CHIR-99021 (CT99021) HCl

Catalog No.S2924

Molecular Weight(MW): 501.8

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.

Cited by 73 Publications

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University of GOTHENBURG, 2014, 5495

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Bachelor of Science, 2012, East China Normal University

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9 Customer Reviews

Differentiation induced by treatment with the Gsk3 inhibitor in hPSCs is β-catenin dependent. H9-7TGP cells were treated with 12 uM CH in mTeSR1 for 4 d. Immunofluorescent staining for Oct4, Isl1, and Nkx2.5 was compared with GFP expression. (Scale bars, 50 uM.)

Proc Natl Acad Sci U S A 2012 109(27):E1848-57. CHIR-99021 (CT99021) HCl purchased from Selleck.

Gpc4 regulates ESC response to Wnt/β-catenin signaling. (E) Quantitative analysis of control and Gpc4-mutant beating foci exposed to the GSK3 inhibitor, CHIR 99021 (1 and 3 μM, from day 0 to day 5). Analysis was done at different time points. Gpc4- mutant cells treated with CHIR 99021 behave as controls (mean±SEM; n=2).

Stem Cells 2012 30, 1863-1874. CHIR-99021 (CT99021) HCl purchased from Selleck.
Characterization of rES cells. A: image of normal rES cell colonies on feeder layers. B: rES colonies were positive for AP staining. CeE: rES colonies readily expressed pluripotent markers, Sox2 (C), Oct4 (D), and SSEA-1 (E). Blue, DAPI. Scale bars: 100 um.

J Genet Genomics 2012 39, 643e651. CHIR-99021 (CT99021) HCl purchased from Selleck.

Inhibition of GSK3 activity induces an autophagic response in human pancreatic cancer cells. PANC1 cells were treated for 24 h with DMSO, CHIR99021 (CHIR; 5 uM) or the mTOR inhibitor Torin1 (250 nM). Autophagosome (punctate LC3B) (D) and lysosome (E) labeling was visualized with a Zeiss LSM700 confocal microscope. Images were acquired with a 20x (D) or 63x (E) objective. Nuclei were stained with DAPI. Scale bars, 20 祄.

J Biol Chem 2015 290(9), 5592-605 . CHIR-99021 (CT99021) HCl purchased from Selleck.
A. Vero cells were pretreated with the indicated concentrations of CHIR-99021 for 1 h and then infected with PEDV (MOI = 1) for 8 or 10 h. Cell lysates were prepared and analyzed using Western blotting.

PLoS One, 2016, 11(8):e0161508. CHIR-99021 (CT99021) HCl purchased from Selleck.

Smad linker phosphorylation involves GSK3 in human melanoma lines. Inhibition of Smad2 and Smad3 linker phosphorylation in the presence of the specific GSK3 specific inhibitor, CT99021. 24 hours post seeding, WM793 and 1205LU cells were serum-starved for about 16 hours, and incubated in the absence (2) or presence (+) of 2 uM of CT99021 for two hours. Immunoblots were performed as in A. p: Phosphorylated. S: Serine; T: Threonine.

PLoS One 2012 7, e47312. CHIR-99021 (CT99021) HCl purchased from Selleck.
SKOV3/DDP cells were treated with a range of concentration of (A) CHIR-99021 or in combination with 20 µM cisplatin for 48 h.

Exp Ther Med, 2016, 12(6):3851-3858. CHIR-99021 (CT99021) HCl purchased from Selleck.

PANC1 cells were treated with GSK3 inhibitors SB216763 (SB 10µM or SB 20µM) or CHIR99021 (CHIR 5µM) for 72h.

CHIR-99021 (CT99021) HCl purchased from Selleck.
Activity of canonical WNT/ β -CATENIN signals induced by CHIR 99021 in the developing human lung. Human lung tissue explants obtained at 15 weeks of gestation were exposed to 0, 5 and 10 μM CHIR 99021 in vitro for 72 h. (A-B) Western blot analysis showed expression of β -CATENIN in human lung tissues. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (C) qRT-PCR analysis detected a dose-dependent increase in WNT signaling transcription factors and target genes following exposure to CHIR 99021. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (D-K) Histology examination showed obvious morphogenetic changes of the airway epithelial cells associated with CHIR 99021 treated lung tubes. Scale bars: D-G =100 μm; H-K = 20 μm.

CHIR-99021 (CT99021) HCl purchased from Selleck.

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Description

Targets

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

In vitro

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. ^[1] In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). ^[2] Unlike lithium chloride and AR-A014418, CHIR-99021 treatment does not reduce the viability of INS-1E cells even at high concentrations. Instead, CHIR-99021 robustly increases the rate of proliferation of INS-1E cells in a dose-dependent manner, and significantly inhibits INS-E cell death induced by high glucose and high palmitate in a concentration-dependent manner. CHIR-99021 promotes primary beta cell replication in isolated rat islets at concentrations as low as 1 μM, with 2-3 fold increase of cell replication at 5 μM of CHIR-99021 treatment. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3-L1	MYTGeY5kfGmxbjDBd5NigQ>?	MUCzJO69VQ>?	NIOzRZc1KGh?	MVXEUXNQ	NYG0XJdFUW6qaXLpeJMheHKnYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdg>?	NIPrRpMyOjB3NUKwNC=>
insulin receptor–expressing CHO-IR	NXGwbFVWTnWwY4Tpc44hSXO\|YYm=	M1jkfFUxOCCwTR?=	NUfBdIhbOzBibXnu	Mkj0SG1UVw>?	MXLBZ5RqfmG2ZYOgS4x6[2:pZX6gV5lvfGijc3WgLGdUMQ>?	NFz5cHUyOjZyNkS5Oy=>
H4IIE	NGHhTVFHfW6ldHnvckBCe3OjeR?=	Ml7aNVAh\|ryP	NHzIZXUzPCCq	NHTzUGhFVVOR	M4j4bHJm\3WuYYTld{DPui2lYYTlcolvKGGldHn2bZR6KGGwZDDUTXJGKGOxboThbY5qdmdicILvcY91\XJiYXP0bZZqfHl?	MoO5NVU{PTBzOUW=
Oct4/Sox2/Klf4-infected MEFs	MUPGeY5kfGmxbjDBd5NigQ>?	NU\3bJlMOTBizszN	MnvuNlgh\A>?	M1fVdGROW09?	MUHQdo9ud3SnczDNSWZ{KHKncILv[5JidW2rbnegWJJidnOmdXPl[EBjgSCRY4S0MEBUd3h{LDDhcoQhU2yoNB?=	MoPiNVk5OzlyNUW=
Sca-1+ HPC	M2jTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NULhW294OiEQvF2=	MmDaOkBl	NVq1S\|NLTE2VTx?=	MWrTfY5memerc4TpZ4FtdHlicILvcY91\XNiU3PhMVEsyqCKUFOgdJJwdGmoZYLheIlwdiCjbnSgZ49td267IH\vdo1ifGmxbjD0c4dmfGincjD3bZRpKEWJRh?=	NHK3SGozOTZ{NEO0PC=>
HMC1.2	MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M4fPPVMxKM7:TR?=	NHXEXoI4OiCq	MWHEUXNQ	M3fTeHJm\HWlZYOgZ4VtdCC\|dYL2bZZidA>?	MWeyNlA{QTNyMR?=
Endothelial cell(EC)	NXzQTGluTnWwY4Tpc44hSXO\|YYm=	Ml3mN{DPxE1?		MmHLSG1UVw>?	M3TDXXBzd22xdHXzJIVv\G:2aHXsbYFtKGOnbHygLGVEMSCmaX\m[ZJmdnSrYYTpc44>	NIryeJAzOjB3MkCwOi=>
PANC1	MkXFRZBweHSxc3nzJGF{e2G7	M4r3[uKhPSEQvF2=	NYLT[2VFPzJiaB?=	NVzKZ\|lKTE2VTx?=	NU\xVFV6XHKrZ3fldpMh[W5iYYDvdJRwfGmlIILld5BwdnOn	MXuyNlIxOTF6Nh?=
INS-1E	MUDGeY5kfGmxbjDBd5NigQ>?	MmK0Nk42KM7:TR?=	NWjidWhHOjRiaB?=	MlewSG1UVw>?	MUXJcoR2[2W\|IHGgdoVlfWO2aX;uJI9nKE6SMTDveoVz\XiycnXzd4lwdg>?	MljoNlI1Ojd5MES=
hiPSC-NPs	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWfCOo9MO+LCid88US=>	Mn34O\|IhcA>?	NGXPSGFFVVOR	NX\2PGlRUW6lcnXhd4V{KGOnbHygdJJwdGmoZYLheIlwdsLi	M1TPZ\|IzPjR{Nki3
platelets	NXXUfVNTTnWwY4Tpc44hSXO\|YYm=	MlP3NVAh\|ryP	MnTDNVUhdWmw	NUXLUFg4TE2VTx?=	MlXHTY5kemWjc3XzJJRpem:vYnnuMY1m\GmjdHXkJJBt[XSnbHX0JIFo\3KnZ3H0bY9vKGGwZDDBWHAhe2WlcnX0bY9v	MV2yN\|I{QTh5Nx?=
DN3	M3;XSmZ2dmO2aX;uJGF{e2G7	NFTyNWIyOCEQvF2=	MnzoPVYhcA>?	NUWwdIg3TE2VTx?=	M2jIS2lv[3KnYYPld{Bk\WyuIHTleoVtd3CvZX70JIFv\CCycn;sbYZmemG2aX;u	NEfremEzOzV{Nkm4PS=>
embryonic stem cells (ESC)	Mn7uSpVv[3Srb36gRZN{[Xl?	MXqzJOK2VQ>?	MlzTNVEh\A>?	NVf0fpVOTE2VTx?=	M{PtWnBzd22xdHXzJJNmdGZvcnXu[ZdidCCxZjDuZeOwfmVvdInw[UBud3W\|ZTDlcYJzgW:waXOgd5RmdSClZXzsd{ApTVOFKR?=	M1jrOVI{QDR\|M{Gy
H460	MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	Mn3hOUDDvU1?	M1rFe\|I1KGh?	M4LTNWROW09?	NULmbGRtWHKxbX;0[ZMh[2WubDDwdo9tcW[ncnH0bY9v	MYWyOFM3PzZ6OB?=
H157	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M3\EOlUhyrWP	NU\aSpNrOjRiaB?=	NHH5N\|NFVVOR	MUnQdo9ud3SnczDj[YxtKHC{b3zp[oVz[XSrb36=	NUTt[nhFOjR\|Nke2PFg>
H460	NVfhN3RISXCxcITvd4l{KEG\|c3H5	MoPSOUDDvU1?	NWPXWldbOjRiaB?=	M4XlOmROW09?	MmrNRZR1\W63YYTld{Bk\WyuIHHwc5B1d3Orcx?=	NHvZPFczPDN4N{[4PC=>
H157	MnLmRZBweHSxc3nzJGF{e2G7	NVLOeFI2PSEEtV2=	NU\v[lRCOjRiaB?=	MXvEUXNQ	MmrLSI9meyCwb4Sgd4lodmmoaXPhcpRtgSCjZn\lZ5Qh[XCxcITvd4l{	M4DCTVI1OzZ5Nki4
A549	M4\6U2Fxd3C2b4Ppd{BCe3OjeR?=	NGDlblI2KML3TR?=	MkC3NlQhcA>?	MU\EUXNQ	MXHJcoNz\WG\|ZYOgZ4VtdCCjcH;weI9{cXN?	Mn;CNlQ{Pjd4OEi=
Neural progenitor cells	NVvzbItkTnWwY4Tpc44hSXO\|YYm=	NX:1fpY4OyEQvF2=	NVzrZVk6OTBiZB?=	M3f1cWROW09?	Moe3TY5lfWOnczDn[Y5memG2aX;uJI9nKG6ndYLhcEBxem:pZX7peI9zKGOnbHzz	Mn\UNlQ3OzhyM{S=
ES-D3	M{Dt[GN6fG:2b4jpZ{BCe3OjeR?=	MVixNOKh\|ryP	NYTke4RvOyCm	M2PGPWROW09?	MoPhTY5lfWOnczDtc4RmemG2ZTDjfZRwfG:6aXPpeJkhf2m2aDDJR\|UxKG:oIESuPUDPxE1?	MkLUNlQ4Pzl\|NkW=
ES-CCE	MYfDfZRwfG:6aXOgRZN{[Xl?	NXH6bFBOOTEEoN88US=>	MojUN{Bl	NWL1cZlETE2VTx?=	NF3Rbm9KdmS3Y3XzJI1w\GW{YYTlJIN6fG:2b4jpZ4l1gQ>?	MmDzNlQ4Pzl\|NkW=
ES-D3	M2LjfGZ2dmO2aX;uJGF{e2G7	M2rVT\|XDqM7:TR?=	NXLHfYtFOyCm	NIDkTmJFVVOR	M3GyVHN1em:wZ3z5JIlv\HWlZYOgeIhmKGGldHn2bZR6KG:oIGfueE9j\XSjLXPheIVvcW5icHH0bJdigQ>?	MU[yOFc4QTN4NR?=
ES-CCE	M{niZmZ2dmO2aX;uJGF{e2G7	MmD5OeKh\|ryP	NVezTYZtOyCm	M1vjeWROW09?	Ml3mV5Rzd26pbImgbY5lfWOnczD0bIUh[WO2aY\peJkhd2ZiV370M4JmfGFvY3H0[Y5qdiCyYYToe4F6	NF70cVMzPDd5OUO2OS=>
SW982	NVjm[JVZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmP4TWM2OD1yLkKxOFE3KM7:TR?=	NH34[IZUSU6JRWK=
GCT	NHXnbHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV;JR\|UxRTBwM{C2O\|Ih\|ryP	MYHTRW5ITVJ?
769-P	MmHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEHyOIdKSzVyPUCuOVg1QTlizszN	NIfSSFJUSU6JRWK=
LOXIMVI	MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXXIfHpCUUN3ME2wMlU5QDN{IN88US=>	M{LNU3NCVkeHUh?=
D-336MG	M1TGUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MU\JR\|UxRTBwOES2NkDPxE1?	MVvTRW5ITVJ?
S-117	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVzJR\|UxRTBwOUKxN\|Eh\|ryP	NF7wVllUSU6JRWK=
D-247MG	NF3jOJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYHUbYtkUUN3ME2wMlk1QDV{IN88US=>	NEm3XGFUSU6JRWK=
TYK-nu	NI\Kc4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXy5U2VlUUN3ME2xMlA4QTF{IN88US=>	MYrTRW5ITVJ?
A498	NVrBNZhFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NED2ZWxKSzVyPUGuN\|A1PjlizszN	NV[yb4lVW0GQR1XS
BCPAP	NV3JdJR{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF3QXmFKSzVyPUGuOlY5QThizszN	MY\TRW5ITVJ?
KYSE-180	M3LYbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoXuTWM2OD1zLkeyO\|g5KM7:TR?=	NHTsO\|dUSU6JRWK=
MIA-PaCa-2	NHvKXWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVfJR\|UxRTFwN{W5O\|ch\|ryP	MXzTRW5ITVJ?
HCC1395	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkjNTWM2OD1zLke4Nlc{KM7:TR?=	M17qd3NCVkeHUh?=
RS4-11	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX\JR\|UxRTFwOUW0NVUh\|ryP	M{XaTHNCVkeHUh?=
NCI-H2122	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoXkTWM2OD1{LkK3Olg1KM7:TR?=	MnnxV2FPT0WU
SNU-423	MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2\GeWlEPTB;Mj60PVc5PyEQvF2=	MlrDV2FPT0WU
SK-LMS-1	Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2nKUGlEPTB;Mj62OFEzQCEQvF2=	NGThdnJUSU6JRWK=
RPMI-7951	NUTZT4o6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2XaTGlEPTB;Mj63NFE6OyEQvF2=	MWPTRW5ITVJ?
COLO-829	MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFK2bVJKSzVyPUKuO\|Y2PCEQvF2=	M2\sTHNCVkeHUh?=
SCC-9	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWLJR\|UxRTJwOUW0PFUh\|ryP	M{L3dXNCVkeHUh?=
A704	M{Kw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4HzbmlEPTB;Mz6wPFEzKM7:TR?=	M{frenNCVkeHUh?=
HOP-62	Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{TJfGlEPTB;Mz6zOlA2PCEQvF2=	M1jM[HNCVkeHUh?=
HCC1569	MoS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXXJR\|UxRTNwNEizNFUh\|ryP	MVvTRW5ITVJ?
A172	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3TXPGlEPTB;Mz63OVQ6QCEQvF2=	NH31TJdUSU6JRWK=
MOLT-16	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVO2cG5{UUN3ME2zMlg5PTV4IN88US=>	NIfxdoxUSU6JRWK=
TE-15	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1fFXGlEPTB;Mz65OVM1OyEQvF2=	M1rZfXNCVkeHUh?=
OE19	Mlz6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnixTWM2OD1\|Lkm2OFUyKM7:TR?=	MlzuV2FPT0WU
MHH-ES-1	M1O4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{KwPWlEPTB;ND6wOFU1PSEQvF2=	NWOwTGRlW0GQR1XS
NKM-1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1GxRmlEPTB;ND6xN\|k4OSEQvF2=	NInNRmhUSU6JRWK=
RCC10RGB	NHXXTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXzJR\|UxRTRwMkm0O\|kh\|ryP	MVfTRW5ITVJ?
BxPC-3	M3;wWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;hTWM2OD12LkewN\|kyKM7:TR?=	MV;TRW5ITVJ?
ALL-PO	NX\ITIlnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4LCPWlEPTB;ND64N\|g2QCEQvF2=	MYLTRW5ITVJ?
SK-OV-3	NHTCUFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4LlemlEPTB;ND65PVM1KM7:TR?=	M1nZeHNCVkeHUh?=
SW1710	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXXJR\|UxRTVwNEK0OVYh\|ryP	MmXOV2FPT0WU
NCI-H2452	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmH3TWM2OD13LkS1OlI5KM7:TR?=	MW\TRW5ITVJ?
D-392MG	NVfTVlRTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3rOPWlEPTB;NT60PVE1PSEQvF2=	NEfkZplUSU6JRWK=
LB2518-MEL	M{fpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4DCU2lEPTB;NT63NlYzPyEQvF2=	MWPTRW5ITVJ?
BL-41	Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUPJR\|UxRTVwOEGyOlYh\|ryP	MXPTRW5ITVJ?
WM-115	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVj0PWRDUUN3ME21MlgyPTB7IN88US=>	M2\XOHNCVkeHUh?=
SK-MEL-2	M4LybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUT4V2lHUUN3ME22MlM5OzR2IN88US=>	M2rycnNCVkeHUh?=
CGTH-W-1	M1fvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGnZTY9KSzVyPU[uOFE4KM7:TR?=	MUjTRW5ITVJ?
BB65-RCC	MlLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MU\JR\|UxRTZwNUOxPVUh\|ryP	M4rsfXNCVkeHUh?=
CAL-85-1	Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXTJR\|UxRTZwNkC5N\|Yh\|ryP	MVzTRW5ITVJ?
RT-112	NY\YUYRWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M13xdGlEPTB;Nz6xOlQ2PiEQvF2=	MnvOV2FPT0WU
MC116	M2rTPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3fsOWlEPTB;Nz6yPFY6OSEQvF2=	M1nBS3NCVkeHUh?=
G-361	M{DYNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGi5RY5KSzVyPUeuOFY2PjFizszN	NGLVNFJUSU6JRWK=
SW1417	NH3YWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3nwcWlEPTB;Nz62OFU5PCEQvF2=	M2Pk[HNCVkeHUh?=
MV-4-11	MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{X2W2lEPTB;OD61OFMxPCEQvF2=	NFnLO2NUSU6JRWK=
CAL-72	MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3fq[GlEPTB;OD63OlEyOyEQvF2=	NH:2TnVUSU6JRWK=
MKN28	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXrJR\|UxRThwOEi1NVYh\|ryP	NY\uSpFEW0GQR1XS
MEG-01	M3LTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHXFOFFKSzVyPUiuPVkxPDNizszN	NF7YRVVUSU6JRWK=
ACHN	M2f2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoS0TWM2OD17LkOwOVQ3KM7:TR?=	MXXTRW5ITVJ?
NCI-H1755	NUTzTphTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoDCTWM2OD17LkO5PVg3KM7:TR?=	MoL3V2FPT0WU
NCI-H64	M{fNbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGDsbXJKSzVyPUmuOFIzPTVizszN	M3XyVnNCVkeHUh?=
COLO-205	NETuU4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHjXOXhKSzVyPUmuOFM5OjFizszN	NG[2S21USU6JRWK=
CTV-1	NWr5TVhXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXjJR\|UxRTlwNEO4PVQh\|ryP	NYTMWXd1W0GQR1XS
U-2-OS	M1foW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXnJR\|UxRTlwNEWwNFYh\|ryP	M2C1e3NCVkeHUh?=
LB996-RCC	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlfqTWM2OD17LkWyN\|k4KM7:TR?=	NXjVWGU4W0GQR1XS
SK-N-DZ	NYnWdIZDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnjyTWM2OD17Lk[1O\|QzKM7:TR?=	NGrlZ41USU6JRWK=
EFM-19	MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2\xfGlEPTB;OT63OVU3PiEQvF2=	MUPTRW5ITVJ?
DBTRG-05MG	NEX4T2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF3h[o5KSzVyPUmuO\|c4PyEQvF2=	NInLS4pUSU6JRWK=
U-118-MG	NEjTO\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MofkTWM2OD17Lkm0OFQ1KM7:TR?=	M17hR3NCVkeHUh?=
LB1047-RCC	M{eySmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXvJR\|UxRTlwOUm3PVgh\|ryP	M3PUXnNCVkeHUh?=
NCI-H28	MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVrJR\|UxRTFyLkS0NVMh\|ryP	Mlr6V2FPT0WU
MZ2-MEL	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHLtWYNKSzVyPUGwMlQ3PzdizszN	MVHTRW5ITVJ?
M059J	NVnxbZNCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV\JR\|UxRTFyLk[xNFIh\|ryP	MkjIV2FPT0WU
HT-3	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHq3XXpKSzVyPUGwMlYyPzlizszN	NES0NYFUSU6JRWK=
SNU-387	Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUHuc2RUUUN3ME2xNE44OjN3IN88US=>	M2HnWXNCVkeHUh?=
NCI-H526	M4P3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoXVTWM2OD1zMT6xN\|Y2KM7:TR?=	NF7xSmRUSU6JRWK=
HEL	NXu5VWhoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NETJe2VKSzVyPUGxMlY2PzlizszN	MkHjV2FPT0WU
PA-1	NHvzc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWHMepBxUUN3ME2xNU46OyEQvF2=	MornV2FPT0WU
PC-14	MmTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX74doZzUUN3ME2xNk4{OjRizszN	MWTTRW5ITVJ?
C8166	M{HEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWTJR\|UxRTF\|LkKzNVgh\|ryP	Mk\pV2FPT0WU
NCI-H82	NIKxc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NITJPIdKSzVyPUGzMlI6ODlizszN	MnezV2FPT0WU
DSH1	NET2Oo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3\pSGlEPTB;MUOuN\|g4QSEQvF2=	MorsV2FPT0WU
T98G	NXLWS2tnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF36NHpKSzVyPUGzMlQ4OTdizszN	NF;nbYJUSU6JRWK=
KU812	NUXWOXBrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYPJR\|UxRTF\|LkWxO\|Uh\|ryP	Ml\HV2FPT0WU
SW48	MoDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVLWcIxDUUN3ME2xN{44OjZ3IN88US=>	M1vJOHNCVkeHUh?=
MEL-HO	M2XvTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHTVVpdKSzVyPUGzMlg5OjlizszN	M3XqRnNCVkeHUh?=
SF539	NGizZXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWHJR\|UxRTF2LkCxNVYh\|ryP	NUjYO5h6W0GQR1XS
NB1	Mn;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVrJR\|UxRTF2LkG5N\|Uh\|ryP	NFXHXpNUSU6JRWK=
ST486	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXnxUI15UUN3ME2xOE4zOjVzIN88US=>	NX;1W2NvW0GQR1XS
LoVo	NIHrNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn\jTWM2OD1zNT6yOlU6KM7:TR?=	NWe0RY9LW0GQR1XS
NH-12	NFvjRYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEi1blhKSzVyPUG2MlAxQTdizszN	NUXBcGVbW0GQR1XS
CCRF-CEM	NUXCXFgxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFnZclVKSzVyPUG2MlY4ODJizszN	M3jlenNCVkeHUh?=
Daudi	NYjqRnFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEjneGxKSzVyPUG3MlYyPDlizszN	MVLTRW5ITVJ?
SIMA	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{\zXGlEPTB;MUeuPVEyQCEQvF2=	M1W2TnNCVkeHUh?=
8305C	MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV;ZUZAxUUN3ME2xPE42OzB3IN88US=>	Mlq1V2FPT0WU
EM-2	NUjQcm9jT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3\nSGlEPTB;MUiuOlI1QCEQvF2=	M4fiPXNCVkeHUh?=
SNU-449	NXvxeZFIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3r0[2lEPTB;MUiuO\|E2KM7:TR?=	MV7TRW5ITVJ?
A101D	NIT4eGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTF7LkK0N{DPxE1?	NELTSnVUSU6JRWK=
MHH-NB-11	M1fIZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NU[0cJFiUUN3ME2xPU42OzR{IN88US=>	MV\TRW5ITVJ?
Becker	M4HWTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M17DXGlEPTB;MkCuNVc4PyEQvF2=	MV7TRW5ITVJ?
NCI-H727	Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXWybW97UUN3ME2yNE4zOTZ7IN88US=>	M3mybHNCVkeHUh?=
HCC1187	NUjKNZYyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoDnTWM2OD1{MD6zOVg6KM7:TR?=	M4DOdnNCVkeHUh?=
KYSE-450	M4TPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEj4RYpKSzVyPUKxMlU{PTRizszN	MkTjV2FPT0WU
SK-MEL-28	MnuyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MojETWM2OD1{MT62PFY{KM7:TR?=	NXzmXplkW0GQR1XS
BPH-1	NFeyNWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoTTTWM2OD1{MT63NFM2KM7:TR?=	MXvTRW5ITVJ?
EoL-1-	NH3tRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkDiTWM2OD1{MT64N\|g2KM7:TR?=	MWLTRW5ITVJ?
TGBC24TKB	NV3aV4NpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWPyRnRGUUN3ME2yNU45QTV5IN88US=>	MVLTRW5ITVJ?
KARPAS-299	NGLiOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUm5UJJvUUN3ME2yNk4yQTV2IN88US=>	MWfTRW5ITVJ?
SW684	NWq3[Fc{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUDmeWVoUUN3ME2yNk4zQDV6IN88US=>	NVHmdlNwW0GQR1XS
RXF393	M4rHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlzYTWM2OD1{Mj62NFY5KM7:TR?=	MnTHV2FPT0WU
LS-513	M{jIfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnvnTWM2OD1{Mj62NVkzKM7:TR?=	MkjOV2FPT0WU
KURAMOCHI	NV3qPI1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml:3TWM2OD1{Mj63NFY6KM7:TR?=	MnLzV2FPT0WU
GI-1	MoLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2\4OWlEPTB;MkKuO\|g1OSEQvF2=	M1flcnNCVkeHUh?=
M14	Mk\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEfVR5ZKSzVyPUKzMlEyOzJizszN	NH3sUm9USU6JRWK=
REH	NGfLTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MULJR\|UxRTJ\|LkG2PVkh\|ryP	NIW3ZpFUSU6JRWK=
K5	NIryZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXXobmQzUUN3ME2yN{42PDh4IN88US=>	NGLyVo9USU6JRWK=
PANC-10-05	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkGwTWM2OD1{ND6wPFk5KM7:TR?=	Ml7XV2FPT0WU
HMV-II	MmnFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF;ldoZKSzVyPUK0MlIyPjNizszN	MmC2V2FPT0WU
NCI-H1963	M3TmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MW\JR\|UxRTJ2LkK4N\|kh\|ryP	M{TRbnNCVkeHUh?=
LU-139	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlPQTWM2OD1{ND64N\|Uh\|ryP	Mn76V2FPT0WU
KASUMI-1	NEDXNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUfJR\|UxRTJ2LkmzNlgh\|ryP	M1HKeXNCVkeHUh?=
RO82-W-1	NYSzbZNYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFvYXlZKSzVyPUK2Mlc{PzdizszN	MW\TRW5ITVJ?
NCI-H1770	M2HPO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NETFW3VKSzVyPUK2Mlg6QDZizszN	M4XUNHNCVkeHUh?=
SNG-M	NVHDT3lOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVXES5BNUUN3ME2yO{4zOjdzIN88US=>	MVTTRW5ITVJ?
KLE	M{\sU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rvW2lEPTB;MkeuNlU3PSEQvF2=	M1TLTXNCVkeHUh?=
NCI-H2170	M1ywU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4jwT2lEPTB;MkeuOVI5OiEQvF2=	NIjxdnpUSU6JRWK=
COLO-792	NUTxfnNuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmjkTWM2OD1{Nz63O\|I5KM7:TR?=	MWTTRW5ITVJ?
ES8	M3T4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmCxTWM2OD1{Nz63PFE1KM7:TR?=	MlXjV2FPT0WU
MC-CAR	NVj3d3p5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3L5dGlEPTB;MkeuO\|kxPyEQvF2=	MXrTRW5ITVJ?
SU-DHL-1	NW\tbHJCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF;XfIFKSzVyPUK3Mlk1PzRizszN	NHvZeW1USU6JRWK=
OAW-28	MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MW\JR\|UxRTJ6LkCwOVIh\|ryP	MWnTRW5ITVJ?
C32	Mn\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NW\xfopqUUN3ME2yPE4xQDJ4IN88US=>	MVTTRW5ITVJ?
SW872	MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHvRcIVKSzVyPUK4MlU{OjZizszN	M2SzW3NCVkeHUh?=
JiyoyeP-2003	MmrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlvPTWM2OD1{OT62O\|E6KM7:TR?=	NFHkSmJUSU6JRWK=
A204	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml21TWM2OD1{OT62PFI5KM7:TR?=	M1;qTHNCVkeHUh?=
IST-MES1	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4n6d2lEPTB;MkmuO\|A6OiEQvF2=	NHu5U5hUSU6JRWK=
LCLC-103H	MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGLoc4pKSzVyPUOwMlIxPTlizszN	M3\4WnNCVkeHUh?=
CAKI-1	Mn3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnPITWM2OD1\|MD6yOlU3KM7:TR?=	NYnJZlZNW0GQR1XS
NALM-6	MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYO3SIVSUUN3ME2zNE41QTZ3IN88US=>	NX\yZmxQW0GQR1XS
SK-MM-2	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGrDS4dKSzVyPUOwMlk4QTJizszN	M{O4PHNCVkeHUh?=
LB373-MEL-D	NIO5TG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3Gw[2lEPTB;M{GuNFA1PyEQvF2=	NXy5PFRbW0GQR1XS
CAS-1	NHXWSIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4\reWlEPTB;M{GuO\|Y3PSEQvF2=	MlHzV2FPT0WU
KNS-42	MoXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3PjNGlEPTB;M{GuPFY3OiEQvF2=	Mn31V2FPT0WU
SW948	NH70UWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1:2NGlEPTB;M{KuO\|U1QCEQvF2=	NV;jVHRqW0GQR1XS
HCC1143	NWDnPIpnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWjHbXREUUN3ME2zNk44QTd7IN88US=>	NXjHTXlKW0GQR1XS
NCI-H1648	NVnTZ4dRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGjtdGZKSzVyPUOyMlg1PjdizszN	MWnTRW5ITVJ?
RVH-421	MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkS3TWM2OD1\|Mz6xOlgh\|ryP	MWjTRW5ITVJ?
KU-19-19	NXjleFZXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{XFS2lEPTB;M{OuO\|U{PCEQvF2=	M325[XNCVkeHUh?=
PFSK-1	M2LCWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmXJTWM2OD1\|ND65NlQyKM7:TR?=	M1f3UXNCVkeHUh?=
TK10	M3nsXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnvBTWM2OD1\|NT6xN\|IzKM7:TR?=	M{DrSnNCVkeHUh?=
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NCI-H1734	MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUfJR\|UxRTZzLkm2OlMh\|ryP	M1j3b3NCVkeHUh?=
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PANC-03-27	M{TTbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NI\UOYdKSzVyPUe4MlQ{PSEQvF2=	MUnTRW5ITVJ?
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KYSE-410	M4rPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1\qTWlEPTB;OECuNlg2PyEQvF2=	NX:wTYRpW0GQR1XS
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NCI-H661	NF;3SGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnPiTWM2OD16MT6zOFQh\|ryP	M{e5UXNCVkeHUh?=
NCI-H1417	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXnDWGo3UUN3ME24NU41OzZ6IN88US=>	M37YNXNCVkeHUh?=
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Mewo	MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnL6TWM2OD17OT61OlA{KM7:TR?=	M4C5PXNCVkeHUh?=
LU-65	M13hVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWDJR\|UxRTFyMT6wPFEh\|ryP	NGTWTJJUSU6JRWK=
Saos-2	Mn[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkPPTWM2OD1zMEGuOFM4KM7:TR?=	Ml;IV2FPT0WU
TE-11	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXnhRZNrUUN3ME2xNFEvPzJ2IN88US=>	M1q2VHNCVkeHUh?=
SK-MES-1	MnL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3zUWGlEPTB;MUCxMlc3OiEQvF2=	M{XWbHNCVkeHUh?=
KE-37	NUjnUmUyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFnMOGNKSzVyPUGwNk46PSEQvF2=	NULUbGplW0GQR1XS
MKN45	NWDQ[mdRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1rOWWlEPTB;MUCzMlU5PCEQvF2=	M3f1OnNCVkeHUh?=
UM-UC-3	M2jIcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIfhPFVKSzVyPUGwN{45PDJizszN	MlrTV2FPT0WU
SNU-C2B	M17ZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlrOTWM2OD1zMEWuNFI{KM7:TR?=	NILIblZUSU6JRWK=
RPMI-8226	M2q2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NI\Pe3ZKSzVyPUGwOk43PzhizszN	MXfTRW5ITVJ?
PANC-08-13	M3m5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3PHOGlEPTB;MUC2Mlg2KM7:TR?=	NXX6Rm1nW0GQR1XS
NCI-H23	NWjac4dyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1rDRmlEPTB;MUC4MlM2PyEQvF2=	NF\hW21USU6JRWK=
HOP-92	MnjKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTFyOD60O\|Uh\|ryP	MluyV2FPT0WU
FTC-133	MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFSzR4tKSzVyPUGwPE41QDhizszN	Mk\WV2FPT0WU
D-263MG	NVfzZVZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF7BT4RKSzVyPUGwPE46PjFizszN	NE\2enJUSU6JRWK=
DU-145	M2P1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVPJR\|UxRTFyOT65OFUh\|ryP	NV3ZdndSW0GQR1XS
A253	MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfPeG9TUUN3ME2xNVAvPDd7IN88US=>	NGjxeGJUSU6JRWK=
HCT-15	NVrVZZlyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUPndJRIUUN3ME2xNVAvPjZzIN88US=>	NXTvbmh[W0GQR1XS
WSU-NHL	NFXm[\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV\JR\|UxRTFzMj6wNUDPxE1?	NETFZ2tUSU6JRWK=
U031	NHixW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWfm[mREUUN3ME2xNVIvODZ3IN88US=>	MVrTRW5ITVJ?
MDA-MB-157	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml7OTWM2OD1zMUKuOFkh\|ryP	MnHTV2FPT0WU
NEC8	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{PnSWlEPTB;MUGyMlYzPCEQvF2=	MnG2V2FPT0WU
SIG-M5	NVrQUHFyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV3mfIZxUUN3ME2xNVMvOTJ3IN88US=>	NFW4ToZUSU6JRWK=
786-0	NVPRfVB6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXuzRo1bUUN3ME2xNVMvPDV\|IN88US=>	NIe4OFhUSU6JRWK=
DMS-273	NYDDbXpZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2DvZ2lEPTB;MUG1MlYyPyEQvF2=	MYnTRW5ITVJ?
Calu-6	NH;kcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVPJR\|UxRTFzNj63PVgh\|ryP	MWfTRW5ITVJ?
HCC1599	NV7sN5BGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1W2d2lEPTB;MUG3MlE2PiEQvF2=	Mn63V2FPT0WU
OVCAR-8	M2mxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1zDO2lEPTB;MUG3MlY3QCEQvF2=	NX\2ZVlbW0GQR1XS
ATN-1	M{C3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEm5eoJKSzVyPUGxO{45OjhizszN	NWTxe2U{W0GQR1XS
RKO	MmPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M13oRWlEPTB;MUG3Mlg6QCEQvF2=	MYHTRW5ITVJ?
SKG-IIIa	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mo\3TWM2OD1zMUiuNVE3KM7:TR?=	NEPoWoRUSU6JRWK=
SUP-T1	MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3e2WmlEPTB;MUG4Mlk2PiEQvF2=	M2PLWnNCVkeHUh?=
KNS-81-FD	NHq2XFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4n5OWlEPTB;MUG5MlQyPyEQvF2=	MWLTRW5ITVJ?
OVCAR-3	NEfQRmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEPWXotKSzVyPUGxPU46OTVizszN	NWPFPJprW0GQR1XS
NCI-N87	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmW2TWM2OD1zMkGuNFQ1KM7:TR?=	MV3TRW5ITVJ?
HuP-T4	NWCxdGx1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH\LbYJKSzVyPUGyNU42PSEQvF2=	MofEV2FPT0WU
KYSE-140	NHv4d3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHTERoRKSzVyPUGyNk4yPDFizszN	MnzsV2FPT0WU
HAL-01	NXG3Zo52T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{LiRmlEPTB;MUKyMlQ6QSEQvF2=	NFW0XHlUSU6JRWK=
HT-29	NUTBc5hlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkKwTWM2OD1zMkKuO\|c5KM7:TR?=	MWDTRW5ITVJ?
OPM-2	M4L3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmO2TWM2OD1zMkOuNVc3KM7:TR?=	NYThUHhxW0GQR1XS
SW1463	MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NInESFdKSzVyPUGyOE4xPzdizszN	NXzueoFUW0GQR1XS
NCI-H2087	MlrYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUTCZoRGUUN3ME2xNlQvOjh\|IN88US=>	NXH1eoRQW0GQR1XS
UMC-11	M4PZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1fuR2lEPTB;MUK2MlA{QCEQvF2=	NXfMW4NrW0GQR1XS
EB-3	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnPTTWM2OD1zMkeuNFE{KM7:TR?=	Mn3PV2FPT0WU
HEC-1	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4W3XmlEPTB;MUK5MlE6QCEQvF2=	NXXI[XRXW0GQR1XS
LU-99A	M3TJR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTF{OT65N\|Eh\|ryP	M{HhfXNCVkeHUh?=
VMRC-RCZ	MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkHsTWM2OD1zM{CuN\|c2KM7:TR?=	NYTs[JpIW0GQR1XS
MFH-ino	NUKycXY6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUPJR\|UxRTF\|MT6xNVQh\|ryP	MnHSV2FPT0WU
HT-1080	M17mZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHf6OYdKSzVyPUGzNk4zODRizszN	NGGzenVUSU6JRWK=
CTB-1	NV;GRmlQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXvkSIgzUUN3ME2xN\|IvQDl5IN88US=>	NFXGTG1USU6JRWK=
Capan-2	Mme5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYnJR\|UxRTF\|Mz65O\|Uh\|ryP	MlzGV2FPT0WU
BB30-HNC	M1fTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIHIcYVKSzVyPUGzOE4yOTZizszN	NUX1eZMxW0GQR1XS
CP50-MEL-B	M{XLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnHDTWM2OD1zM{SuNkDPxE1?	NHi4PGpUSU6JRWK=
JEG-3	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWDielVUUUN3ME2xN\|QvOzV7IN88US=>	MomxV2FPT0WU
NCI-H1437	M4TpfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWnJR\|UxRTF\|ND61PUDPxE1?	MoPyV2FPT0WU
NOS-1	M1rPU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnjyTWM2OD1zM{SuO\|Y2KM7:TR?=	MX3TRW5ITVJ?
G-402	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGHnT3pKSzVyPUGzOU4zQTVizszN	MoLNV2FPT0WU
OAW-42	M1Oxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUG4d4gzUUN3ME2xN\|cvQDV4IN88US=>	NXLTdmg2W0GQR1XS
Ca-Ski	M{CxN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkPzTWM2OD1zM{iuPFMyKM7:TR?=	Mli4V2FPT0WU
BHT-101	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoDuTWM2OD1zNECuNlA5KM7:TR?=	MorzV2FPT0WU
OVCAR-4	M17DRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVjJR\|UxRTF2MD63OFkh\|ryP	NF3lRW5USU6JRWK=
Detroit562	M1O4TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIPLbVdKSzVyPUG0NU41PjZizszN	NYTJWoJUW0GQR1XS
OCI-AML2	MknPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{jVZmlEPTB;MUSxMlUxPyEQvF2=	MmPGV2FPT0WU
OE33	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXrjZm9EUUN3ME2xOFEvPzl6IN88US=>	MYXTRW5ITVJ?
YKG-1	NY[wR\|JCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUPJR\|UxRTF2Mj64PFkh\|ryP	Mn3VV2FPT0WU
CCF-STTG1	NUjq[I1lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlK1TWM2OD1zNEOuN\|M1KM7:TR?=	NVX4NYVwW0GQR1XS
NCI-H810	MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVm0XHBXUUN3ME2xOFMvPjh5IN88US=>	NHzOPYlUSU6JRWK=
SCC-25	M{KyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnqzTWM2OD1zNESuNFA2KM7:TR?=	NWDZcFZXW0GQR1XS
HTC-C3	M3u3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWK3V4hZUUN3ME2xOFUvODd3IN88US=>	M2LONHNCVkeHUh?=
G-401	NGH6d2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFLQ[\|lKSzVyPUG0OU45OzVizszN	MkSzV2FPT0WU
OMC-1	M2TGVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV;JR\|UxRTF2NT65Olch\|ryP	NYTVTIlRW0GQR1XS
LK-2	M4H0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1rLdWlEPTB;MUS3MlE1OyEQvF2=	NFjNellUSU6JRWK=
SW13	NVjsb3RTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{i5N2lEPTB;MUS3MlI2OyEQvF2=	M1HFTHNCVkeHUh?=
BB49-HNC	M3e2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXTCc2t{UUN3ME2xOFcvPDB2IN88US=>	MXTTRW5ITVJ?
DMS-114	NUnBWpkxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVPrbpl4UUN3ME2xOFcvPDRzIN88US=>	MlvTV2FPT0WU
GCIY	MkjPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmTxTWM2OD1zNEeuO\|k4KM7:TR?=	NF\3[IFUSU6JRWK=
GAMG	NHy2UHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUjJR\|UxRTF2OD6yOFch\|ryP	M33SSXNCVkeHUh?=
KYSE-520	NHPLUoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4r5dmlEPTB;MUS4MlU1KM7:TR?=	NID6UZpUSU6JRWK=
LB647-SCLC	NG\UUHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIX2Z5ZKSzVyPUG0PE42PjJizszN	NH;s[oxUSU6JRWK=
639-V	NG\KbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEDsUFJKSzVyPUG0PE44ODVizszN	Mnu1V2FPT0WU
TE-9	M3fm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;vTWM2OD1zNEmuOFQ{KM7:TR?=	NGKxdVVUSU6JRWK=
Caov-3	NWPXOYZYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MULJR\|UxRTF2OT63NVQh\|ryP	NInsVJBUSU6JRWK=
L-540	MkjoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XZcGlEPTB;MUS5Mlc2KM7:TR?=	MVfTRW5ITVJ?
NCI-H748	MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYXJR\|UxRTF3MD6yNFkh\|ryP	MlfrV2FPT0WU
GDM-1	M1jpSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1fXcmlEPTB;MUWxMlE{PSEQvF2=	NGn4SZFUSU6JRWK=
GAK	MoXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYfvVIhrUUN3ME2xOVEvOzd2IN88US=>	M4fxe3NCVkeHUh?=
AsPC-1	MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTF3Mj63OlQh\|ryP	NYL6NZU2W0GQR1XS
MDA-MB-361	M4rmdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUPK[ldmUUN3ME2xOVMvOTZ2IN88US=>	MV\TRW5ITVJ?
TT	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXTJR\|UxRTF3Mz60PUDPxE1?	M{XnSXNCVkeHUh?=
Calu-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEfMW4VKSzVyPUG1OE4xODNizszN	NFHRd3RUSU6JRWK=
RERF-LC-MS	M3PCS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF7LclNKSzVyPUG1OE44PzJizszN	M3\qN3NCVkeHUh?=
DK-MG	MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmTITWM2OD1zNUWuNVg{KM7:TR?=	NWr2PJk4W0GQR1XS
CAL-120	NHnIVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUPJR\|UxRTF3NT64NlEh\|ryP	MmDrV2FPT0WU
HCC1419	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NETkSGRKSzVyPUG1Ok4xPzdizszN	NXjOc45OW0GQR1XS
DG-75	NXLBfmk6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVLLPYQ3UUN3ME2xOVYvPjl2IN88US=>	Mk\oV2FPT0WU
HCC38	M4PlWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGD6e3pKSzVyPUG1O{4{PjlizszN	MkPrV2FPT0WU
HCC70	NYTzUolJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NW\tXFJrUUN3ME2xOVkvOjR{IN88US=>	M1LnfnNCVkeHUh?=
ES4	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV\JR\|UxRTF3OT6zPVYh\|ryP	M1\tNXNCVkeHUh?=
NCI-H2052	M4nQcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlLZTWM2OD1zNUmuOVg{KM7:TR?=	M1[3WnNCVkeHUh?=
EFO-27	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIPLeYNKSzVyPUG2NE42QDRizszN	NUDWd2JVW0GQR1XS
CAL-62	M{DtXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2XpN2lEPTB;MU[yMlYyOyEQvF2=	M1K4bHNCVkeHUh?=
CHP-212	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWO0epB7UUN3ME2xOlMvPjJ4IN88US=>	M1vKeXNCVkeHUh?=
AU565	M{PqR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2nkfmlEPTB;MU[zMlY1KM7:TR?=	NF\XNJpUSU6JRWK=
Ca9-22	NHTQeJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHfFeGRKSzVyPUG2OE4{OjFizszN	MYrTRW5ITVJ?
EFO-21	Ml;JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{TETmlEPTB;MU[1MlQ2KM7:TR?=	Mn30V2FPT0WU
KINGS-1	NGnKPVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV\JR\|UxRTF4Nz6zOVQh\|ryP	MmTVV2FPT0WU
JVM-2	MnnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXXJR\|UxRTF4Nz60OVEh\|ryP	MVLTRW5ITVJ?
OVCAR-5	NInQeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGCyfYlKSzVyPUG2PE4{ODlizszN	M1uwTHNCVkeHUh?=
Calu-3	NHXLWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXnGOpl{UUN3ME2xOlgvOzFzIN88US=>	NYG3[Y1YW0GQR1XS
CP66-MEL	MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoXTTWM2OD1zNkiuOFE2KM7:TR?=	NEXIfpFUSU6JRWK=
KYSE-150	MlixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MonPTWM2OD1zNkmuOlM3KM7:TR?=	NEXFSI9USU6JRWK=
Daoy	NUHSW3lFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX;JR\|UxRTF4OT64PVEh\|ryP	M1TFe3NCVkeHUh?=
HUTU-80	NHfsSmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWDtelBuUUN3ME2xO\|EvODN{IN88US=>	M3zHR3NCVkeHUh?=
SW620	NXr3c5AzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYDJR\|UxRTF5MT61N\|Uh\|ryP	MlnhV2FPT0WU
HuO-3N1	MnL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV3JR\|UxRTF5Mj6yO\|Mh\|ryP	NVn1Tot3W0GQR1XS
HH	NHHGXYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVLJR\|UxRTF5Mz64OFgh\|ryP	NFLLfmxUSU6JRWK=
ME-180	Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF7pWJBKSzVyPUG3OE4xOTZizszN	M4jCUnNCVkeHUh?=
SW756	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEfYZ4FKSzVyPUG3OE45PjNizszN	MkPDV2FPT0WU
LNCaP-Clone-FGC	NHyzdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2D3TWlEPTB;MUe1Mlg3OSEQvF2=	M1nHU3NCVkeHUh?=
YT	NHSxUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnryTWM2OD1zN{[uN\|k6KM7:TR?=	NX:wVGRsW0GQR1XS
EW-3	NX7CW4pVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIHFNYJKSzVyPUG3Ok42PTVizszN	MYTTRW5ITVJ?
COLO-741	MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnHXTWM2OD1zN{euOVYyKM7:TR?=	NIPoW\|JUSU6JRWK=
SK-NEP-1	M2PiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXjJR\|UxRTF5Nz64NFYh\|ryP	M1nMVnNCVkeHUh?=
NB10	NIr3bo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTF5Nz64OFYh\|ryP	MmewV2FPT0WU
SF126	MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEPRNm1KSzVyPUG3PU41OzJizszN	M4T2bXNCVkeHUh?=
NCI-H522	M4q2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHywNXpKSzVyPUG4NU4xPTlizszN	NHzPOlRUSU6JRWK=
PSN1	M2rERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEKwT\|FKSzVyPUG4NU43PiEQvF2=	NEXHTI9USU6JRWK=
GI-ME-N	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEPzZpZKSzVyPUG4NU43PzJizszN	NVvidFNTW0GQR1XS
SBC-5	MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{jreWlEPTB;MUixMlk{PCEQvF2=	MkLSV2FPT0WU
ONS-76	NXHQPWJXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MonYTWM2OD1zOEKuN\|g4KM7:TR?=	NHTwfJNUSU6JRWK=
LOUCY	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4fjWGlEPTB;MUiyMlY5QCEQvF2=	MnqxV2FPT0WU
SN12C	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlfVTWM2OD1zOEKuPFI6KM7:TR?=	M1;3WHNCVkeHUh?=
A427	M2HzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHHZSWRKSzVyPUG4OE43OzFizszN	MYTTRW5ITVJ?
DOK	NEPLdYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3m4cGlEPTB;MUi0MlY1OyEQvF2=	MXHTRW5ITVJ?
MDA-MB-415	M2DoRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXSxfXpLUUN3ME2xPFQvPjVzIN88US=>	MXHTRW5ITVJ?
MRK-nu-1	MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVrJR\|UxRTF6ND65O\|Ih\|ryP	MojIV2FPT0WU
LB2241-RCC	NVzFWXk3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEHpSYhKSzVyPUG4OU4yPDVizszN	NX\xcGNXW0GQR1XS
NCI-H1563	M1XCcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkX5TWM2OD1zOEWuNlA6KM7:TR?=	M1PyXnNCVkeHUh?=
MDA-MB-453	NH\0dpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NI\aVnZKSzVyPUG4Ok46PDFizszN	NHKx[Y9USU6JRWK=
MONO-MAC-6	NEnURXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkjhTWM2OD1zOEeuN\|kzKM7:TR?=	NUj6bXJ[W0GQR1XS
CAPAN-1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4riNGlEPTB;MUi3MlQ2OyEQvF2=	NIrqVIdUSU6JRWK=
SK-LU-1	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUHJR\|UxRTF6OD60Nlgh\|ryP	NI\jR\|BUSU6JRWK=
NCI-H1299	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkPjTWM2OD1zOEiuO\|E6KM7:TR?=	MmDuV2FPT0WU
KG-1	MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHG3fGxKSzVyPUG4PU44QThizszN	NXK5cHY6W0GQR1XS
ETK-1	M1XD[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVfJR\|UxRTF7MD6xPFEh\|ryP	MojsV2FPT0WU
NCI-H838	NFH1cpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3jpc2lEPTB;MUmwMlM1KM7:TR?=	MYfTRW5ITVJ?
HCE-4	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlfuTWM2OD1zOUCuPVkzKM7:TR?=	NFL6XXRUSU6JRWK=
A2780	MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFjaZZJKSzVyPUG5Nk45QTFizszN	MoK1V2FPT0WU
COLO-668	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnHKTWM2OD1zOUOuNVU4KM7:TR?=	M1\HSnNCVkeHUh?=
HGC-27	M4fPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoLMTWM2OD1zOUWuOVM5KM7:TR?=	NGnmbIFUSU6JRWK=
SW1088	NYLEOpcxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1zBdWlEPTB;MUm1MlY4PyEQvF2=	MV;TRW5ITVJ?
KOSC-2	NGLrXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFrS[GxKSzVyPUG5OU45OThizszN	MmLEV2FPT0WU
TE-1	M3LIUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3rHeGlEPTB;MUm2MlI3KM7:TR?=	MmrFV2FPT0WU
SW780	M4ThN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkX0TWM2OD1zOU[uO\|M1KM7:TR?=	MmLQV2FPT0WU
22RV1	M1ribmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{\HbGlEPTB;MUm3MlQzPCEQvF2=	MU\TRW5ITVJ?
IA-LM	M3K4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXj5SWFmUUN3ME2xPVcvQDJ{IN88US=>	MlvWV2FPT0WU
TE-5	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYjMNWlTUUN3ME2xPVgvODN\|IN88US=>	MWLTRW5ITVJ?
JVM-3	M1PoWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTF7OD60NVkh\|ryP	M4jZdHNCVkeHUh?=
HT55	NFfTR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnvHTWM2OD1zOUmuNVkzKM7:TR?=	MXHTRW5ITVJ?
QIMR-WIL	M2XFTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkXxTWM2OD1{MECuNVE3KM7:TR?=	MYfTRW5ITVJ?
SJRH30	MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXHJR\|UxRTJyMD61NVUh\|ryP	Mn7jV2FPT0WU
COLO-679	M1npZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVjJR\|UxRTJyMD64OVkh\|ryP	M3LzWXNCVkeHUh?=
MDA-MB-231	M1jXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWLJR\|UxRTJyMD65NFIh\|ryP	Mnr3V2FPT0WU
MFM-223	NXLrOIRkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M37hcWlEPTB;MkCxMlU5PyEQvF2=	NYDFXFZVW0GQR1XS
MFE-280	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoLPTWM2OD1{MEGuPVYyKM7:TR?=	MXnTRW5ITVJ?
LAMA-84	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1LrdmlEPTB;MkCyMlA4OyEQvF2=	NWXXfYxYW0GQR1XS
LS-1034	Mnq3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2rXOmlEPTB;MkCyMlU2OyEQvF2=	NYXsPWdZW0GQR1XS
NCI-H345	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NELZVm9KSzVyPUKwN{4xOjdizszN	NYXNXoR1W0GQR1XS
KYSE-70	NYLRemluT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlLmTWM2OD1{MEOuPFc6KM7:TR?=	Mlm4V2FPT0WU
EGI-1	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF3tSGtKSzVyPUKwOE45OzNizszN	NVLxVVhWW0GQR1XS
RPMI-2650	NGfFN\|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3q2TWlEPTB;MkC1MlQ3PyEQvF2=	NVnuc2lwW0GQR1XS
NCI-H1651	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn7aTWM2OD1{ME[uO\|Mh\|ryP	NHO0[3JUSU6JRWK=
HPAF-II	NYTxbYI2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXzYVoN3UUN3ME2yNFkvPjdzIN88US=>	M3PHWHNCVkeHUh?=
NUGC-3	NHLTNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEDwfGpKSzVyPUKwPU43PzhizszN	M4KydnNCVkeHUh?=
DJM-1	M2rHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{DIU2lEPTB;MkC5Mlg6PyEQvF2=	MljSV2FPT0WU
MHH-PREB-1	NUP6VpdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGf1cGpKSzVyPUKxNE4{QDFizszN	MkfkV2FPT0WU
EW-18	NEPhS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVvOTnFoUUN3ME2yNVAvPzZ\|IN88US=>	MmHDV2FPT0WU
BT-20	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYPWWItbUUN3ME2yNVAvQTh4IN88US=>	MnjsV2FPT0WU
A431	NWDLepFoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFHLPVBKSzVyPUKxNU4zQTlizszN	M2j2OXNCVkeHUh?=
TCCSUP	NVPvO3lwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2D0SmlEPTB;MkGxMlU{OyEQvF2=	NWXSb\|BuW0GQR1XS
HO-1-N-1	NYH3NIU4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVLJR\|UxRTJzMj64PVQh\|ryP	M3fxTHNCVkeHUh?=
NCI-H69	M1\x[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3;pdmlEPTB;MkG0MlE5PSEQvF2=	Mof2V2FPT0WU
ES7	NWi3dVlET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mo\WTWM2OD1{MUSuPFc5KM7:TR?=	MlvnV2FPT0WU
C3A	NFHsS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH;MPItKSzVyPUKxOU42PzVizszN	MVzTRW5ITVJ?
UACC-257	Mk\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3Xz[GlEPTB;MkG3MlQ{KM7:TR?=	M17lV3NCVkeHUh?=
DMS-153	NEXvRmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVPWRVVEUUN3ME2yNVcvQDN4IN88US=>	NF;G[oRUSU6JRWK=
LB771-HNC	NYCwSVUxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYTId5BzUUN3ME2yNVcvQDl\|IN88US=>	MUHTRW5ITVJ?
HOS	NVn5UIo3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXy4[IltUUN3ME2yNVgvQSEQvF2=	M1;SfnNCVkeHUh?=
THP-1	MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mlv4TWM2OD1{MUmuOlA3KM7:TR?=	MmTxV2FPT0WU
SCC-4	NILaZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUn4eVZ[UUN3ME2yNlAvOzV\|IN88US=>	Mkm0V2FPT0WU
SCC-3	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{PYZmlEPTB;MkKwMlU4PyEQvF2=	NFrXOHdUSU6JRWK=
BC-1	M1LTb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWrJR\|UxRTJ{MD63PVkh\|ryP	MljOV2FPT0WU
NCI-H1618	NV3rUoxKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYrJR\|UxRTJ{MT6wNVgh\|ryP	MVTTRW5ITVJ?
CaR-1	NFPuWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LEd2lEPTB;MkKxMlI2OSEQvF2=	MkjrV2FPT0WU
NCI-H1355	M3LmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYq1TXpZUUN3ME2yNlEvOzd5IN88US=>	NGPGeJRUSU6JRWK=
NCI-H1993	MmHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmHGTWM2OD1{MkKuNlM6KM7:TR?=	NGHOTllUSU6JRWK=
NCI-H1623	NI\abmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{TN[GlEPTB;MkKyMlM5QSEQvF2=	NIDHOGZUSU6JRWK=
AGS	MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfTWYRHUUN3ME2yNlIvPTJ\|IN88US=>	NGq3PG9USU6JRWK=
SAS	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn;4TWM2OD1{MkOuO\|k3KM7:TR?=	M4Doc3NCVkeHUh?=
HCC1937	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml7OTWM2OD1{MkSuN\|g6KM7:TR?=	NYjFUXlDW0GQR1XS
NCI-H209	MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHjMN25KSzVyPUKyOk42OyEQvF2=	NGf3TGVUSU6JRWK=
NCI-H322M	MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoKzTWM2OD1{MkiuNFE6KM7:TR?=	NXnzbmJjW0GQR1XS
CHL-1	NV;PcYN7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHrWSodKSzVyPUKyPE4yOyEQvF2=	MkmzV2FPT0WU
NCI-H630	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUDJR\|UxRTJ\|Mj64PVch\|ryP	MW\TRW5ITVJ?
5637	Mn3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVnJR\|UxRTJ\|Mz6wNFMh\|ryP	NF;adIxUSU6JRWK=
MSTO-211H	NWn2U5NXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoXSTWM2OD1{M{OuNlc3KM7:TR?=	MYHTRW5ITVJ?
YAPC	NWn0UmNyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mnm1TWM2OD1{M{SuNlU{KM7:TR?=	MlKwV2FPT0WU
SW1783	NIfaSI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXHQ[m5uUUN3ME2yN\|QvPDFizszN	MoLsV2FPT0WU
GB-1	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DIOWlEPTB;MkO1MlE4PyEQvF2=	NHvROplUSU6JRWK=
NCI-H520	NVHlV2tzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIPjPXpKSzVyPUKzOU44PDFizszN	Mm[wV2FPT0WU
NOMO-1	NFjXZpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHXnNXZKSzVyPUKzOk4xOiEQvF2=	NVvBNVhlW0GQR1XS
NCCIT	MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoT0TWM2OD1{M{[uPFc{KM7:TR?=	MonlV2FPT0WU
SW954	M4nvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3fLeGlEPTB;MkO3Mlg3QCEQvF2=	NXPlZphNW0GQR1XS
MOLT-4	MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn;wTWM2OD1{NEGuNlA6KM7:TR?=	MVrTRW5ITVJ?
EB2	MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXfJR\|UxRTJ2MT65NFch\|ryP	MnS2V2FPT0WU
IPC-298	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYDJR\|UxRTJ2Mj6wO\|Ih\|ryP	MoLwV2FPT0WU
GP5d	Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWL2U41FUUN3ME2yOFIvPjF4IN88US=>	M1TVdXNCVkeHUh?=
HN	NWX5XHFJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX;JR\|UxRTJ2Mj65PVEh\|ryP	MUDTRW5ITVJ?
BFTC-909	NH;nVHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUD6UJpUUUN3ME2yOFMvOTF6IN88US=>	MkjOV2FPT0WU
ES5	MkPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYeyS\|dqUUN3ME2yOFUvODN6IN88US=>	NUnPbmFXW0GQR1XS
SK-HEP-1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTJ2Nj6wOFMh\|ryP	NVrHZVRrW0GQR1XS
T47D	M2\oSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEH3VXhKSzVyPUK0O{4xOTNizszN	NWTaO4NLW0GQR1XS
KYSE-510	Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4XSRmlEPTB;MkS3MlUyPyEQvF2=	M4KzfHNCVkeHUh?=
LC-1F	NH\rOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUPJR\|UxRTJ2OD6xOVYh\|ryP	NHjHS2tUSU6JRWK=
NCI-H1693	NHHSbYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlL6TWM2OD1{NEmuOFk2KM7:TR?=	NUGwO3BCW0GQR1XS
COR-L23	NGnueFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVHJR\|UxRTJ3MD60NVIh\|ryP	MWrTRW5ITVJ?
NCI-H2228	NVvZfXdYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlTtTWM2OD1{NUCuPFY1KM7:TR?=	M4Dzd3NCVkeHUh?=
NCI-H460	MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrITWM2OD1{NUGuOFE4KM7:TR?=	NGq1OZFUSU6JRWK=
TGBC1TKB	M4f5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXX6PIhjUUN3ME2yOVIvQDd3IN88US=>	Mk\iV2FPT0WU
NCI-H1304	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1H4OGlEPTB;MkWzMlE2PiEQvF2=	M{H2b3NCVkeHUh?=
CAL-27	NEn6[mRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVzJR\|UxRTJ3Mz60PFUh\|ryP	M2HHSXNCVkeHUh?=
NCI-H187	NFvFOIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGjsdYRKSzVyPUK1Ok44PiEQvF2=	NX;sbpFiW0GQR1XS
HSC-2	NEHzUoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkX4TWM2OD1{NUiuOVg1KM7:TR?=	MlvHV2FPT0WU
CAL-39	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF\SW5RKSzVyPUK2NE4zPzJizszN	MVvTRW5ITVJ?
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NCI-H1522	MkLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYHmOppFUUN3ME2zN\|QvOzN7IN88US=>	Mni1V2FPT0WU
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NCI-H2030	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHGwUG1KSzVyPUO0NU43ODlizszN	M4jjVHNCVkeHUh?=
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CAL-54	Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MY\JR\|UxRTN2NT64O\|kh\|ryP	NVv5Z3JFW0GQR1XS
DOHH-2	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3\3emlEPTB;M{S2MlY2KM7:TR?=	MkK4V2FPT0WU
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COLO-684	NXrlbGpwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWHJR\|UxRTR2OD64PFgh\|ryP	NGHieXNUSU6JRWK=
DMS-79	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4XEemlEPTB;NES5MlY5KM7:TR?=	NXqzflZkW0GQR1XS
EW-1	NV2wOpNDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVfJR\|UxRTR3Mj64PFgh\|ryP	NIf5fnRUSU6JRWK=
MS-1	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFP0VFhKSzVyPUS1OE4{QDVizszN	MlXwV2FPT0WU
A4-Fuk	NIXmbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVfGZZE1UUN3ME20OVQvPTB5IN88US=>	M{[1UHNCVkeHUh?=
TALL-1	MlnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUPHd3NGUUN3ME20OVUvOjl5IN88US=>	NWHTe3liW0GQR1XS
SCLC-21H	NVvpdVdDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWLJR\|UxRTR3NT62PVkh\|ryP	NX;ORVlLW0GQR1XS
KMS-12-PE	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEm3cHNKSzVyPUS1Ok45OjJizszN	NH7ndWpUSU6JRWK=
TE-441-T	MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEHvfGZKSzVyPUS1O{4yQDZizszN	NVTrSHZ6W0GQR1XS
A3-KAW	NVTwTXZlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXTJR\|UxRTR4MD64OFEh\|ryP	MmXsV2FPT0WU
NCI-H1092	NFPMc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGDINpdKSzVyPUS2N{46PDNizszN	NV7oSWN5W0GQR1XS
COR-L279	NGfUR5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{Wze2lEPTB;NE[0Mlg1PyEQvF2=	NWPP[HVHW0GQR1XS
NCI-SNU-5	NGDQUlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWXxbXA{UUN3ME20O\|IvOjhizszN	M3P0VHNCVkeHUh?=
JAR	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGnIVpRKSzVyPUS3OE44QDhizszN	M3qxS3NCVkeHUh?=
NCI-H446	M1[1c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mo[yTWM2OD12N{euNFgh\|ryP	NXPsT3NTW0GQR1XS
HDLM-2	NHXYcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkHTTWM2OD12OECuPFY6KM7:TR?=	M1u3VHNCVkeHUh?=
D-283MED	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmXZTWM2OD12OEiuPVI1KM7:TR?=	MUjTRW5ITVJ?
NCI-H1395	MmPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmHCTWM2OD12OEmuNFA1KM7:TR?=	NXjCUmpYW0GQR1XS
RPMI-6666	NH:1fmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXPJR\|UxRTR7MT6zPVgh\|ryP	MUXTRW5ITVJ?
CPC-N	M3rjUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4Pw[WlEPTB;NUCyMlA3OyEQvF2=	MX;TRW5ITVJ?
EC-GI-10	M4jCT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV7JR\|UxRTVyMj6xOlkh\|ryP	MWnTRW5ITVJ?
CA46	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYqzSmlzUUN3ME21NFQvPDB5IN88US=>	NHy2TY5USU6JRWK=
EHEB	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUPJR\|UxRTVyNz6yNFgh\|ryP	M4fTV3NCVkeHUh?=
RPMI-8402	Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2CzVWlEPTB;NUGwMlAzOSEQvF2=	NH3YXmhUSU6JRWK=
DU-4475	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1fxW2lEPTB;NUGxMlExOSEQvF2=	NYm4d2Z[W0GQR1XS
P12-ICHIKAWA	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnLFTWM2OD13MUGuOFE3KM7:TR?=	MoL4V2FPT0WU
NCI-H1694	NIe5W45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYLJR\|UxRTVzMj60N\|kh\|ryP	Mn;UV2FPT0WU
NCI-H2171	M3rRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUPJR\|UxRTVzMj63NFUh\|ryP	Mk\xV2FPT0WU
Mo-T	Ml;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFjNdJZKSzVyPUWxOU4yOTZizszN	M3vMWXNCVkeHUh?=
HL-60	MlfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MV;JR\|UxRTV{Mj65NlQh\|ryP	MkO4V2FPT0WU
NCI-H1436	M1z4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFWyV2JKSzVyPUWyN{4xPjRizszN	MUTTRW5ITVJ?
NCI-H510A	NWLGVZI2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV\HV\|VZUUN3ME21NlQvPjl4IN88US=>	M2S3RXNCVkeHUh?=
NCI-H2081	Mmn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVjJR\|UxRTV{NT61NVMh\|ryP	M2DVOXNCVkeHUh?=
NB5	M3;jUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4\BbmlEPTB;NUK2MlQ{KM7:TR?=	NFTM[3FUSU6JRWK=
NCI-H2227	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHHLU29KSzVyPUWzNE4zPTRizszN	MmLjV2FPT0WU
HSC-4	M3vydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2LhWmlEPTB;NUO5MlI6OyEQvF2=	MUfTRW5ITVJ?
RL	Mlz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYP4cpJjUUN3ME21OFIvPDR{IN88US=>	MonPV2FPT0WU
EVSA-T	MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlT6TWM2OD13NEOuOlg1KM7:TR?=	M3fGTnNCVkeHUh?=
NCI-H889	M3\4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2e5PGlEPTB;NUS3MlI{KM7:TR?=	NHv1VmRUSU6JRWK=
COLO-320-HSR	NG\zVHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYnJR\|UxRTV3MT6zOUDPxE1?	M1;Le3NCVkeHUh?=
EW-11	M2DzTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHexb2dKSzVyPUW1Nk4{QTlizszN	MWjTRW5ITVJ?
UACC-812	NEHTWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2L6fmlEPTB;NUW5MlM6OSEQvF2=	NFf2OoJUSU6JRWK=
CAL-148	M{HuS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{HsOGlEPTB;NU[1MlA5QSEQvF2=	M{ixTnNCVkeHUh?=
K052	M1LHTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIfodZNKSzVyPUW3PU4zOTNizszN	MV\TRW5ITVJ?
L-428	M4LBTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVPxfVl2UUN3ME22NFAvPjdzIN88US=>	NGqwXoRUSU6JRWK=
LP-1	MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3i4RWlEPTB;NkCzMlU5PyEQvF2=	MlXIV2FPT0WU
ML-2	MnrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MofQTWM2OD14ME[uOVc6KM7:TR?=	NH3ZbnJUSU6JRWK=
KARPAS-45	MnPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTZzOD6yNlEh\|ryP	MlnwV2FPT0WU
HT	MnrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXr2SHB4UUN3ME22NlIvPzh3IN88US=>	NEfsUlNUSU6JRWK=
NCI-H226	NYTsUmc2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTZ{OD6zOVMh\|ryP	NEfEXpZUSU6JRWK=
L-363	MlOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUL5VpA1UUN3ME22OFgvODZ2IN88US=>	NYT6flZOW0GQR1XS
IM-9	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{X5XGlEPTB;NkWxMlU1OSEQvF2=	MWDTRW5ITVJ?
TUR	NWX3PWx{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnfUTWM2OD14N{GuN\|IzKM7:TR?=	NUDGfGtvW0GQR1XS
NCI-SNU-16	M4j1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUjscWFyUUN3ME22PFAvPDZ{IN88US=>	NX7uN4ZwW0GQR1XS
NCI-SNU-1	NGLFT\|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYHJR\|UxRTZ7MD6xO\|Ih\|ryP	Mmj1V2FPT0WU
U-87-MG	Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3zzeWlEPTB;Nkm0MlU5PSEQvF2=	M4jXVHNCVkeHUh?=
KM-H2	NY\zVVJET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MW\JR\|UxRTZ7OT6wOVkh\|ryP	M3;XcHNCVkeHUh?=
DEL	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH7uZnFKSzVyPUewNE45OzhizszN	NH7vVWpUSU6JRWK=
KARPAS-422	M3rJWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NH;wT5ZKSzVyPUe4PU4{OTVizszN	NGP3bYFUSU6JRWK=
BC-3	NXHr[m5WT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mof5TWM2OD16MEWuNlA{KM7:TR?=	MV3TRW5ITVJ?
NCI-H1155	M1T4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4DUUWlEPTB;OEG4MlA2QSEQvF2=	MUHTRW5ITVJ?
NCI-H1581	M37RfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkHqTWM2OD17MECuNlMyKM7:TR?=	NULZW414W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo

Oral administration of CHIR-99021 at 30 mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR-99021 at 16 or 48 mg/kg 1 hour before oral glucose challenges in ZDF rats significantly improves glucose tolerance with 14% and 33% reduction in plasma glucose at 16 mg/kg and 48 mg/kg, respectively, and the higher dose of CHIR-99021 also reduces hyperglycemia before the oral glucose challenge. ^[1] Administration of CHIR-99021 significantly augments hematopoietic repopulation in recipient mice transplanted with mouse or human hematopoietic stem cells (HSCs), suggesting that GSK-3 is a specific modulator of HSC activity. ^[4]

Protocol

Kinase Assay: ^[1]	+ Expand Cell-free kinase assays: Polypropylene 96-well plates are filled with 300 μL/well buffer (50 mM tris HCl, 10 mM MgCl₂, 1 mM EGTA, 1 mM dithiothreitol, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) containing 27 nM GSK-3α or 29 nM GSK-3β, and 0.5 μM biotin-CREB peptide substrate. Various concentrations of CHIR-99021 are added in 3.5 μL of DMSO, followed by 50 μL of ATP stock to yield a final concentration of 1 μM ATP in all cell-free assays. After incubation, triplicate 100-μL aliquots are transferred to Combiplate eight plates containing 100 μL/well 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with PBS, filled with 200 μL of scintillation fluid, sealed, left 30 minutes, and counted in a scintillation counter. All steps are performed at room temperature.
Cell Research: ^[3]	+ Expand Cell lines: INS-1E Concentrations: Dissolved in DMSO, final concentrations ~ 20 μM Incubation Time: 1, or 4 days Method: Cells are maintained for 24 hours in starvation medium (culture medium with only 5 mM glucose, 1% fetal calf serum). Then cells are exposed to various concentrations of CHIR-99021 for 1, or 4 days. Cell number is measured by staining of cellular DNA with CyQuant dye, which becomes fluorescent when bound to DNA. Fluorescence is measured after 30 minutes of incubation using the FLUOstar Optima reader. Cell replication is determined by BrdUrd incorporation. BrdUrd labeling solution is added to the medium for the last 4 hours before the cells are fixed using FixDenat solution and incubated with monoclonal anti-BrdUrd-POD antibodies. After substrate solution is added to each well, the light emission is measured in a microplate luminometer using the Analyst HT detection system. (Only for Reference)
Animal Research: ^[1]	+ Expand Animal Models: Female db/db mice or male ZDF rats with type 2 diabetes Formulation: Formulated as solutions in 20 mM citrate-buffered 15% Captisol or as fine suspensions in 0.5% carboxymethylcellulose. Dosages: ~48 mg/kg Administration: Orally (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL (185.33 mM)
	Ethanol	2 mg/mL (3.98 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	24mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Molecular Weight	501.8
Formula	C₂₂H₁₈Cl₂N_8.HCl
CAS No.	1797989-42-4
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
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C8=C7/X	C8:	LOG(C8):

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?
Answer:
The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.
Question 2:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
Answer:
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
Question 3:
What is the difference between S2924 and S1263? Which one is better for differentiation?
Answer:
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Selective GSK-3 Inhibitor

TWS119 : GSK-3β-selective, IC50 of 30 nM.
Most Potent GSK-3 Inhibitor

CHIR-98014 : GSK-3α, IC50=0.65 nM; GSK-3β, IC50=0.58 nM.
GSK-3 Inhibitor in Clinical Trial

Tideglusib : Phase II for Alzheimer's disease.
Newest GSK-3 Inhibitor

AZD1080 : Orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively.

Related GSK-3 Products

CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
LY2090314 ^New

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
TDZD-8 ^New

TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
TWS119

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology.
SB216763

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.
Tideglusib

Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
CHIR-98014

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
BIO

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.

Features:The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.
AR-A014418

AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and K_i of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
IM-12

IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

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CHIR-99021 (CT99021) HCl

Cited by 73 Publications

9 Customer Reviews

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products

Choose Your Country or Region

By Signaling Pathways

By product type

CHIR-99021 (CT99021) HCl

Cited by 73 Publications

9 Customer Reviews

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)