CHIR-99021 (CT99021) HCl

Name: CHIR-99021 (CT99021) HCl
Brand: Selleck Chemicals
SKU: S2924
Rating: 5 (337 reviews)

For research use only.

Catalog No.S2924

337 publications

CHIR-99021 (CT99021) HCl Chemical Structure

CAS No. 1797989-42-4

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.

Selleck's CHIR-99021 (CT99021) HCl has been cited by 337 publications

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Bachelor of Science, 2012, East China Normal University

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Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Description

Targets

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

In vitro

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. ^[1] In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). ^[2] Unlike lithium chloride and AR-A014418, CHIR-99021 treatment does not reduce the viability of INS-1E cells even at high concentrations. Instead, CHIR-99021 robustly increases the rate of proliferation of INS-1E cells in a dose-dependent manner, and significantly inhibits INS-E cell death induced by high glucose and high palmitate in a concentration-dependent manner. CHIR-99021 promotes primary beta cell replication in isolated rat islets at concentrations as low as 1 μM, with 2-3 fold increase of cell replication at 5 μM of CHIR-99021 treatment. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
NCI-H1581	M3TsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYrJR\|UxRTlyMD6yN\|Eh\|ryP	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H1155	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3vtOGlEPTB;OEG4MlA2QSEQvF2=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
BC-3	NXH5O41wT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NE\ofnhKSzVyPUiwOU4zODNizszN	NXS2dHhpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
KARPAS-422	NV[yZ5NMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFnFdo9KSzVyPUe4PU4{OTVizszN	MoL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
DEL	Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NF\XWJZKSzVyPUewNE45OzhizszN	NGj2V2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
KM-H2	M1f6eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Mn7CTWM2OD14OUmuNFU6KM7:TR?=	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
U-87-MG	NGG2b4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1HNcWlEPTB;Nkm0MlU5PSEQvF2=	M4nne\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-1	NH70XI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV;JR\|UxRTZ7MD6xO\|Ih\|ryP	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-SNU-16	NV\4cG1wT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MnXNTWM2OD14OECuOFYzKM7:TR?=	M2n3WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
TUR	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUDJR\|UxRTZ5MT6zNlIh\|ryP	NYLESI54RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
IM-9	M3;y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{XufWlEPTB;NkWxMlU1OSEQvF2=	M3\adVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
L-363	Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGDmN25KSzVyPU[0PE4xPjRizszN	M3K3elxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H226	M{Ppemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1zQfmlEPTB;NkK4MlM2OyEQvF2=	NEPselE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HT	MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGPQ[4JKSzVyPU[yNk44QDVizszN	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KARPAS-45	MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NEjGR3dKSzVyPU[xPE4zOjFizszN	NYrGcWI1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
ML-2	MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHz2PGZKSzVyPU[wOk42PzlizszN	NUHuS5ZwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LP-1	NInDc4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFfkO\|hKSzVyPU[wN{42QDdizszN	NVTPfllRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
L-428	NVW0W241T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mk[xTWM2OD14MECuOlcyKM7:TR?=	NYDYeYR3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
K052	NITOO4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV3tOG1YUUN3ME21O\|kvOjF\|IN88US=>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
CAL-148	NFXPT\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWTJR\|UxRTV4NT6wPFkh\|ryP	NX2xWW1CRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
UACC-812	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFH5OXhKSzVyPUW1PU4{QTFizszN	NUm5O\|c4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
EW-11	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnLYTWM2OD13NUKuN\|k6KM7:TR?=	M3;ab\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COLO-320-HSR	MojsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFLtXFBKSzVyPUW1NU4{PSEQvF2=	M1vJXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H889	NU\OWW9vT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NX[yZo91UUN3ME21OFcvOjNizszN	M33IVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
EVSA-T	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXrJR\|UxRTV2Mz62PFQh\|ryP	NUm4[mdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
RL	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NV;Hb3BtUUN3ME21OFIvPDR{IN88US=>	NYPxdo5zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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NCI-H2227	Mke1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYH5TlFMUUN3ME21N\|AvOjV2IN88US=>	NIWxZlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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NCI-H510A	NUPyNGMyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF6zOW1KSzVyPUWyOE43QTZizszN	NXraWm1mRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H1436	NHPM[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlfPTWM2OD13MkOuNFY1KM7:TR?=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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RPMI-8402	MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NG[3WVRKSzVyPUWxNE4xOjFizszN	M336fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
EHEB	M3G4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUXwe49nUUN3ME21NFcvOjB6IN88US=>	Mnm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
CA46	MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYnZT4dYUUN3ME21NFQvPDB5IN88US=>	NIXxV4g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
EC-GI-10	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mkn1TWM2OD13MEKuNVY6KM7:TR?=	NUO5XJRmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
CPC-N	NYfSSlM{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXvx[\|RwUUN3ME21NFIvODZ\|IN88US=>	Mk\PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
RPMI-6666	NF\zblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NY\KcVlWUUN3ME20PVEvOzl6IN88US=>	NGXaVYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H1395	MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M{T2b2lEPTB;NEi5MlAxPCEQvF2=	NWLFVnl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
D-283MED	NHS5Om5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NHyzeWVKSzVyPUS4PE46OjRizszN	MmXJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HDLM-2	NHTFeJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmfxTWM2OD12OECuPFY6KM7:TR?=	NV\vZWRyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H446	NHS4WGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4XEdGlEPTB;NEe3MlA5KM7:TR?=	M3rxUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
JAR	MmLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoHHTWM2OD12N{SuO\|g5KM7:TR?=	M1TBOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-5	NFu3OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUTJR\|UxRTR5Mj6yPEDPxE1?	M1\3RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COR-L279	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHXEUnhKSzVyPUS2OE45PDdizszN	NHnBSZE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H1092	NEjk[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2XYZmlEPTB;NE[zMlk1OyEQvF2=	NEHneXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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TE-441-T	M2CwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NELIWpNKSzVyPUS1O{4yQDZizszN	NI\aU2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
KMS-12-PE	NIrj[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NV7EO257UUN3ME20OVYvQDJ{IN88US=>	NInZc2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SCLC-21H	NH\KTZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVWydZRoUUN3ME20OVUvPjl7IN88US=>	NW\lbIt6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
TALL-1	MlnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M3;EVGlEPTB;NEW1MlI6PyEQvF2=	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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MS-1	NHTScoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4X3WGlEPTB;NEW0MlM5PSEQvF2=	NUKyR3FLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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DMS-79	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXTicGpDUUN3ME20OFkvPjhizszN	M2LpSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COLO-684	MoHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTR2OD64PFgh\|ryP	NIjS[ok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
BL-70	NFzMfXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MofJTWM2OD12M{muOFI6KM7:TR?=	M2i1S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
AM-38	M1nUc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkfiTWM2OD12M{iuOVQh\|ryP	NWL3N5lZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
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MDA-MB-134-VI	MlHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFX2SZpKSzVyPUSzNU4xOzNizszN	M4DSeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H2141	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlfOTWM2OD12MkSuN\|g5KM7:TR?=	MoDXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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OCI-AML2	M2nGR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlPVTWM2OD1zNEGuOVA4KM7:TR?=	NXzoeGdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
Detroit562	M3\QbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MnPqTWM2OD1zNEGuOFY3KM7:TR?=	M2PUOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
OVCAR-4	M1zQfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWX4fIdwUUN3ME2xOFAvPzR7IN88US=>	MmPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
BHT-101	NGDO[mtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFzldZJKSzVyPUG0NE4zODhizszN	NGPDTIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
Ca-Ski	NGjuT2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NYfFfJVoUUN3ME2xN\|gvQDNzIN88US=>	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
OAW-42	NFL4eWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVjJR\|UxRTF\|Nz64OVYh\|ryP	M332SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
G-402	NGjoVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFXzNotKSzVyPUGzOU4zQTVizszN	NHezcHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NOS-1	MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHPLWW9KSzVyPUGzOE44PjVizszN	MnLNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H1437	MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M17hXGlEPTB;MUO0MlU6KM7:TR?=	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
JEG-3	NEPPTYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWPJR\|UxRTF\|ND6zOVkh\|ryP	NEnHNGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
CP50-MEL-B	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUHpZ4VJUUN3ME2xN\|QvOiEQvF2=	MlizQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
BB30-HNC	NH36fHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVX4W2NJUUN3ME2xN\|QvOTF4IN88US=>	MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
Capan-2	MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYDJR\|UxRTF\|Mz65O\|Uh\|ryP	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
CTB-1	NVLJVWY3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYTKVZd5UUN3ME2xN\|IvQDl5IN88US=>	NGnIPHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HT-1080	NWW3UoFsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUXXVJhvUUN3ME2xN\|IvOjB2IN88US=>	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MFH-ino	NGDrXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUDJR\|UxRTF\|MT6xNVQh\|ryP	NFzmZXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
VMRC-RCZ	M4XSU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3G3WmlEPTB;MUOwMlM4PSEQvF2=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
LU-99A	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoLJTWM2OD1zMkmuPVMyKM7:TR?=	NGjVfIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HEC-1	NX7VbIVVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGnkdGdKSzVyPUGyPU4yQThizszN	NHjGZpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
EB-3	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV\JR\|UxRTF{Nz6wNVMh\|ryP	M1zmd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
UMC-11	NX;rR3E2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUjUPIRWUUN3ME2xNlYvODN6IN88US=>	M2[5WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H2087	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXLNeZpKUUN3ME2xNlQvOjh\|IN88US=>	NF\QSFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SW1463	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NIHsdWtKSzVyPUGyOE4xPzdizszN	NGnwPWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
OPM-2	NITLZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{X2WWlEPTB;MUKzMlE4PiEQvF2=	M1\4[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
HT-29	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHnZbm9KSzVyPUGyNk44PzhizszN	MlTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HAL-01	NEPWc5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWPJR\|UxRTF{Mj60PVkh\|ryP	M37HRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KYSE-140	MlnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXTJR\|UxRTF{Mj6xOFEh\|ryP	NFL0WpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HuP-T4	M{HoOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYjJR\|UxRTF{MT61OUDPxE1?	M2KwWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-N87	M2nrSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1;Sb2lEPTB;MUKxMlA1PCEQvF2=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
OVCAR-3	NXq1SZpVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGrTepFKSzVyPUGxPU46OTVizszN	M1vmNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KNS-81-FD	NH;Fe2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mly2TWM2OD1zMUmuOFE4KM7:TR?=	NYX1XYc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SUP-T1	NU\xRnRwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUDJR\|UxRTFzOD65OVYh\|ryP	M1j3TVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SKG-IIIa	MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M2nCeWlEPTB;MUG4MlEyPiEQvF2=	MofKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
RKO	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFXLV\|lKSzVyPUGxO{45QThizszN	MoHqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
ATN-1	MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYDJR\|UxRTFzNz64Nlgh\|ryP	MkeyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
OVCAR-8	MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NH3GdGZKSzVyPUGxO{43PjhizszN	NXKzd\|dNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HCC1599	MnPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVfXd2NTUUN3ME2xNVcvOTV4IN88US=>	M3q2dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
Calu-6	MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2L0cWlEPTB;MUG2Mlc6QCEQvF2=	NGr6PGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
DMS-273	M4T4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUTqWItXUUN3ME2xNVUvPjF5IN88US=>	MknZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
786-0	Ml34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoPDTWM2OD1zMUOuOFU{KM7:TR?=	MmrtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SIG-M5	MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3[wU2lEPTB;MUGzMlEzPSEQvF2=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NEC8	NXjhTnNtT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4my[mlEPTB;MUGyMlYzPCEQvF2=	MkLEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MDA-MB-157	MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NWX6XVJEUUN3ME2xNVIvPDlizszN	NYHrSJBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
U031	M1TYN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlOzTWM2OD1zMUKuNFY2KM7:TR?=	MoDsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
WSU-NHL	MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M125[GlEPTB;MUGyMlAyKM7:TR?=	NWTYeXRrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HCT-15	MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MXjJR\|UxRTFzMD62OlEh\|ryP	M4K2TFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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SIMA	NYfsSldDT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWmzVWt6UUN3ME2xO{46OTF6IN88US=>	Mn3YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
Daudi	MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYTJR\|UxRTF5Lk[xOFkh\|ryP	MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
CCRF-CEM	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1T0[GlEPTB;MU[uOlcxOiEQvF2=	NIq5bXA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NH-12	M2LvdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYXJR\|UxRTF4LkCwPVch\|ryP	NYDGepc1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LoVo	NFrjUmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlLQTWM2OD1zNT6yOlU6KM7:TR?=	NW\j[ZJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
ST486	NFfoXVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M1Lt[GlEPTB;MUSuNlI2OSEQvF2=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NB1	M3LIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MmHiTWM2OD1zND6xPVM2KM7:TR?=	NYLrTJc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SF539	NWPkcHBVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MVjJR\|UxRTF2LkCxNVYh\|ryP	NHTEVWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SW48	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGHM[HdKSzVyPUGzMlczPjVizszN	NI\2R209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
MEL-HO	NVHUd\|BzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1L1XmlEPTB;MUOuPFgzQSEQvF2=	MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KU812	NUnt[W9GT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NG\OUFdKSzVyPUGzMlUyPzVizszN	MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
T98G	M{nO[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MlTHTWM2OD1zMz60O\|E4KM7:TR?=	M2q4UFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
DSH1	MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWLJR\|UxRTF\|LkO4O\|kh\|ryP	NXfEOFBORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H82	MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWrt[JdNUUN3ME2xN{4zQTB7IN88US=>	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
C8166	NEfSUGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWHJR\|UxRTF\|LkKzNVgh\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
PC-14	M1;VZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoPvTWM2OD1zMj6zNlQh\|ryP	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
PA-1	NUW2bpNvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NFLuPWFKSzVyPUGxMlk{KM7:TR?=	NUTGdlBLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HEL	M1u5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NX\XfI5sUUN3ME2xNU43PTd7IN88US=>	M1H4XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H526	NXX1W\|VVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUHXUXVCUUN3ME2xNU4yOzZ3IN88US=>	M3XqclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SNU-387	M1P4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MU\JR\|UxRTFyLkeyN\|Uh\|ryP	NInaXGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HT-3	NUjQdGx6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn\ITWM2OD1zMD62NVc6KM7:TR?=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
M059J	NX3oNphPT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVLxR4NkUUN3ME2xNE43OTB{IN88US=>	NGPnVFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
MZ2-MEL	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUjBfWl4UUN3ME2xNE41Pjd5IN88US=>	NUfWZlZ1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H28	MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUDqWI5oUUN3ME2xNE41PDF\|IN88US=>	NEjwN3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
LB1047-RCC	M3vUTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{i3[mlEPTB;OT65PVc6QCEQvF2=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
U-118-MG	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYTJR\|UxRTlwOUS0OFQh\|ryP	MoPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
DBTRG-05MG	NXHVUG56T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYrzXY55UUN3ME25Mlc4PzdizszN	NFvVe249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
EFM-19	NH;QUIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MlnYTWM2OD17Lke1OVY3KM7:TR?=	NFi2fVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SK-N-DZ	MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NXzUb2tqUUN3ME25MlY2PzR{IN88US=>	NX\nPFlXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LB996-RCC	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MUDJR\|UxRTlwNUKzPVch\|ryP	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
U-2-OS	MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3[0emlEPTB;OT60OVAxPiEQvF2=	M4OwOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
CTV-1	M{HU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUf4SHp3UUN3ME25MlQ{QDl2IN88US=>	M1z5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COLO-205	MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MU\JR\|UxRTlwNEO4NlEh\|ryP	M{PId\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H64	MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYn3RWpyUUN3ME25MlQzOjV3IN88US=>	NITMfXk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H1755	NYLMfWJvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MkHKTWM2OD17LkO5PVg3KM7:TR?=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
ACHN	NVnHWmFYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NGfPSYFKSzVyPUmuN\|A2PDZizszN	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MEG-01	NXHRW2gxT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVvWUFRoUUN3ME24Mlk6ODR\|IN88US=>	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MKN28	Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NG\ZU2JKSzVyPUiuPFg2OTZizszN	NUHJU\|dHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
CAL-72	MoHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUfJR\|UxRThwN{[xNVMh\|ryP	Mlm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MV-4-11	M3ryOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGXDWZVKSzVyPUiuOVQ{ODRizszN	M37nSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SW1417	NYHiUIN3T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MonQTWM2OD15Lk[0OVg1KM7:TR?=	MoXHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
G-361	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUCwO4dUUUN3ME23MlQ3PTZzIN88US=>	NWPsUZo2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MC116	MofVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUPBb\|dLUUN3ME23MlI5PjlzIN88US=>	M{PpNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
RT-112	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnzxTWM2OD15LkG2OFU3KM7:TR?=	NGH3XXQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
CAL-85-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGexWnlKSzVyPU[uOlA6OzZizszN	M1fRRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
BB65-RCC	NV3FOolrT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NF3EXG1KSzVyPU[uOVMyQTVizszN	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
CGTH-W-1	NHnU[WpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mk\ZTWM2OD14LkSxO{DPxE1?	M3vm[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
WM-115	NHPhZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWrJR\|UxRTVwOEG1NFkh\|ryP	MmjBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SK-MEL-2	NHHOSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkHYTWM2OD14LkO4N\|Q1KM7:TR?=	NGXGXZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
BL-41	M2XESWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUG5NoI3UUN3ME21MlgyOjZ4IN88US=>	M4\xZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
LB2518-MEL	NYnDWGZjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3LQcWlEPTB;NT63NlYzPyEQvF2=	NGDaXZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
D-392MG	M{HtfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWfLUlI2UUN3ME21MlQ6OTR3IN88US=>	Ml7PQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H2452	Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoH0TWM2OD13LkS1OlI5KM7:TR?=	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SW1710	M4O4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXPJR\|UxRTVwNEK0OVYh\|ryP	M{nDbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SK-OV-3	M4nSXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4PUOmlEPTB;ND65PVM1KM7:TR?=	M4LrOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
ALL-PO	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1jJR2lEPTB;ND64N\|g2QCEQvF2=	MlfkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
BxPC-3	Ml\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVTJR\|UxRTRwN{CzPVEh\|ryP	MmfhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
RCC10RGB	MmC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NIjGUJVKSzVyPUSuNlk1PzlizszN	NFPlR4s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NKM-1	NGLWO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXjJR\|UxRTRwMUO5O\|Eh\|ryP	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MHH-ES-1	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWHJR\|UxRTRwMES1OFUh\|ryP	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
OE19	MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUPXd5hiUUN3ME2zMlk3PDVzIN88US=>	MmT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
TE-15	MnntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NUnUSotjUUN3ME2zMlk2OzR\|IN88US=>	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MOLT-16	MkjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHe1N4hKSzVyPUOuPFg2PTZizszN	MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
A172	NUjRdXZYT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M2XRPGlEPTB;Mz63OVQ6QCEQvF2=	NXPmUIhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
HCC1569	MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NVT2SW9xUUN3ME2zMlQ5OzB3IN88US=>	NHzycVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HOP-62	NXjKNnFvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MlfnTWM2OD1\|LkO2NFU1KM7:TR?=	NEfK[3I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
A704	NXr4clFwT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MX\JR\|UxRTNwMEixNkDPxE1?	NX:yOJFyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SCC-9	MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NWD5N3A2UUN3ME2yMlk2PDh3IN88US=>	Mlm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
COLO-829	NF7pNZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkLaTWM2OD1{Lke2OVQh\|ryP	NHG3NlA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
RPMI-7951	MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MVfJR\|UxRTJwN{CxPVMh\|ryP	MkLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SK-LMS-1	NELkNpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NWDW[VZiUUN3ME2yMlY1OTJ6IN88US=>	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SNU-423	NHPkN5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MY\JR\|UxRTJwNEm3PFch\|ryP	M1LFW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H2122	NWDIN\|hQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUDYV3FVUUN3ME2yMlI4Pjh2IN88US=>	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
RS4-11	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NF;zfGpKSzVyPUGuPVU1OTVizszN	NFXyeVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HCC1395	NXXGUoxJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWT2UoFRUUN3ME2xMlc5Ojd\|IN88US=>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MIA-PaCa-2	NXfuXFBjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWTJR\|UxRTFwN{W5O\|ch\|ryP	M{XmRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KYSE-180	NHfhbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MnzRTWM2OD1zLkeyO\|g5KM7:TR?=	NUPVcIVMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
BCPAP	MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmnETWM2OD1zLk[2PFk5KM7:TR?=	NHX6bmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
A498	NHfISIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NVXxZ29xUUN3ME2xMlMxPDZ7IN88US=>	M37mNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
TYK-nu	NVvPUoFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MU\JR\|UxRTFwMEe5NVIh\|ryP	MmS4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
D-247MG	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NHLRWppKSzVyPUCuPVQ5PTJizszN	NUXld4FLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
S-117	NEj6eGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVfJR\|UxRTBwOUKxN\|Eh\|ryP	NWP0c\|N2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
D-336MG	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M2\UO2lEPTB;MD64OFYzKM7:TR?=	NHOyU5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
LOXIMVI	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVTJR\|UxRTBwNUi4N\|Ih\|ryP	M2PSTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
769-P	M{njWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NHfnTWxKSzVyPUCuOVg1QTlizszN	NHG3NJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
GCT	M1X5bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{TybGlEPTB;MD6zNFY4OiEQvF2=	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SW982	M{OxcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MkC1TWM2OD1yLkKxOFE3KM7:TR?=	M1GwWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
ES-CCE	M4\lfWZ2dmO2aX;uJGF{e2G7	NVHBdmw3PcLizszN	MYOzJIQ>	NWfJT5o1TE2VTx?=	NYfrc\|R[W3S{b37ncJkhcW6mdXPld{B1cGViYXP0bZZqfHlib3[gW451N2KndHGtZ4F1\W6rbjDwZZRpf2G7	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd5OUO2OUc,OjR5N{mzOlU9N2F-
ES-D3	MYnGeY5kfGmxbjDBd5NigQ>?	MXq1xsDPxE1?	MVyzJIQ>	NI\nPI1FVVOR	M4TNcnN1em:wZ3z5JIlv\HWlZYOgeIhmKGGldHn2bZR6KG:oIGfueE9j\XSjLXPheIVvcW5icHH0bJdigQ>?	NGDyNmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEe3PVM3PSd-MkS3O\|k{PjV:L3G+
ES-CCE	NF;H[WVEgXSxdH;4bYMhSXO\|YYm=	M2DSNlExyqEQvF2=	MVuzJIQ>	NVjxOWRvTE2VTx?=	M3HZVWlv\HWlZYOgcY9l\XKjdHWgZ5l1d3SxeHnjbZR6	MnfYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5N{mzOlUoRjJ2N{e5N\|Y2RC:jPh?=
ES-D3	MWXDfZRwfG:6aXOgRZN{[Xl?	MlzaNVDDqM7:TR?=	NYXSSIZ{OyCm	NEjsZZpFVVOR	MYPJcoR2[2W\|IH3v[IVz[XSnIHP5eI91d3irY3n0fUB4cXSqIFnDOVAhd2ZiND65JO69VQ>?	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd5OUO2OUc,OjR5N{mzOlU9N2F-
Neural progenitor cells	NHraeIFHfW6ldHnvckBCe3OjeR?=	NYTIZmM5OyEQvF2=	NGTDWXIyOCCm	MlnvSG1UVw>?	MnLFTY5lfWOnczDn[Y5memG2aX;uJI9nKG6ndYLhcEBxem:pZX7peI9zKGOnbHzz	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ\|OECzOEc,OjR4M{iwN\|Q9N2F-
A549	NGTLWGlCeG:ydH;zbZMhSXO\|YYm=	NH7KeZg2KML3TR?=	NF73XpgzPCCq	MlyxSG1UVw>?	MXjJcoNz\WG\|ZYOgZ4VtdCCjcH;weI9{cXN?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4N{[4PEc,OjR\|Nke2PFg9N2F-
H157	MWfBdI9xfG:\|aYOgRZN{[Xl?	NUnJ[Xc{PSEEtV2=	MYWyOEBp	M17oemROW09?	MoO4SI9meyCwb4Sgd4lodmmoaXPhcpRtgSCjZn\lZ5Qh[XCxcITvd4l{	NYnBcJhtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlc3QDhpPkK0N\|Y4Pjh6PD;hQi=>
H460	MUDBdI9xfG:\|aYOgRZN{[Xl?	NGjiOWM2KML3TR?=	MlvZNlQhcA>?	NGXEcYhFVVOR	M4HlemF1fGWwdXH0[ZMh[2WubDDhdI9xfG:\|aYO=	NGfpXGU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEO2O\|Y5QCd-MkSzOlc3QDh:L3G+
H157	NIjHSINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	M13VWVUhyrWP	NH3WTYYzPCCq	M{fJV2ROW09?	NY\N[4t5WHKxbX;0[ZMh[2WubDDwdo9tcW[ncnH0bY9v	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4N{[4PEc,OjR\|Nke2PFg9N2F-
H460	NUPGdlFpT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MX61JOK2VQ>?	NEnpN3EzPCCq	MUnEUXNQ	NGjMcWNRem:vb4Tld{Bk\WyuIIDyc4xq\mW{YYTpc44>	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4N{[4PEc,OjR\|Nke2PFg9N2F-
embryonic stem cells (ESC)	MX\GeY5kfGmxbjDBd5NigQ>?	NGGxdGg{KML3TR?=	M2mwd\|EyKGR?	M{faNmROW09?	NHruVJVRem:vb4Tld{B{\WyoLYLlcoV4[Wxib3[gcoHEt3[nLYT5dIUhdW:3c3Wg[Y1jenmxbnnjJJN1\W1iY3XscJMhMEWVQzm=	MorGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NEOzNVIoRjJ\|OESzN\|EzRC:jPh?=
DN3	MUTGeY5kfGmxbjDBd5NigQ>?	MkCwNVAh\|ryP	NYjVe3BHQTZiaB?=	NHTtZ3BFVVOR	M4jSfWlv[3KnYYPld{Bk\WyuIHTleoVtd3CvZX70JIFv\CCycn;sbYZmemG2aX;u	NWXoeZZIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1NlY6QDlpPkKzOVI3QTh7PD;hQi=>
platelets	Ml3SSpVv[3Srb36gRZN{[Xl?	MlnJNVAh\|ryP	NUHWb5dqOTVibXnu	MYDEUXNQ	NXjpfnp1UW6lcnXhd4V{KHSqcn;tZolvNW2nZHnheIVlKHCuYYTlcIV1KGGpZ4Ll[4F1cW:wIHHu[EBCXFBic3XjdoV1cW:w	NIK3bGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{KzPVg4Pyd-MkOyN\|k5Pzd:L3G+
hiPSC-NPs	NWe4VWVHT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVnyfYpbO+LCid88US=>	NUXuOHA2PzJiaB?=	NXrBe5lMTE2VTx?=	NX7GXmI2UW6lcnXhd4V{KGOnbHygdJJwdGmoZYLheIlwdsLi	MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4NEK2PFcoRjJ{NkSyOlg4RC:jPh?=
INS-1E	NUTsbnZQTnWwY4Tpc44hSXO\|YYm=	M4HFS\|IvPSEQvF2=	M4LqVFI1KGh?	MVPEUXNQ	MULJcoR2[2W\|IHGgdoVlfWO2aX;uJI9nKE6SMTDveoVz\XiycnXzd4lwdg>?	M4rpNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEK3O\|A1Lz5{MkSyO\|cxPDxxYU6=
PANC1	MnzoRZBweHSxc3nzJGF{e2G7	NGDn[3XDqDVizszN	NHW4NZU4OiCq	NF;FS3hFVVOR	NGDKXllVemmpZ3Xyd{BidiCjcH;weI91cWNicnXzdI9ve2V?	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJyMUG4Okc,OjJ{MEGxPFY9N2F-
Endothelial cell(EC)	M1S1OmZ2dmO2aX;uJGF{e2G7	NYnacGNGOyEQvF2=		NUnFbYI2TE2VTx?=	MofTVJJwdW:2ZYOg[Y5ld3SqZXzpZYwh[2WubDCoSWMqKGSrZn\ldoVvfGmjdHnvci=>	M{\jelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEWyNFA3Lz5{MkC1NlAxPjxxYU6=
HMC1.2	NV;YWlQyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MUezNEDPxE1?	NEjLcGw4OiCq	MmH0SG1UVw>?	NGHueXNT\WS3Y3XzJINmdGxic4Xyeol3[Wx?	MoK5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyM{mzNFEoRjJ{MEO5N\|AyRC:jPh?=
Sca-1+ HPC	MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MojZNkDPxE1?	NILK[Ig3KGR?	NGH4fZZFVVOR	NH[4UZRUgW6ncnfpd5Rq[2GubImgdJJwdW:2ZYOgV4NiNTFtwrDIVGMheHKxbHnm[ZJifGmxbjDhcoQh[2:ub375JIZwem2jdHnvckB1d2endHjldkB4cXSqIFXHSi=>	M33nWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkK0N\|Q5Lz5{MU[yOFM1QDxxYU6=
Oct4/Sox2/Klf4-infected MEFs	NYH2N2ZmTnWwY4Tpc44hSXO\|YYm=	NGribpMyOCEQvF2=	MW[yPEBl	NXHnbVNRTE2VTx?=	MWnQdo9ud3SnczDNSWZ{KHKncILv[5JidW2rbnegWJJidnOmdXPl[EBjgSCRY4S0MEBUd3h{LDDhcoQhU2yoNB?=	MknTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl6M{mwOVUoRjF7OEO5NFU2RC:jPh?=
H4IIE	MlXNSpVv[3Srb36gRZN{[Xl?	NX3VcJRPOTBizszN	NGL1WVMzPCCq	MmTGSG1UVw>?	MlXXVoVofWyjdHXzJO6zNWOjdHXubY4h[WO2aY\peJkh[W6mIGTJVmUh[2:wdHHpcolv\yCycn;tc5RmeiCjY4Tpeol1gQ>?	NIXy[Fc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUO1NFE6PSd-MUWzOVAyQTV:L3G+
insulin receptor–expressing CHO-IR	NUO3fYZiTnWwY4Tpc44hSXO\|YYm=	MV61NFAhdk1?	Ml7zN\|AhdWmw	M3jlVGROW09?	M3;VeGFkfGm4YYTld{BIdHmlb3flckBUgW62aHHz[UApT1Nr	MoTBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTJ4ME[0PVcoRjF{NkC2OFk4RC:jPh?=
3T3-L1	NXz5RZhMTnWwY4Tpc44hSXO\|YYm=	NX2wNmd4OyEQvF2=	MWi0JIg>	MnHLSG1UVw>?	MUTJcohq[mm2czDwdoVi\Gmyb3P5eIUh\GmoZnXy[Y51cWG2aX;u	NUfEbI9[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUKwOVUzODBpPkGyNFU2OjByPD;hQi=>
CHO-IR	M4rkcWZ2dmO2aX;uJGF{e2G7		M2\LWFMxKG2rbh?=		Ml3iSWM2OD1yLke3JO69VQ>?	Mn3KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjlyMU[xNlEoRjJ7MEG2NVIyRC:jPh?=
HepG2	NHPMPYhHfW6ldHnvckBCe3OjeR?=		NX\yS3FyOyCq		MULFR\|UxRTFwNTFOwG0>	Mof6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NkGwNlMoRjJ{Mk[xNFI{RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cleaved PARP / CD31 / VE-Cadherin / α-SMA / vimentin; PubMed: 30709379 J Exp Clin Cancer Res NCI-H460 cells were co-cultured with HUVECs in a 3D culture system, and then treated with 1 μM CHIR-99021, 10 μM or 20 μM Cisplatin, or a combination of both, for 24 h. Cells were harvested and immunoblotted with anti-cleaved PARP, anti-CD31, anti-VE-cadherin, anti-α-SMA, anti-vimentin, and anti-β-actin antibodies. CTNNB1; PubMed: 23993102 Cell Treatment with the GSK3β inhibitor CHIR-99021 led to increased levels of β-catenin in RKO and HT29 (non-mutant) cells. β-catenin; PubMed: 24165128 J Biol Chem HeLa cells were treated with 5 μm CHIR-99021 for the indicated times. The samples were analyzed by Western blot.	30709379 23993102 24165128
Growth inhibition assay	Cell viability; PubMed: 22039301 J Immunol HMC-1.2 cells were cultured in the absence or presence of GSK3β inhibitor (CHIR 99021, 3–30 µM) and viability cell count was assessed by trypan blue dye exclusion after 24 h, 48 h or 72 h. All data are presented as the mean ± SEM of three independent experiments conducted in triplicate. p < 0.05, p < 0.001* p < 0.0001*** vs vehicle treated control cells.	22039301
Immunofluorescence	SOX10 / EdU; PubMed: 28174705 Cell Mol Gastroenterol Hepatol Incorporation of EdU (white arrowheads) into SOX10+ ENS (enteric nervous system) cells with and without CHIR-99021. Oct3/4; PubMed: 24779365 BMC Res Notes Fluorescence micrographs showing the protein expression of Brachyury/Oct3/4 after a three day differentiation of ES-D3 cells with BIO (0.5 μM), SB-216763 (5 μM), CHIR-99021 (5 μM), or CHIR-98014 (1 μM). Nuclei were counterstained with DAPI (blue). The merge is shown in yellow. Original magnification 400x. Scale bar = 50 μm.	28174705 24779365

In vivo

Oral administration of CHIR-99021 at 30 mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR-99021 at 16 or 48 mg/kg 1 hour before oral glucose challenges in ZDF rats significantly improves glucose tolerance with 14% and 33% reduction in plasma glucose at 16 mg/kg and 48 mg/kg, respectively, and the higher dose of CHIR-99021 also reduces hyperglycemia before the oral glucose challenge. ^[1] Administration of CHIR-99021 significantly augments hematopoietic repopulation in recipient mice transplanted with mouse or human hematopoietic stem cells (HSCs), suggesting that GSK-3 is a specific modulator of HSC activity. ^[4]

Protocol

Kinase Assay: ^[1]	- Collapse Cell-free kinase assays: Polypropylene 96-well plates are filled with 300 μL/well buffer (50 mM tris HCl, 10 mM MgCl₂, 1 mM EGTA, 1 mM dithiothreitol, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) containing 27 nM GSK-3α or 29 nM GSK-3β, and 0.5 μM biotin-CREB peptide substrate. Various concentrations of CHIR-99021 are added in 3.5 μL of DMSO, followed by 50 μL of ATP stock to yield a final concentration of 1 μM ATP in all cell-free assays. After incubation, triplicate 100-μL aliquots are transferred to Combiplate eight plates containing 100 μL/well 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with PBS, filled with 200 μL of scintillation fluid, sealed, left 30 minutes, and counted in a scintillation counter. All steps are performed at room temperature.
Cell Research: ^[3]	- Collapse Cell lines: INS-1E Concentrations: Dissolved in DMSO, final concentrations ~ 20 μM Incubation Time: 1, or 4 days Method: Cells are maintained for 24 hours in starvation medium (culture medium with only 5 mM glucose, 1% fetal calf serum). Then cells are exposed to various concentrations of CHIR-99021 for 1, or 4 days. Cell number is measured by staining of cellular DNA with CyQuant dye, which becomes fluorescent when bound to DNA. Fluorescence is measured after 30 minutes of incubation using the FLUOstar Optima reader. Cell replication is determined by BrdUrd incorporation. BrdUrd labeling solution is added to the medium for the last 4 hours before the cells are fixed using FixDenat solution and incubated with monoclonal anti-BrdUrd-POD antibodies. After substrate solution is added to each well, the light emission is measured in a microplate luminometer using the Analyst HT detection system. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: Female db/db mice or male ZDF rats with type 2 diabetes Dosages: ~48 mg/kg Administration: Orally (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL (185.33 mM)
	Ethanol	2 mg/mL (3.98 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	24mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Molecular Weight	501.8
Formula	C₂₂H₁₈Cl₂N_8.HCl
CAS No.	1797989-42-4
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?
Answer:
The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.
Question 2:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
Answer:
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
Question 3:
What is the difference between S2924 and S1263? Which one is better for differentiation?
Answer:
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Selective GSK-3 Inhibitor

TWS119 : GSK-3β-selective, IC50 of 30 nM.
Most Potent GSK-3 Inhibitor

CHIR-98014 : GSK-3α, IC50=0.65 nM; GSK-3β, IC50=0.58 nM.
GSK-3 Inhibitor in Clinical Trial

Tideglusib : Phase II for Alzheimer's disease.
Newest GSK-3 Inhibitor

AZD1080 : Orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively.

Related GSK-3 Products

CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
LY2090314 ^New

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
TDZD-8 ^New

TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
TWS119

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.
SB216763

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.
Tideglusib (NP031112)

Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
CHIR-98014

CHIR-98014 (CT98014) is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
BIO

BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.

Features:The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.
AR-A014418

AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and K_i of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.

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CHIR-99021 (CT99021) HCl