Natl Acad Sci U S A 2012 109(27):E1848-57. CHIR-99021 (CT99021) HCl purchased from Selleck.

Gpc4 regulates ESC response to Wnt/β-catenin signaling. (E) Quantitative analysis of control and Gpc4-mutant beating foci exposed to the GSK3 inhibitor, CHIR 99021 (1 and 3 μM, from day 0 to day 5). Analysis was done at different time points. Gpc4- mutant cells treated with CHIR 99021 behave as controls (mean±SEM; n=2).

Stem Cells 2012 30, 1863-1874. CHIR-99021 (CT99021) HCl purchased from Selleck.
Characterization of rES cells. A: image of normal rES cell colonies on feeder layers. B: rES colonies were positive for AP staining. CeE: rES colonies readily expressed pluripotent markers, Sox2 (C), Oct4 (D), and SSEA-1 (E). Blue, DAPI. Scale bars: 100 um.

J Genet Genomics 2012 39, 643e651. CHIR-99021 (CT99021) HCl purchased from Selleck.

Inhibition of GSK3 activity induces an autophagic response in human pancreatic cancer cells. PANC1 cells were treated for 24 h with DMSO, CHIR99021 (CHIR; 5 uM) or the mTOR inhibitor Torin1 (250 nM). Autophagosome (punctate LC3B) (D) and lysosome (E) labeling was visualized with a Zeiss LSM700 confocal microscope. Images were acquired with a 20x (D) or 63x (E) objective. Nuclei were stained with DAPI. Scale bars, 20 祄.

J Biol Chem 2015 290(9), 5592-605 . CHIR-99021 (CT99021) HCl purchased from Selleck.
A. Vero cells were pretreated with the indicated concentrations of CHIR-99021 for 1 h and then infected with PEDV (MOI = 1) for 8 or 10 h. Cell lysates were prepared and analyzed using Western blotting.

PLoS One, 2016, 11(8):e0161508. CHIR-99021 (CT99021) HCl purchased from Selleck.

Smad linker phosphorylation involves GSK3 in human melanoma lines. Inhibition of Smad2 and Smad3 linker phosphorylation in the presence of the specific GSK3 specific inhibitor, CT99021. 24 hours post seeding, WM793 and 1205LU cells were serum-starved for about 16 hours, and incubated in the absence (2) or presence (+) of 2 uM of CT99021 for two hours. Immunoblots were performed as in A. p: Phosphorylated. S: Serine; T: Threonine.

PLoS One 2012 7, e47312. CHIR-99021 (CT99021) HCl purchased from Selleck.
SKOV3/DDP cells were treated with a range of concentration of (A) CHIR-99021 or in combination with 20 µM cisplatin for 48 h.

Exp Ther Med, 2016, 12(6):3851-3858. CHIR-99021 (CT99021) HCl purchased from Selleck.

PANC1 cells were treated with GSK3 inhibitors SB216763 (SB 10µM or SB 20µM) or CHIR99021 (CHIR 5µM) for 72h.

CHIR-99021 (CT99021) HCl purchased from Selleck.
Activity of canonical WNT/ β -CATENIN signals induced by CHIR 99021 in the developing human lung. Human lung tissue explants obtained at 15 weeks of gestation were exposed to 0, 5 and 10 μM CHIR 99021 in vitro for 72 h. (A-B) Western blot analysis showed expression of β -CATENIN in human lung tissues. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (C) qRT-PCR analysis detected a dose-dependent increase in WNT signaling transcription factors and target genes following exposure to CHIR 99021. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (D-K) Histology examination showed obvious morphogenetic changes of the airway epithelial cells associated with CHIR 99021 treated lung tubes. Scale bars: D-G =100 μm; H-K = 20 μm.

CHIR-99021 (CT99021) HCl purchased from Selleck.

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Description

Targets

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

In vitro

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. ^[1] In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). ^[2] Unlike lithium chloride and AR-A014418, CHIR-99021 treatment does not reduce the viability of INS-1E cells even at high concentrations. Instead, CHIR-99021 robustly increases the rate of proliferation of INS-1E cells in a dose-dependent manner, and significantly inhibits INS-E cell death induced by high glucose and high palmitate in a concentration-dependent manner. CHIR-99021 promotes primary beta cell replication in isolated rat islets at concentrations as low as 1 μM, with 2-3 fold increase of cell replication at 5 μM of CHIR-99021 treatment. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3-L1	NUHIPZJlTnWwY4Tpc44hSXO\|YYm=	M3\qelMh\|ryP	Mn3qOEBp	NUTFe2E{TE2VTx?=	MnTvTY5pcWKrdIOgdJJm[WSrcH;jfZRmKGSrZn\ldoVvfGmjdHnvci=>	NFjUSXkyOjB3NUKwNC=>
insulin receptor–expressing CHO-IR	NVPxV2J2TnWwY4Tpc44hSXO\|YYm=	M3m1WFUxOCCwTR?=	NX[ydoZ6OzBibXnu	NVG2RWZjTE2VTx?=	M{XRXmFkfGm4YYTld{BIdHmlb3flckBUgW62aHHz[UApT1Nr	MlT3NVI3ODZ2OUe=
H4IIE	MWHGeY5kfGmxbjDBd5NigQ>?	NHnFRmwyOCEQvF2=	NWH1Z4dIOjRiaB?=	Mk[1SG1UVw>?	MoPRVoVofWyjdHXzJO6zNWOjdHXubY4h[WO2aY\peJkh[W6mIGTJVmUh[2:wdHHpcolv\yCycn;tc5RmeiCjY4Tpeol1gQ>?	MnizNVU{PTBzOUW=
Oct4/Sox2/Klf4-infected MEFs	NH3IOlRHfW6ldHnvckBCe3OjeR?=	MVWxNEDPxE1?	NUn2WY4zOjhiZB?=	NV\oZoloTE2VTx?=	MorLVJJwdW:2ZYOgUWVHeyC{ZYDyc4dz[W2vaX7nJHRz[W6\|ZIXj[YQh[nliT3P0OEwhW2:6MjygZY5lKEuuZkS=	M1P3OFE6QDN7MEW1
Sca-1+ HPC	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NFzzSm0zKM7:TR?=	MmTLOkBl	NHj4VpZFVVOR	M3PWXnN6dmW{Z3nzeIlk[WyueTDwdo9ud3SnczDTZ4EuOSwEoFjQR{Bxem:uaX\ldoF1cW:wIHHu[EBkd2yxbomg[o9zdWG2aX;uJJRw\2W2aHXyJJdqfGhiRVfG	NGHpcJMzOTZ{NEO0PC=>
HMC1.2	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M{TkbVMxKM7:TR?=	MkPhO\|IhcA>?	NYPHNoc4TE2VTx?=	NHXRd5BT\WS3Y3XzJINmdGxic4Xyeol3[Wx?	MYSyNlA{QTNyMR?=
Endothelial cell(EC)	M1LBeGZ2dmO2aX;uJGF{e2G7	NEf6O5A{KM7:TR?=		NUPOXFZNTE2VTx?=	MX\Qdo9ud3SnczDlcoRwfGinbHnhcEBk\WyuIDjFR{kh\GmoZnXy[Y51cWG2aX;u	NVe0OZpIOjJyNUKwNFY>
PANC1	MWnBdI9xfG:\|aYOgRZN{[Xl?	M3i5eOKhPSEQvF2=	NWjjSmxDPzJiaB?=	NWGx[pNPTE2VTx?=	NI\NfVNVemmpZ3Xyd{BidiCjcH;weI91cWNicnXzdI9ve2V?	NXXycYJzOjJ{MEGxPFY>
INS-1E	NWrhdJE6TnWwY4Tpc44hSXO\|YYm=	MX[yMlUh\|ryP	M2izVlI1KGh?	M3u4XmROW09?	M33PNmlv\HWlZYOgZUBz\WS3Y4Tpc44hd2ZiTmCxJI93\XKneIDy[ZN{cW:w	MojWNlI1Ojd5MES=
hiPSC-NPs	MlPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVvBb5ZOO+LCid88US=>	M1Xj[lczKGh?	NGjKb3VFVVOR	MkLHTY5kemWjc3XzJINmdGxicILvcIln\XKjdHnvcuKh	MVyyNlY1OjZ6Nx?=
platelets	MmrnSpVv[3Srb36gRZN{[Xl?	M4m0RlExKM7:TR?=	MV2xOUBucW5?	NGfMSmxFVVOR	NH3XTpRKdmO{ZXHz[ZMhfGi{b33ibY4udWWmaXH0[YQheGyjdHXs[ZQh[WepcnXnZZRqd25iYX7kJGFVWCC\|ZXPy[ZRqd25?	MXuyN\|I{QTh5Nx?=
DN3	NFn2Wo1HfW6ldHnvckBCe3OjeR?=	MlXWNVAh\|ryP	NInDc5I6PiCq	M3\RVGROW09?	M2Dtcmlv[3KnYYPld{Bk\WyuIHTleoVtd3CvZX70JIFv\CCycn;sbYZmemG2aX;u	MkK4NlM2OjZ7OEm=
embryonic stem cells (ESC)	MV;GeY5kfGmxbjDBd5NigQ>?	NXT5WIJROyEEtV2=	MUSxNUBl	MlTsSG1UVw>?	M1;JSHBzd22xdHXzJJNmdGZvcnXu[ZdidCCxZjDuZeOwfmVvdInw[UBud3W\|ZTDlcYJzgW:waXOgd5RmdSClZXzsd{ApTVOFKR?=	MUCyN\|g1OzNzMh?=
H460	Mon0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mo\nOUDDvU1?	Ml3iNlQhcA>?	NWfxO5h4TE2VTx?=	MlvOVJJwdW:2ZYOgZ4VtdCCycn;sbYZmemG2aX;u	MVSyOFM3PzZ6OB?=
H157	NFLMZnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYG1JOK2VQ>?	MUKyOEBp	NY\zc\|h{TE2VTx?=	NWjVeoxIWHKxbX;0[ZMh[2WubDDwdo9tcW[ncnH0bY9v	M2GwNVI1OzZ5Nki4
H460	M2\INWFxd3C2b4Ppd{BCe3OjeR?=	MUG1JOK2VQ>?	NVi2WmVyOjRiaB?=	NEPBNY9FVVOR	MUHBeJRmdnWjdHXzJINmdGxiYYDvdJRwe2m\|	M1jDelI1OzZ5Nki4
H157	M3KwWmFxd3C2b4Ppd{BCe3OjeR?=	NI\IS4I2KML3TR?=	MYqyOEBp	NGPQUXZFVVOR	MmLGSI9meyCwb4Sgd4lodmmoaXPhcpRtgSCjZn\lZ5Qh[XCxcITvd4l{	M3LNelI1OzZ5Nki4
A549	M4L2dmFxd3C2b4Ppd{BCe3OjeR?=	M3vpelUhyrWP	M4LaSFI1KGh?	NHnFTZRFVVOR	NVP5T4JWUW6lcnXhd4V{KGOnbHygZZBweHSxc3nz	MVWyOFM3PzZ6OB?=
Neural progenitor cells	MoX0SpVv[3Srb36gRZN{[Xl?	NEXicmE{KM7:TR?=	NUPGVFdSOTBiZB?=	MlvjSG1UVw>?	NHP6[ZdKdmS3Y3XzJIdmdmW{YYTpc44hd2ZibnX1doFtKHC{b3flcol1d3JiY3XscJM>	MVeyOFY{QDB\|NB?=
ES-D3	MU\DfZRwfG:6aXOgRZN{[Xl?	NWPsV5plOTEEoN88US=>	M{e2SFMh\A>?	NVzLdmZZTE2VTx?=	M3HLdGlv\HWlZYOgcY9l\XKjdHWgZ5l1d3SxeHnjbZR6KHerdHigTWM2OCCxZjC0Mlkh\|ryP	NWP6UGZvOjR5N{mzOlU>
ES-CCE	MXHDfZRwfG:6aXOgRZN{[Xl?	NIHyXGoyOMLizszN	MoLBN{Bl	M{i5cmROW09?	NHLOWnJKdmS3Y3XzJI1w\GW{YYTlJIN6fG:2b4jpZ4l1gQ>?	NWX2O5k3OjR5N{mzOlU>
ES-D3	NVvnUmRNTnWwY4Tpc44hSXO\|YYm=	NFi3bpc2yqEQvF2=	MUWzJIQ>	MVfEUXNQ	MXTTeJJwdmeueTDpcoR2[2W\|IITo[UBi[3Srdnn0fUBw\iCZboSvZoV1[S2lYYTlcolvKHCjdHj3ZZk>	MnfnNlQ4Pzl\|NkW=
ES-CCE	MXzGeY5kfGmxbjDBd5NigQ>?	MYK1xsDPxE1?	NIDXVIE{KGR?	M1jjTWROW09?	NFzNNVNUfHKxbnfsfUBqdmS3Y3XzJJRp\SCjY4Tpeol1gSCxZjDXcpQw[mW2YT3jZZRmdmmwIIDheIh4[Xl?	Mn\nNlQ4Pzl\|NkW=
SW982	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIHtOIFKSzVyPUCuNlE1OTZizszN	M2HtfnNCVkeHUh?=
GCT	NI\CNmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYG2NnJEUUN3ME2wMlMxPjd{IN88US=>	M4LrW3NCVkeHUh?=
769-P	NEPGb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWG1OJRQUUN3ME2wMlU5PDl7IN88US=>	NV\2WXhFW0GQR1XS
LOXIMVI	NFTYd4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MojYTWM2OD1yLkW4PFMzKM7:TR?=	NXLUV4hXW0GQR1XS
D-336MG	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXrJR\|UxRTBwOES2NkDPxE1?	NEjhcY9USU6JRWK=
S-117	NHrFPWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NI\RTVNKSzVyPUCuPVIyOzFizszN	NXn3VY0zW0GQR1XS
D-247MG	M4D0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlPyTWM2OD1yLkm0PFUzKM7:TR?=	Mo\1V2FPT0WU
TYK-nu	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWDWfFRXUUN3ME2xMlA4QTF{IN88US=>	M4nqTXNCVkeHUh?=
A498	NUT2NZVxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX3JR\|UxRTFwM{C0Olkh\|ryP	MV;TRW5ITVJ?
BCPAP	NHX5UJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWDEWXR3UUN3ME2xMlY3QDl6IN88US=>	M4H5bHNCVkeHUh?=
KYSE-180	M1vq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlO0TWM2OD1zLkeyO\|g5KM7:TR?=	NFfvd4lUSU6JRWK=
MIA-PaCa-2	MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlHLTWM2OD1zLke1PVc4KM7:TR?=	MlHMV2FPT0WU
HCC1395	M4rheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWn5UGVwUUN3ME2xMlc5Ojd\|IN88US=>	NXqwRXQ2W0GQR1XS
RS4-11	M1vXbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXSwdFFuUUN3ME2xMlk2PDF3IN88US=>	Mnu3V2FPT0WU
NCI-H2122	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUjpe3MzUUN3ME2yMlI4Pjh2IN88US=>	M2fuVHNCVkeHUh?=
SNU-423	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEPjW4tKSzVyPUKuOFk4QDdizszN	MXzTRW5ITVJ?
SK-LMS-1	M4LoWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2jjT2lEPTB;Mj62OFEzQCEQvF2=	NX7UbW1GW0GQR1XS
RPMI-7951	NW\QeHdYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIrSU2VKSzVyPUKuO\|AyQTNizszN	M{C1[XNCVkeHUh?=
COLO-829	NUXXR3o6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEfYcoJKSzVyPUKuO\|Y2PCEQvF2=	MXjTRW5ITVJ?
SCC-9	MlizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFvCOlVKSzVyPUKuPVU1QDVizszN	MnjrV2FPT0WU
A704	MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NU\ZNWU4UUN3ME2zMlA5OTJizszN	NHvpb2NUSU6JRWK=
HOP-62	NGPUblhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIXTRWJKSzVyPUOuN\|YxPTRizszN	NVL1eZFwW0GQR1XS
HCC1569	NVHvXI5HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXS4fHBRUUN3ME2zMlQ5OzB3IN88US=>	MWnTRW5ITVJ?
A172	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmrETWM2OD1\|Lke1OFk5KM7:TR?=	NHK1RmNUSU6JRWK=
MOLT-16	NXzRem5zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYLpTmVjUUN3ME2zMlg5PTV4IN88US=>	M3TaUHNCVkeHUh?=
TE-15	NYnyNmRKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2TDbWlEPTB;Mz65OVM1OyEQvF2=	MXTTRW5ITVJ?
OE19	M{TwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVmyXoRuUUN3ME2zMlk3PDVzIN88US=>	M3vYO3NCVkeHUh?=
MHH-ES-1	NXfF[GVQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXLJR\|UxRTRwMES1OFUh\|ryP	MVzTRW5ITVJ?
NKM-1	M1PScmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVrVeVJzUUN3ME20MlE{QTdzIN88US=>	MWDTRW5ITVJ?
RCC10RGB	NUHpbnZKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHHNVI1KSzVyPUSuNlk1PzlizszN	MlzsV2FPT0WU
BxPC-3	M3\lTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFHpNpFKSzVyPUSuO\|A{QTFizszN	NFXsSY5USU6JRWK=
ALL-PO	NFviTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1O1d2lEPTB;ND64N\|g2QCEQvF2=	NH7mVmlUSU6JRWK=
SK-OV-3	M3TVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUTwWVVYUUN3ME20Mlk6OzRizszN	NVzkfZE6W0GQR1XS
SW1710	NHLmPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV\JR\|UxRTVwNEK0OVYh\|ryP	NILZW\|BUSU6JRWK=
NCI-H2452	NG\ndlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1XnXWlEPTB;NT60OVYzQCEQvF2=	MniyV2FPT0WU
D-392MG	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4n6RmlEPTB;NT60PVE1PSEQvF2=	NV[5[pZMW0GQR1XS
LB2518-MEL	MmnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYD6cXlXUUN3ME21MlczPjJ5IN88US=>	NEGx[IpUSU6JRWK=
BL-41	MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYXJR\|UxRTVwOEGyOlYh\|ryP	M1nEUHNCVkeHUh?=
WM-115	NWPJWFBrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmfGTWM2OD13LkixOVA6KM7:TR?=	NWnBRlhvW0GQR1XS
SK-MEL-2	M2LrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFn4XWhKSzVyPU[uN\|g{PDRizszN	MkfYV2FPT0WU
CGTH-W-1	NF;IbXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFvnWmZKSzVyPU[uOFE4KM7:TR?=	MU\TRW5ITVJ?
BB65-RCC	MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1q4bWlEPTB;Nj61N\|E6PSEQvF2=	NFrLZ\|FUSU6JRWK=
CAL-85-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3j1cGlEPTB;Nj62NFk{PiEQvF2=	MorIV2FPT0WU
RT-112	M4HjNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFPVbXpKSzVyPUeuNVY1PTZizszN	NHvxN\|JUSU6JRWK=
MC116	NUPSWGlHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmK4TWM2OD15LkK4OlkyKM7:TR?=	NIWxe\|NUSU6JRWK=
G-361	M1LtOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTdwNE[1OlEh\|ryP	MVrTRW5ITVJ?
SW1417	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWS4fpdlUUN3ME23MlY1PTh2IN88US=>	NUTURotFW0GQR1XS
MV-4-11	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRThwNUSzNFQh\|ryP	MYXTRW5ITVJ?
CAL-72	Mn7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MluyTWM2OD16Lke2NVE{KM7:TR?=	MmLFV2FPT0WU
MKN28	NWDQdVliT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXPJR\|UxRThwOEi1NVYh\|ryP	MoLZV2FPT0WU
MEG-01	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFTyTphKSzVyPUiuPVkxPDNizszN	M1PwTHNCVkeHUh?=
ACHN	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3vJUmlEPTB;OT6zNFU1PiEQvF2=	MlLiV2FPT0WU
NCI-H1755	MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHG0T\|lKSzVyPUmuN\|k6QDZizszN	MVrTRW5ITVJ?
NCI-H64	MliyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTlwNEKyOVUh\|ryP	M13CSnNCVkeHUh?=
COLO-205	NG\SeJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUfzVWgxUUN3ME25MlQ{QDJzIN88US=>	M{fBS3NCVkeHUh?=
CTV-1	NXPGSWlXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkLnTWM2OD17LkSzPFk1KM7:TR?=	Mmf4V2FPT0WU
U-2-OS	NVjP[2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUHydY1KUUN3ME25MlQ2ODB4IN88US=>	Mn3VV2FPT0WU
LB996-RCC	Ml:2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1m3O2lEPTB;OT61NlM6PyEQvF2=	NXvoc3hYW0GQR1XS
SK-N-DZ	NXP4SJRGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXPJR\|UxRTlwNkW3OFIh\|ryP	MnjXV2FPT0WU
EFM-19	M{\6SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVHJR\|UxRTlwN{W1OlYh\|ryP	NHf4b5BUSU6JRWK=
DBTRG-05MG	NXTDfpZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUfRXYh6UUN3ME25Mlc4PzdizszN	M37VSHNCVkeHUh?=
U-118-MG	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mmq3TWM2OD17Lkm0OFQ1KM7:TR?=	NXPDeJFyW0GQR1XS
LB1047-RCC	Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV7JR\|UxRTlwOUm3PVgh\|ryP	MkTZV2FPT0WU
NCI-H28	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXHJR\|UxRTFyLkS0NVMh\|ryP	NVu4PHM1W0GQR1XS
MZ2-MEL	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVrJR\|UxRTFyLkS2O\|ch\|ryP	M3nvO3NCVkeHUh?=
M059J	M3;hNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFrVdFBKSzVyPUGwMlYyODJizszN	NF7ySJdUSU6JRWK=
HT-3	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnO3TWM2OD1zMD62NVc6KM7:TR?=	NFK2UJlUSU6JRWK=
SNU-387	NGnTR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUTGVHN5UUN3ME2xNE44OjN3IN88US=>	NYHKWZJ1W0GQR1XS
NCI-H526	M3v0eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF7JVnhKSzVyPUGxMlE{PjVizszN	NYTL[2RRW0GQR1XS
HEL	MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnezTWM2OD1zMT62OVc6KM7:TR?=	MUTTRW5ITVJ?
PA-1	M17KNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1XIN2lEPTB;MUGuPVMh\|ryP	NFKyOI1USU6JRWK=
PC-14	NWLwVXp1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVjYUXJZUUN3ME2xNk4{OjRizszN	NFWyXoNUSU6JRWK=
C8166	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFvxWmhKSzVyPUGzMlI{OThizszN	NXzLSZJRW0GQR1XS
NCI-H82	NGfUV4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF\qOnpKSzVyPUGzMlI6ODlizszN	M4nOVnNCVkeHUh?=
DSH1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYHoW4F3UUN3ME2xN{4{QDd7IN88US=>	NHr6ZmJUSU6JRWK=
T98G	MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEHNTI9KSzVyPUGzMlQ4OTdizszN	MYXTRW5ITVJ?
KU812	MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFr3PYhKSzVyPUGzMlUyPzVizszN	NIDmbVRUSU6JRWK=
SW48	NGfFe3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2\hR2lEPTB;MUOuO\|I3PSEQvF2=	M4LjbXNCVkeHUh?=
MEL-HO	NHLzSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVrJR\|UxRTF\|Lki4Nlkh\|ryP	MUPTRW5ITVJ?
SF539	M3XlNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVrVZWtOUUN3ME2xOE4xOTF4IN88US=>	Mon1V2FPT0WU
NB1	NEXFeJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3vUc2lEPTB;MUSuNVk{PSEQvF2=	MkjYV2FPT0WU
ST486	NEK1PXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHfa[JNKSzVyPUG0MlIzPTFizszN	M4nXTXNCVkeHUh?=
LoVo	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmDHTWM2OD1zNT6yOlU6KM7:TR?=	NXvFSpRRW0GQR1XS
NH-12	NHnCeZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEXTWWRKSzVyPUG2MlAxQTdizszN	MV7TRW5ITVJ?
CCRF-CEM	NFr5TG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NED4SnhKSzVyPUG2MlY4ODJizszN	MW\TRW5ITVJ?
Daudi	NI\4SWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUTGb3ZLUUN3ME2xO{43OTR7IN88US=>	MXvTRW5ITVJ?
SIMA	M2XTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MY\JR\|UxRTF5LkmxNVgh\|ryP	MoXhV2FPT0WU
8305C	NUPDdHU6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1XiOmlEPTB;MUiuOVMxPSEQvF2=	MVrTRW5ITVJ?
EM-2	NFLueWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2TKOGlEPTB;MUiuOlI1QCEQvF2=	Mom5V2FPT0WU
SNU-449	NYfSPZg2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXLVbnJxUUN3ME2xPE44OTVizszN	NX3qSWY1W0GQR1XS
A101D	M2S3[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVy2dYtrUUN3ME2xPU4zPDNizszN	MmHtV2FPT0WU
MHH-NB-11	NIPIUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFn1ZoFKSzVyPUG5MlU{PDJizszN	NUXhTIJwW0GQR1XS
Becker	M4fhdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIDLSGpKSzVyPUKwMlE4PzdizszN	M1zSR3NCVkeHUh?=
NCI-H727	NFXXTJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1\hWGlEPTB;MkCuNlE3QSEQvF2=	MVvTRW5ITVJ?
HCC1187	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTJyLkO1PFkh\|ryP	NEPlU2pUSU6JRWK=
KYSE-450	NUnKdmpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M16zSGlEPTB;MkGuOVM2PCEQvF2=	NFPYPVFUSU6JRWK=
SK-MEL-28	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NW\FU2Y6UUN3ME2yNU43QDZ\|IN88US=>	MXHTRW5ITVJ?
BPH-1	NFS3V25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MorCTWM2OD1{MT63NFM2KM7:TR?=	M1vxTnNCVkeHUh?=
EoL-1-	M3\jVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2HTeGlEPTB;MkGuPFM5PSEQvF2=	NFy0SXJUSU6JRWK=
TGBC24TKB	M1H5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1SwRWlEPTB;MkGuPFk2PyEQvF2=	M1mwWXNCVkeHUh?=
KARPAS-299	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2[4UGlEPTB;MkKuNVk2PCEQvF2=	M1PETXNCVkeHUh?=
SW684	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnzzTWM2OD1{Mj6yPFU5KM7:TR?=	MV7TRW5ITVJ?
RXF393	NGPz[GJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkjOTWM2OD1{Mj62NFY5KM7:TR?=	MUnTRW5ITVJ?
LS-513	MkHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGrSdHFKSzVyPUKyMlYyQTJizszN	M1zzVXNCVkeHUh?=
KURAMOCHI	NWfhW2xrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWrmSIZ3UUN3ME2yNk44ODZ7IN88US=>	Mnr4V2FPT0WU
GI-1	MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn\ETWM2OD1{Mj63PFQyKM7:TR?=	NY\iTlA5W0GQR1XS
M14	M{DhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUnJR\|UxRTJ\|LkGxN\|Ih\|ryP	NGnGXlFUSU6JRWK=
REH	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUPJR\|UxRTJ\|LkG2PVkh\|ryP	M{i5[XNCVkeHUh?=
K5	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlrkTWM2OD1{Mz61OFg3KM7:TR?=	NF\NV49USU6JRWK=
PANC-10-05	NFexemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX3JR\|UxRTJ2LkC4PVgh\|ryP	NXnOZ4NtW0GQR1XS
HMV-II	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnjXTWM2OD1{ND6yNVY{KM7:TR?=	MlvzV2FPT0WU
NCI-H1963	NVvPPWVKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnPGTWM2OD1{ND6yPFM6KM7:TR?=	MV;TRW5ITVJ?
LU-139	NWTa[YF3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVnsfZFVUUN3ME2yOE45OzVizszN	NUS0VYhJW0GQR1XS
KASUMI-1	MlPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWfJR\|UxRTJ2LkmzNlgh\|ryP	MWDTRW5ITVJ?
RO82-W-1	NU\jXWxHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVzJR\|UxRTJ4LkezO\|ch\|ryP	MWfTRW5ITVJ?
NCI-H1770	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4L5fmlEPTB;Mk[uPFk5PiEQvF2=	M2r2dnNCVkeHUh?=
SNG-M	M3fYb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXjJR\|UxRTJ5LkKyO\|Eh\|ryP	MX7TRW5ITVJ?
KLE	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHfGTnlKSzVyPUK3MlI2PjVizszN	MnLBV2FPT0WU
NCI-H2170	M4TI[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFfaWZRKSzVyPUK3MlUzQDJizszN	M3WxN3NCVkeHUh?=
COLO-792	M2PWdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEnjPFNKSzVyPUK3Mlc4OjhizszN	M{fsXHNCVkeHUh?=
ES8	MnvjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2LYXmlEPTB;MkeuO\|gyPCEQvF2=	Mn7UV2FPT0WU
MC-CAR	Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnfrTWM2OD1{Nz63PVA4KM7:TR?=	NIfqd3BUSU6JRWK=
SU-DHL-1	NI\qTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTJ5Lkm0O\|Qh\|ryP	M{fwNHNCVkeHUh?=
OAW-28	NGnVVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYnJR\|UxRTJ6LkCwOVIh\|ryP	M4HtN3NCVkeHUh?=
C32	NV\mPW9XT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHf0eZdKSzVyPUK4MlA5OjZizszN	NWLneGUxW0GQR1XS
SW872	NUnlT45XT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkXCTWM2OD1{OD61N\|I3KM7:TR?=	M3n6Z3NCVkeHUh?=
JiyoyeP-2003	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFfZfJdKSzVyPUK5MlY4OTlizszN	NYTPRpZxW0GQR1XS
A204	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2jzZmlEPTB;MkmuOlgzQCEQvF2=	MnO5V2FPT0WU
IST-MES1	MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2jVW2lEPTB;MkmuO\|A6OiEQvF2=	M3TMWnNCVkeHUh?=
LCLC-103H	NEfJTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXLZTpNpUUN3ME2zNE4zODV7IN88US=>	NFnLWZlUSU6JRWK=
CAKI-1	M2jFc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkTDTWM2OD1\|MD6yOlU3KM7:TR?=	MnPVV2FPT0WU
NALM-6	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnP2TWM2OD1\|MD60PVY2KM7:TR?=	MkjOV2FPT0WU
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MZ1-PC	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MY\JR\|UxRTl2LkW5PFQh\|ryP	MYXTRW5ITVJ?
MEL-JUSO	MnjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XsU2lEPTB;OUSuPVU1KM7:TR?=	NIHWTVBUSU6JRWK=
RMG-I	NYLUR\|FWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUfJR\|UxRTl3LkGwO\|Ih\|ryP	MWfTRW5ITVJ?
A2058	M1\jS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{DvfGlEPTB;OUWuOFYyPyEQvF2=	NH;LUGJUSU6JRWK=
Caov-4	MkjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFvCW5hKSzVyPUm1MlY5PSEQvF2=	M1zuWXNCVkeHUh?=
OS-RC-2	MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn:wTWM2OD17Nz60OlEh\|ryP	M33X[3NCVkeHUh?=
MKN7	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4n1[GlEPTB;OUeuO\|Q{QSEQvF2=	NUfhOlZvW0GQR1XS
U-698-M	NYrBeotRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYnJR\|UxRTl6Lkm0PFkh\|ryP	Moj5V2FPT0WU
PC-3	NUG2PGZQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEW1SINKSzVyPUm5MlA2PjRizszN	Moq4V2FPT0WU
NCI-H292	M4P4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnnJTWM2OD17OT6zNFA1KM7:TR?=	NHW0d3ZUSU6JRWK=
IGR-1	NVnmVVY2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFLGOWVKSzVyPUm5MlMyOTlizszN	NVXhdpY1W0GQR1XS
Mewo	NYW4e\|F4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUjJR\|UxRTl7LkW2NFMh\|ryP	MWfTRW5ITVJ?
LU-65	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkDzTWM2OD1zMEGuNFgyKM7:TR?=	NGHa[oJUSU6JRWK=
Saos-2	M1v1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHruNWNKSzVyPUGwNU41OzdizszN	MUXTRW5ITVJ?
TE-11	M37rOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NITuN2tKSzVyPUGwNU44OjRizszN	MVTTRW5ITVJ?
SK-MES-1	NVizSoU3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVfZUZlGUUN3ME2xNFEvPzZ{IN88US=>	NGK4VXBUSU6JRWK=
KE-37	Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFraUINKSzVyPUGwNk46PSEQvF2=	NWT1[otpW0GQR1XS
MKN45	NFvaV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF30cYNKSzVyPUGwN{42QDRizszN	NF;vSnJUSU6JRWK=
UM-UC-3	MmjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFuxdmFKSzVyPUGwN{45PDJizszN	MoniV2FPT0WU
SNU-C2B	NIflU4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYPJR\|UxRTFyNT6wNlMh\|ryP	MWHTRW5ITVJ?
RPMI-8226	M2PObGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoP1TWM2OD1zME[uOlc5KM7:TR?=	Ml;PV2FPT0WU
PANC-08-13	NHrZT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NULoXllTUUN3ME2xNFYvQDVizszN	NIfBOYhUSU6JRWK=
NCI-H23	NWnVTnVRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIWwT2lKSzVyPUGwPE4{PTdizszN	M13ZZnNCVkeHUh?=
HOP-92	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2nUWGlEPTB;MUC4MlQ4PSEQvF2=	MlvyV2FPT0WU
FTC-133	NV[1cGd6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmDGTWM2OD1zMEiuOFg5KM7:TR?=	NXXlcZh1W0GQR1XS
D-263MG	NWWwNlhmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWHweGt2UUN3ME2xNFgvQTZzIN88US=>	NIi0PHRUSU6JRWK=
DU-145	NEfpbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX3JR\|UxRTFyOT65OFUh\|ryP	NGTmPGlUSU6JRWK=
A253	NF;aXmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF;MVYdKSzVyPUGxNE41PzlizszN	NYixc\|dIW0GQR1XS
HCT-15	NYe0WWp[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF3aT3JKSzVyPUGxNE43PjFizszN	MVzTRW5ITVJ?
WSU-NHL	MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4HiS2lEPTB;MUGyMlAyKM7:TR?=	Mlq5V2FPT0WU
U031	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWnJR\|UxRTFzMj6wOlUh\|ryP	M{i0WnNCVkeHUh?=
MDA-MB-157	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGO3OVRKSzVyPUGxNk41QSEQvF2=	MnrKV2FPT0WU
NEC8	NWnXZZJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mo\XTWM2OD1zMUKuOlI1KM7:TR?=	NUOyTVhUW0GQR1XS
SIG-M5	MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWXvS2RKUUN3ME2xNVMvOTJ3IN88US=>	MV3TRW5ITVJ?
786-0	NFvZ[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHruN3lKSzVyPUGxN{41PTNizszN	MlnYV2FPT0WU
DMS-273	NHnEVopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1:zb2lEPTB;MUG1MlYyPyEQvF2=	MXzTRW5ITVJ?
Calu-6	M2TWO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmXWTWM2OD1zMU[uO\|k5KM7:TR?=	MkjVV2FPT0WU
HCC1599	NEO5fWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{XJ[mlEPTB;MUG3MlE2PiEQvF2=	NIjkR2NUSU6JRWK=
OVCAR-8	Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF7pTohKSzVyPUGxO{43PjhizszN	MnPWV2FPT0WU
ATN-1	M1v0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkL5TWM2OD1zMUeuPFI5KM7:TR?=	NFnlUYZUSU6JRWK=
RKO	NHvtbYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVTJR\|UxRTFzNz64PVgh\|ryP	NWjtVYpZW0GQR1XS
SKG-IIIa	Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF3sXm1KSzVyPUGxPE4yOTZizszN	M3\WcHNCVkeHUh?=
SUP-T1	MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmriTWM2OD1zMUiuPVU3KM7:TR?=	NHi2OG9USU6JRWK=
KNS-81-FD	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkPlTWM2OD1zMUmuOFE4KM7:TR?=	NWLWSG96W0GQR1XS
OVCAR-3	NYrBTHJGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn;sTWM2OD1zMUmuPVE2KM7:TR?=	MWHTRW5ITVJ?
NCI-N87	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoLNTWM2OD1zMkGuNFQ1KM7:TR?=	MWjTRW5ITVJ?
HuP-T4	MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEDtUmVKSzVyPUGyNU42PSEQvF2=	NVK1XWx{W0GQR1XS
KYSE-140	NEPoOoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWXUcIg3UUN3ME2xNlIvOTRzIN88US=>	M4ixUnNCVkeHUh?=
HAL-01	MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MULJR\|UxRTF{Mj60PVkh\|ryP	M{CwWHNCVkeHUh?=
HT-29	MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MorxTWM2OD1zMkKuO\|c5KM7:TR?=	NGqyUFdUSU6JRWK=
OPM-2	NGP2OGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHr5XIZKSzVyPUGyN{4yPzZizszN	MXXTRW5ITVJ?
SW1463	NVzEUIUzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mk\JTWM2OD1zMkSuNFc4KM7:TR?=	NHTKcHVUSU6JRWK=
NCI-H2087	M2PiWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYnDWXZyUUN3ME2xNlQvOjh\|IN88US=>	MnjsV2FPT0WU
UMC-11	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIHXc5VKSzVyPUGyOk4xOzhizszN	NYroeGxJW0GQR1XS
EB-3	MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYHJR\|UxRTF{Nz6wNVMh\|ryP	NEe0bmtUSU6JRWK=
HEC-1	NGfxUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIG5clFKSzVyPUGyPU4yQThizszN	Ml7sV2FPT0WU
LU-99A	NEn2bYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGjDfIlKSzVyPUGyPU46OzFizszN	NHvzXJJUSU6JRWK=
VMRC-RCZ	NVnkSG5vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlzBTWM2OD1zM{CuN\|c2KM7:TR?=	NYG1d5NHW0GQR1XS
MFH-ino	NICw[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3\CUGlEPTB;MUOxMlEyPCEQvF2=	MXTTRW5ITVJ?
HT-1080	NUPqZ5RpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUPJR\|UxRTF\|Mj6yNFQh\|ryP	M4rPT3NCVkeHUh?=
CTB-1	NWfRTYtsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mm\PTWM2OD1zM{KuPFk4KM7:TR?=	MYXTRW5ITVJ?
Capan-2	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXzJR\|UxRTF\|Mz65O\|Uh\|ryP	NG\CelZUSU6JRWK=
BB30-HNC	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGP2WmZKSzVyPUGzOE4yOTZizszN	MYDTRW5ITVJ?
CP50-MEL-B	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{[4WmlEPTB;MUO0MlIh\|ryP	MlrCV2FPT0WU
JEG-3	M{fOTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NILCWJZKSzVyPUGzOE4{PTlizszN	MVPTRW5ITVJ?
NCI-H1437	NIi2O2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlPXTWM2OD1zM{SuOVkh\|ryP	NGnTVmlUSU6JRWK=
NOS-1	M4TUcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFTw[pBKSzVyPUGzOE44PjVizszN	Mn\oV2FPT0WU
G-402	NIHCU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHq2OGtKSzVyPUGzOU4zQTVizszN	MUPTRW5ITVJ?
OAW-42	NFX5W21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYi0d3dFUUN3ME2xN\|cvQDV4IN88US=>	MXvTRW5ITVJ?
Ca-Ski	NVH6TGpCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NI\UWlJKSzVyPUGzPE45OzFizszN	MYLTRW5ITVJ?
BHT-101	NIKwOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3rqcGlEPTB;MUSwMlIxQCEQvF2=	MlXvV2FPT0WU
OVCAR-4	M3n6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWfucYsyUUN3ME2xOFAvPzR7IN88US=>	NYCwTY04W0GQR1XS
Detroit562	NWHWeYZNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVrJR\|UxRTF2MT60OlYh\|ryP	NV3DW4pRW0GQR1XS
OCI-AML2	NVrSVGl3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnHmTWM2OD1zNEGuOVA4KM7:TR?=	NV3VN2xTW0GQR1XS
OE33	MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVLQd4RsUUN3ME2xOFEvPzl6IN88US=>	MXPTRW5ITVJ?
YKG-1	NXPBfnpST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX7OeolwUUN3ME2xOFIvQDh7IN88US=>	NWLDd3RVW0GQR1XS
CCF-STTG1	NIHnd2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnPaTWM2OD1zNEOuN\|M1KM7:TR?=	MWXTRW5ITVJ?
NCI-H810	M3TQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFHRW3ZKSzVyPUG0N{43QDdizszN	M4jCOHNCVkeHUh?=
SCC-25	M{OwRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWfIU2F{UUN3ME2xOFQvODB3IN88US=>	M{DXdnNCVkeHUh?=
HTC-C3	MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mle4TWM2OD1zNEWuNFc2KM7:TR?=	MWXTRW5ITVJ?
G-401	MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYfJR\|UxRTF2NT64N\|Uh\|ryP	M{[xVnNCVkeHUh?=
OMC-1	NGG2XHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV7XT5dTUUN3ME2xOFUvQTZ5IN88US=>	M33HT3NCVkeHUh?=
LK-2	M2jTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV3JR\|UxRTF2Nz6xOFMh\|ryP	Mnn3V2FPT0WU
SW13	M3joZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1PWO2lEPTB;MUS3MlI2OyEQvF2=	M3zsV3NCVkeHUh?=
BB49-HNC	M4nSdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIPGeZRKSzVyPUG0O{41ODRizszN	NVjDV3czW0GQR1XS
DMS-114	NETRXo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2jjdmlEPTB;MUS3MlQ1OSEQvF2=	M3PoWnNCVkeHUh?=
GCIY	NHXtfZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4\wemlEPTB;MUS3Mlc6PyEQvF2=	MXvTRW5ITVJ?
GAMG	M2C1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4[xO2lEPTB;MUS4MlI1PyEQvF2=	M{P1WnNCVkeHUh?=
KYSE-520	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUS2fJluUUN3ME2xOFgvPTRizszN	M4\PSHNCVkeHUh?=
LB647-SCLC	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVvNZYJZUUN3ME2xOFgvPTZ{IN88US=>	NWPlZWdPW0GQR1XS
639-V	NGXKSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTF2OD63NFUh\|ryP	MWfTRW5ITVJ?
TE-9	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTF2OT60OFMh\|ryP	MlL4V2FPT0WU
Caov-3	MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mny0TWM2OD1zNEmuO\|E1KM7:TR?=	M1j2cnNCVkeHUh?=
L-540	M3:5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlrJTWM2OD1zNEmuO\|Uh\|ryP	MoTQV2FPT0WU
NCI-H748	NVnYS2Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{nHdmlEPTB;MUWwMlIxQSEQvF2=	NHviNZRUSU6JRWK=
GDM-1	NUXYOI1bT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVPh[3FTUUN3ME2xOVEvOTN3IN88US=>	M2fkUnNCVkeHUh?=
GAK	NGnxbmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnWzTWM2OD1zNUGuN\|c1KM7:TR?=	NIDHWXBUSU6JRWK=
AsPC-1	NGG4emhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Moq3TWM2OD1zNUKuO\|Y1KM7:TR?=	NFrhcVNUSU6JRWK=
MDA-MB-361	M{jIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoT0TWM2OD1zNUOuNVY1KM7:TR?=	MX7TRW5ITVJ?
TT	NH;3XIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX;JR\|UxRTF3Mz60PUDPxE1?	MnvTV2FPT0WU
Calu-1	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DHfmlEPTB;MUW0MlAxOyEQvF2=	NE\KdnZUSU6JRWK=
RERF-LC-MS	NUD0SmRYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHvIdmFKSzVyPUG1OE44PzJizszN	M1r6cXNCVkeHUh?=
DK-MG	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{Sy[WlEPTB;MUW1MlE5OyEQvF2=	NGTDUFVUSU6JRWK=
CAL-120	NFzKbGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV;uZ2ZpUUN3ME2xOVUvQDJzIN88US=>	NVe3VmRWW0GQR1XS
HCC1419	M2\tfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVLB[FNKUUN3ME2xOVYvODd5IN88US=>	M{ny[3NCVkeHUh?=
DG-75	MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmC2TWM2OD1zNU[uOlk1KM7:TR?=	M3vhfHNCVkeHUh?=
HCC38	NULIV3RtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2PNdWlEPTB;MUW3MlM3QSEQvF2=	M1rKfnNCVkeHUh?=
HCC70	NYrDUlF7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3PvVmlEPTB;MUW5MlI1OiEQvF2=	NELEOZJUSU6JRWK=
ES4	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXjnbpd1UUN3ME2xOVkvOzl4IN88US=>	NHL2OYxUSU6JRWK=
NCI-H2052	NVKyRll{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFSwPGlKSzVyPUG1PU42QDNizszN	MlKzV2FPT0WU
EFO-27	MljDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXj5dpM4UUN3ME2xOlAvPTh2IN88US=>	Mlj4V2FPT0WU
CAL-62	NG\wTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkDNTWM2OD1zNkKuOlE{KM7:TR?=	MXXTRW5ITVJ?
CHP-212	NHP4VJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4jUXWlEPTB;MU[zMlYzPiEQvF2=	NHX3NGlUSU6JRWK=
AU565	NFi3W21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3TTb2lEPTB;MU[zMlY1KM7:TR?=	M3zPe3NCVkeHUh?=
Ca9-22	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MW\JR\|UxRTF4ND6zNlEh\|ryP	M2nEWHNCVkeHUh?=
EFO-21	NWTNc5lrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NID5fWJKSzVyPUG2OU41PSEQvF2=	M1\DUnNCVkeHUh?=
KINGS-1	MkfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWTJR\|UxRTF4Nz6zOVQh\|ryP	MY\TRW5ITVJ?
JVM-2	NH\EZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlHNTWM2OD1zNkeuOFUyKM7:TR?=	MVfTRW5ITVJ?
OVCAR-5	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1LGfmlEPTB;MU[4MlMxQSEQvF2=	NVrMb5poW0GQR1XS
Calu-3	NU\qVG5CT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGXsWHFKSzVyPUG2PE4{OTFizszN	M3PLWnNCVkeHUh?=
CP66-MEL	NIfuT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnfwTWM2OD1zNkiuOFE2KM7:TR?=	MV\TRW5ITVJ?
KYSE-150	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYj2emRqUUN3ME2xOlkvPjN4IN88US=>	M1vTeXNCVkeHUh?=
Daoy	NF72RVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3vNN2lEPTB;MU[5Mlg6OSEQvF2=	MVLTRW5ITVJ?
HUTU-80	MlPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWnJR\|UxRTF5MT6wN\|Ih\|ryP	M{nlZXNCVkeHUh?=
SW620	NGfneoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWDxW5VUUUN3ME2xO\|EvPTN3IN88US=>	NYXL[2RGW0GQR1XS
HuO-3N1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWfJR\|UxRTF5Mj6yO\|Mh\|ryP	NI\2VHBUSU6JRWK=
HH	M3jQPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mk\MTWM2OD1zN{OuPFQ5KM7:TR?=	MYLTRW5ITVJ?
ME-180	NUfIdoZCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlnUTWM2OD1zN{SuNFE3KM7:TR?=	M17idHNCVkeHUh?=
SW756	NVK4PHcyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUjJR\|UxRTF5ND64OlMh\|ryP	NHj5TGRUSU6JRWK=
LNCaP-Clone-FGC	MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3fT[mlEPTB;MUe1Mlg3OSEQvF2=	M4LsN3NCVkeHUh?=
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EW-3	M2[yVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXHJR\|UxRTF5Nj61OVUh\|ryP	NYnNOVdyW0GQR1XS
COLO-741	NVLSdJk1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{flT2lEPTB;MUe3MlU3OSEQvF2=	NYPT[\|RbW0GQR1XS
SK-NEP-1	Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmXWTWM2OD1zN{euPFA3KM7:TR?=	MVTTRW5ITVJ?
NB10	NFnTUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVrJR\|UxRTF5Nz64OFYh\|ryP	MUjTRW5ITVJ?
SF126	MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlnaTWM2OD1zN{muOFMzKM7:TR?=	NX;oZ5pGW0GQR1XS
NCI-H522	M{nSWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXf4fpZ{UUN3ME2xPFEvODV7IN88US=>	MoTmV2FPT0WU
PSN1	NEL5bZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVWyelBvUUN3ME2xPFEvPjZizszN	MkLLV2FPT0WU
GI-ME-N	NUTwfpdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIjReXpKSzVyPUG4NU43PzJizszN	MlG5V2FPT0WU
SBC-5	NHvwTYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NY\mZ5R6UUN3ME2xPFEvQTN2IN88US=>	MXzTRW5ITVJ?
ONS-76	NU\EclRTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4X1W2lEPTB;MUiyMlM5PyEQvF2=	NWOydGNZW0GQR1XS
LOUCY	MonWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVnyNpdVUUN3ME2xPFIvPjh6IN88US=>	NImwPY5USU6JRWK=
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A427	M2HQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTF6ND62N\|Eh\|ryP	NXOy[HY1W0GQR1XS
DOK	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV7JR\|UxRTF6ND62OFMh\|ryP	MVHTRW5ITVJ?
MDA-MB-415	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3L6cmlEPTB;MUi0MlY2OSEQvF2=	Ml34V2FPT0WU
MRK-nu-1	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1fY[mlEPTB;MUi0Mlk4OiEQvF2=	Mn;6V2FPT0WU
LB2241-RCC	M2r6Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmjmTWM2OD1zOEWuNVQ2KM7:TR?=	M3u3cXNCVkeHUh?=
NCI-H1563	MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHTGbGdKSzVyPUG4OU4zODlizszN	MYXTRW5ITVJ?
MDA-MB-453	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXzJXIpjUUN3ME2xPFYvQTRzIN88US=>	NEjXSXNUSU6JRWK=
MONO-MAC-6	MmPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTF6Nz6zPVIh\|ryP	M{LJ[3NCVkeHUh?=
CAPAN-1	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX7pb5ZRUUN3ME2xPFcvPDV\|IN88US=>	MXXTRW5ITVJ?
SK-LU-1	NX74RW1HT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml;xTWM2OD1zOEiuOFI5KM7:TR?=	Ml3mV2FPT0WU
NCI-H1299	NGXuVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NY\UZ3lzUUN3ME2xPFgvPzF7IN88US=>	M3\JSXNCVkeHUh?=
KG-1	MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWfJR\|UxRTF6OT63PVgh\|ryP	MYfTRW5ITVJ?
ETK-1	NYTleYNVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlLjTWM2OD1zOUCuNVgyKM7:TR?=	M3u3b3NCVkeHUh?=
NCI-H838	MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlXJTWM2OD1zOUCuN\|Qh\|ryP	NIrCSZJUSU6JRWK=
HCE-4	MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYnNb3VkUUN3ME2xPVAvQTl{IN88US=>	Ml7wV2FPT0WU
A2780	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIXVbZRKSzVyPUG5Nk45QTFizszN	NXPyfXdyW0GQR1XS
COLO-668	NEXEbIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYrJR\|UxRTF7Mz6xOVch\|ryP	NEH1XnVUSU6JRWK=
HGC-27	NEnENodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2D4c2lEPTB;MUm1MlU{QCEQvF2=	MVPTRW5ITVJ?
SW1088	MnPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGS4[4NKSzVyPUG5OU43PzdizszN	MVvTRW5ITVJ?
KOSC-2	MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIXIR4tKSzVyPUG5OU45OThizszN	MUnTRW5ITVJ?
TE-1	MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkXhTWM2OD1zOU[uNlYh\|ryP	MoXnV2FPT0WU
SW780	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXrpboV3UUN3ME2xPVYvPzN2IN88US=>	NUPuUmxyW0GQR1XS
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IA-LM	M{\hd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXTJR\|UxRTF7Nz64NlIh\|ryP	NUjrVHl4W0GQR1XS
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JVM-3	M4nMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFHBcnZKSzVyPUG5PE41OTlizszN	NX7xVYpPW0GQR1XS
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QIMR-WIL	M2TDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2ryWGlEPTB;MkCwMlEyPiEQvF2=	NYXoeYw3W0GQR1XS
SJRH30	NHOwVo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mm[2TWM2OD1{MECuOVE2KM7:TR?=	MlnNV2FPT0WU
COLO-679	NHOwfYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH3ve5VKSzVyPUKwNE45PTlizszN	NUPkWYl7W0GQR1XS
MDA-MB-231	NHXVTlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXXJR\|UxRTJyMD65NFIh\|ryP	NVPxTmJkW0GQR1XS
MFM-223	NXTqfZN6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX;JR\|UxRTJyMT61PFch\|ryP	MULTRW5ITVJ?
MFE-280	M{fwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVvJR\|UxRTJyMT65OlEh\|ryP	MUTTRW5ITVJ?
LAMA-84	NEHrcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlvPTWM2OD1{MEKuNFc{KM7:TR?=	NELm[IRUSU6JRWK=
LS-1034	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkfiTWM2OD1{MEKuOVU{KM7:TR?=	MVXTRW5ITVJ?
NCI-H345	M1\NS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmPvTWM2OD1{MEOuNFI4KM7:TR?=	M17vVHNCVkeHUh?=
KYSE-70	NGTGR4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH7kSnNKSzVyPUKwN{45PzlizszN	NG\mZnRUSU6JRWK=
EGI-1	Ml7uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3rPNGlEPTB;MkC0Mlg{OyEQvF2=	MlfQV2FPT0WU
RPMI-2650	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVzJR\|UxRTJyNT60Olch\|ryP	MXPTRW5ITVJ?
NCI-H1651	M2nEd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUTJR\|UxRTJyNj63N{DPxE1?	NUT2[VgzW0GQR1XS
HPAF-II	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{C3dmlEPTB;MkC5MlY4OSEQvF2=	MkDUV2FPT0WU
NUGC-3	M3H4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYXJR\|UxRTJyOT62O\|gh\|ryP	NF7FWVRUSU6JRWK=
DJM-1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUHJR\|UxRTJyOT64PVch\|ryP	NV7ITnlTW0GQR1XS
MHH-PREB-1	NULwS3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUfQXY9vUUN3ME2yNVAvOzhzIN88US=>	NHrrTZpUSU6JRWK=
EW-18	M1T4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWrOfm1iUUN3ME2yNVAvPzZ\|IN88US=>	NWHnNHd7W0GQR1XS
BT-20	MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NU\scZA3UUN3ME2yNVAvQTh4IN88US=>	MUfTRW5ITVJ?
A431	NEnmXHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3;kcWlEPTB;MkGxMlI6QSEQvF2=	Mn3tV2FPT0WU
TCCSUP	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mkj5TWM2OD1{MUGuOVM{KM7:TR?=	NYPZRY5ZW0GQR1XS
HO-1-N-1	MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnPsTWM2OD1{MUKuPFk1KM7:TR?=	MoW5V2FPT0WU
NCI-H69	Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1;ubmlEPTB;MkG0MlE5PSEQvF2=	NIq1fpRUSU6JRWK=
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UACC-257	MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFnYfopKSzVyPUKxO{41OyEQvF2=	MUfTRW5ITVJ?
DMS-153	NELqV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEfpfFVKSzVyPUKxO{45OzZizszN	M2XQW3NCVkeHUh?=
LB771-HNC	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTJzNz64PVMh\|ryP	MULTRW5ITVJ?
HOS	NGW1ZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWnJR\|UxRTJzOD65JO69VQ>?	MkXMV2FPT0WU
THP-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnjQTWM2OD1{MUmuOlA3KM7:TR?=	MW\TRW5ITVJ?
SCC-4	NYfW[Yo5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXPTVoxnUUN3ME2yNlAvOzV\|IN88US=>	MVHTRW5ITVJ?
SCC-3	NWTPZlEzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX7UXVdPUUN3ME2yNlAvPTd5IN88US=>	NVn6R28xW0GQR1XS
BC-1	M3fUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1u2N2lEPTB;MkKwMlc6QSEQvF2=	NHvOT2ZUSU6JRWK=
NCI-H1618	M3HGXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{TZdmlEPTB;MkKxMlAyQCEQvF2=	NWC3TpRKW0GQR1XS
CaR-1	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NETqS4lKSzVyPUKyNU4zPTFizszN	NYTpWHB2W0GQR1XS
NCI-H1355	NYPpdZhUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlHwTWM2OD1{MkGuN\|c4KM7:TR?=	NHfxS\|dUSU6JRWK=
NCI-H1993	M1SxSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIOyb2tKSzVyPUKyNk4zOzlizszN	NWLlRnhxW0GQR1XS
NCI-H1623	NU\leoE1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIrVUJlKSzVyPUKyNk4{QDlizszN	MYnTRW5ITVJ?
AGS	NWXx[YpvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUnIblZjUUN3ME2yNlIvPTJ\|IN88US=>	NIX0cphUSU6JRWK=
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HCC1937	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkH2TWM2OD1{MkSuN\|g6KM7:TR?=	NHLZbplUSU6JRWK=
NCI-H209	Mn;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX3JR\|UxRTJ{Nj61N{DPxE1?	NF;3bFVUSU6JRWK=
NCI-H322M	MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV3PXHU2UUN3ME2yNlgvODF7IN88US=>	MoHKV2FPT0WU
CHL-1	M2Tw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX\uPFNyUUN3ME2yNlgvOTNizszN	MVfTRW5ITVJ?
NCI-H630	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEXUNotKSzVyPUKzNk45QTdizszN	NEHndW5USU6JRWK=
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MSTO-211H	M{HHfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYnJR\|UxRTJ\|Mz6yO\|Yh\|ryP	NXP3TFI2W0GQR1XS
YAPC	NH7pUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3;CVWlEPTB;MkO0MlI2OyEQvF2=	Mmj6V2FPT0WU
SW1783	NIHKc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPw[IhEUUN3ME2yN\|QvPDFizszN	NV[yOXcxW0GQR1XS
GB-1	M17kVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml7zTWM2OD1{M{WuNVc4KM7:TR?=	NG\TNm9USU6JRWK=
NCI-H520	NUGzOm1vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWfJR\|UxRTJ\|NT63OFEh\|ryP	NX;KWVhJW0GQR1XS
NOMO-1	M3:4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn\iTWM2OD1{M{[uNFIh\|ryP	MonKV2FPT0WU
NCCIT	NUH4d2lyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYqxc24{UUN3ME2yN\|YvQDd\|IN88US=>	MWPTRW5ITVJ?
SW954	NYjiRYdXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn7CTWM2OD1{M{euPFY5KM7:TR?=	MmPUV2FPT0WU
MOLT-4	NYnlTY1sT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmHMTWM2OD1{NEGuNlA6KM7:TR?=	M2HsUXNCVkeHUh?=
EB2	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXHy[2d6UUN3ME2yOFEvQTB5IN88US=>	MmnMV2FPT0WU
IPC-298	M2DXdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFXMW2NKSzVyPUK0Nk4xPzJizszN	MUHTRW5ITVJ?
GP5d	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1PNNGlEPTB;MkSyMlYyPiEQvF2=	NHvIUFhUSU6JRWK=
HN	NWDK[lhsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn30TWM2OD1{NEKuPVkyKM7:TR?=	MXrTRW5ITVJ?
BFTC-909	MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIO0WHhKSzVyPUK0N{4yOThizszN	NHzjXGdUSU6JRWK=
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SK-HEP-1	MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mlr5TWM2OD1{NE[uNFQ{KM7:TR?=	NGjkeWRUSU6JRWK=
T47D	MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn:1TWM2OD1{NEeuNFE{KM7:TR?=	NIL5UVJUSU6JRWK=
KYSE-510	NUDRXJR4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXzJR\|UxRTJ2Nz61NVch\|ryP	Mn34V2FPT0WU
LC-1F	M2nyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3;5dWlEPTB;MkS4MlE2PiEQvF2=	NUPiblJEW0GQR1XS
NCI-H1693	MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1HpUWlEPTB;MkS5MlQ6PSEQvF2=	MXXTRW5ITVJ?
COR-L23	NH;DZmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUHteoN6UUN3ME2yOVAvPDF{IN88US=>	MYLTRW5ITVJ?
NCI-H2228	M2rMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYOwU4tEUUN3ME2yOVAvQDZ2IN88US=>	NV3qVpB6W0GQR1XS
NCI-H460	M4e0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVTSVGI4UUN3ME2yOVEvPDF5IN88US=>	MmXiV2FPT0WU
TGBC1TKB	Mlj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGXV[mFKSzVyPUK1Nk45PzVizszN	NVHSeJBKW0GQR1XS
NCI-H1304	Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2rnZWlEPTB;MkWzMlE2PiEQvF2=	Mm\BV2FPT0WU
CAL-27	M3Tsfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEDVdlRKSzVyPUK1N{41QDVizszN	MXPTRW5ITVJ?
NCI-H187	MmPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnK4TWM2OD1{NU[uO\|Yh\|ryP	M{X2S3NCVkeHUh?=
HSC-2	NXrtRnE2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NI\JWJRKSzVyPUK1PE42QDRizszN	NX3hTJZlW0GQR1XS
CAL-39	NVPXemdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnrTTWM2OD1{NkCuNlczKM7:TR?=	Mmr6V2FPT0WU
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VA-ES-BJ	M1fJVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MX7JR\|UxRTJ4MT65NVgh\|ryP	NYPSenc4W0GQR1XS
A673	MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlzyTWM2OD1{NkeuNFI2KM7:TR?=	NG[1SIJUSU6JRWK=
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CAL-12T	NV;QRW9iT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3zxOmlEPTB;Mk[4MlM3PiEQvF2=	M4XZOXNCVkeHUh?=
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MDA-MB-468	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXvJR\|UxRTJ4OT6zN\|Mh\|ryP	MVLTRW5ITVJ?
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MHH-CALL-2	M1rCdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYL1NYpPUUN3ME2yOlkvQTJizszN	M2XzWXNCVkeHUh?=
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BEN	NWnE[lU1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmDFTWM2OD1{N{[uOFYyKM7:TR?=	MWnTRW5ITVJ?
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CAMA-1	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUjJR\|UxRTJ5OD6yO\|kh\|ryP	MnL6V2FPT0WU
NCI-H1792	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NE[3fWpKSzVyPUK3PU4yQDdizszN	M3mwdHNCVkeHUh?=
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TGW	MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGjneGVKSzVyPUK4N{4xPThizszN	M2XPRnNCVkeHUh?=
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NCI-H2009	MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mk\sTWM2OD1{OEOuPVU{KM7:TR?=	M1vjS3NCVkeHUh?=
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EW-7	NFnuPJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTJ6NT6yN\|Ih\|ryP	NGf3cXhUSU6JRWK=
NCI-H1882	Mo\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVvzZXVnUUN3ME2yPFYvODN3IN88US=>	M2HrVHNCVkeHUh?=
GMS-10	M17pdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnnWTWM2OD1{OEeuNVg{KM7:TR?=	NIHiSXRUSU6JRWK=
HC-1	M1X5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHvXOHRKSzVyPUK5NE43ODJizszN	MonqV2FPT0WU
ABC-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYjnSlZYUUN3ME2yPVEvODZ7IN88US=>	MYDTRW5ITVJ?
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HT-1197	NYHER5RUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnrwTWM2OD1{OUKuPFc6KM7:TR?=	NFXrN45USU6JRWK=
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NCI-H524	MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4LKZmlEPTB;Mkm1Mlc3QSEQvF2=	NXjMPHNWW0GQR1XS
SW626	NXG4RnZkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn7QTWM2OD1{OU[uNVE2KM7:TR?=	MWLTRW5ITVJ?
NCI-H2347	MmPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYnSNmduUUN3ME2yPVYvPDJ3IN88US=>	MlP5V2FPT0WU
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RL95-2	NGHjfZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2rMbWlEPTB;M{CwMlI1PyEQvF2=	MX3TRW5ITVJ?
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HLE	NIHDRnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFnWN25KSzVyPUOwNU45OThizszN	MonWV2FPT0WU
COLO-680N	M3riOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWrCVlFWUUN3ME2zNFIvQDl\|IN88US=>	M{TWUHNCVkeHUh?=
PLC-PRF-5	M33VW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEjkZYNKSzVyPUOwOE46ODdizszN	NHixNXBUSU6JRWK=
SCC-15	Ml;MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFy1W4RKSzVyPUOwOk4xOTdizszN	NIDQWlZUSU6JRWK=
ECC12	M1;o[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEPSZnlKSzVyPUOxNE4zPTRizszN	MkW5V2FPT0WU
A388	MkS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUfJR\|UxRTNzMj6wNlIh\|ryP	M1PIc3NCVkeHUh?=
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CAL-51	MnzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2mxd2lEPTB;M{KxMlQxOyEQvF2=	MnH0V2FPT0WU
HD-MY-Z	NHPGZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFrCVZFKSzVyPUOyNU41ODlizszN	MWrTRW5ITVJ?
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SK-MEL-24	Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUHJR\|UxRTN{ND6xNVEh\|ryP	M37zNnNCVkeHUh?=
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NCI-H1522	NUDNTnpKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M122NmlEPTB;M{O0MlM{QSEQvF2=	NVrEdY9GW0GQR1XS
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LAN-6	MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWLJR\|UxRTN\|Nj65O\|ch\|ryP	NEfZWJdUSU6JRWK=
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NCI-H441	Mn;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXTJR\|UxRTN2MT60NVgh\|ryP	NXrObFZ7W0GQR1XS
NCI-H2030	M2TZdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXfJR\|UxRTN2MT62NFkh\|ryP	MmTFV2FPT0WU
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CAL-54	M1\vSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn\pTWM2OD1\|NEWuPFc6KM7:TR?=	NXXaWJFRW0GQR1XS
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NCI-H720	NE\jXlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1vm[WlEPTB;M{S5Mlg1PiEQvF2=	MoDCV2FPT0WU
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NCI-H1838	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVfJR\|UxRTN3OT65PFch\|ryP	NY[3TWl4W0GQR1XS
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COR-L88	M3PQV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYL1XJRLUUN3ME2zPFMvPjd5IN88US=>	NVK1SVFUW0GQR1XS
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NCI-H719	Ml74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkW1TWM2OD1\|OUGuPFk{KM7:TR?=	NFftSFlUSU6JRWK=
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MES-SA	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3nXdWlEPTB;NEC5Mlk5KM7:TR?=	NGPHb\|JUSU6JRWK=
NCI-H716	NGXaZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWXM[G5UUUN3ME20NVAvODd3IN88US=>	NVXJXGg1W0GQR1XS
GR-ST	M4HuTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUi5ZZo3UUN3ME20NVAvPDl5IN88US=>	NVXpVI1KW0GQR1XS
KY821	NXnpd3hbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnvzTWM2OD12MUSuNFg3KM7:TR?=	NEDWT5hUSU6JRWK=
NCI-H2141	NV\CcHN3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUHIUmhQUUN3ME20NlQvOzh6IN88US=>	MYDTRW5ITVJ?
MDA-MB-134-VI	M{DyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWPJR\|UxRTR\|MT6wN\|Mh\|ryP	NFrTbmRUSU6JRWK=
RH-1	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUjJR\|UxRTR\|NT6wPUDPxE1?	NWDYb\|dnW0GQR1XS
AM-38	MonCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIq5UW9KSzVyPUSzPE42PCEQvF2=	MoT5V2FPT0WU
BL-70	M3X0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{\PNmlEPTB;NEO5MlQzQSEQvF2=	Ml\sV2FPT0WU
COLO-684	M3zXd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVfJR\|UxRTR2OD64PFgh\|ryP	NYPRfVNlW0GQR1XS
DMS-79	NEH3XmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUfJR\|UxRTR2OT62PEDPxE1?	MYLTRW5ITVJ?
EW-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3vZUGlEPTB;NEWyMlg5QCEQvF2=	M1\hSnNCVkeHUh?=
MS-1	Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnfmTWM2OD12NUSuN\|g2KM7:TR?=	NULsb4JjW0GQR1XS
A4-Fuk	NWO5boxPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3XpOGlEPTB;NEW0MlUxPyEQvF2=	NHTDdlFUSU6JRWK=
TALL-1	NEW2PXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4j0XGlEPTB;NEW1MlI6PyEQvF2=	MmHTV2FPT0WU
SCLC-21H	NELxW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mlm5TWM2OD12NUWuOlk6KM7:TR?=	NE\sTmhUSU6JRWK=
KMS-12-PE	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWHjbphXUUN3ME20OVYvQDJ{IN88US=>	NEny[GxUSU6JRWK=
TE-441-T	MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYDPXG1XUUN3ME20OVcvOTh4IN88US=>	M{TveXNCVkeHUh?=
A3-KAW	Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVjJR\|UxRTR4MD64OFEh\|ryP	M2\zSHNCVkeHUh?=
NCI-H1092	M2rYU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{DYOmlEPTB;NE[zMlk1OyEQvF2=	NFLHe45USU6JRWK=
COR-L279	NVn2N3JTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYCwfoNbUUN3ME20OlQvQDR5IN88US=>	NGTIRXhUSU6JRWK=
NCI-SNU-5	Ml;3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2juZWlEPTB;NEeyMlI5KM7:TR?=	M1v0T3NCVkeHUh?=
JAR	MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUDJR\|UxRTR5ND63PFgh\|ryP	NV\wPHpDW0GQR1XS
NCI-H446	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3m5UGlEPTB;NEe3MlA5KM7:TR?=	NUK0eIZmW0GQR1XS
HDLM-2	M4nVWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NE\PRXpKSzVyPUS4NE45PjlizszN	NWq1OHNYW0GQR1XS
D-283MED	NITYNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYrWOFlQUUN3ME20PFgvQTJ2IN88US=>	MVHTRW5ITVJ?
NCI-H1395	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mmj1TWM2OD12OEmuNFA1KM7:TR?=	MmXiV2FPT0WU
RPMI-6666	NV\PWoxTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnHJTWM2OD12OUGuN\|k5KM7:TR?=	MWXTRW5ITVJ?
CPC-N	NXn4ZpdFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV3JR\|UxRTVyMj6wOlMh\|ryP	NY\nZW01W0GQR1XS
EC-GI-10	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVzHOnJ4UUN3ME21NFIvOTZ7IN88US=>	NILvOYhUSU6JRWK=
CA46	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4LMOWlEPTB;NUC0MlQxPyEQvF2=	NXO5eZBWW0GQR1XS
EHEB	NUDhbmVsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHjnT3RKSzVyPUWwO{4zODhizszN	MmTuV2FPT0WU
RPMI-8402	MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVPXW3luUUN3ME21NVAvODJzIN88US=>	MXnTRW5ITVJ?
DU-4475	NHnuS\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmS5TWM2OD13MUGuNVAyKM7:TR?=	NH\DdGpUSU6JRWK=
P12-ICHIKAWA	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYfOdVl6UUN3ME21NVEvPDF4IN88US=>	MlTFV2FPT0WU
NCI-H1694	MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHy0SZhKSzVyPUWxNk41OzlizszN	M3vj[nNCVkeHUh?=
NCI-H2171	M2OxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2f4XWlEPTB;NUGyMlcxPSEQvF2=	NXzLcIpKW0GQR1XS
Mo-T	M4DsNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYDJR\|UxRTVzNT6xNVYh\|ryP	NUL2eHN[W0GQR1XS
HL-60	MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmXVTWM2OD13MkKuPVI1KM7:TR?=	NIjSRllUSU6JRWK=
NCI-H1436	M1H6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXnJR\|UxRTV{Mz6wOlQh\|ryP	NYDHZ5Z{W0GQR1XS
NCI-H510A	M3XHeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{T6TmlEPTB;NUK0MlY6PiEQvF2=	MYLTRW5ITVJ?
NCI-H2081	NGTCdHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mmn4TWM2OD13MkWuOVE{KM7:TR?=	NHX3cIRUSU6JRWK=
NB5	NETvcpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn7vTWM2OD13Mk[uOFMh\|ryP	M2niWnNCVkeHUh?=
NCI-H2227	NGnH[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3XNPWlEPTB;NUOwMlI2PCEQvF2=	MXXTRW5ITVJ?
HSC-4	M2fHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWX2O3M3UUN3ME21N\|kvOjl\|IN88US=>	MYnTRW5ITVJ?
RL	M3PMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVfJR\|UxRTV2Mj60OFIh\|ryP	M4DaRXNCVkeHUh?=
EVSA-T	NFvmO2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFSyZmpKSzVyPUW0N{43QDRizszN	NUW3[25OW0GQR1XS
NCI-H889	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn\rTWM2OD13NEeuNlMh\|ryP	NGrnO\|FUSU6JRWK=
COLO-320-HSR	NE\6dm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUWzbllEUUN3ME21OVEvOzVizszN	MUnTRW5ITVJ?
EW-11	NHLQNVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4XVVGlEPTB;NUWyMlM6QSEQvF2=	M2qwfXNCVkeHUh?=
UACC-812	NFXiemtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIC5XVdKSzVyPUW1PU4{QTFizszN	NH;PW5ZUSU6JRWK=
CAL-148	M{\2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVf3UY5NUUN3ME21OlUvODh7IN88US=>	NWW1N5d{W0GQR1XS
K052	NFXPUWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEKxVXRKSzVyPUW3PU4zOTNizszN	NFzUeJdUSU6JRWK=
L-428	MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVqyOYptUUN3ME22NFAvPjdzIN88US=>	M3HFfXNCVkeHUh?=
LP-1	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2\JfGlEPTB;NkCzMlU5PyEQvF2=	M3;Y[HNCVkeHUh?=
ML-2	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmPWTWM2OD14ME[uOVc6KM7:TR?=	M4SyT3NCVkeHUh?=
KARPAS-45	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWDLU5hyUUN3ME22NVgvOjJzIN88US=>	NIDLc\|JUSU6JRWK=
HT	M{XB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGTzZphKSzVyPU[yNk44QDVizszN	NXzv[GsyW0GQR1XS
NCI-H226	M4ftdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXPJR\|UxRTZ{OD6zOVMh\|ryP	MnfoV2FPT0WU
L-363	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWrJR\|UxRTZ2OD6wOlQh\|ryP	MmDXV2FPT0WU
IM-9	NY\FdYFVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4Pnd2lEPTB;NkWxMlU1OSEQvF2=	MXXTRW5ITVJ?
TUR	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWnBO\|g5UUN3ME22O\|EvOzJ{IN88US=>	NXW3RoIxW0GQR1XS
NCI-SNU-16	NV3PbnhTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXPJR\|UxRTZ6MD60OlIh\|ryP	M4nhcXNCVkeHUh?=
NCI-SNU-1	MoKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NE\tdJZKSzVyPU[5NE4yPzJizszN	MnfBV2FPT0WU
U-87-MG	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVnJR\|UxRTZ7ND61PFUh\|ryP	NYnKUY11W0GQR1XS
KM-H2	Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFfjd5lKSzVyPU[5PU4xPTlizszN	NXT4fZc4W0GQR1XS
DEL	NFW3TG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2DEcWlEPTB;N{CwMlg{QCEQvF2=	M1v6OHNCVkeHUh?=
KARPAS-422	NGTwNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXr1[IZ4UUN3ME23PFkvOzF3IN88US=>	NFnXTYVUSU6JRWK=
BC-3	NVnvVY9yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{fuSGlEPTB;OEC1MlIxOyEQvF2=	Mn;GV2FPT0WU
NCI-H1155	MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkTXTWM2OD16MUiuNFU6KM7:TR?=	NH3sZ3VUSU6JRWK=
NCI-H1581	M2XqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NInYd2ZKSzVyPUmwNE4zOzFizszN	NGn0Wo9USU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo

Oral administration of CHIR-99021 at 30 mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR-99021 at 16 or 48 mg/kg 1 hour before oral glucose challenges in ZDF rats significantly improves glucose tolerance with 14% and 33% reduction in plasma glucose at 16 mg/kg and 48 mg/kg, respectively, and the higher dose of CHIR-99021 also reduces hyperglycemia before the oral glucose challenge. ^[1] Administration of CHIR-99021 significantly augments hematopoietic repopulation in recipient mice transplanted with mouse or human hematopoietic stem cells (HSCs), suggesting that GSK-3 is a specific modulator of HSC activity. ^[4]

Protocol

Kinase Assay: ^[1]	+ Expand Cell-free kinase assays: Polypropylene 96-well plates are filled with 300 μL/well buffer (50 mM tris HCl, 10 mM MgCl₂, 1 mM EGTA, 1 mM dithiothreitol, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) containing 27 nM GSK-3α or 29 nM GSK-3β, and 0.5 μM biotin-CREB peptide substrate. Various concentrations of CHIR-99021 are added in 3.5 μL of DMSO, followed by 50 μL of ATP stock to yield a final concentration of 1 μM ATP in all cell-free assays. After incubation, triplicate 100-μL aliquots are transferred to Combiplate eight plates containing 100 μL/well 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with PBS, filled with 200 μL of scintillation fluid, sealed, left 30 minutes, and counted in a scintillation counter. All steps are performed at room temperature.
Cell Research: ^[3]	+ Expand Cell lines: INS-1E Concentrations: Dissolved in DMSO, final concentrations ~ 20 μM Incubation Time: 1, or 4 days Method: Cells are maintained for 24 hours in starvation medium (culture medium with only 5 mM glucose, 1% fetal calf serum). Then cells are exposed to various concentrations of CHIR-99021 for 1, or 4 days. Cell number is measured by staining of cellular DNA with CyQuant dye, which becomes fluorescent when bound to DNA. Fluorescence is measured after 30 minutes of incubation using the FLUOstar Optima reader. Cell replication is determined by BrdUrd incorporation. BrdUrd labeling solution is added to the medium for the last 4 hours before the cells are fixed using FixDenat solution and incubated with monoclonal anti-BrdUrd-POD antibodies. After substrate solution is added to each well, the light emission is measured in a microplate luminometer using the Analyst HT detection system. (Only for Reference)
Animal Research: ^[1]	+ Expand Animal Models: Female db/db mice or male ZDF rats with type 2 diabetes Formulation: Formulated as solutions in 20 mM citrate-buffered 15% Captisol or as fine suspensions in 0.5% carboxymethylcellulose. Dosages: ~48 mg/kg Administration: Orally (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL (185.33 mM)
	Ethanol	2 mg/mL (3.98 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	24mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Molecular Weight	501.8
Formula	C₂₂H₁₈Cl₂N_8.HCl
CAS No.	1797989-42-4
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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C1=C0/X	C1:	LOG(C1):
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C3=C2/X	C3:	LOG(C3):
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C8=C7/X	C8:	LOG(C8):

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?
Answer:
The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.
Question 2:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
Answer:
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
Question 3:
What is the difference between S2924 and S1263? Which one is better for differentiation?
Answer:
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Selective GSK-3 Inhibitor

TWS119 : GSK-3β-selective, IC50 of 30 nM.
Most Potent GSK-3 Inhibitor

CHIR-98014 : GSK-3α, IC50=0.65 nM; GSK-3β, IC50=0.58 nM.
GSK-3 Inhibitor in Clinical Trial

Tideglusib : Phase II for Alzheimer's disease.
Newest GSK-3 Inhibitor

AZD1080 : Orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively.

Related GSK-3 Products4

CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
LY2090314 ^New

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
TDZD-8 ^New

TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
TWS119

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology.
SB216763

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.
Tideglusib

Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
CHIR-98014

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
BIO

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.

Features:The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.
AR-A014418

AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and K_i of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
IM-12

IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

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CHIR-99021 (CT99021) HCl

Cited by 74 Publications

9 Customer Reviews

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

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Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products4

Choose Your Country or Region

By Signaling Pathways

By product type

CHIR-99021 (CT99021) HCl

Cited by 74 Publications

9 Customer Reviews

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)