CHIR-99021 (CT99021) HCl

Catalog No.S2924

Molecular Weight(MW): 501.8

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2.

Cited by 80 Publications

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University of GOTHENBURG, 2014, 5495

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Bachelor of Science, 2012, East China Normal University

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Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Description

Targets

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

In vitro

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. ^[1] In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). ^[2] Unlike lithium chloride and AR-A014418, CHIR-99021 treatment does not reduce the viability of INS-1E cells even at high concentrations. Instead, CHIR-99021 robustly increases the rate of proliferation of INS-1E cells in a dose-dependent manner, and significantly inhibits INS-E cell death induced by high glucose and high palmitate in a concentration-dependent manner. CHIR-99021 promotes primary beta cell replication in isolated rat islets at concentrations as low as 1 μM, with 2-3 fold increase of cell replication at 5 μM of CHIR-99021 treatment. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
3T3-L1	MmLtSpVv[3Srb36gRZN{[Xl?	Ml35N{DPxE1?	M2G3PVQhcA>?	MnPTSG1UVw>?	M4SxU2lvcGmkaYTzJJBz\WGmaYDvZ5l1\SCmaX\m[ZJmdnSrYYTpc44>	NEOxWXUyOjB3NUKwNC=>
insulin receptor–expressing CHO-IR	M1PabmZ2dmO2aX;uJGF{e2G7	NIiwOGs2ODBibl2=	MlnHN\|AhdWmw	NG\hTlFFVVOR	NIjLbHNC[3SrdnH0[ZMhT2y7Y3;n[Y4hW3mwdHjhd4UhMEeVKR?=	NULDNoU5OTJ4ME[0PVc>
H4IIE	MmPoSpVv[3Srb36gRZN{[Xl?	MXmxNEDPxE1?	M1PRU\|I1KGh?	MnW1SG1UVw>?	M{X5PXJm\3WuYYTld{DPui2lYYTlcolvKGGldHn2bZR6KGGwZDDUTXJGKGOxboThbY5qdmdicILvcY91\XJiYXP0bZZqfHl?	NWq1PYZGOTV\|NUCxPVU>
Oct4/Sox2/Klf4-infected MEFs	NFPXVFFHfW6ldHnvckBCe3OjeR?=	M4nX[\|ExKM7:TR?=	Ml7XNlgh\A>?	MX3EUXNQ	NI\YbY5Rem:vb4Tld{BOTU[\|IILldJJw\3KjbX3pcochXHKjboPkeYNm\CCkeTDPZ5Q1NCCVb4iyMEBidmRiS3zmOC=>	NHLoTGIyQTh\|OUC1OS=>
Sca-1+ HPC	M1fQTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MX6yJO69VQ>?	MnH2OkBl	MXfEUXNQ	MmnHV5lv\XKpaYP0bYNidGy7IIDyc41wfGW\|IGPjZU0yM8LiSGDDJJBzd2yrZnXyZZRqd25iYX7kJINwdG:weTDmc5Ju[XSrb36geI9o\XSqZYKge4l1cCCHR1[=	MVmyNVYzPDN2OB?=
HMC1.2	M3;WZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MWGzNEDPxE1?	M4\zclczKGh?	NYDRSoN7TE2VTx?=	M3;sPXJm\HWlZYOgZ4VtdCC\|dYL2bZZidA>?	MUGyNlA{QTNyMR?=
Endothelial cell(EC)	MUnGeY5kfGmxbjDBd5NigQ>?	NX3EZmdCOyEQvF2=		M4XLXGROW09?	NWDKeI1rWHKxbX;0[ZMh\W6mb4To[Yxq[WxiY3XscEApTUNrIHTp[oZmemWwdHnheIlwdg>?	NIPxdlMzOjB3MkCwOi=>
PANC1	NIfO[2VCeG:ydH;zbZMhSXO\|YYm=	MYRCpFUh\|ryP	NWT2eVBGPzJiaB?=	MXXEUXNQ	M3TBfXRzcWepZYLzJIFvKGGyb4D0c5Rq[yC{ZYPwc45{\Q>?	M2DySFIzOjBzMUi2
INS-1E	NXn2[XZJTnWwY4Tpc44hSXO\|YYm=	MVeyMlUh\|ryP	NIL4N\|YzPCCq	MkP1SG1UVw>?	MmTmTY5lfWOnczDhJJJm\HWldHnvckBw\iCQUEGgc5ZmemW6cILld5Nqd25?	NVHzXVNVOjJ2Mke3NFQ>
hiPSC-NPs	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NH3IblE{6oDLzszN	MnTCO\|IhcA>?	NX;nTYRGTE2VTx?=	MXPJcoNz\WG\|ZYOgZ4VtdCCycn;sbYZmemG2aX;uxsA>	M2HTTVIzPjR{Nki3
platelets	MXrGeY5kfGmxbjDBd5NigQ>?	NHHJ[\|AyOCEQvF2=	MWqxOUBucW5?	NFfvZ5VFVVOR	NHL5clFKdmO{ZXHz[ZMhfGi{b33ibY4udWWmaXH0[YQheGyjdHXs[ZQh[WepcnXnZZRqd25iYX7kJGFVWCC\|ZXPy[ZRqd25?	MXyyN\|I{QTh5Nx?=
DN3	M1zFfGZ2dmO2aX;uJGF{e2G7	MV[xNEDPxE1?	M2DDR\|k3KGh?	MoP0SG1UVw>?	MWjJcoNz\WG\|ZYOgZ4VtdCCmZY\lcI9xdWWwdDDhcoQheHKxbHnm[ZJifGmxbh?=	M13pZVI{PTJ4OUi5
embryonic stem cells (ESC)	NYDWW3NlTnWwY4Tpc44hSXO\|YYm=	M4Hqd\|MhyrWP	M2S0V\|EyKGR?	NF7FeFNFVVOR	M4XLcnBzd22xdHXzJJNmdGZvcnXu[ZdidCCxZjDuZeOwfmVvdInw[UBud3W\|ZTDlcYJzgW:waXOgd5RmdSClZXzsd{ApTVOFKR?=	MoT6NlM5PDN\|MUK=
H460	NXzmNZJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVHq[pI4PSEEtV2=	M3S5eVI1KGh?	Mn\CSG1UVw>?	M4jpTnBzd22xdHXzJINmdGxicILvcIln\XKjdHnvci=>	M3X1UFI1OzZ5Nki4
H157	Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NV;pXpJ4PSEEtV2=	MX:yOEBp	MWDEUXNQ	Mn7LVJJwdW:2ZYOgZ4VtdCCycn;sbYZmemG2aX;u	NEj0UGgzPDN4N{[4PC=>
H460	MVvBdI9xfG:\|aYOgRZN{[Xl?	NHnYUVU2KML3TR?=	MnLvNlQhcA>?	MlT0SG1UVw>?	M4roXmF1fGWwdXH0[ZMh[2WubDDhdI9xfG:\|aYO=	M2[0SlI1OzZ5Nki4
H157	MUPBdI9xfG:\|aYOgRZN{[Xl?	MWW1JOK2VQ>?	MXSyOEBp	MX7EUXNQ	MVnEc4V{KG6xdDDzbYdvcW[rY3HueIx6KGGoZnXjeEBieG:ydH;zbZM>	MVyyOFM3PzZ6OB?=
A549	M2HiUGFxd3C2b4Ppd{BCe3OjeR?=	NEPnPIg2KML3TR?=	NFjCdWkzPCCq	NFX3c5NFVVOR	MmH1TY5kemWjc3XzJINmdGxiYYDvdJRwe2m\|	NVLlVJUyOjR\|Nke2PFg>
Neural progenitor cells	NFPRUFVHfW6ldHnvckBCe3OjeR?=	MVWzJO69VQ>?	M3nVSFExKGR?	M2rIU2ROW09?	MVfJcoR2[2W\|IHflcoVz[XSrb36gc4YhdmW3cnHsJJBzd2enbnn0c5Ih[2WubIO=	M3K2WFI1PjN6MEO0
ES-D3	Mlz4R5l1d3SxeHnjJGF{e2G7	NIjqbJkyOMLizszN	M17SfFMh\A>?	M1viS2ROW09?	MYfJcoR2[2W\|IH3v[IVz[XSnIHP5eI91d3irY3n0fUB4cXSqIFnDOVAhd2ZiND65JO69VQ>?	NUTDSIRQOjR5N{mzOlU>
ES-CCE	NVnrfW55S3m2b4TvfIlkKEG\|c3H5	MmDSNVDDqM7:TR?=	MUCzJIQ>	MlH1SG1UVw>?	M3X0d2lv\HWlZYOgcY9l\XKjdHWgZ5l1d3SxeHnjbZR6	NGLXT3czPDd5OUO2OS=>
ES-D3	MVXGeY5kfGmxbjDBd5NigQ>?	NFvrXo42yqEQvF2=	M4n2SVMh\A>?	MmTaSG1UVw>?	MmDRV5Rzd26pbImgbY5lfWOnczD0bIUh[WO2aY\peJkhd2ZiV370M4JmfGFvY3H0[Y5qdiCyYYToe4F6	NYLLXY5jOjR5N{mzOlU>
ES-CCE	MX\GeY5kfGmxbjDBd5NigQ>?	NU\LUlNPPcLizszN	M{LuW\|Mh\A>?	NIXHVpNFVVOR	MoDQV5Rzd26pbImgbY5lfWOnczD0bIUh[WO2aY\peJkhd2ZiV370M4JmfGFvY3H0[Y5qdiCyYYToe4F6	MWqyOFc4QTN4NR?=
SW982	M{Xr[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MW\JR\|UxRTBwMkG0NVYh\|ryP	NVzqfpNPW0GQR1XS
GCT	NXrCenkyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4XFRmlEPTB;MD6zNFY4OiEQvF2=	MVvTRW5ITVJ?
769-P	MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUXJR\|UxRTBwNUi0PVkh\|ryP	NVzZbIFHW0GQR1XS
LOXIMVI	NVnnVZlIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M{fjOWlEPTB;MD61PFg{OiEQvF2=	NV3IWZZCW0GQR1XS
D-336MG	MnL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV3JWYY4UUN3ME2wMlg1PjJizszN	NE[w[5ZUSU6JRWK=
S-117	NI\xcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mkm0TWM2OD1yLkmyNVMyKM7:TR?=	M{f5WXNCVkeHUh?=
D-247MG	MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHHTTmlKSzVyPUCuPVQ5PTJizszN	NFjWUoFUSU6JRWK=
TYK-nu	M17re2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoXJTWM2OD1zLkC3PVEzKM7:TR?=	Mly2V2FPT0WU
A498	NXP5RZFPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHS1ZVJKSzVyPUGuN\|A1PjlizszN	MliyV2FPT0WU
BCPAP	NV3rPZlJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2fyPWlEPTB;MT62Olg6QCEQvF2=	MlL6V2FPT0WU
KYSE-180	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEH6OoJKSzVyPUGuO\|I4QDhizszN	M37DPXNCVkeHUh?=
MIA-PaCa-2	NXHjVpdsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml\zTWM2OD1zLke1PVc4KM7:TR?=	Ml2zV2FPT0WU
HCC1395	NX3wdnlTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEjTW2lKSzVyPUGuO\|gzPzNizszN	M3fMOHNCVkeHUh?=
RS4-11	MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIDDRXFKSzVyPUGuPVU1OTVizszN	NXT1bVlzW0GQR1XS
NCI-H2122	NXrW[I9lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3vDS2lEPTB;Mj6yO\|Y5PCEQvF2=	Mn3oV2FPT0WU
SNU-423	NX;MZWJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUfpcnl5UUN3ME2yMlQ6Pzh5IN88US=>	M3XWc3NCVkeHUh?=
SK-LMS-1	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWLJR\|UxRTJwNkSxNlgh\|ryP	MXvTRW5ITVJ?
RPMI-7951	NIn1SYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGS2R21KSzVyPUKuO\|AyQTNizszN	MlLMV2FPT0WU
COLO-829	MoP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3[ySmlEPTB;Mj63OlU1KM7:TR?=	NXK3TmFrW0GQR1XS
SCC-9	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkDNTWM2OD1{Lkm1OFg2KM7:TR?=	MUjTRW5ITVJ?
A704	M3TrbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXrJR\|UxRTNwMEixNkDPxE1?	M3jpdnNCVkeHUh?=
HOP-62	M3vqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2KxUmlEPTB;Mz6zOlA2PCEQvF2=	MoWwV2FPT0WU
HCC1569	NFjCWGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVvIUGRIUUN3ME2zMlQ5OzB3IN88US=>	NHvnbWRUSU6JRWK=
A172	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MULJR\|UxRTNwN{W0PVgh\|ryP	MVHTRW5ITVJ?
MOLT-16	NWHBbYZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnrITWM2OD1\|Lki4OVU3KM7:TR?=	Mki5V2FPT0WU
TE-15	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV\JR\|UxRTNwOUWzOFMh\|ryP	NIPYWlNUSU6JRWK=
OE19	NH\ReHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHXWRoVKSzVyPUOuPVY1PTFizszN	MUfTRW5ITVJ?
MHH-ES-1	M{PaSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFK1S2xKSzVyPUSuNFQ2PDVizszN	NInOd5NUSU6JRWK=
NKM-1	MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFftdmxKSzVyPUSuNVM6PzFizszN	MmLzV2FPT0WU
RCC10RGB	M4\Kb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFLCbZBKSzVyPUSuNlk1PzlizszN	MoHqV2FPT0WU
BxPC-3	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoLNTWM2OD12LkewN\|kyKM7:TR?=	MXnTRW5ITVJ?
ALL-PO	Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV;0fpJ2UUN3ME20Mlg{QDV6IN88US=>	M3fBT3NCVkeHUh?=
SK-OV-3	M3TCU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoXLTWM2OD12Lkm5N\|Qh\|ryP	M{jsb3NCVkeHUh?=
SW1710	MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{fIWmlEPTB;NT60NlQ2PiEQvF2=	Ml:4V2FPT0WU
NCI-H2452	NXviSZNoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mny5TWM2OD13LkS1OlI5KM7:TR?=	MoLXV2FPT0WU
D-392MG	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHnmO3NKSzVyPUWuOFkyPDVizszN	MV7TRW5ITVJ?
LB2518-MEL	Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTVwN{K2Nlch\|ryP	MUXTRW5ITVJ?
BL-41	NX34T2RiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3XwdWlEPTB;NT64NVI3PiEQvF2=	NWjxXXFRW0GQR1XS
WM-115	M4KwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlG4TWM2OD13LkixOVA6KM7:TR?=	M2S1NnNCVkeHUh?=
SK-MEL-2	MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTZwM{izOFQh\|ryP	MmjQV2FPT0WU
CGTH-W-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUfYXoI2UUN3ME22MlQyPyEQvF2=	NF3WXm9USU6JRWK=
BB65-RCC	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHn6[WFKSzVyPU[uOVMyQTVizszN	MoTmV2FPT0WU
CAL-85-1	M2DmeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mnf3TWM2OD14Lk[wPVM3KM7:TR?=	MYHTRW5ITVJ?
RT-112	NGfFbnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M33UO2lEPTB;Nz6xOlQ2PiEQvF2=	MnfXV2FPT0WU
MC116	NHTNWZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NULlOINDUUN3ME23MlI5PjlzIN88US=>	NVjPOnVYW0GQR1XS
G-361	NHrpb\|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUfOXZhqUUN3ME23MlQ3PTZzIN88US=>	MYLTRW5ITVJ?
SW1417	NIDud4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MU\JR\|UxRTdwNkS1PFQh\|ryP	NHX6WXJUSU6JRWK=
MV-4-11	NFP2d5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn;WTWM2OD16LkW0N\|A1KM7:TR?=	M4\4eHNCVkeHUh?=
CAL-72	NHriT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUjJR\|UxRThwN{[xNVMh\|ryP	NGnvNW5USU6JRWK=
MKN28	NF3SNYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{POdmlEPTB;OD64PFUyPiEQvF2=	MXXTRW5ITVJ?
MEG-01	MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXzBTmZ2UUN3ME24Mlk6ODR\|IN88US=>	NX\XXlNoW0GQR1XS
ACHN	NGTuSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn3lTWM2OD17LkOwOVQ3KM7:TR?=	NX7Ecnk3W0GQR1XS
NCI-H1755	M2DvZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFjke3pKSzVyPUmuN\|k6QDZizszN	MXvTRW5ITVJ?
NCI-H64	MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn;0TWM2OD17LkSyNlU2KM7:TR?=	Mnj4V2FPT0WU
COLO-205	M2fWc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHLPZpNKSzVyPUmuOFM5OjFizszN	Ml35V2FPT0WU
CTV-1	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFjUN3NKSzVyPUmuOFM5QTRizszN	NHKxSpRUSU6JRWK=
U-2-OS	NGjX[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1jYPWlEPTB;OT60OVAxPiEQvF2=	NYi2OJBOW0GQR1XS
LB996-RCC	M2jKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnPqTWM2OD17LkWyN\|k4KM7:TR?=	Ml7VV2FPT0WU
SK-N-DZ	NFTL[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlPFTWM2OD17Lk[1O\|QzKM7:TR?=	M1HU[XNCVkeHUh?=
EFM-19	M1jH[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVPJR\|UxRTlwN{W1OlYh\|ryP	MmXCV2FPT0WU
DBTRG-05MG	M1\RSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4HqTGlEPTB;OT63O\|c4KM7:TR?=	NHPhWGdUSU6JRWK=
U-118-MG	NYDVO5lLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MV\JR\|UxRTlwOUS0OFQh\|ryP	M3y1O3NCVkeHUh?=
LB1047-RCC	NWjke\|V4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEGycGtKSzVyPUmuPVk4QThizszN	MnPrV2FPT0WU
NCI-H28	NEHKeZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFHSVJFKSzVyPUGwMlQ1OTNizszN	M4raRXNCVkeHUh?=
MZ2-MEL	Mkn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGXMVVhKSzVyPUGwMlQ3PzdizszN	MVnTRW5ITVJ?
M059J	NEfYUJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXP1SllUUUN3ME2xNE43OTB{IN88US=>	NYHCWYp5W0GQR1XS
HT-3	NVrUUVZuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlrMTWM2OD1zMD62NVc6KM7:TR?=	NVe3[\|RFW0GQR1XS
SNU-387	M1f4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVLJR\|UxRTFyLkeyN\|Uh\|ryP	NIfGR4pUSU6JRWK=
NCI-H526	NIPtWG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1vybGlEPTB;MUGuNVM3PSEQvF2=	M{SwcnNCVkeHUh?=
HEL	M2\PZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTFzLk[1O\|kh\|ryP	NUiyeWdLW0GQR1XS
PA-1	MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVLJR\|UxRTFzLkmzJO69VQ>?	NFfpXHNUSU6JRWK=
PC-14	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkjOTWM2OD1zMj6zNlQh\|ryP	MV7TRW5ITVJ?
C8166	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEjnOYpKSzVyPUGzMlI{OThizszN	NGnBcpBUSU6JRWK=
NCI-H82	Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGXE[3lKSzVyPUGzMlI6ODlizszN	MWfTRW5ITVJ?
DSH1	NXvubYZFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV3SVIlJUUN3ME2xN{4{QDd7IN88US=>	MYrTRW5ITVJ?
T98G	NI\yR2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTF\|LkS3NVch\|ryP	MWrTRW5ITVJ?
KU812	NV3nb3dST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWDJR\|UxRTF\|LkWxO\|Uh\|ryP	NXjJbJFlW0GQR1XS
SW48	M3XsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF7tWoVKSzVyPUGzMlczPjVizszN	M1jo[3NCVkeHUh?=
MEL-HO	MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWrJR\|UxRTF\|Lki4Nlkh\|ryP	MU\TRW5ITVJ?
SF539	MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3i3ZmlEPTB;MUSuNFEyPiEQvF2=	NV\tfmtoW0GQR1XS
NB1	MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHvLOJBKSzVyPUG0MlE6OzVizszN	NFfmcW5USU6JRWK=
ST486	NVjBSJZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYPJR\|UxRTF2LkKyOVEh\|ryP	MUXTRW5ITVJ?
LoVo	NFX5V4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MULJR\|UxRTF3LkK2OVkh\|ryP	NGKyXm9USU6JRWK=
NH-12	MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3;tOmlEPTB;MU[uNFA6PyEQvF2=	NYjHfFYyW0GQR1XS
CCRF-CEM	NGXVPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3XOUWlEPTB;MU[uOlcxOiEQvF2=	MnjLV2FPT0WU
Daudi	NVvGT29mT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnG1TWM2OD1zNz62NVQ6KM7:TR?=	M1vJTnNCVkeHUh?=
SIMA	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHLad\|ZKSzVyPUG3MlkyOThizszN	M3y0NXNCVkeHUh?=
8305C	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIDOeFdKSzVyPUG4MlU{ODVizszN	NEjBVZdUSU6JRWK=
EM-2	M4WwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEPMdYtKSzVyPUG4MlYzPDhizszN	MYHTRW5ITVJ?
SNU-449	NEjZPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NImzU4NKSzVyPUG4MlcyPSEQvF2=	MXHTRW5ITVJ?
A101D	MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVj6UoIzUUN3ME2xPU4zPDNizszN	MkPRV2FPT0WU
MHH-NB-11	M4LrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTF7LkWzOFIh\|ryP	NVXSNJQ3W0GQR1XS
Becker	NF73N4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NG\kTXlKSzVyPUKwMlE4PzdizszN	NEH1fWFUSU6JRWK=
NCI-H727	NIH6fZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXnUc4NEUUN3ME2yNE4zOTZ7IN88US=>	NVS2eFRpW0GQR1XS
HCC1187	NIj6O\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWn3T3RFUUN3ME2yNE4{PTh7IN88US=>	NFn2dZZUSU6JRWK=
KYSE-450	MkDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYjJR\|UxRTJzLkWzOVQh\|ryP	M3LuPHNCVkeHUh?=
SK-MEL-28	Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX73O3g2UUN3ME2yNU43QDZ\|IN88US=>	M4qwcHNCVkeHUh?=
BPH-1	NHjUVZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFrU[2hKSzVyPUKxMlcxOzVizszN	NFjzVYNUSU6JRWK=
EoL-1-	MljZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVfJR\|UxRTJzLkizPFUh\|ryP	NHfUXpNUSU6JRWK=
TGBC24TKB	MlXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGj2WXdKSzVyPUKxMlg6PTdizszN	Mn:3V2FPT0WU
KARPAS-299	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVG2XmRUUUN3ME2yNk4yQTV2IN88US=>	NFH0N4JUSU6JRWK=
SW684	NXLUVpRuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV\VcnVkUUN3ME2yNk4zQDV6IN88US=>	MkT4V2FPT0WU
RXF393	NWfWVIxIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MXHJR\|UxRTJ{Lk[wOlgh\|ryP	MUnTRW5ITVJ?
LS-513	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHTuNmJKSzVyPUKyMlYyQTJizszN	NE\UNFhUSU6JRWK=
KURAMOCHI	M4\6UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYrJR\|UxRTJ{LkewOlkh\|ryP	M{DwVnNCVkeHUh?=
GI-1	MmnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NXXaPHFYUUN3ME2yNk44QDRzIN88US=>	NF[5TYdUSU6JRWK=
M14	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NH7zPWFKSzVyPUKzMlEyOzJizszN	NFnhVYZUSU6JRWK=
REH	NFX1bYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2iycGlEPTB;MkOuNVY6QSEQvF2=	NHfXb4JUSU6JRWK=
K5	MlniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWPJR\|UxRTJ\|LkW0PFYh\|ryP	MoXoV2FPT0WU
PANC-10-05	MnnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUPJR\|UxRTJ2LkC4PVgh\|ryP	M1;tVHNCVkeHUh?=
HMV-II	M4TzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEDiZoxKSzVyPUK0MlIyPjNizszN	NUTIXHBDW0GQR1XS
NCI-H1963	Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTJ2LkK4N\|kh\|ryP	NW\LeJlzW0GQR1XS
LU-139	NHXLcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2C5RWlEPTB;MkSuPFM2KM7:TR?=	NX74N\|Z1W0GQR1XS
KASUMI-1	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{DUc2lEPTB;MkSuPVMzQCEQvF2=	M3H4T3NCVkeHUh?=
RO82-W-1	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXLJR\|UxRTJ4LkezO\|ch\|ryP	NGXSTIZUSU6JRWK=
NCI-H1770	M{TjW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWPibYduUUN3ME2yOk45QTh4IN88US=>	M1uxWXNCVkeHUh?=
SNG-M	NWe0b4lxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHOzNGVKSzVyPUK3MlIzPzFizszN	MoPsV2FPT0WU
KLE	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWnXWo95UUN3ME2yO{4zPTZ3IN88US=>	MmfSV2FPT0WU
NCI-H2170	NF73dZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTJ5LkWyPFIh\|ryP	M1fVOXNCVkeHUh?=
COLO-792	NIP6dFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYrDPIlJUUN3ME2yO{44PzJ6IN88US=>	NWrPepNLW0GQR1XS
ES8	MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2nKdGlEPTB;MkeuO\|gyPCEQvF2=	M3fVfXNCVkeHUh?=
MC-CAR	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXnJR\|UxRTJ5Lke5NFch\|ryP	NVrRPG5lW0GQR1XS
SU-DHL-1	Ml3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYS4UHMyUUN3ME2yO{46PDd2IN88US=>	M3;2eXNCVkeHUh?=
OAW-28	NVL3U4xET3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnLXTWM2OD1{OD6wNFUzKM7:TR?=	MWjTRW5ITVJ?
C32	M3vFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlqzTWM2OD1{OD6wPFI3KM7:TR?=	NELOXZVUSU6JRWK=
SW872	NUnsdYw2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoTwTWM2OD1{OD61N\|I3KM7:TR?=	MYXTRW5ITVJ?
JiyoyeP-2003	MoW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4fO[2lEPTB;MkmuOlcyQSEQvF2=	MUnTRW5ITVJ?
A204	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTJ7Lk[4Nlgh\|ryP	NHK4d\|ZUSU6JRWK=
IST-MES1	NEHKUWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWHJR\|UxRTJ7LkewPVIh\|ryP	Mn7iV2FPT0WU
LCLC-103H	MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3vQNmlEPTB;M{CuNlA2QSEQvF2=	NY\Jc3VFW0GQR1XS
CAKI-1	M3HCeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlixTWM2OD1\|MD6yOlU3KM7:TR?=	M2LpOXNCVkeHUh?=
NALM-6	M{XYWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MV7JR\|UxRTNyLkS5OlUh\|ryP	NFe0RmdUSU6JRWK=
SK-MM-2	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV\OOpF3UUN3ME2zNE46Pzl{IN88US=>	NUXOU3JwW0GQR1XS
LB373-MEL-D	MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2HIfmlEPTB;M{GuNFA1PyEQvF2=	MnyzV2FPT0WU
CAS-1	Mn;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUfTXnNGUUN3ME2zNU44PjZ3IN88US=>	NFTHbmRUSU6JRWK=
KNS-42	M3X2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUjJR\|UxRTNzLki2OlIh\|ryP	MV;TRW5ITVJ?
SW948	M3TjSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkXJTWM2OD1\|Mj63OVQ5KM7:TR?=	NWj2VIRpW0GQR1XS
HCC1143	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHv5XFJKSzVyPUOyMlc6PzlizszN	MnfhV2FPT0WU
NCI-H1648	NV;mZ5JVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mmi5TWM2OD1\|Mj64OFY4KM7:TR?=	NFnlR4NUSU6JRWK=
RVH-421	M4OzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGXh[3NKSzVyPUOzMlE3QCEQvF2=	MmT2V2FPT0WU
KU-19-19	NEDMTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmfPTWM2OD1\|Mz63OVM1KM7:TR?=	NYTkRnM3W0GQR1XS
PFSK-1	NEjNZpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mnv4TWM2OD1\|ND65NlQyKM7:TR?=	NHLpNndUSU6JRWK=
TK10	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGfuU4VKSzVyPUO1MlE{OjJizszN	NVy1W\|VoW0GQR1XS
IGROV-1	NXPrPXluT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWLuUG56UUN3ME2zOU4{PDF4IN88US=>	NWPkUZA3W0GQR1XS
EFE-184	M1TxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NFe4[49KSzVyPUO1MlkyPyEQvF2=	MUXTRW5ITVJ?
8505C	MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3jKZ2lEPTB;M{WuPVI6PCEQvF2=	MYLTRW5ITVJ?
SK-UT-1	NIfndo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFewNmJKSzVyPUO2MlM{OzFizszN	NYHLfJJ{W0GQR1XS
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SK-MES-1	NGH5[5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXPJR\|UxRTFyMT63OlIh\|ryP	NVTJNZg3W0GQR1XS
KE-37	M4[yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mne0TWM2OD1zMEKuPVUh\|ryP	NUKxN5RnW0GQR1XS
MKN45	NGrlTWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NG[zVGlKSzVyPUGwN{42QDRizszN	NFP2[lBUSU6JRWK=
UM-UC-3	NHvSUGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn3pTWM2OD1zMEOuPFQzKM7:TR?=	MYHTRW5ITVJ?
SNU-C2B	NWf1TY1zT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH7XVodKSzVyPUGwOU4xOjNizszN	NHjQSG9USU6JRWK=
RPMI-8226	NHXFTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MorNTWM2OD1zME[uOlc5KM7:TR?=	MnL2V2FPT0WU
PANC-08-13	MkPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGC0U5BKSzVyPUGwOk45PSEQvF2=	NYThdFVVW0GQR1XS
NCI-H23	NWHpS5hRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml;ITWM2OD1zMEiuN\|U4KM7:TR?=	MULTRW5ITVJ?
HOP-92	MnG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1PVWWlEPTB;MUC4MlQ4PSEQvF2=	NWf4NohjW0GQR1XS
FTC-133	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2LhVGlEPTB;MUC4MlQ5QCEQvF2=	NXzFZXNLW0GQR1XS
D-263MG	NF3FNlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYjJR\|UxRTFyOD65OlEh\|ryP	MlTqV2FPT0WU
DU-145	Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MU\JR\|UxRTFyOT65OFUh\|ryP	Ml7mV2FPT0WU
A253	NXniPHRmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVjkfI1kUUN3ME2xNVAvPDd7IN88US=>	MnvOV2FPT0WU
HCT-15	NH[1WnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTFzMD62OlEh\|ryP	NFjyUoVUSU6JRWK=
WSU-NHL	NF\kcVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NILlcIVKSzVyPUGxNk4xOSEQvF2=	NXL6c3VMW0GQR1XS
U031	NXi0O\|VmT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mo\3TWM2OD1zMUKuNFY2KM7:TR?=	Mn7ZV2FPT0WU
MDA-MB-157	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlX3TWM2OD1zMUKuOFkh\|ryP	Mk\SV2FPT0WU
NEC8	NILxc2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGi2dIJKSzVyPUGxNk43OjRizszN	NW\JelVnW0GQR1XS
SIG-M5	NIXq[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M173TGlEPTB;MUGzMlEzPSEQvF2=	M{j0[XNCVkeHUh?=
786-0	NFX0W\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NEmyZnlKSzVyPUGxN{41PTNizszN	MoPRV2FPT0WU
DMS-273	NUT1V45wT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGPGbFBKSzVyPUGxOU43OTdizszN	MojwV2FPT0WU
Calu-6	M{X4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWHZ[ZB6UUN3ME2xNVYvPzl6IN88US=>	M4fXUXNCVkeHUh?=
HCC1599	M1PrOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlLjTWM2OD1zMUeuNVU3KM7:TR?=	NHK5V5pUSU6JRWK=
OVCAR-8	Mm\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVXJR\|UxRTFzNz62Olgh\|ryP	M4XqdXNCVkeHUh?=
ATN-1	NX2xbW8yT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHzUVIVKSzVyPUGxO{45OjhizszN	NF\VUZBUSU6JRWK=
RKO	Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NG\WVmFKSzVyPUGxO{45QThizszN	MVXTRW5ITVJ?
SKG-IIIa	NFrxUYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVnJR\|UxRTFzOD6xNVYh\|ryP	M3XCbHNCVkeHUh?=
SUP-T1	NX;T[WNbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWXJR\|UxRTFzOD65OVYh\|ryP	MUDTRW5ITVJ?
KNS-81-FD	M16xTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1jmbGlEPTB;MUG5MlQyPyEQvF2=	Mk\UV2FPT0WU
OVCAR-3	NF\BN3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2LoXGlEPTB;MUG5MlkyPSEQvF2=	NXe4bHNoW0GQR1XS
NCI-N87	M1LXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;NTWM2OD1zMkGuNFQ1KM7:TR?=	NF3xcWpUSU6JRWK=
HuP-T4	NXX4dIJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2HSU2lEPTB;MUKxMlU2KM7:TR?=	M3;KbHNCVkeHUh?=
KYSE-140	MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEHVO3pKSzVyPUGyNk4yPDFizszN	NHO5eHZUSU6JRWK=
HAL-01	MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXHJR\|UxRTF{Mj60PVkh\|ryP	M{\PRXNCVkeHUh?=
HT-29	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUfjRll3UUN3ME2xNlIvPzd6IN88US=>	NU\aUIgyW0GQR1XS
OPM-2	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2XFeGlEPTB;MUKzMlE4PiEQvF2=	M1v6OXNCVkeHUh?=
SW1463	MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGDCPFdKSzVyPUGyOE4xPzdizszN	MonIV2FPT0WU
NCI-H2087	MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXHJR\|UxRTF{ND6yPFMh\|ryP	MnPSV2FPT0WU
UMC-11	NIn4PYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2\VfGlEPTB;MUK2MlA{QCEQvF2=	M2riRnNCVkeHUh?=
EB-3	NFuxTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXftd2x3UUN3ME2xNlcvODF\|IN88US=>	NV;PcVAyW0GQR1XS
HEC-1	NXfBeItnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWPJR\|UxRTF{OT6xPVgh\|ryP	MWTTRW5ITVJ?
LU-99A	M3j6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmnjTWM2OD1zMkmuPVMyKM7:TR?=	MXLTRW5ITVJ?
VMRC-RCZ	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWnJR\|UxRTF\|MD6zO\|Uh\|ryP	NVX1UI9OW0GQR1XS
MFH-ino	NVL5cm5JT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVTJR\|UxRTF\|MT6xNVQh\|ryP	Mnj2V2FPT0WU
HT-1080	NVLiblRyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUfJR\|UxRTF\|Mj6yNFQh\|ryP	MlztV2FPT0WU
CTB-1	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGC2[ItKSzVyPUGzNk45QTdizszN	M1i4cnNCVkeHUh?=
Capan-2	NFyyTlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVnJR\|UxRTF\|Mz65O\|Uh\|ryP	MVvTRW5ITVJ?
BB30-HNC	NUf6WJp{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlTaTWM2OD1zM{SuNVE3KM7:TR?=	MmLqV2FPT0WU
CP50-MEL-B	M{fmO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXXJR\|UxRTF\|ND6yJO69VQ>?	NIXGS\|BUSU6JRWK=
JEG-3	NEnwR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn7iTWM2OD1zM{SuN\|U6KM7:TR?=	MXLTRW5ITVJ?
NCI-H1437	NGf3SWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NI\BcIhKSzVyPUGzOE42QSEQvF2=	M4CzZXNCVkeHUh?=
NOS-1	M1j0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlzoTWM2OD1zM{SuO\|Y2KM7:TR?=	MnqzV2FPT0WU
G-402	NU[zPW1LT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnjUTWM2OD1zM{WuNlk2KM7:TR?=	Ml2zV2FPT0WU
OAW-42	M{f2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1m0c2lEPTB;MUO3Mlg2PiEQvF2=	MnuxV2FPT0WU
Ca-Ski	M{nQVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2XUc2lEPTB;MUO4Mlg{OSEQvF2=	NV;sPFR[W0GQR1XS
BHT-101	NVywWWJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEjnOGZKSzVyPUG0NE4zODhizszN	M1;ze3NCVkeHUh?=
OVCAR-4	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV\4SVR7UUN3ME2xOFAvPzR7IN88US=>	M{TTenNCVkeHUh?=
Detroit562	Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2XObWlEPTB;MUSxMlQ3PiEQvF2=	NXjIcJd5W0GQR1XS
OCI-AML2	NGTtWpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NITKRpJKSzVyPUG0NU42ODdizszN	NWi2VodTW0GQR1XS
OE33	MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NInXe5BKSzVyPUG0NU44QThizszN	NFrDcVhUSU6JRWK=
YKG-1	Mk\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYXJR\|UxRTF2Mj64PFkh\|ryP	M3TkN3NCVkeHUh?=
CCF-STTG1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX3JR\|UxRTF2Mz6zN\|Qh\|ryP	MU\TRW5ITVJ?
NCI-H810	MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEPEPW5KSzVyPUG0N{43QDdizszN	NUGwUnF{W0GQR1XS
SCC-25	Mnr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHzXUnlKSzVyPUG0OE4xODVizszN	NX;CPIJvW0GQR1XS
HTC-C3	NUHITXpRT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnTQTWM2OD1zNEWuNFc2KM7:TR?=	M2DicnNCVkeHUh?=
G-401	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYjJR\|UxRTF2NT64N\|Uh\|ryP	NGqxd2lUSU6JRWK=
OMC-1	M4jqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MU\JR\|UxRTF2NT65Olch\|ryP	M2fPcXNCVkeHUh?=
LK-2	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIK2eY5KSzVyPUG0O{4yPDNizszN	MX3TRW5ITVJ?
SW13	MnfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXPJR\|UxRTF2Nz6yOVMh\|ryP	NFHJU3pUSU6JRWK=
BB49-HNC	Ml\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUjqXGdDUUN3ME2xOFcvPDB2IN88US=>	MYfTRW5ITVJ?
DMS-114	NE[0[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVnZZmdHUUN3ME2xOFcvPDRzIN88US=>	MmrjV2FPT0WU
GCIY	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MofSTWM2OD1zNEeuO\|k4KM7:TR?=	MonoV2FPT0WU
GAMG	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEDXU4NKSzVyPUG0PE4zPDdizszN	MkGxV2FPT0WU
KYSE-520	MoXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlTZTWM2OD1zNEiuOVQh\|ryP	NF;uW3pUSU6JRWK=
LB647-SCLC	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV3JR\|UxRTF2OD61OlIh\|ryP	NH7PTFBUSU6JRWK=
639-V	NW\GeWlzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4Wy[GlEPTB;MUS4MlcxPSEQvF2=	MlX5V2FPT0WU
TE-9	NWrtcJJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlL2TWM2OD1zNEmuOFQ{KM7:TR?=	MnLKV2FPT0WU
Caov-3	NX3QUIluT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mm[wTWM2OD1zNEmuO\|E1KM7:TR?=	M1;VeXNCVkeHUh?=
L-540	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYTsbGxOUUN3ME2xOFkvPzVizszN	M{\1bXNCVkeHUh?=
NCI-H748	Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGX0d2RKSzVyPUG1NE4zODlizszN	NGLPOVZUSU6JRWK=
GDM-1	NIj5[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{\wbmlEPTB;MUWxMlE{PSEQvF2=	NYjwUIN4W0GQR1XS
GAK	MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mn\oTWM2OD1zNUGuN\|c1KM7:TR?=	MnKwV2FPT0WU
AsPC-1	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlzMTWM2OD1zNUKuO\|Y1KM7:TR?=	M3\6W3NCVkeHUh?=
MDA-MB-361	NXHx[mo5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoToTWM2OD1zNUOuNVY1KM7:TR?=	MVfTRW5ITVJ?
TT	NXnZeIJLT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M33EdmlEPTB;MUWzMlQ6KM7:TR?=	MnjHV2FPT0WU
Calu-1	NH;nb3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml[xTWM2OD1zNUSuNFA{KM7:TR?=	MW\TRW5ITVJ?
RERF-LC-MS	Mn;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYHJR\|UxRTF3ND63O\|Ih\|ryP	NW\QUpNOW0GQR1XS
DK-MG	NIO0dI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlvZTWM2OD1zNUWuNVg{KM7:TR?=	NXzsZYRLW0GQR1XS
CAL-120	M1yyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYrkWmZlUUN3ME2xOVUvQDJzIN88US=>	MXPTRW5ITVJ?
HCC1419	NGLxNHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUHSS4xMUUN3ME2xOVYvODd5IN88US=>	NUDLTGtkW0GQR1XS
DG-75	NUTKZoJIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3:zVmlEPTB;MUW2MlY6PCEQvF2=	MYPTRW5ITVJ?
HCC38	NHnEUHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MonQTWM2OD1zNUeuN\|Y6KM7:TR?=	M1G1[3NCVkeHUh?=
HCC70	NYH5bIpQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYftNHhFUUN3ME2xOVkvOjR{IN88US=>	M37MeHNCVkeHUh?=
ES4	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkjnTWM2OD1zNUmuN\|k3KM7:TR?=	NEO2dVZUSU6JRWK=
NCI-H2052	M1rSPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1nET2lEPTB;MUW5MlU5OyEQvF2=	M{T5[XNCVkeHUh?=
EFO-27	NHjndWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXfJR\|UxRTF4MD61PFQh\|ryP	MXvTRW5ITVJ?
CAL-62	NXf0RmR6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUTJR\|UxRTF4Mj62NVMh\|ryP	NHvnb3ZUSU6JRWK=
CHP-212	MkP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHn2cm1KSzVyPUG2N{43OjZizszN	NYXOWZRLW0GQR1XS
AU565	M3fnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHvLR3pKSzVyPUG2N{43PCEQvF2=	NI[1SYFUSU6JRWK=
Ca9-22	NFn2SGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2TqZ2lEPTB;MU[0MlMzOSEQvF2=	MmfJV2FPT0WU
EFO-21	NYPtNlFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnjWTWM2OD1zNkWuOFUh\|ryP	NX\U[WkzW0GQR1XS
KINGS-1	M3jyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlPmTWM2OD1zNkeuN\|U1KM7:TR?=	NWS2N3d3W0GQR1XS
JVM-2	MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIr2eGNKSzVyPUG2O{41PTFizszN	MXfTRW5ITVJ?
OVCAR-5	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVfJR\|UxRTF4OD6zNFkh\|ryP	MWHTRW5ITVJ?
Calu-3	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWf1SJdiUUN3ME2xOlgvOzFzIN88US=>	Mo[3V2FPT0WU
CP66-MEL	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFTuT\|dKSzVyPUG2PE41OTVizszN	MlTlV2FPT0WU
KYSE-150	Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVvJR\|UxRTF4OT62N\|Yh\|ryP	MVrTRW5ITVJ?
Daoy	M{X3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NY\t[oZjUUN3ME2xOlkvQDlzIN88US=>	MVTTRW5ITVJ?
HUTU-80	MlT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWXCNoNGUUN3ME2xO\|EvODN{IN88US=>	NVjl[WhSW0GQR1XS
SW620	NXe4U3NiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVfodZhtUUN3ME2xO\|EvPTN3IN88US=>	NFPnZ45USU6JRWK=
HuO-3N1	M1XqcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmjLTWM2OD1zN{KuNlc{KM7:TR?=	NWLQZZQ3W0GQR1XS
HH	M{PGTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGTjOoJKSzVyPUG3N{45PDhizszN	MXrTRW5ITVJ?
ME-180	M332RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGT3WlBKSzVyPUG3OE4xOTZizszN	MWDTRW5ITVJ?
SW756	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIWxNZFKSzVyPUG3OE45PjNizszN	MkDuV2FPT0WU
LNCaP-Clone-FGC	Mm\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MX;JR\|UxRTF5NT64OlEh\|ryP	NFPBSIhUSU6JRWK=
YT	M1nnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3m3cGlEPTB;MUe2MlM6QSEQvF2=	Ml\YV2FPT0WU
EW-3	NFK4NW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVvJR\|UxRTF5Nj61OVUh\|ryP	Mof2V2FPT0WU
COLO-741	NWXWR2xkT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYjJR\|UxRTF5Nz61OlEh\|ryP	NX7sNVQ2W0GQR1XS
SK-NEP-1	Mnj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUjJR\|UxRTF5Nz64NFYh\|ryP	MWPTRW5ITVJ?
NB10	M4rVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVu0cINVUUN3ME2xO\|cvQDR4IN88US=>	NFmwe\|NUSU6JRWK=
SF126	NH3VV\|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{TST2lEPTB;MUe5MlQ{OiEQvF2=	NHzIfmRUSU6JRWK=
NCI-H522	Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlW4TWM2OD1zOEGuNFU6KM7:TR?=	NWe2XHhSW0GQR1XS
PSN1	M{\TZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn;3TWM2OD1zOEGuOlYh\|ryP	MnfTV2FPT0WU
GI-ME-N	M{\nXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NITRNopKSzVyPUG4NU43PzJizszN	MXLTRW5ITVJ?
SBC-5	NYfBOFRtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYXJR\|UxRTF6MT65N\|Qh\|ryP	MmnqV2FPT0WU
ONS-76	M1L0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnnvTWM2OD1zOEKuN\|g4KM7:TR?=	NGXMUnBUSU6JRWK=
LOUCY	Ml7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUDJR\|UxRTF6Mj62PFgh\|ryP	MonPV2FPT0WU
SN12C	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFHYPJFKSzVyPUG4Nk45OjlizszN	M2XiXnNCVkeHUh?=
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DOK	Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVHJR\|UxRTF6ND62OFMh\|ryP	MlryV2FPT0WU
MDA-MB-415	MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4m1cWlEPTB;MUi0MlY2OSEQvF2=	NFLPVIxUSU6JRWK=
MRK-nu-1	M{jv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkL1TWM2OD1zOESuPVczKM7:TR?=	MWHTRW5ITVJ?
LB2241-RCC	MnzyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWToS2kzUUN3ME2xPFUvOTR3IN88US=>	Mk[0V2FPT0WU
NCI-H1563	NE[wVJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NIrpdFlKSzVyPUG4OU4zODlizszN	Mln0V2FPT0WU
MDA-MB-453	NVzmd45TT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWL0VYJkUUN3ME2xPFYvQTRzIN88US=>	MoTkV2FPT0WU
MONO-MAC-6	NULGVXNXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3nUWGlEPTB;MUi3MlM6OiEQvF2=	MWTTRW5ITVJ?
CAPAN-1	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mmq0TWM2OD1zOEeuOFU{KM7:TR?=	MWfTRW5ITVJ?
SK-LU-1	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4r0R2lEPTB;MUi4MlQzQCEQvF2=	M375XnNCVkeHUh?=
NCI-H1299	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWDJR\|UxRTF6OD63NVkh\|ryP	MWnTRW5ITVJ?
KG-1	M2C2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NULpc3M3UUN3ME2xPFkvPzl6IN88US=>	NWOyXYZFW0GQR1XS
ETK-1	NIfBUJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NX:1PHFKUUN3ME2xPVAvOThzIN88US=>	M33jbnNCVkeHUh?=
NCI-H838	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NU\HU5NvUUN3ME2xPVAvOzRizszN	MVvTRW5ITVJ?
HCE-4	MnLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVLJR\|UxRTF7MD65PVIh\|ryP	M17iUHNCVkeHUh?=
A2780	M2O5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHHHcHZKSzVyPUG5Nk45QTFizszN	MVHTRW5ITVJ?
COLO-668	MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmS5TWM2OD1zOUOuNVU4KM7:TR?=	NHXJW5BUSU6JRWK=
HGC-27	NWPFdIJyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWjJR\|UxRTF7NT61N\|gh\|ryP	MV\TRW5ITVJ?
SW1088	MofRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{fYeWlEPTB;MUm1MlY4PyEQvF2=	MnfyV2FPT0WU
KOSC-2	MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYjpNFRFUUN3ME2xPVUvQDF6IN88US=>	NEXVWm9USU6JRWK=
TE-1	MoC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXnJR\|UxRTF7Nj6yOkDPxE1?	M4Dw[nNCVkeHUh?=
SW780	NYTSN2tuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmHkTWM2OD1zOU[uO\|M1KM7:TR?=	NWnPR282W0GQR1XS
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IA-LM	NFHObm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVjJR\|UxRTF7Nz64NlIh\|ryP	NFjZUZFUSU6JRWK=
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JVM-3	M{CzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXK3PItGUUN3ME2xPVgvPDF7IN88US=>	NUfacoF{W0GQR1XS
HT55	NFXaOXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUG3RndWUUN3ME2xPVkvOTl{IN88US=>	NHrrWFhUSU6JRWK=
QIMR-WIL	NIjvU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnPuTWM2OD1{MECuNVE3KM7:TR?=	NXXnO4RMW0GQR1XS
SJRH30	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml;KTWM2OD1{MECuOVE2KM7:TR?=	MXnTRW5ITVJ?
COLO-679	NX\ZVWgyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmH0TWM2OD1{MECuPFU6KM7:TR?=	MmPhV2FPT0WU
MDA-MB-231	M2LjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHzDS\|RKSzVyPUKwNE46ODJizszN	MUPTRW5ITVJ?
MFM-223	NV\hXIx7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUfH[YVHUUN3ME2yNFEvPTh5IN88US=>	NVOyclc5W0GQR1XS
MFE-280	M{PaO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M13OVGlEPTB;MkCxMlk3OSEQvF2=	NHG4dY9USU6JRWK=
LAMA-84	MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkjrTWM2OD1{MEKuNFc{KM7:TR?=	M{\vR3NCVkeHUh?=
LS-1034	NYXBT441T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWLJR\|UxRTJyMj61OVMh\|ryP	M3SzNXNCVkeHUh?=
NCI-H345	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlL3TWM2OD1{MEOuNFI4KM7:TR?=	NYi1SGJQW0GQR1XS
KYSE-70	NHXwNFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NUm5b48yUUN3ME2yNFMvQDd7IN88US=>	Mn;KV2FPT0WU
EGI-1	NFHTcZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXzhXoNTUUN3ME2yNFQvQDN\|IN88US=>	Mkm3V2FPT0WU
RPMI-2650	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NYnkWnZ1UUN3ME2yNFUvPDZ5IN88US=>	MnvFV2FPT0WU
NCI-H1651	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXfJR\|UxRTJyNj63N{DPxE1?	MXPTRW5ITVJ?
HPAF-II	M{PzNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVPJR\|UxRTJyOT62O\|Eh\|ryP	NFPi[plUSU6JRWK=
NUGC-3	Mle0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoXlTWM2OD1{MEmuOlc5KM7:TR?=	NHrYO3VUSU6JRWK=
DJM-1	NGXvc3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWLaOoVOUUN3ME2yNFkvQDl5IN88US=>	M4q2[nNCVkeHUh?=
MHH-PREB-1	M2niOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2HpXGlEPTB;MkGwMlM5OSEQvF2=	MlLWV2FPT0WU
EW-18	NV;YbYpTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml;PTWM2OD1{MUCuO\|Y{KM7:TR?=	M{jDTXNCVkeHUh?=
BT-20	MkHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVHONllQUUN3ME2yNVAvQTh4IN88US=>	MWHTRW5ITVJ?
A431	NXPtXFljT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkjOTWM2OD1{MUGuNlk6KM7:TR?=	MXTTRW5ITVJ?
TCCSUP	NWTvU5V[T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml3xTWM2OD1{MUGuOVM{KM7:TR?=	MYHTRW5ITVJ?
HO-1-N-1	MnizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mkf0TWM2OD1{MUKuPFk1KM7:TR?=	Mn;MV2FPT0WU
NCI-H69	MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mnz1TWM2OD1{MUSuNVg2KM7:TR?=	M4q1VHNCVkeHUh?=
ES7	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF7VO5JKSzVyPUKxOE45PzhizszN	NYjjXlJTW0GQR1XS
C3A	M{HXOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoWyTWM2OD1{MUWuOVc2KM7:TR?=	MnHvV2FPT0WU
UACC-257	MljKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NX7scoJmUUN3ME2yNVcvPDNizszN	M33CUXNCVkeHUh?=
DMS-153	MoTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVSwSJpWUUN3ME2yNVcvQDN4IN88US=>	MkfpV2FPT0WU
LB771-HNC	M1rYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{HnUmlEPTB;MkG3Mlg6OyEQvF2=	MmTFV2FPT0WU
HOS	M2HlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYHJR\|UxRTJzOD65JO69VQ>?	NFnMe5RUSU6JRWK=
THP-1	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkPSTWM2OD1{MUmuOlA3KM7:TR?=	NWX0XHg3W0GQR1XS
SCC-4	NI\PSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXzNfFBzUUN3ME2yNlAvOzV\|IN88US=>	M3nlVnNCVkeHUh?=
SCC-3	M1f6dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUHJR\|UxRTJ{MD61O\|ch\|ryP	MkDGV2FPT0WU
BC-1	NEjGfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1izU2lEPTB;MkKwMlc6QSEQvF2=	NXvsNmJlW0GQR1XS
NCI-H1618	MoTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NV[wUpV7UUN3ME2yNlEvODF6IN88US=>	NWWyd5hIW0GQR1XS
CaR-1	MnjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M{KwRmlEPTB;MkKxMlI2OSEQvF2=	M1XscnNCVkeHUh?=
NCI-H1355	M4j4Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4\s[2lEPTB;MkKxMlM4PyEQvF2=	NHzJbJNUSU6JRWK=
NCI-H1993	NYHHPWxDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NI[0T25KSzVyPUKyNk4zOzlizszN	M2j2SHNCVkeHUh?=
NCI-H1623	M2ixfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkX0TWM2OD1{MkKuN\|g6KM7:TR?=	M3LSOHNCVkeHUh?=
AGS	MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmfUTWM2OD1{MkKuOVI{KM7:TR?=	NVrH[JJWW0GQR1XS
SAS	MmDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFvxS4VKSzVyPUKyN{44QTZizszN	NXLZVIFDW0GQR1XS
HCC1937	NIjBeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NU[5T\|NWUUN3ME2yNlQvOzh7IN88US=>	M2LjSnNCVkeHUh?=
NCI-H209	MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH;mUo1KSzVyPUKyOk42OyEQvF2=	NXKyfW1zW0GQR1XS
NCI-H322M	NHPhcpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3LlPWlEPTB;MkK4MlAyQSEQvF2=	MmXaV2FPT0WU
CHL-1	MmK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUnhUoJEUUN3ME2yNlgvOTNizszN	M1HpOnNCVkeHUh?=
NCI-H630	M{TIZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MVvJR\|UxRTJ\|Mj64PVch\|ryP	NX7iXFFbW0GQR1XS
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MSTO-211H	M2jKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGTNfoNKSzVyPUKzN{4zPzZizszN	NIjsWJNUSU6JRWK=
YAPC	MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYD0NHpjUUN3ME2yN\|QvOjV\|IN88US=>	NIjyR3VUSU6JRWK=
SW1783	NGX6W3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXHJR\|UxRTJ\|ND60NUDPxE1?	MoLvV2FPT0WU
GB-1	NVTRe3dFT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWqwNmc3UUN3ME2yN\|UvOTd5IN88US=>	MkPGV2FPT0WU
NCI-H520	MlTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mlq0TWM2OD1{M{WuO\|QyKM7:TR?=	MXnTRW5ITVJ?
NOMO-1	NUHaSHlbT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4n2ZWlEPTB;MkO2MlAzKM7:TR?=	NEnlNmtUSU6JRWK=
NCCIT	NFvOSoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXraTVV{UUN3ME2yN\|YvQDd\|IN88US=>	M2jSOnNCVkeHUh?=
SW954	NILUTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M33QUmlEPTB;MkO3Mlg3QCEQvF2=	NWrB[m9oW0GQR1XS
MOLT-4	Mkf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVjYeo5kUUN3ME2yOFEvOjB7IN88US=>	NYnlSnpFW0GQR1XS
EB2	MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoTHTWM2OD1{NEGuPVA4KM7:TR?=	NEO2NIJUSU6JRWK=
IPC-298	MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1[1ZmlEPTB;MkSyMlA4OiEQvF2=	NITtU\|hUSU6JRWK=
GP5d	NWjvNZBwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmHkTWM2OD1{NEKuOlE3KM7:TR?=	MWfTRW5ITVJ?
HN	M4XKV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGfqVmZKSzVyPUK0Nk46QTFizszN	NI\VfW5USU6JRWK=
BFTC-909	NEe5e2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWjJR\|UxRTJ2Mz6xNVgh\|ryP	NVm3Xlh7W0GQR1XS
ES5	NIDlV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWPJR\|UxRTJ2NT6wN\|gh\|ryP	MlPiV2FPT0WU
SK-HEP-1	NUjuPINJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUjJR\|UxRTJ2Nj6wOFMh\|ryP	M2GwOXNCVkeHUh?=
T47D	NVjhbHpIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHXFW45KSzVyPUK0O{4xOTNizszN	MYnTRW5ITVJ?
KYSE-510	M{jWV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlXxTWM2OD1{NEeuOVE4KM7:TR?=	MVTTRW5ITVJ?
LC-1F	M4W1cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHPzTpRKSzVyPUK0PE4yPTZizszN	MYrTRW5ITVJ?
NCI-H1693	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NITIRXpKSzVyPUK0PU41QTVizszN	MoXmV2FPT0WU
COR-L23	M1rJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUPmcoRKUUN3ME2yOVAvPDF{IN88US=>	MmPuV2FPT0WU
NCI-H2228	NFzEfIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NInWTXdKSzVyPUK1NE45PjRizszN	MW\TRW5ITVJ?
NCI-H460	Mkn6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLxeG5KSzVyPUK1NU41OTdizszN	MlfoV2FPT0WU
TGBC1TKB	NILtPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWTJR\|UxRTJ3Mj64O\|Uh\|ryP	NWDTNXpNW0GQR1XS
NCI-H1304	NUfEc3VWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVzJR\|UxRTJ3Mz6xOVYh\|ryP	MlXKV2FPT0WU
CAL-27	M{XNXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NYD5TGNUUUN3ME2yOVMvPDh3IN88US=>	M2jU[XNCVkeHUh?=
NCI-H187	NXzIbppwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2\4PWlEPTB;MkW2Mlc3KM7:TR?=	M2GyeHNCVkeHUh?=
HSC-2	NF\ubIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{PpUGlEPTB;MkW4MlU5PCEQvF2=	M3vkc3NCVkeHUh?=
CAL-39	MnnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkeyTWM2OD1{NkCuNlczKM7:TR?=	M4i4eXNCVkeHUh?=
HuH-7	MlTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUHJR\|UxRTJ4MD65PVYh\|ryP	MWDTRW5ITVJ?
MMAC-SF	M4e4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mkm0TWM2OD1{NkGuNVkzKM7:TR?=	MmP1V2FPT0WU
VA-ES-BJ	MnXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYDJR\|UxRTJ4MT65NVgh\|ryP	M3fIU3NCVkeHUh?=
A673	Mn\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmnCTWM2OD1{NkeuNFI2KM7:TR?=	M{PEdnNCVkeHUh?=
LU-165	M4rpXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NXvGfGlVUUN3ME2yOlcvQTRzIN88US=>	MkCyV2FPT0WU
CAL-12T	NV7tWVRXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3rDR2lEPTB;Mk[4MlM3PiEQvF2=	MnHPV2FPT0WU
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MDA-MB-468	NF73VpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYXIVVdXUUN3ME2yOlkvOzN\|IN88US=>	M4\MRnNCVkeHUh?=
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MHH-CALL-2	NH22S2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1;pemlEPTB;Mk[5MlkzKM7:TR?=	MUXTRW5ITVJ?
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NCI-H1882	MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH;oNZdKSzVyPUK4Ok4xOzVizszN	NEXoWllUSU6JRWK=
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NCI-H2347	MoHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NY[5ZlNYUUN3ME2yPVYvPDJ3IN88US=>	M3izTXNCVkeHUh?=
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CAL-51	M3f4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX7GXY9rUUN3ME2zNlEvPDB\|IN88US=>	NFjaU2JUSU6JRWK=
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NCI-H1522	MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MljrTWM2OD1\|M{SuN\|M6KM7:TR?=	NETDcVVUSU6JRWK=
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CAL-54	MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3Lj[mlEPTB;M{S1Mlg4QSEQvF2=	Mo\HV2FPT0WU
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NCI-H720	M1vXfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXzJR\|UxRTN2OT64OFYh\|ryP	M4jJR3NCVkeHUh?=
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NCI-H2126	Mnu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFzaR4VKSzVyPUO1PE42OjFizszN	Ml3QV2FPT0WU
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MDA-MB-134-VI	NXz3Rm1uT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnOyTWM2OD12M{GuNFM{KM7:TR?=	NW\VXldPW0GQR1XS
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SCLC-21H	NH[3T\|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NF;GUnJKSzVyPUS1OU43QTlizszN	NG\6UnBUSU6JRWK=
KMS-12-PE	NHfvVmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWHuT\|J2UUN3ME20OVYvQDJ{IN88US=>	MX;TRW5ITVJ?
TE-441-T	NUfJeIhVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVrJR\|UxRTR3Nz6xPFYh\|ryP	NEHrfWVUSU6JRWK=
A3-KAW	NG\iRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlzvTWM2OD12NkCuPFQyKM7:TR?=	NEK0T\|VUSU6JRWK=
NCI-H1092	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{j1V2lEPTB;NE[zMlk1OyEQvF2=	MlX2V2FPT0WU
COR-L279	NGfJWWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXH3cFE5UUN3ME20OlQvQDR5IN88US=>	M3iwPHNCVkeHUh?=
NCI-SNU-5	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkH3TWM2OD12N{KuNlgh\|ryP	MYTTRW5ITVJ?
JAR	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYHJR\|UxRTR5ND63PFgh\|ryP	MW\TRW5ITVJ?
NCI-H446	M2G0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXLJR\|UxRTR5Nz6wPEDPxE1?	MXLTRW5ITVJ?
HDLM-2	Mke5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2r0cWlEPTB;NEiwMlg3QSEQvF2=	M1TqbnNCVkeHUh?=
D-283MED	M{jt[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIHqNXNKSzVyPUS4PE46OjRizszN	NYrWW5pRW0GQR1XS
NCI-H1395	NEnhNW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3nm[mlEPTB;NEi5MlAxPCEQvF2=	NXHpbXB4W0GQR1XS
RPMI-6666	NH[xVpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVTuXpdGUUN3ME20PVEvOzl6IN88US=>	NVXsTWNxW0GQR1XS
CPC-N	NFHzS49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4XIcGlEPTB;NUCyMlA3OyEQvF2=	M3XJZnNCVkeHUh?=
EC-GI-10	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3WxbmlEPTB;NUCyMlE3QSEQvF2=	M1PLbnNCVkeHUh?=
CA46	NXO3N5k1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mlv5TWM2OD13MESuOFA4KM7:TR?=	M4rkcXNCVkeHUh?=
EHEB	MorkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnHsTWM2OD13MEeuNlA5KM7:TR?=	M3nUbXNCVkeHUh?=
RPMI-8402	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;YbXVyUUN3ME21NVAvODJzIN88US=>	MnXWV2FPT0WU
DU-4475	Mn3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIX3TJBKSzVyPUWxNU4yODFizszN	MnzKV2FPT0WU
P12-ICHIKAWA	MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4n3d2lEPTB;NUGxMlQyPiEQvF2=	NX\4WIRrW0GQR1XS
NCI-H1694	NELUT5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXnJR\|UxRTVzMj60N\|kh\|ryP	NYnhfFVKW0GQR1XS
NCI-H2171	NVmyT\|RIT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MoH3TWM2OD13MUKuO\|A2KM7:TR?=	MljkV2FPT0WU
Mo-T	NUTUe49lT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYHJR\|UxRTVzNT6xNVYh\|ryP	NVOwVWhoW0GQR1XS
HL-60	NH\mSWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NXnJWlM1UUN3ME21NlIvQTJ2IN88US=>	NXz4So9LW0GQR1XS
NCI-H1436	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{nBSmlEPTB;NUKzMlA3PCEQvF2=	NUX5PYVNW0GQR1XS
NCI-H510A	NULXTJhGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2P4S2lEPTB;NUK0MlY6PiEQvF2=	NFfmbm5USU6JRWK=
NCI-H2081	NIq2TFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmHmTWM2OD13MkWuOVE{KM7:TR?=	M2TwRnNCVkeHUh?=
NB5	NV24WGcyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFm1c\|NKSzVyPUWyOk41OyEQvF2=	NH7lTnNUSU6JRWK=
NCI-H2227	MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;pT21[UUN3ME21N\|AvOjV2IN88US=>	MVnTRW5ITVJ?
HSC-4	NFX5dFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml:1TWM2OD13M{muNlk{KM7:TR?=	MkXTV2FPT0WU
RL	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2f3bGlEPTB;NUSyMlQ1OiEQvF2=	M3naSXNCVkeHUh?=
EVSA-T	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml60TWM2OD13NEOuOlg1KM7:TR?=	NW\jbHNFW0GQR1XS
NCI-H889	NH3t[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4q4fmlEPTB;NUS3MlI{KM7:TR?=	MlrwV2FPT0WU
COLO-320-HSR	NFnqW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnL2TWM2OD13NUGuN\|Uh\|ryP	NEHXNnlUSU6JRWK=
EW-11	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGPrVnhKSzVyPUW1Nk4{QTlizszN	MnTtV2FPT0WU
UACC-812	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkDkTWM2OD13NUmuN\|kyKM7:TR?=	NIm2R2xUSU6JRWK=
CAL-148	MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX7JR\|UxRTV4NT6wPFkh\|ryP	MmjvV2FPT0WU
K052	MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2DTUWlEPTB;NUe5MlIyOyEQvF2=	M3PBfnNCVkeHUh?=
L-428	NInodYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVfJR\|UxRTZyMD62O\|Eh\|ryP	Mme1V2FPT0WU
LP-1	M3\EUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1fGZWlEPTB;NkCzMlU5PyEQvF2=	NG\aWllUSU6JRWK=
ML-2	MnnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlX6TWM2OD14ME[uOVc6KM7:TR?=	M{XrZXNCVkeHUh?=
KARPAS-45	NV7reoZNT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFTVOlRKSzVyPU[xPE4zOjFizszN	NUXSOWwyW0GQR1XS
HT	NVrIWnA6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUjEV\|lFUUN3ME22NlIvPzh3IN88US=>	NGPYdHZUSU6JRWK=
NCI-H226	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2DmfGlEPTB;NkK4MlM2OyEQvF2=	NVTNR3RRW0GQR1XS
L-363	Mm\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M4HacmlEPTB;NkS4MlA3PCEQvF2=	Ml7SV2FPT0WU
IM-9	NWjWWIZrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUDn[5FtUUN3ME22OVEvPTRzIN88US=>	MojCV2FPT0WU
TUR	NV7Oc5NnT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NEjORpBKSzVyPU[3NU4{OjJizszN	M{HtV3NCVkeHUh?=
NCI-SNU-16	MlXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NEizd4FKSzVyPU[4NE41PjJizszN	MnjDV2FPT0WU
NCI-SNU-1	NXO5NVNYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVX0blVuUUN3ME22PVAvOTd{IN88US=>	NVnheJZYW0GQR1XS
U-87-MG	MkfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoHyTWM2OD14OUSuOVg2KM7:TR?=	MXHTRW5ITVJ?
KM-H2	NIfOfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1LQNWlEPTB;Nkm5MlA2QSEQvF2=	MmHNV2FPT0WU
DEL	Mlm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3S1W2lEPTB;N{CwMlg{QCEQvF2=	MoWyV2FPT0WU
KARPAS-422	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NE\VNpNKSzVyPUe4PU4{OTVizszN	Ml34V2FPT0WU
BC-3	M1XwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NY[1Woh6UUN3ME24NFUvOjB\|IN88US=>	MXrTRW5ITVJ?
NCI-H1155	NH36VIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2jPV2lEPTB;OEG4MlA2QSEQvF2=	M3LYO3NCVkeHUh?=
NCI-H1581	NEjOcVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlXXTWM2OD17MECuNlMyKM7:TR?=	MXTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cleaved PARP / CD31 / VE-Cadherin / α-SMA / vimentin; PubMed: 30709379 J Exp Clin Cancer Res NCI-H460 cells were co-cultured with HUVECs in a 3D culture system, and then treated with 1 μM CHIR-99021, 10 μM or 20 μM Cisplatin, or a combination of both, for 24 h. Cells were harvested and immunoblotted with anti-cleaved PARP, anti-CD31, anti-VE-cadherin, anti-α-SMA, anti-vimentin, and anti-β-actin antibodies. CTNNB1; PubMed: 23993102 Cell Treatment with the GSK3β inhibitor CHIR-99021 led to increased levels of β-catenin in RKO and HT29 (non-mutant) cells. β-catenin; PubMed: 24165128 J Biol Chem HeLa cells were treated with 5 μm CHIR-99021 for the indicated times. The samples were analyzed by Western blot.	30709379 23993102 24165128
Growth inhibition assay	Cell viability; PubMed: 22039301 J Immunol HMC-1.2 cells were cultured in the absence or presence of GSK3β inhibitor (CHIR 99021, 3–30 µM) and viability cell count was assessed by trypan blue dye exclusion after 24 h, 48 h or 72 h. All data are presented as the mean ± SEM of three independent experiments conducted in triplicate. p < 0.05, p < 0.001* p < 0.0001*** vs vehicle treated control cells.	22039301
Immunofluorescence	SOX10 / EdU; PubMed: 28174705 Cell Mol Gastroenterol Hepatol Incorporation of EdU (white arrowheads) into SOX10+ ENS (enteric nervous system) cells with and without CHIR-99021. Oct3/4; PubMed: 24779365 BMC Res Notes Fluorescence micrographs showing the protein expression of Brachyury/Oct3/4 after a three day differentiation of ES-D3 cells with BIO (0.5 μM), SB-216763 (5 μM), CHIR-99021 (5 μM), or CHIR-98014 (1 μM). Nuclei were counterstained with DAPI (blue). The merge is shown in yellow. Original magnification 400x. Scale bar = 50 μm.	28174705 24779365

In vivo

Oral administration of CHIR-99021 at 30 mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR-99021 at 16 or 48 mg/kg 1 hour before oral glucose challenges in ZDF rats significantly improves glucose tolerance with 14% and 33% reduction in plasma glucose at 16 mg/kg and 48 mg/kg, respectively, and the higher dose of CHIR-99021 also reduces hyperglycemia before the oral glucose challenge. ^[1] Administration of CHIR-99021 significantly augments hematopoietic repopulation in recipient mice transplanted with mouse or human hematopoietic stem cells (HSCs), suggesting that GSK-3 is a specific modulator of HSC activity. ^[4]

Protocol

Kinase Assay: ^[1]	+ Expand Cell-free kinase assays: Polypropylene 96-well plates are filled with 300 μL/well buffer (50 mM tris HCl, 10 mM MgCl₂, 1 mM EGTA, 1 mM dithiothreitol, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) containing 27 nM GSK-3α or 29 nM GSK-3β, and 0.5 μM biotin-CREB peptide substrate. Various concentrations of CHIR-99021 are added in 3.5 μL of DMSO, followed by 50 μL of ATP stock to yield a final concentration of 1 μM ATP in all cell-free assays. After incubation, triplicate 100-μL aliquots are transferred to Combiplate eight plates containing 100 μL/well 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with PBS, filled with 200 μL of scintillation fluid, sealed, left 30 minutes, and counted in a scintillation counter. All steps are performed at room temperature.
Cell Research: ^[3]	+ Expand Cell lines: INS-1E Concentrations: Dissolved in DMSO, final concentrations ~ 20 μM Incubation Time: 1, or 4 days Method: Cells are maintained for 24 hours in starvation medium (culture medium with only 5 mM glucose, 1% fetal calf serum). Then cells are exposed to various concentrations of CHIR-99021 for 1, or 4 days. Cell number is measured by staining of cellular DNA with CyQuant dye, which becomes fluorescent when bound to DNA. Fluorescence is measured after 30 minutes of incubation using the FLUOstar Optima reader. Cell replication is determined by BrdUrd incorporation. BrdUrd labeling solution is added to the medium for the last 4 hours before the cells are fixed using FixDenat solution and incubated with monoclonal anti-BrdUrd-POD antibodies. After substrate solution is added to each well, the light emission is measured in a microplate luminometer using the Analyst HT detection system. (Only for Reference)
Animal Research: ^[1]	+ Expand Animal Models: Female db/db mice or male ZDF rats with type 2 diabetes Formulation: Formulated as solutions in 20 mM citrate-buffered 15% Captisol or as fine suspensions in 0.5% carboxymethylcellulose. Dosages: ~48 mg/kg Administration: Orally (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL (185.33 mM)
	Ethanol	2 mg/mL (3.98 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	24mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Molecular Weight	501.8
Formula	C₂₂H₁₈Cl₂N_8.HCl
CAS No.	1797989-42-4
Storage	3 years -20°C powder
Storage	2 years -80°C in solvent
Synonyms	N/A

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C1=C0/X	C1:	LOG(C1):
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C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?
Answer:
The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.
Question 2:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
Answer:
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
Question 3:
What is the difference between S2924 and S1263? Which one is better for differentiation?
Answer:
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Selective GSK-3 Inhibitor

TWS119 : GSK-3β-selective, IC50 of 30 nM.
Most Potent GSK-3 Inhibitor

CHIR-98014 : GSK-3α, IC50=0.65 nM; GSK-3β, IC50=0.58 nM.
GSK-3 Inhibitor in Clinical Trial

Tideglusib : Phase II for Alzheimer's disease.
Newest GSK-3 Inhibitor

AZD1080 : Orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively.

Related GSK-3 Products4

CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs.
LY2090314 ^New

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
TDZD-8 ^New

TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
TWS119

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology.
SB216763

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.
Tideglusib

Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
CHIR-98014

CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
BIO

BIO is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.

Features:The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.
AR-A014418

AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and K_i of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
IM-12

IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

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CHIR-99021 (CT99021) HCl

Cited by 80 Publications

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Chemical Information Download CHIR-99021 (CT99021) HCl SDF

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products4

Choose Your Country or Region

By Signaling Pathways

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CHIR-99021 (CT99021) HCl

Cited by 80 Publications

Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Protocol

References

Solubility (25°C)

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Bio Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Dilution Calculator

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

The Serial Dilution Calculator Equation

Serial Dilutions

Computed Result

Molecular Weight Calculator

Total Molecular Weight: g/mol

Instructions to calculate molar mass (molecular weight) of a chemical compound:

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molarity Calculator

Tech Support

Frequently Asked Questions

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Related GSK-3 Products4

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)