CHIR-99021 (CT99021) HCl

Catalog No.S2924

Molecular Weight(MW): 501.8

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.

Cited by 73 Publications

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University of GOTHENBURG, 2014, 5495

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Bachelor of Science, 2012, East China Normal University

PubMed:

9 Customer Reviews

Differentiation induced by treatment with the Gsk3 inhibitor in hPSCs is β-catenin dependent. H9-7TGP cells were treated with 12 uM CH in mTeSR1 for 4 d. Immunofluorescent staining for Oct4, Isl1, and Nkx2.5 was compared with GFP expression. (Scale bars, 50 uM.)

Proc Natl Acad Sci U S A 2012 109(27):E1848-57. CHIR-99021 (CT99021) HCl purchased from Selleck.

Gpc4 regulates ESC response to Wnt/β-catenin signaling. (E) Quantitative analysis of control and Gpc4-mutant beating foci exposed to the GSK3 inhibitor, CHIR 99021 (1 and 3 μM, from day 0 to day 5). Analysis was done at different time points. Gpc4- mutant cells treated with CHIR 99021 behave as controls (mean±SEM; n=2).

Stem Cells 2012 30, 1863-1874. CHIR-99021 (CT99021) HCl purchased from Selleck.
Characterization of rES cells. A: image of normal rES cell colonies on feeder layers. B: rES colonies were positive for AP staining. CeE: rES colonies readily expressed pluripotent markers, Sox2 (C), Oct4 (D), and SSEA-1 (E). Blue, DAPI. Scale bars: 100 um.

J Genet Genomics 2012 39, 643e651. CHIR-99021 (CT99021) HCl purchased from Selleck.

Inhibition of GSK3 activity induces an autophagic response in human pancreatic cancer cells. PANC1 cells were treated for 24 h with DMSO, CHIR99021 (CHIR; 5 uM) or the mTOR inhibitor Torin1 (250 nM). Autophagosome (punctate LC3B) (D) and lysosome (E) labeling was visualized with a Zeiss LSM700 confocal microscope. Images were acquired with a 20x (D) or 63x (E) objective. Nuclei were stained with DAPI. Scale bars, 20 祄.

J Biol Chem 2015 290(9), 5592-605 . CHIR-99021 (CT99021) HCl purchased from Selleck.
A. Vero cells were pretreated with the indicated concentrations of CHIR-99021 for 1 h and then infected with PEDV (MOI = 1) for 8 or 10 h. Cell lysates were prepared and analyzed using Western blotting.

PLoS One, 2016, 11(8):e0161508. CHIR-99021 (CT99021) HCl purchased from Selleck.

Smad linker phosphorylation involves GSK3 in human melanoma lines. Inhibition of Smad2 and Smad3 linker phosphorylation in the presence of the specific GSK3 specific inhibitor, CT99021. 24 hours post seeding, WM793 and 1205LU cells were serum-starved for about 16 hours, and incubated in the absence (2) or presence (+) of 2 uM of CT99021 for two hours. Immunoblots were performed as in A. p: Phosphorylated. S: Serine; T: Threonine.

PLoS One 2012 7, e47312. CHIR-99021 (CT99021) HCl purchased from Selleck.
SKOV3/DDP cells were treated with a range of concentration of (A) CHIR-99021 or in combination with 20 µM cisplatin for 48 h.

Exp Ther Med, 2016, 12(6):3851-3858. CHIR-99021 (CT99021) HCl purchased from Selleck.

PANC1 cells were treated with GSK3 inhibitors SB216763 (SB 10µM or SB 20µM) or CHIR99021 (CHIR 5µM) for 72h.

CHIR-99021 (CT99021) HCl purchased from Selleck.
Activity of canonical WNT/ β -CATENIN signals induced by CHIR 99021 in the developing human lung. Human lung tissue explants obtained at 15 weeks of gestation were exposed to 0, 5 and 10 μM CHIR 99021 in vitro for 72 h. (A-B) Western blot analysis showed expression of β -CATENIN in human lung tissues. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (C) qRT-PCR analysis detected a dose-dependent increase in WNT signaling transcription factors and target genes following exposure to CHIR 99021. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (D-K) Histology examination showed obvious morphogenetic changes of the airway epithelial cells associated with CHIR 99021 treated lung tubes. Scale bars: D-G =100 μm; H-K = 20 μm.

CHIR-99021 (CT99021) HCl purchased from Selleck.

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Description

Targets

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

In vitro

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. ^[1] In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). ^[2] Unlike lithium chloride and AR-A014418, CHIR-99021 treatment does not reduce the viability of INS-1E cells even at high concentrations. Instead, CHIR-99021 robustly increases the rate of proliferation of INS-1E cells in a dose-dependent manner, and significantly inhibits INS-E cell death induced by high glucose and high palmitate in a concentration-dependent manner. CHIR-99021 promotes primary beta cell replication in isolated rat islets at concentrations as low as 1 μM, with 2-3 fold increase of cell replication at 5 μM of CHIR-99021 treatment. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3-L1	MWrGeY5kfGmxbjDBd5NigQ>?	MmHNN{DPxE1?	Ml3HOEBp	MkHrSG1UVw>?	NX3V[5ZvUW6qaXLpeJMheHKnYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdg>?	M{H5[FEzODV3MkCw
insulin receptor–expressing CHO-IR	MYjGeY5kfGmxbjDBd5NigQ>?	MX21NFAhdk1?	NFPtXm8{OCCvaX6=	NGDFRWlFVVOR	MlzuRYN1cX[jdHXzJGdtgWOxZ3XuJHN6dnSqYYPlJEhIWyl?	NUjvV3BkOTJ4ME[0PVc>
H4IIE	MnTXSpVv[3Srb36gRZN{[Xl?	MnrENVAh\|ryP	MVuyOEBp	NISxWIdFVVOR	MljtVoVofWyjdHXzJO6zNWOjdHXubY4h[WO2aY\peJkh[W6mIGTJVmUh[2:wdHHpcolv\yCycn;tc5RmeiCjY4Tpeol1gQ>?	MnS4NVU{PTBzOUW=
Oct4/Sox2/Klf4-infected MEFs	MUHGeY5kfGmxbjDBd5NigQ>?	M4[1OFExKM7:TR?=	M{X3N\|I5KGR?	NEXyeWxFVVOR	MoPHVJJwdW:2ZYOgUWVHeyC{ZYDyc4dz[W2vaX7nJHRz[W6\|ZIXj[YQh[nliT3P0OEwhW2:6MjygZY5lKEuuZkS=	MXSxPVg{QTB3NR?=
Sca-1+ HPC	Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MoTWNkDPxE1?	MU[2JIQ>	M1T5WWROW09?	MU\TfY5memerc4TpZ4FtdHlicILvcY91\XNiU3PhMVEsyqCKUFOgdJJwdGmoZYLheIlwdiCjbnSgZ49td267IH\vdo1ifGmxbjD0c4dmfGincjD3bZRpKEWJRh?=	NYDqUWhrOjF4MkSzOFg>
HMC1.2	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4DwPFMxKM7:TR?=	NUjFe5NbPzJiaB?=	NUHNdGl6TE2VTx?=	NV[1TJNNWmWmdXPld{Bk\WyuIIP1dpZqfmGu	NWGy[INwOjJyM{mzNFE>
Endothelial cell(EC)	M3XsVWZ2dmO2aX;uJGF{e2G7	Ml\tN{DPxE1?		NXrzO2RRTE2VTx?=	MUjQdo9ud3SnczDlcoRwfGinbHnhcEBk\WyuIDjFR{kh\GmoZnXy[Y51cWG2aX;u	MWGyNlA2OjByNh?=
PANC1	NH:1OW9CeG:ydH;zbZMhSXO\|YYm=	NEP4UJTDqDVizszN	MWG3NkBp	MYfEUXNQ	MoqyWJJq\2encoOgZY4h[XCxcITveIlkKHKnc4DvcpNm	NF7a[FAzOjJyMUG4Oi=>
INS-1E	MoTMSpVv[3Srb36gRZN{[Xl?	NYLtNXpyOi53IN88US=>	NEfqRXIzPCCq	NVXKN3lyTE2VTx?=	MXTJcoR2[2W\|IHGgdoVlfWO2aX;uJI9nKE6SMTDveoVz\XiycnXzd4lwdg>?	NXXPV2lTOjJ2Mke3NFQ>
hiPSC-NPs	NGT1dIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NWf6ellEO+LCid88US=>	NH;vTIM4OiCq	MnTKSG1UVw>?	M3XVbmlv[3KnYYPld{Bk\WyuIIDyc4xq\mW{YYTpc47DqA>?	Mny3NlI3PDJ4OEe=
platelets	MlnOSpVv[3Srb36gRZN{[Xl?	NVHqcI5COTBizszN	MXSxOUBucW5?	MUDEUXNQ	MWTJcoNz\WG\|ZYOgeIhzd22kaX6tcYVlcWG2ZXSgdIxifGWuZYSgZYdoemWpYYTpc44h[W6mIFHUVEB{\WO{ZYTpc44>	MnTNNlMzOzl6N{e=
DN3	MoXXSpVv[3Srb36gRZN{[Xl?	MoPmNVAh\|ryP	MXS5OkBp	NWS4ToZwTE2VTx?=	NX7hbIc5UW6lcnXhd4V{KGOnbHyg[IV3\WyxcH3lcpQh[W6mIIDyc4xq\mW{YYTpc44>	M3:1NlI{PTJ4OUi5
embryonic stem cells (ESC)	NEXFdWRHfW6ldHnvckBCe3OjeR?=	NWTZ[VVKOyEEtV2=	NEPZO40yOSCm	NWH6[pFsTE2VTx?=	MWDQdo9ud3SnczDz[YxnNXKnbnX3ZYwhd2ZibnJDs5ZmNXS7cHWgcY92e2ViZX3idplwdmmlIIP0[Y0h[2WubIOgLGVUSyl?	NU\zZphIOjN6NEOzNVI>
H460	M4TodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MVW1JOK2VQ>?	MmizNlQhcA>?	MoPDSG1UVw>?	MV;Qdo9ud3SnczDj[YxtKHC{b3zp[oVz[XSrb36=	MmTMNlQ{Pjd4OEi=
H157	NITS[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NUfzemlEPSEEtV2=	NH\keWgzPCCq	MWrEUXNQ	MXnQdo9ud3SnczDj[YxtKHC{b3zp[oVz[XSrb36=	NHz3Um4zPDN4N{[4PC=>
H460	MUTBdI9xfG:\|aYOgRZN{[Xl?	Mn;tOUDDvU1?	MljzNlQhcA>?	MWfEUXNQ	M{TncmF1fGWwdXH0[ZMh[2WubDDhdI9xfG:\|aYO=	MVKyOFM3PzZ6OB?=
H157	NXS4VoZiSXCxcITvd4l{KEG\|c3H5	MXm1JOK2VQ>?	MnTSNlQhcA>?	NIHWSoFFVVOR	NGXD[FlFd2W\|IH7veEB{cWewaX\pZ4FvfGy7IHHm[oVkfCCjcH;weI9{cXN?	M2[5SlI1OzZ5Nki4
A549	MXfBdI9xfG:\|aYOgRZN{[Xl?	MnTYOUDDvU1?	MmTkNlQhcA>?	NVjRbWJoTE2VTx?=	M36wUmlv[3KnYYPld{Bk\WyuIHHwc5B1d3Orcx?=	NX[we5RnOjR\|Nke2PFg>
Neural progenitor cells	M3vkUWZ2dmO2aX;uJGF{e2G7	NYfTdIs2OyEQvF2=	MX2xNEBl	MmTjSG1UVw>?	NGfMd2RKdmS3Y3XzJIdmdmW{YYTpc44hd2ZibnX1doFtKHC{b3flcol1d3JiY3XscJM>	NYXkNoZEOjR4M{iwN\|Q>
ES-D3	NGjmOWdEgXSxdH;4bYMhSXO\|YYm=	Mk\qNVDDqM7:TR?=	MnXSN{Bl	Mkn1SG1UVw>?	NYSzdpBSUW6mdXPld{Bud2SncnH0[UBkgXSxdH;4bYNqfHlid3n0bEBKSzVyIH;mJFQvQSEQvF2=	MlK0NlQ4Pzl\|NkW=
ES-CCE	Mon5R5l1d3SxeHnjJGF{e2G7	MYKxNOKh\|ryP	NYS0Z\|FEOyCm	NYTNS4F{TE2VTx?=	MkDTTY5lfWOnczDtc4RmemG2ZTDjfZRwfG:6aXPpeJk>	NIXiR2gzPDd5OUO2OS=>
ES-D3	MWfGeY5kfGmxbjDBd5NigQ>?	NUTaOJgyPcLizszN	NYC2Z\|ZOOyCm	NH;YUYpFVVOR	M163[3N1em:wZ3z5JIlv\HWlZYOgeIhmKGGldHn2bZR6KG:oIGfueE9j\XSjLXPheIVvcW5icHH0bJdigQ>?	NFPjXlQzPDd5OUO2OS=>
ES-CCE	MkPRSpVv[3Srb36gRZN{[Xl?	MXO1xsDPxE1?	MoLsN{Bl	MXPEUXNQ	MmfjV5Rzd26pbImgbY5lfWOnczD0bIUh[WO2aY\peJkhd2ZiV370M4JmfGFvY3H0[Y5qdiCyYYToe4F6	NXPTfWFpOjR5N{mzOlU>
SW982	MkjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NInse\|ZKSzVyPUCuNlE1OTZizszN	Mo\NV2FPT0WU
GCT	NHS4PFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4TVU2lEPTB;MD6zNFY4OiEQvF2=	NF;zbplUSU6JRWK=
769-P	NXPHbXVjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlLXTWM2OD1yLkW4OFk6KM7:TR?=	NHuzOW9USU6JRWK=
LOXIMVI	M3zXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4ixNGlEPTB;MD61PFg{OiEQvF2=	NIj3foVUSU6JRWK=
D-336MG	M3TnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTBwOES2NkDPxE1?	M3v0XnNCVkeHUh?=
S-117	NVyyUYJPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH7EdHlKSzVyPUCuPVIyOzFizszN	NVW5UmR6W0GQR1XS
D-247MG	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVXJR\|UxRTBwOUS4OVIh\|ryP	MXjTRW5ITVJ?
TYK-nu	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIq5WYRKSzVyPUGuNFc6OTJizszN	NIrOW5lUSU6JRWK=
A498	MoTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Ml6wTWM2OD1zLkOwOFY6KM7:TR?=	NUPO[ZdUW0GQR1XS
BCPAP	NGfSeIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3TGXWlEPTB;MT62Olg6QCEQvF2=	MmPaV2FPT0WU
KYSE-180	NUL6SHZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MULJR\|UxRTFwN{K3PFgh\|ryP	M1\GNXNCVkeHUh?=
MIA-PaCa-2	NXH1blJzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHXXOolKSzVyPUGuO\|U6PzdizszN	NFzYNXBUSU6JRWK=
HCC1395	Mk\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWnleVFTUUN3ME2xMlc5Ojd\|IN88US=>	NHHP[o9USU6JRWK=
RS4-11	NG[0TXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmriTWM2OD1zLkm1OFE2KM7:TR?=	MkO3V2FPT0WU
NCI-H2122	MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3riPGlEPTB;Mj6yO\|Y5PCEQvF2=	M365XHNCVkeHUh?=
SNU-423	M3nxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF3xbGxKSzVyPUKuOFk4QDdizszN	NUPJRY9wW0GQR1XS
SK-LMS-1	NVXXcngyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml22TWM2OD1{Lk[0NVI5KM7:TR?=	M3r5U3NCVkeHUh?=
RPMI-7951	NGG4doFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVPJR\|UxRTJwN{CxPVMh\|ryP	MXTTRW5ITVJ?
COLO-829	MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVXNcHFEUUN3ME2yMlc3PTRizszN	NWrud5pIW0GQR1XS
SCC-9	MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUXFdJZRUUN3ME2yMlk2PDh3IN88US=>	NH\hS2ZUSU6JRWK=
A704	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVnUdFA2UUN3ME2zMlA5OTJizszN	NIHjN3BUSU6JRWK=
HOP-62	MnjIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn;FTWM2OD1\|LkO2NFU1KM7:TR?=	MVfTRW5ITVJ?
HCC1569	MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVrsdIZUUUN3ME2zMlQ5OzB3IN88US=>	M4rlZXNCVkeHUh?=
A172	NGDGO2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVzJR\|UxRTNwN{W0PVgh\|ryP	M1nCW3NCVkeHUh?=
MOLT-16	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoLHTWM2OD1\|Lki4OVU3KM7:TR?=	NFey[pZUSU6JRWK=
TE-15	M3vOXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWfJR\|UxRTNwOUWzOFMh\|ryP	M1LLS3NCVkeHUh?=
OE19	MnLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnHVTWM2OD1\|Lkm2OFUyKM7:TR?=	MUnTRW5ITVJ?
MHH-ES-1	M3;hNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MU\JR\|UxRTRwMES1OFUh\|ryP	M4DuUXNCVkeHUh?=
NKM-1	MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXfJR\|UxRTRwMUO5O\|Eh\|ryP	NUiwfoxjW0GQR1XS
RCC10RGB	NXy1RodXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{jiWWlEPTB;ND6yPVQ4QSEQvF2=	MlPoV2FPT0WU
BxPC-3	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYHGO5NXUUN3ME20MlcxOzlzIN88US=>	NX7nblNvW0GQR1XS
ALL-PO	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTRwOEO4OVgh\|ryP	NGfuT5RUSU6JRWK=
SK-OV-3	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX3JR\|UxRTRwOUmzOEDPxE1?	Mom2V2FPT0WU
SW1710	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH;XbmVKSzVyPUWuOFI1PTZizszN	MXfTRW5ITVJ?
NCI-H2452	M2XPZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXzJR\|UxRTVwNEW2Nlgh\|ryP	NFnobnBUSU6JRWK=
D-392MG	M4fRTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NV3C[lhDUUN3ME21MlQ6OTR3IN88US=>	M1jrcXNCVkeHUh?=
LB2518-MEL	MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIHHOXlKSzVyPUWuO\|I3OjdizszN	Mo\sV2FPT0WU
BL-41	MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mof6TWM2OD13LkixNlY3KM7:TR?=	NWe5WIJiW0GQR1XS
WM-115	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{jVW2lEPTB;NT64NVUxQSEQvF2=	MXPTRW5ITVJ?
SK-MEL-2	MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlLQTWM2OD14LkO4N\|Q1KM7:TR?=	NIX4PHFUSU6JRWK=
CGTH-W-1	MkK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXHJR\|UxRTZwNEG3JO69VQ>?	M3\VdnNCVkeHUh?=
BB65-RCC	M2PVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MULJR\|UxRTZwNUOxPVUh\|ryP	M1XKV3NCVkeHUh?=
CAL-85-1	Mk\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3j3eGlEPTB;Nj62NFk{PiEQvF2=	M3nxdnNCVkeHUh?=
RT-112	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHLzb49KSzVyPUeuNVY1PTZizszN	Mo\SV2FPT0WU
MC116	NX;X[5p5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFn2R2RKSzVyPUeuNlg3QTFizszN	MYfTRW5ITVJ?
G-361	M{WyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkjMTWM2OD15LkS2OVYyKM7:TR?=	MXLTRW5ITVJ?
SW1417	NYCzRmtDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NU\2UG9lUUN3ME23MlY1PTh2IN88US=>	Mn6wV2FPT0WU
MV-4-11	NFzIbJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWHNZ\|NjUUN3ME24MlU1OzB2IN88US=>	MVXTRW5ITVJ?
CAL-72	NXjLOZdwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4PUV2lEPTB;OD63OlEyOyEQvF2=	M{HOSXNCVkeHUh?=
MKN28	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUPnUW56UUN3ME24Mlg5PTF4IN88US=>	NHzuTo9USU6JRWK=
MEG-01	NFXrOIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MU\JR\|UxRThwOUmwOFMh\|ryP	NVGw[oJqW0GQR1XS
ACHN	MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFXXTIJKSzVyPUmuN\|A2PDZizszN	M3jCcHNCVkeHUh?=
NCI-H1755	NFzWcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mnm1TWM2OD17LkO5PVg3KM7:TR?=	M4j6eXNCVkeHUh?=
NCI-H64	M4G5emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHrsOIxKSzVyPUmuOFIzPTVizszN	NIfjRnVUSU6JRWK=
COLO-205	NILwc29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFi4PY1KSzVyPUmuOFM5OjFizszN	MX\TRW5ITVJ?
CTV-1	NXXqbHhHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX7JR\|UxRTlwNEO4PVQh\|ryP	NXi3NFlzW0GQR1XS
U-2-OS	MoL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWDrfIlHUUN3ME25MlQ2ODB4IN88US=>	NWXhRnY6W0GQR1XS
LB996-RCC	Mk\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2HocGlEPTB;OT61NlM6PyEQvF2=	M1X1fXNCVkeHUh?=
SK-N-DZ	NGDnbplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn\TTWM2OD17Lk[1O\|QzKM7:TR?=	NIjNV2RUSU6JRWK=
EFM-19	M2nL[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYrzfY12UUN3ME25Mlc2PTZ4IN88US=>	NVLnbY9vW0GQR1XS
DBTRG-05MG	NYS1VWM6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYHJR\|UxRTlwN{e3O{DPxE1?	NG\CXGpUSU6JRWK=
U-118-MG	M4nn[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NY\xUmhXUUN3ME25Mlk1PDR2IN88US=>	NWrBUW9VW0GQR1XS
LB1047-RCC	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEXQcopKSzVyPUmuPVk4QThizszN	M4Dq[nNCVkeHUh?=
NCI-H28	M2HzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoDTTWM2OD1zMD60OFE{KM7:TR?=	NIXMW5pUSU6JRWK=
MZ2-MEL	M1O1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFTLfVVKSzVyPUGwMlQ3PzdizszN	NFXO[3NUSU6JRWK=
M059J	NFjTbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUjJR\|UxRTFyLk[xNFIh\|ryP	NX7ZVnJLW0GQR1XS
HT-3	NGHQTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGrGPYdKSzVyPUGwMlYyPzlizszN	MXnTRW5ITVJ?
SNU-387	MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoPMTWM2OD1zMD63NlM2KM7:TR?=	MVLTRW5ITVJ?
NCI-H526	MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXjJR\|UxRTFzLkGzOlUh\|ryP	NGHoToZUSU6JRWK=
HEL	Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWrJR\|UxRTFzLk[1O\|kh\|ryP	MWrTRW5ITVJ?
PA-1	M3;VdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVfhdVNpUUN3ME2xNU46OyEQvF2=	NI\4N2dUSU6JRWK=
PC-14	NXPFdFN3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX;JR\|UxRTF{LkOyOEDPxE1?	Mnz6V2FPT0WU
C8166	NVXWdGM5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkHCTWM2OD1zMz6yN\|E5KM7:TR?=	NVr5VotoW0GQR1XS
NCI-H82	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlG2TWM2OD1zMz6yPVA6KM7:TR?=	MmXxV2FPT0WU
DSH1	M4nyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2rIWmlEPTB;MUOuN\|g4QSEQvF2=	M1:2U3NCVkeHUh?=
T98G	M2H4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYrJR\|UxRTF\|LkS3NVch\|ryP	NU[z[IQxW0GQR1XS
KU812	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYjJR\|UxRTF\|LkWxO\|Uh\|ryP	NHu1NWlUSU6JRWK=
SW48	M3LNVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mle4TWM2OD1zMz63NlY2KM7:TR?=	NFXRVotUSU6JRWK=
MEL-HO	M4X5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1HSdGlEPTB;MUOuPFgzQSEQvF2=	MoLNV2FPT0WU
SF539	M3Lxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVLj[5NnUUN3ME2xOE4xOTF4IN88US=>	MYXTRW5ITVJ?
NB1	MlfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEjIfVVKSzVyPUG0MlE6OzVizszN	NH2wXFJUSU6JRWK=
ST486	NUX0T\|FFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{[zcWlEPTB;MUSuNlI2OSEQvF2=	NGDEeZpUSU6JRWK=
LoVo	NHHS[\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHr2PZZKSzVyPUG1MlI3PTlizszN	NYDNN4s6W0GQR1XS
NH-12	NH3FcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF7TXI9KSzVyPUG2MlAxQTdizszN	NYTQdYJrW0GQR1XS
CCRF-CEM	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmO2TWM2OD1zNj62O\|AzKM7:TR?=	MUDTRW5ITVJ?
Daudi	Mly2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX3GSHFuUUN3ME2xO{43OTR7IN88US=>	MVLTRW5ITVJ?
SIMA	NXy1XYd4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVLqWI03UUN3ME2xO{46OTF6IN88US=>	MnLXV2FPT0WU
8305C	Mmn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWDlRmRWUUN3ME2xPE42OzB3IN88US=>	NFrBXllUSU6JRWK=
EM-2	NXnnVJZqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnTJTWM2OD1zOD62NlQ5KM7:TR?=	NH23ZlhUSU6JRWK=
SNU-449	MlrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3HVXmlEPTB;MUiuO\|E2KM7:TR?=	MoKxV2FPT0WU
A101D	M1jPemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MY\JR\|UxRTF7LkK0N{DPxE1?	Mkn1V2FPT0WU
MHH-NB-11	MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3S2NWlEPTB;MUmuOVM1OiEQvF2=	MXHTRW5ITVJ?
Becker	MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFz5[JVKSzVyPUKwMlE4PzdizszN	MVvTRW5ITVJ?
NCI-H727	NX;3WJpZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2HHN2lEPTB;MkCuNlE3QSEQvF2=	M2H3TnNCVkeHUh?=
HCC1187	NWDhWXpyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2XNT2lEPTB;MkCuN\|U5QSEQvF2=	NGDJRoFUSU6JRWK=
KYSE-450	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NILy[3pKSzVyPUKxMlU{PTRizszN	NVu2ZnRDW0GQR1XS
SK-MEL-28	NVPH[lFQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTJzLk[4OlMh\|ryP	M37xNnNCVkeHUh?=
BPH-1	NW\RUlNNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYqyZ3c6UUN3ME2yNU44ODN3IN88US=>	Mn7ZV2FPT0WU
EoL-1-	M4TSeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NV:2UFI3UUN3ME2yNU45Ozh3IN88US=>	NITsUmRUSU6JRWK=
TGBC24TKB	NYL6V3d7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M121NWlEPTB;MkGuPFk2PyEQvF2=	MVXTRW5ITVJ?
KARPAS-299	M1\2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYnmV4ZMUUN3ME2yNk4yQTV2IN88US=>	MmPpV2FPT0WU
SW684	M2TRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NE\abnZKSzVyPUKyMlI5PThizszN	MnWwV2FPT0WU
RXF393	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DLcWlEPTB;MkKuOlA3QCEQvF2=	M{LSeHNCVkeHUh?=
LS-513	MlW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWi3bnduUUN3ME2yNk43OTl{IN88US=>	MVPTRW5ITVJ?
KURAMOCHI	NGjUSVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV3JR\|UxRTJ{LkewOlkh\|ryP	MoPlV2FPT0WU
GI-1	NVnp[mRjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NE[5V4xKSzVyPUKyMlc5PDFizszN	NFThTXZUSU6JRWK=
M14	M4W3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmPNTWM2OD1{Mz6xNVMzKM7:TR?=	MUDTRW5ITVJ?
REH	Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEnvdJVKSzVyPUKzMlE3QTlizszN	Mom3V2FPT0WU
K5	M4Xjb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYDJR\|UxRTJ\|LkW0PFYh\|ryP	M33qO3NCVkeHUh?=
PANC-10-05	M3jrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTJ2LkC4PVgh\|ryP	M3j0THNCVkeHUh?=
HMV-II	M3i5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn[yTWM2OD1{ND6yNVY{KM7:TR?=	MorpV2FPT0WU
NCI-H1963	M2jnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYDOcY5qUUN3ME2yOE4zQDN7IN88US=>	MlPhV2FPT0WU
LU-139	NULJN41uT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYjJR\|UxRTJ2LkizOUDPxE1?	M{[0[HNCVkeHUh?=
KASUMI-1	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2TlSmlEPTB;MkSuPVMzQCEQvF2=	M{XOWnNCVkeHUh?=
RO82-W-1	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX3JR\|UxRTJ4LkezO\|ch\|ryP	M3excHNCVkeHUh?=
NCI-H1770	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M17ScGlEPTB;Mk[uPFk5PiEQvF2=	M{TLT3NCVkeHUh?=
SNG-M	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV\JR\|UxRTJ5LkKyO\|Eh\|ryP	MlXsV2FPT0WU
KLE	NWGxWVZvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlWyTWM2OD1{Nz6yOVY2KM7:TR?=	MWDTRW5ITVJ?
NCI-H2170	M{m1fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFiyNZhKSzVyPUK3MlUzQDJizszN	NYrEdZlIW0GQR1XS
COLO-792	NEjUfmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXHJR\|UxRTJ5Lke3Nlgh\|ryP	M4TyU3NCVkeHUh?=
ES8	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2XkTGlEPTB;MkeuO\|gyPCEQvF2=	M3TyTnNCVkeHUh?=
MC-CAR	Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYPT[YNMUUN3ME2yO{44QTB5IN88US=>	NVPzeXh3W0GQR1XS
SU-DHL-1	M1:0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3raVWlEPTB;MkeuPVQ4PCEQvF2=	NHfUZ2hUSU6JRWK=
OAW-28	NGH3e\|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVy2RY9zUUN3ME2yPE4xODV{IN88US=>	NFf2dHpUSU6JRWK=
C32	NWPVNog1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4X3fWlEPTB;MkiuNFgzPiEQvF2=	NVL4NGxbW0GQR1XS
SW872	Mmq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NG[3UVlKSzVyPUK4MlU{OjZizszN	MkP6V2FPT0WU
JiyoyeP-2003	NYS5SnNkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mk\oTWM2OD1{OT62O\|E6KM7:TR?=	NUP4VYFYW0GQR1XS
A204	NVTHWIRoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGP3VYhKSzVyPUK5MlY5OjhizszN	MUDTRW5ITVJ?
IST-MES1	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkPETWM2OD1{OT63NFkzKM7:TR?=	MXvTRW5ITVJ?
LCLC-103H	MkCzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGL5T3lKSzVyPUOwMlIxPTlizszN	NHTMTFNUSU6JRWK=
CAKI-1	M3rEUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHLpbHpKSzVyPUOwMlI3PTZizszN	NIHJSZJUSU6JRWK=
NALM-6	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXTySFhuUUN3ME2zNE41QTZ3IN88US=>	MYLTRW5ITVJ?
SK-MM-2	NVTQVVFbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2PCSGlEPTB;M{CuPVc6OiEQvF2=	NIG3UG5USU6JRWK=
LB373-MEL-D	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUHJR\|UxRTNzLkCwOFch\|ryP	NXvGbVhbW0GQR1XS
CAS-1	MlHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVjafFE2UUN3ME2zNU44PjZ3IN88US=>	M2H2U3NCVkeHUh?=
KNS-42	NI\DTm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnX5TWM2OD1\|MT64OlYzKM7:TR?=	NUT3OW55W0GQR1XS
SW948	NYfr[VIxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXPJR\|UxRTN{Lke1OFgh\|ryP	M4\qRXNCVkeHUh?=
HCC1143	MmG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWDJR\|UxRTN{Lke5O\|kh\|ryP	M3zzVHNCVkeHUh?=
NCI-H1648	MoKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYHTcXg3UUN3ME2zNk45PDZ5IN88US=>	NFnaSWFUSU6JRWK=
RVH-421	NX;aVIFQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHXCWmFKSzVyPUOzMlE3QCEQvF2=	MYXTRW5ITVJ?
KU-19-19	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTN\|Lke1N\|Qh\|ryP	MkHwV2FPT0WU
PFSK-1	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEfEXm9KSzVyPUO0MlkzPDFizszN	MY\TRW5ITVJ?
TK10	NHfBNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUTCUGJtUUN3ME2zOU4yOzJ{IN88US=>	MnnRV2FPT0WU
IGROV-1	NITrUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MofvTWM2OD1\|NT6zOFE3KM7:TR?=	MmHnV2FPT0WU
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LU-65	NVTxenc4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mnm2TWM2OD1zMEGuNFgyKM7:TR?=	NUnqT2lqW0GQR1XS
Saos-2	NILtS2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFm3S3ZKSzVyPUGwNU41OzdizszN	NIfPdIZUSU6JRWK=
TE-11	MoDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2\3fmlEPTB;MUCxMlczPCEQvF2=	MYjTRW5ITVJ?
SK-MES-1	NYXBcHpUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmO4TWM2OD1zMEGuO\|YzKM7:TR?=	MXPTRW5ITVJ?
KE-37	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mmj6TWM2OD1zMEKuPVUh\|ryP	MXjTRW5ITVJ?
MKN45	NULLTGpCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVXsd4FbUUN3ME2xNFMvPTh2IN88US=>	NGrNS2hUSU6JRWK=
UM-UC-3	MoSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWDBR49GUUN3ME2xNFMvQDR{IN88US=>	NEnYRYNUSU6JRWK=
SNU-C2B	M1npbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MW\JR\|UxRTFyNT6wNlMh\|ryP	M1PjXnNCVkeHUh?=
RPMI-8226	NFXsfWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXfJR\|UxRTFyNj62O\|gh\|ryP	MXnTRW5ITVJ?
PANC-08-13	MkXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlLzTWM2OD1zME[uPFUh\|ryP	NFTtNWVUSU6JRWK=
NCI-H23	NGnsd3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEKzVJZKSzVyPUGwPE4{PTdizszN	NHHDOWtUSU6JRWK=
HOP-92	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1u1bGlEPTB;MUC4MlQ4PSEQvF2=	MXzTRW5ITVJ?
FTC-133	NHrkdI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH;DZlFKSzVyPUGwPE41QDhizszN	M4qzTnNCVkeHUh?=
D-263MG	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4e5TWlEPTB;MUC4Mlk3OSEQvF2=	MVjTRW5ITVJ?
DU-145	NIrjT2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnnXTWM2OD1zMEmuPVQ2KM7:TR?=	M4TrRXNCVkeHUh?=
A253	NWT1NIxRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2\pb2lEPTB;MUGwMlQ4QSEQvF2=	MkHXV2FPT0WU
HCT-15	NFfNSnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFzNcVNKSzVyPUGxNE43PjFizszN	NGDKbWdUSU6JRWK=
WSU-NHL	NHrWepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUfJR\|UxRTFzMj6wNUDPxE1?	NFnnNJJUSU6JRWK=
U031	NE\FfndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2juW2lEPTB;MUGyMlA3PSEQvF2=	NYn6UXRnW0GQR1XS
MDA-MB-157	Ml\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3HMSGlEPTB;MUGyMlQ6KM7:TR?=	NUTiXVZPW0GQR1XS
NEC8	MmLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX\JR\|UxRTFzMj62NlQh\|ryP	M3fycnNCVkeHUh?=
SIG-M5	NUn4SWI{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NW[xe5FQUUN3ME2xNVMvOTJ3IN88US=>	M{XMdXNCVkeHUh?=
786-0	Mnr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWrJR\|UxRTFzMz60OVMh\|ryP	NHrtTo5USU6JRWK=
DMS-273	M{HzfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoK3TWM2OD1zMUWuOlE4KM7:TR?=	NF;BWHJUSU6JRWK=
Calu-6	Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWLJR\|UxRTFzNj63PVgh\|ryP	MmHOV2FPT0WU
HCC1599	M2fDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGjZU\|ZKSzVyPUGxO{4yPTZizszN	NWDQSFFRW0GQR1XS
OVCAR-8	MlXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1\x[WlEPTB;MUG3MlY3QCEQvF2=	M3nGU3NCVkeHUh?=
ATN-1	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnrMTWM2OD1zMUeuPFI5KM7:TR?=	MXnTRW5ITVJ?
RKO	NVjuR\|VCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUHGRnpmUUN3ME2xNVcvQDl6IN88US=>	NHK1VlJUSU6JRWK=
SKG-IIIa	NVzJXYd4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1vOemlEPTB;MUG4MlEyPiEQvF2=	NF;5fGhUSU6JRWK=
SUP-T1	MofmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NU[wdY5TUUN3ME2xNVgvQTV4IN88US=>	NV23SGRzW0GQR1XS
KNS-81-FD	M36zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{nDTmlEPTB;MUG5MlQyPyEQvF2=	NXvVU\|drW0GQR1XS
OVCAR-3	NVrPXHgzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3;FWGlEPTB;MUG5MlkyPSEQvF2=	NY[1Upd3W0GQR1XS
NCI-N87	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYrNOGZ2UUN3ME2xNlEvODR2IN88US=>	MXrTRW5ITVJ?
HuP-T4	NHfLe5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3Ppd2lEPTB;MUKxMlU2KM7:TR?=	NYroW2pxW0GQR1XS
KYSE-140	NYfCZ49kT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnzUTWM2OD1zMkKuNVQyKM7:TR?=	MYTTRW5ITVJ?
HAL-01	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;OSmhMUUN3ME2xNlIvPDl7IN88US=>	NIroZnVUSU6JRWK=
HT-29	M2ntXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkHKTWM2OD1zMkKuO\|c5KM7:TR?=	MWPTRW5ITVJ?
OPM-2	MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHnDU41KSzVyPUGyN{4yPzZizszN	NVnyfYMzW0GQR1XS
SW1463	M3nh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlfKTWM2OD1zMkSuNFc4KM7:TR?=	M{j3V3NCVkeHUh?=
NCI-H2087	NHO0RoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEfWUHpKSzVyPUGyOE4zQDNizszN	MoPlV2FPT0WU
UMC-11	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoDkTWM2OD1zMk[uNFM5KM7:TR?=	NYi0O4FKW0GQR1XS
EB-3	MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{DUbmlEPTB;MUK3MlAyOyEQvF2=	NWSwd2tkW0GQR1XS
HEC-1	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXfJR\|UxRTF{OT6xPVgh\|ryP	MkO5V2FPT0WU
LU-99A	NIjQWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVH6OlNwUUN3ME2xNlkvQTNzIN88US=>	NGfwU2dUSU6JRWK=
VMRC-RCZ	NH\MTnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVrJR\|UxRTF\|MD6zO\|Uh\|ryP	NX\SZpJyW0GQR1XS
MFH-ino	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoT4TWM2OD1zM{GuNVE1KM7:TR?=	NX;xZVR5W0GQR1XS
HT-1080	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTF\|Mj6yNFQh\|ryP	MV7TRW5ITVJ?
CTB-1	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVjJR\|UxRTF\|Mj64PVch\|ryP	NXPHe5l3W0GQR1XS
Capan-2	M2DnOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlfETWM2OD1zM{OuPVc2KM7:TR?=	Mlj2V2FPT0WU
BB30-HNC	NYfnO49tT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn\STWM2OD1zM{SuNVE3KM7:TR?=	NV\r[WV{W0GQR1XS
CP50-MEL-B	NXn0b4hLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MULJR\|UxRTF\|ND6yJO69VQ>?	NYD2UG9bW0GQR1XS
JEG-3	MnPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWfJR\|UxRTF\|ND6zOVkh\|ryP	MV;TRW5ITVJ?
NCI-H1437	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1nnR2lEPTB;MUO0MlU6KM7:TR?=	NYKzdll6W0GQR1XS
NOS-1	M4XEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWK0NlZRUUN3ME2xN\|QvPzZ3IN88US=>	M2\GWnNCVkeHUh?=
G-402	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWfmNGdZUUN3ME2xN\|UvOjl3IN88US=>	MnHjV2FPT0WU
OAW-42	Mmm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF\qXoFKSzVyPUGzO{45PTZizszN	M2\YWnNCVkeHUh?=
Ca-Ski	M2\WdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFXYR2hKSzVyPUGzPE45OzFizszN	MmXkV2FPT0WU
BHT-101	M1rwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXnJR\|UxRTF2MD6yNFgh\|ryP	NWX2Z5pYW0GQR1XS
OVCAR-4	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHWzRm1KSzVyPUG0NE44PDlizszN	M4q3fnNCVkeHUh?=
Detroit562	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4D2fWlEPTB;MUSxMlQ3PiEQvF2=	NGHzfZBUSU6JRWK=
OCI-AML2	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUnJR\|UxRTF2MT61NFch\|ryP	MVvTRW5ITVJ?
OE33	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NW\hdGRLUUN3ME2xOFEvPzl6IN88US=>	M3TMdnNCVkeHUh?=
YKG-1	NFXiXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MX3JR\|UxRTF2Mj64PFkh\|ryP	NUnCO\|J4W0GQR1XS
CCF-STTG1	M1\rXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX3TWWlrUUN3ME2xOFMvOzN2IN88US=>	NEDLNlJUSU6JRWK=
NCI-H810	MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWDUbZR5UUN3ME2xOFMvPjh5IN88US=>	MlzTV2FPT0WU
SCC-25	NEHDeGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEPOfJBKSzVyPUG0OE4xODVizszN	Ml\sV2FPT0WU
HTC-C3	Ml6yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnPYTWM2OD1zNEWuNFc2KM7:TR?=	NGDKeItUSU6JRWK=
G-401	MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYP1Tlc5UUN3ME2xOFUvQDN3IN88US=>	NWrScZpjW0GQR1XS
OMC-1	Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTF2NT65Olch\|ryP	NWPDUYpwW0GQR1XS
LK-2	Ml2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVjPb3dzUUN3ME2xOFcvOTR\|IN88US=>	M4qz[HNCVkeHUh?=
SW13	NFzkdJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXfJR\|UxRTF2Nz6yOVMh\|ryP	NH:5O3lUSU6JRWK=
BB49-HNC	M4nHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmO5TWM2OD1zNEeuOFA1KM7:TR?=	NXTKbGd6W0GQR1XS
DMS-114	M4DJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUnJR\|UxRTF2Nz60OFEh\|ryP	NYTleJBCW0GQR1XS
GCIY	M4DJWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXXJR\|UxRTF2Nz63PVch\|ryP	NFjnUmlUSU6JRWK=
GAMG	NYD1SYJtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoPhTWM2OD1zNEiuNlQ4KM7:TR?=	M1f3eHNCVkeHUh?=
KYSE-520	NU[5enZuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2LFfmlEPTB;MUS4MlU1KM7:TR?=	MXnTRW5ITVJ?
LB647-SCLC	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NInXXohKSzVyPUG0PE42PjJizszN	MljGV2FPT0WU
639-V	M{nYSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTF2OD63NFUh\|ryP	MXLTRW5ITVJ?
TE-9	MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlHETWM2OD1zNEmuOFQ{KM7:TR?=	M1:5fnNCVkeHUh?=
Caov-3	NGDCUW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIWyWWlKSzVyPUG0PU44OTRizszN	NWX0Umc6W0GQR1XS
L-540	NYC3TpNPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXvJR\|UxRTF2OT63OUDPxE1?	NX7LcHVtW0GQR1XS
NCI-H748	M1HneWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUDJR\|UxRTF3MD6yNFkh\|ryP	MoXlV2FPT0WU
GDM-1	NWnP[ZdoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYXVPYpRUUN3ME2xOVEvOTN3IN88US=>	NF7jPFNUSU6JRWK=
GAK	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn7mTWM2OD1zNUGuN\|c1KM7:TR?=	NWrYR5REW0GQR1XS
AsPC-1	MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFf4WopKSzVyPUG1Nk44PjRizszN	Mmf1V2FPT0WU
MDA-MB-361	NGPqZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1rDU2lEPTB;MUWzMlE3PCEQvF2=	M2TlSHNCVkeHUh?=
TT	MkOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlrVTWM2OD1zNUOuOFkh\|ryP	NFrPU4tUSU6JRWK=
Calu-1	NF;ablFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIeySHVKSzVyPUG1OE4xODNizszN	NHW5N5FUSU6JRWK=
RERF-LC-MS	NGDoW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFrlOWRKSzVyPUG1OE44PzJizszN	MX;TRW5ITVJ?
DK-MG	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NG\kZWNKSzVyPUG1OU4yQDNizszN	NV;QfWV[W0GQR1XS
CAL-120	NWqyU2FoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmniTWM2OD1zNUWuPFIyKM7:TR?=	MoDDV2FPT0WU
HCC1419	M3XocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX;4[VhjUUN3ME2xOVYvODd5IN88US=>	NH:2Xo1USU6JRWK=
DG-75	NEXKXYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MorDTWM2OD1zNU[uOlk1KM7:TR?=	M{\6NnNCVkeHUh?=
HCC38	NGnYV2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlPhTWM2OD1zNUeuN\|Y6KM7:TR?=	NWDmeJpNW0GQR1XS
HCC70	NWD4SZR6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVLJR\|UxRTF3OT6yOFIh\|ryP	NF;MfXNUSU6JRWK=
ES4	MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NETt[YFKSzVyPUG1PU4{QTZizszN	MXXTRW5ITVJ?
NCI-H2052	NXvn[4xST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEW3TopKSzVyPUG1PU42QDNizszN	NEDYcoFUSU6JRWK=
EFO-27	NGXoSmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnrETWM2OD1zNkCuOVg1KM7:TR?=	MYDTRW5ITVJ?
CAL-62	NYm1SnQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmeyTWM2OD1zNkKuOlE{KM7:TR?=	NIKzdYlUSU6JRWK=
CHP-212	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUXqfFJIUUN3ME2xOlMvPjJ4IN88US=>	NEPBV5FUSU6JRWK=
AU565	NW\iVGRtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MojqTWM2OD1zNkOuOlQh\|ryP	MoHBV2FPT0WU
Ca9-22	MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYTJR\|UxRTF4ND6zNlEh\|ryP	M3HBW3NCVkeHUh?=
EFO-21	MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{LrVmlEPTB;MU[1MlQ2KM7:TR?=	NVPocYF7W0GQR1XS
KINGS-1	MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{G5RWlEPTB;MU[3MlM2PCEQvF2=	MU\TRW5ITVJ?
JVM-2	NE[yUnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYnXd4diUUN3ME2xOlcvPDVzIN88US=>	MVjTRW5ITVJ?
OVCAR-5	M{njXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NI\4XnFKSzVyPUG2PE4{ODlizszN	MkPmV2FPT0WU
Calu-3	NF\ZWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MoO5TWM2OD1zNkiuN\|EyKM7:TR?=	NEfPT5lUSU6JRWK=
CP66-MEL	NIPvdVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnrkTWM2OD1zNkiuOFE2KM7:TR?=	M4TyZnNCVkeHUh?=
KYSE-150	NUHJO\|F5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWHJR\|UxRTF4OT62N\|Yh\|ryP	M3X2[HNCVkeHUh?=
Daoy	M2r4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmXRTWM2OD1zNkmuPFkyKM7:TR?=	M{PNfnNCVkeHUh?=
HUTU-80	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlzPTWM2OD1zN{GuNFMzKM7:TR?=	M{TJSXNCVkeHUh?=
SW620	MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYnuUVZ7UUN3ME2xO\|EvPTN3IN88US=>	Ml3oV2FPT0WU
HuO-3N1	NG\4VFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{L4e2lEPTB;MUeyMlI4OyEQvF2=	MX;TRW5ITVJ?
HH	NFK4c3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml7oTWM2OD1zN{OuPFQ5KM7:TR?=	MnTuV2FPT0WU
ME-180	NEX4VphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFvlfIlKSzVyPUG3OE4xOTZizszN	M2PMbXNCVkeHUh?=
SW756	NWqwUFlUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn7uTWM2OD1zN{SuPFY{KM7:TR?=	MX3TRW5ITVJ?
LNCaP-Clone-FGC	NIjrfIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4XkSGlEPTB;MUe1Mlg3OSEQvF2=	NWPQOGNxW0GQR1XS
YT	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmPzTWM2OD1zN{[uN\|k6KM7:TR?=	M1fpZnNCVkeHUh?=
EW-3	MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4G3RmlEPTB;MUe2MlU2PSEQvF2=	NFT4[3BUSU6JRWK=
COLO-741	NGPzcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVfJR\|UxRTF5Nz61OlEh\|ryP	MX;TRW5ITVJ?
SK-NEP-1	M2rSemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1X4VmlEPTB;MUe3MlgxPiEQvF2=	NIfI[\|JUSU6JRWK=
NB10	MorpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF7wN2lKSzVyPUG3O{45PDZizszN	NWT0bIpWW0GQR1XS
SF126	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkizTWM2OD1zN{muOFMzKM7:TR?=	NE\KXXpUSU6JRWK=
NCI-H522	M1zU[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVXrVFdiUUN3ME2xPFEvODV7IN88US=>	MnnYV2FPT0WU
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GI-ME-N	NF:4NYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWjj[JlEUUN3ME2xPFEvPjd{IN88US=>	MXPTRW5ITVJ?
SBC-5	M3HEU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mlf1TWM2OD1zOEGuPVM1KM7:TR?=	NXnxN4xDW0GQR1XS
ONS-76	M{iwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVLJR\|UxRTF6Mj6zPFch\|ryP	M3WyenNCVkeHUh?=
LOUCY	NXT4dnYzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYPoXohpUUN3ME2xPFIvPjh6IN88US=>	M3\n[XNCVkeHUh?=
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A427	NHvWRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWLJR\|UxRTF6ND62N\|Eh\|ryP	MljzV2FPT0WU
DOK	NFLFSVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXXEbJlZUUN3ME2xPFQvPjR\|IN88US=>	NXvCPXY5W0GQR1XS
MDA-MB-415	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml\STWM2OD1zOESuOlUyKM7:TR?=	NFXiNGFUSU6JRWK=
MRK-nu-1	M3\zbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnLiTWM2OD1zOESuPVczKM7:TR?=	MUjTRW5ITVJ?
LB2241-RCC	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTF6NT6xOFUh\|ryP	M{DvWHNCVkeHUh?=
NCI-H1563	NFXZWVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYPpPXFUUUN3ME2xPFUvOjB7IN88US=>	Mmm2V2FPT0WU
MDA-MB-453	Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{LCdWlEPTB;MUi2Mlk1OSEQvF2=	NFuyWndUSU6JRWK=
MONO-MAC-6	NIK5OnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4fM[mlEPTB;MUi3MlM6OiEQvF2=	M3zhNnNCVkeHUh?=
CAPAN-1	NIjpbZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2TYXGlEPTB;MUi3MlQ2OyEQvF2=	M2nXZ3NCVkeHUh?=
SK-LU-1	NEm1VGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnnRTWM2OD1zOEiuOFI5KM7:TR?=	NHm0TJJUSU6JRWK=
NCI-H1299	M17JXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MWPJR\|UxRTF6OD63NVkh\|ryP	M1GzOnNCVkeHUh?=
KG-1	NE\pc4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml7jTWM2OD1zOEmuO\|k5KM7:TR?=	NFeye\|ZUSU6JRWK=
ETK-1	NFy0ZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlLmTWM2OD1zOUCuNVgyKM7:TR?=	MkfCV2FPT0WU
NCI-H838	NW\QWItPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXrvcIUxUUN3ME2xPVAvOzRizszN	MYPTRW5ITVJ?
HCE-4	MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX\JR\|UxRTF7MD65PVIh\|ryP	NU\GemR1W0GQR1XS
A2780	NXr1SGtUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX7JR\|UxRTF7Mj64PVEh\|ryP	MkfkV2FPT0WU
COLO-668	NU[yOZZST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYfJR\|UxRTF7Mz6xOVch\|ryP	MlHCV2FPT0WU
HGC-27	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MU\JR\|UxRTF7NT61N\|gh\|ryP	NUn4b5N1W0GQR1XS
SW1088	NHXhUVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTF7NT62O\|ch\|ryP	NHT5NIZUSU6JRWK=
KOSC-2	NIfW[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3jRZWlEPTB;MUm1MlgyQCEQvF2=	NWrlUWhXW0GQR1XS
TE-1	M160e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYr5e2Q4UUN3ME2xPVYvOjZizszN	NHS2c3pUSU6JRWK=
SW780	NG\Vd3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWrJR\|UxRTF7Nj63N\|Qh\|ryP	M4H4WnNCVkeHUh?=
22RV1	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mmn4TWM2OD1zOUeuOFI1KM7:TR?=	M1PqfHNCVkeHUh?=
IA-LM	NULMfpFCT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEjte3RKSzVyPUG5O{45OjJizszN	NVnUWFRIW0GQR1XS
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JVM-3	Mn\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{XONGlEPTB;MUm4MlQyQSEQvF2=	NE\FNJpUSU6JRWK=
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QIMR-WIL	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYjJR\|UxRTJyMD6xNVYh\|ryP	MlPZV2FPT0WU
SJRH30	NWr4d4JxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoX5TWM2OD1{MECuOVE2KM7:TR?=	M3HkOXNCVkeHUh?=
COLO-679	NX\ke5BJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlTJTWM2OD1{MECuPFU6KM7:TR?=	NETWTolUSU6JRWK=
MDA-MB-231	NW\je5lFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnPETWM2OD1{MECuPVAzKM7:TR?=	NUi1OXU5W0GQR1XS
MFM-223	NH:0NFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWe1[3BxUUN3ME2yNFEvPTh5IN88US=>	NVPhUW9wW0GQR1XS
MFE-280	MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NE\OeoJKSzVyPUKwNU46PjFizszN	MX3TRW5ITVJ?
LAMA-84	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1HScmlEPTB;MkCyMlA4OyEQvF2=	NV3nbGJQW0GQR1XS
LS-1034	MkDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1O2fGlEPTB;MkCyMlU2OyEQvF2=	MlXJV2FPT0WU
NCI-H345	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4HsZWlEPTB;MkCzMlAzPyEQvF2=	NY\HVHg6W0GQR1XS
KYSE-70	NX7mZWRYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHnkPWFKSzVyPUKwN{45PzlizszN	Ml2wV2FPT0WU
EGI-1	M{fYVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTJyND64N\|Mh\|ryP	Mlm2V2FPT0WU
RPMI-2650	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF7rbIZKSzVyPUKwOU41PjdizszN	MWnTRW5ITVJ?
NCI-H1651	NXLncmtjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWTyb2dMUUN3ME2yNFYvPzNizszN	M1vocnNCVkeHUh?=
HPAF-II	NYTodZNJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX7JR\|UxRTJyOT62O\|Eh\|ryP	M13tWHNCVkeHUh?=
NUGC-3	M4DSdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYrJR\|UxRTJyOT62O\|gh\|ryP	MX7TRW5ITVJ?
DJM-1	NYD3ZpdET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYDJR\|UxRTJyOT64PVch\|ryP	MYHTRW5ITVJ?
MHH-PREB-1	MlvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEHtV\|lKSzVyPUKxNE4{QDFizszN	MYnTRW5ITVJ?
EW-18	NID5OVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWG3cohDUUN3ME2yNVAvPzZ\|IN88US=>	MXjTRW5ITVJ?
BT-20	M1m1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXP2SmlLUUN3ME2yNVAvQTh4IN88US=>	M1y0RnNCVkeHUh?=
A431	NHHGPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVvMRW8zUUN3ME2yNVEvOjl7IN88US=>	MUXTRW5ITVJ?
TCCSUP	NIXLXY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFrFZnhKSzVyPUKxNU42OzNizszN	MWXTRW5ITVJ?
HO-1-N-1	NFXWZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3PYXGlEPTB;MkGyMlg6PCEQvF2=	MVXTRW5ITVJ?
NCI-H69	NHy3eJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnLmTWM2OD1{MUSuNVg2KM7:TR?=	NXvHcGYzW0GQR1XS
ES7	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWXCW2lPUUN3ME2yNVQvQDd6IN88US=>	MlPCV2FPT0WU
C3A	Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmLLTWM2OD1{MUWuOVc2KM7:TR?=	NHTxTVBUSU6JRWK=
UACC-257	NFfteoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUDieWZOUUN3ME2yNVcvPDNizszN	MYjTRW5ITVJ?
DMS-153	NXjqd4V1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIjxOYZKSzVyPUKxO{45OzZizszN	MVrTRW5ITVJ?
LB771-HNC	NXXBXlZPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M324ZWlEPTB;MkG3Mlg6OyEQvF2=	NUPYPHVrW0GQR1XS
HOS	Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnPUTWM2OD1{MUiuPUDPxE1?	M4nRWXNCVkeHUh?=
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SCC-4	NYrLfohQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXHJR\|UxRTJ{MD6zOVMh\|ryP	MojvV2FPT0WU
SCC-3	NIXUVJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUPJR\|UxRTJ{MD61O\|ch\|ryP	Mnv6V2FPT0WU
BC-1	MkC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIDWVXFKSzVyPUKyNE44QTlizszN	M1L2PXNCVkeHUh?=
NCI-H1618	NVzLcXNxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHrFSpNKSzVyPUKyNU4xOThizszN	MVPTRW5ITVJ?
CaR-1	NVP3eZJPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NIizW3dKSzVyPUKyNU4zPTFizszN	NEfNSGtUSU6JRWK=
NCI-H1355	NV;lXppuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1vYOmlEPTB;MkKxMlM4PyEQvF2=	NUmzeXRPW0GQR1XS
NCI-H1993	M1HEdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkDaTWM2OD1{MkKuNlM6KM7:TR?=	NU\BNGhmW0GQR1XS
NCI-H1623	M1\aVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVvGdIh1UUN3ME2yNlIvOzh7IN88US=>	MX\TRW5ITVJ?
AGS	NEHrT3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmfiTWM2OD1{MkKuOVI{KM7:TR?=	NU\DVWZbW0GQR1XS
SAS	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIjOO2FKSzVyPUKyN{44QTZizszN	Mk\TV2FPT0WU
HCC1937	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRTJ{ND6zPFkh\|ryP	NWKyenRYW0GQR1XS
NCI-H209	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3LOPGlEPTB;MkK2MlU{KM7:TR?=	MVPTRW5ITVJ?
NCI-H322M	NFvHSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVjKT5lzUUN3ME2yNlgvODF7IN88US=>	NVf2cW0xW0GQR1XS
CHL-1	NHHuWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVjWcHhJUUN3ME2yNlgvOTNizszN	NULuS3JHW0GQR1XS
NCI-H630	NH;GVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mlf5TWM2OD1{M{KuPFk4KM7:TR?=	MUPTRW5ITVJ?
5637	M1PkXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn35TWM2OD1{M{OuNFA{KM7:TR?=	M4L4c3NCVkeHUh?=
MSTO-211H	NFXpNIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUfzRZh5UUN3ME2yN\|MvOjd4IN88US=>	MnXuV2FPT0WU
YAPC	NYO0SIhET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF25OZJKSzVyPUKzOE4zPTNizszN	MVjTRW5ITVJ?
SW1783	MnnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3T5PGlEPTB;MkO0MlQyKM7:TR?=	NGe2WYJUSU6JRWK=
GB-1	MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUDhNotMUUN3ME2yN\|UvOTd5IN88US=>	M1jPc3NCVkeHUh?=
NCI-H520	NHX4eFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1\FZWlEPTB;MkO1Mlc1OSEQvF2=	MoHRV2FPT0WU
NOMO-1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnzSTWM2OD1{M{[uNFIh\|ryP	MXjTRW5ITVJ?
NCCIT	MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2XNb2lEPTB;MkO2Mlg4OyEQvF2=	MVvTRW5ITVJ?
SW954	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3\aSmlEPTB;MkO3Mlg3QCEQvF2=	MVzTRW5ITVJ?
MOLT-4	NIPNPIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXTJR\|UxRTJ2MT6yNFkh\|ryP	NYm3RXFsW0GQR1XS
EB2	MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWPJR\|UxRTJ2MT65NFch\|ryP	M3HyU3NCVkeHUh?=
IPC-298	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUXJR\|UxRTJ2Mj6wO\|Ih\|ryP	M2nFdHNCVkeHUh?=
GP5d	NIPqUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVm5RWd1UUN3ME2yOFIvPjF4IN88US=>	NF;XZ2pUSU6JRWK=
HN	NXX5NZhqT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTJ2Mj65PVEh\|ryP	MV\TRW5ITVJ?
BFTC-909	MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFHpUYhKSzVyPUK0N{4yOThizszN	Mmf0V2FPT0WU
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SK-HEP-1	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFfuNYdKSzVyPUK0Ok4xPDNizszN	NVzIS2J5W0GQR1XS
T47D	MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXjvb3QxUUN3ME2yOFcvODF\|IN88US=>	M3nSSnNCVkeHUh?=
KYSE-510	M4i2b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYfjR4xpUUN3ME2yOFcvPTF5IN88US=>	NH\POmxUSU6JRWK=
LC-1F	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV2z[FZrUUN3ME2yOFgvOTV4IN88US=>	M1rlZ3NCVkeHUh?=
NCI-H1693	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTJ2OT60PVUh\|ryP	MnT0V2FPT0WU
COR-L23	Ml\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4XrVmlEPTB;MkWwMlQyOiEQvF2=	MkjrV2FPT0WU
NCI-H2228	M{exVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEH6ToJKSzVyPUK1NE45PjRizszN	M{XZ[HNCVkeHUh?=
NCI-H460	M3rnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFu0dJpKSzVyPUK1NU41OTdizszN	Mk\NV2FPT0WU
TGBC1TKB	NXnyXWVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWrJR\|UxRTJ3Mj64O\|Uh\|ryP	MVjTRW5ITVJ?
NCI-H1304	M3nY[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MofoTWM2OD1{NUOuNVU3KM7:TR?=	M3HSWHNCVkeHUh?=
CAL-27	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYH6UIFvUUN3ME2yOVMvPDh3IN88US=>	NWPHblJ5W0GQR1XS
NCI-H187	MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mm\hTWM2OD1{NU[uO\|Yh\|ryP	NHT4PWRUSU6JRWK=
HSC-2	MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3G5cWlEPTB;MkW4MlU5PCEQvF2=	NWD4O\|V3W0GQR1XS
CAL-39	NYjqS\|BpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV\N[nJvUUN3ME2yOlAvOjd{IN88US=>	M1npNHNCVkeHUh?=
HuH-7	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4j1d2lEPTB;Mk[wMlk6PiEQvF2=	Mn7uV2FPT0WU
MMAC-SF	MmriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{PmO2lEPTB;Mk[xMlE6OiEQvF2=	NYTU[ndwW0GQR1XS
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NCI-H441	M3e1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYfJR\|UxRTN2MT60NVgh\|ryP	MorPV2FPT0WU
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EW-1	NUPOVog{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmDDTWM2OD12NUKuPFg5KM7:TR?=	MULTRW5ITVJ?
MS-1	NHK2OnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3XPPWlEPTB;NEW0MlM5PSEQvF2=	MXrTRW5ITVJ?
A4-Fuk	M3jteWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUnJR\|UxRTR3ND61NFch\|ryP	MmL2V2FPT0WU
TALL-1	MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVLJR\|UxRTR3NT6yPVch\|ryP	M2XGVnNCVkeHUh?=
SCLC-21H	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M17ONGlEPTB;NEW1MlY6QSEQvF2=	NVTMOFRmW0GQR1XS
KMS-12-PE	MkDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFrYT5ZKSzVyPUS1Ok45OjJizszN	NYX4OFBUW0GQR1XS
TE-441-T	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEDVZo1KSzVyPUS1O{4yQDZizszN	NVTndWh7W0GQR1XS
A3-KAW	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUjJR\|UxRTR4MD64OFEh\|ryP	MkHRV2FPT0WU
NCI-H1092	NFjhd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFzWb\|NKSzVyPUS2N{46PDNizszN	MX\TRW5ITVJ?
COR-L279	M3Tmdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTR4ND64OFch\|ryP	NVjhPIhQW0GQR1XS
NCI-SNU-5	NUH4R4hPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1LRUmlEPTB;NEeyMlI5KM7:TR?=	M1XlTnNCVkeHUh?=
JAR	M1PaWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVLTd4ZUUUN3ME20O\|QvPzh6IN88US=>	NYTn[\|RCW0GQR1XS
NCI-H446	NUPwSGVUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{C1fGlEPTB;NEe3MlA5KM7:TR?=	Mlu0V2FPT0WU
HDLM-2	NV3seJA4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmXuTWM2OD12OECuPFY6KM7:TR?=	MlmxV2FPT0WU
D-283MED	NV76XG5OT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHvxUXZKSzVyPUS4PE46OjRizszN	M2PMenNCVkeHUh?=
NCI-H1395	NF7wV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1HFd2lEPTB;NEi5MlAxPCEQvF2=	NWe4eJJqW0GQR1XS
RPMI-6666	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkLXTWM2OD12OUGuN\|k5KM7:TR?=	MULTRW5ITVJ?
CPC-N	NWP6VlY2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH:1d2VKSzVyPUWwNk4xPjNizszN	M1TB[nNCVkeHUh?=
EC-GI-10	NHv5VIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MorLTWM2OD13MEKuNVY6KM7:TR?=	M1fDS3NCVkeHUh?=
CA46	NYPnXIF1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHPhbVNKSzVyPUWwOE41ODdizszN	NXXNT\|BsW0GQR1XS
EHEB	MoHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnrVTWM2OD13MEeuNlA5KM7:TR?=	NIq0dIdUSU6JRWK=
RPMI-8402	NEXmT2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NH\pU5FKSzVyPUWxNE4xOjFizszN	NY\JbJJZW0GQR1XS
DU-4475	Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mly4TWM2OD13MUGuNVAyKM7:TR?=	M1nQS3NCVkeHUh?=
P12-ICHIKAWA	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml;VTWM2OD13MUGuOFE3KM7:TR?=	NWnVdpFyW0GQR1XS
NCI-H1694	NGXhSYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUXJR\|UxRTVzMj60N\|kh\|ryP	NYXIOpFkW0GQR1XS
NCI-H2171	MnHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1LsZmlEPTB;NUGyMlcxPSEQvF2=	M1O0W3NCVkeHUh?=
Mo-T	NWO2XINtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVvJR\|UxRTVzNT6xNVYh\|ryP	M2DPVHNCVkeHUh?=
HL-60	NVqzSHNlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoG5TWM2OD13MkKuPVI1KM7:TR?=	MYTTRW5ITVJ?
NCI-H1436	MorUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYjpTXhlUUN3ME21NlMvODZ2IN88US=>	M3vWXXNCVkeHUh?=
NCI-H510A	NFLLUXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1Wzd2lEPTB;NUK0MlY6PiEQvF2=	NWPJbZg4W0GQR1XS
NCI-H2081	MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGf5OYZKSzVyPUWyOU42OTNizszN	NIfpVXBUSU6JRWK=
NB5	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVPM[HFqUUN3ME21NlYvPDNizszN	NV3OfJE6W0GQR1XS
NCI-H2227	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUHJR\|UxRTV\|MD6yOVQh\|ryP	MX\TRW5ITVJ?
HSC-4	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{K0UmlEPTB;NUO5MlI6OyEQvF2=	MlvDV2FPT0WU
RL	NHr5PHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NY\sXlMxUUN3ME21OFIvPDR{IN88US=>	M1vBSXNCVkeHUh?=
EVSA-T	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEHy[oVKSzVyPUW0N{43QDRizszN	MkPXV2FPT0WU
NCI-H889	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2XSRmlEPTB;NUS3MlI{KM7:TR?=	NWftXZBUW0GQR1XS
COLO-320-HSR	NWHU[I1pT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2LpcWlEPTB;NUWxMlM2KM7:TR?=	NFLtdZNUSU6JRWK=
EW-11	MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH7lSZlKSzVyPUW1Nk4{QTlizszN	NGXvUVJUSU6JRWK=
UACC-812	NIDncpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXvJR\|UxRTV3OT6zPVEh\|ryP	MlLmV2FPT0WU
CAL-148	MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmCyTWM2OD13NkWuNFg6KM7:TR?=	M4jIenNCVkeHUh?=
K052	Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfBOJVEUUN3ME21O\|kvOjF\|IN88US=>	M2LwbHNCVkeHUh?=
L-428	NGDwdVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M33BOWlEPTB;NkCwMlY4OSEQvF2=	M1rxTXNCVkeHUh?=
LP-1	MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkHHTWM2OD14MEOuOVg4KM7:TR?=	MXrTRW5ITVJ?
ML-2	M2H0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVTJR\|UxRTZyNj61O\|kh\|ryP	MXHTRW5ITVJ?
KARPAS-45	NGPXeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2HnTGlEPTB;NkG4MlIzOSEQvF2=	MkTDV2FPT0WU
HT	NEnUb4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUTJR\|UxRTZ{Mj63PFUh\|ryP	M1HyZ3NCVkeHUh?=
NCI-H226	MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn[3TWM2OD14MkiuN\|U{KM7:TR?=	MnrIV2FPT0WU
L-363	NVvTRYpNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4X5NmlEPTB;NkS4MlA3PCEQvF2=	M2TyeXNCVkeHUh?=
IM-9	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYfqb3lOUUN3ME22OVEvPTRzIN88US=>	MVTTRW5ITVJ?
TUR	NGW4ZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUixbodYUUN3ME22O\|EvOzJ{IN88US=>	NGnXcZRUSU6JRWK=
NCI-SNU-16	MnqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEXIZXdKSzVyPU[4NE41PjJizszN	NIq0SZRUSU6JRWK=
NCI-SNU-1	Ml6wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYXJR\|UxRTZ7MD6xO\|Ih\|ryP	M4LI[nNCVkeHUh?=
U-87-MG	NFLy[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV7UPVBFUUN3ME22PVQvPTh3IN88US=>	MVrTRW5ITVJ?
KM-H2	MnzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnzPTWM2OD14OUmuNFU6KM7:TR?=	NYHO[Wx6W0GQR1XS
DEL	MnfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mor5TWM2OD15MECuPFM5KM7:TR?=	NFHmW\|NUSU6JRWK=
KARPAS-422	NWPyc3oyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlSxTWM2OD15OEmuN\|E2KM7:TR?=	M4LienNCVkeHUh?=
BC-3	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnfqTWM2OD16MEWuNlA{KM7:TR?=	M1:xVHNCVkeHUh?=
NCI-H1155	M4HDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M13sXWlEPTB;OEG4MlA2QSEQvF2=	NFT5WJlUSU6JRWK=
NCI-H1581	NEHv[GVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2L4e2lEPTB;OUCwMlI{OSEQvF2=	MkLlV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo

Oral administration of CHIR-99021 at 30 mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR-99021 at 16 or 48 mg/kg 1 hour before oral glucose challenges in ZDF rats significantly improves glucose tolerance with 14% and 33% reduction in plasma glucose at 16 mg/kg and 48 mg/kg, respectively, and the higher dose of CHIR-99021 also reduces hyperglycemia before the oral glucose challenge. ^[1] Administration of CHIR-99021 significantly augments hematopoietic repopulation in recipient mice transplanted with mouse or human hematopoietic stem cells (HSCs), suggesting that GSK-3 is a specific modulator of HSC activity. ^[4]

Protocol

Kinase Assay: ^[1]	+ Expand Cell-free kinase assays: Polypropylene 96-well plates are filled with 300 μL/well buffer (50 mM tris HCl, 10 mM MgCl₂, 1 mM EGTA, 1 mM dithiothreitol, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) containing 27 nM GSK-3α or 29 nM GSK-3β, and 0.5 μM biotin-CREB peptide substrate. Various concentrations of CHIR-99021 are added in 3.5 μL of DMSO, followed by 50 μL of ATP stock to yield a final concentration of 1 μM ATP in all cell-free assays. After incubation, triplicate 100-μL aliquots are transferred to Combiplate eight plates containing 100 μL/well 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with PBS, filled with 200 μL of scintillation fluid, sealed, left 30 minutes, and counted in a scintillation counter. All steps are performed at room temperature.
Cell Research: ^[3]	+ Expand Cell lines: INS-1E Concentrations: Dissolved in DMSO, final concentrations ~ 20 μM Incubation Time: 1, or 4 days Method: Cells are maintained for 24 hours in starvation medium (culture medium with only 5 mM glucose, 1% fetal calf serum). Then cells are exposed to various concentrations of CHIR-99021 for 1, or 4 days. Cell number is measured by staining of cellular DNA with CyQuant dye, which becomes fluorescent when bound to DNA. Fluorescence is measured after 30 minutes of incubation using the FLUOstar Optima reader. Cell replication is determined by BrdUrd incorporation. BrdUrd labeling solution is added to the medium for the last 4 hours before the cells are fixed using FixDenat solution and incubated with monoclonal anti-BrdUrd-POD antibodies. After substrate solution is added to each well, the light emission is measured in a microplate luminometer using the Analyst HT detection system. (Only for Reference)
Animal Research: ^[1]	+ Expand Animal Models: Female db/db mice or male ZDF rats with type 2 diabetes Formulation: Formulated as solutions in 20 mM citrate-buffered 15% Captisol or as fine suspensions in 0.5% carboxymethylcellulose. Dosages: ~48 mg/kg Administration: Orally (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL (185.33 mM)
	Ethanol	2 mg/mL (3.98 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	24mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Molecular Weight	501.8
Formula	C₂₂H₁₈Cl₂N_8.HCl
CAS No.	1797989-42-4
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
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C8=C7/X	C8:	LOG(C8):

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?
Answer:
The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.
Question 2:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
Answer:
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
Question 3:
What is the difference between S2924 and S1263? Which one is better for differentiation?
Answer:
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Selective GSK-3 Inhibitor

TWS119 : GSK-3β-selective, IC50 of 30 nM.
Most Potent GSK-3 Inhibitor

CHIR-98014 : GSK-3α, IC50=0.65 nM; GSK-3β, IC50=0.58 nM.
GSK-3 Inhibitor in Clinical Trial

Tideglusib : Phase II for Alzheimer's disease.
Newest GSK-3 Inhibitor

AZD1080 : Orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively.

Related GSK-3 Products4

CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
LY2090314 ^New

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
TDZD-8 ^New

TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
TWS119

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology.
SB216763

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.
Tideglusib

Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
CHIR-98014

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
BIO

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.

Features:The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.
AR-A014418

AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and K_i of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
IM-12

IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

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CHIR-99021 (CT99021) HCl

Cited by 73 Publications

9 Customer Reviews

Purity & Quality Control

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Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products4

Choose Your Country or Region

By Signaling Pathways

By product type

CHIR-99021 (CT99021) HCl

Cited by 73 Publications

9 Customer Reviews

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)