CHIR-99021 (CT99021) HCl

Name: CHIR-99021 (CT99021) HCl
Brand: Selleck Chemicals
SKU: S2924
Rating: 5 (279 reviews)

For research use only.

Catalog No.S2924

279 publications

CHIR-99021 (CT99021) HCl Chemical Structure

CAS No. 1797989-42-4

CHIR-99021 (CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.

Selleck's CHIR-99021 (CT99021) HCl has been cited by 279 publications

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Cell Res, 2020, 1-18

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ACS Infect Dis, 2020, 21

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Acta Pharmacol Sin, 2020, 10.1038/s41401-020-0452-0

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Nature, 2020, 10.1038/s41586-020-2631-z

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EMBO Rep, 2020, e49863

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Metabolites, 2020, 10(8):E302

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Blood, 2019, blood.2019001037

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Proc Natl Acad Sci U S A, 2019, 116(39):19523-19529

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Cell Syst, 2019, 8(5):427-445

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Cell Rep, 2019, 26(13):3643-3656

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Cell Rep, 2019,

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Front Neurosci, 2019, 13:867

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Cell Cycle, 2019, 18(19):2495-2508

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Biol Open, 2019, 8(11)bio046367

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Mol Med Rep, 2019, 19(6):5440-5452

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Exp Ther Med, 2019, 17(6):4547-4553

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Gastroenterology, 2018, 155(5):1508-1523.e10

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Mol Cell, 2018, 70(5):949-960

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Nat Commun, 2018, 9(1):5230

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Sci Adv, 2018, 4(5):eaat0351

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Cell Rep, 2018, 25(7):1966-1981.e4

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Proteomics, 2018, 18(14):e1800102

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J Tissue Eng Regen Med, 2018, 12(2):349-359

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Biol Open, 2018, 7(1)bio029264

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Cell Res, 2017, 27(6):815-829

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Cancer Lett, 2017, 403:195-205

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JCI Insight, 2017, 2(18)

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Elife, 2016, 5e21459

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Bachelor of Science, 2012, East China Normal University

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Purity & Quality Control

Choose Selective GSK-3 Inhibitors

Biological Activity

Description

Targets

GSK-3β ^[1] (Cell-free assay)	GSK-3α ^[1] (Cell-free assay)
6.7 nM	10 nM

In vitro

CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. Furthermore, CHIR-99021 shows only weak binding to a panel of 22 pharmacologically relevant receptors and little inhibitory activity against a panel of 23 nonkinase enzymes. CHIR-99021 induces the activation of glycogen synthase (GS) in insulin receptor-expressing CHO-IR cells with EC50 of 0.763 μM. ^[1] In addition to simulating the actions of insulin, inhibition of GSK-3 by CHIR-99021 (3 μM) increases free cytosolic β-catenin by 1.9-fold, mimicking the canonical Wnt signaling pathway in 3T3-L1 preadipocytes. During any of the first 3 days of differentiation, CHIR-99021 treatment inhibits the preadipocyte differentiation with IC50 of 0.3 μM by blocking induction of CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ). ^[2] Unlike lithium chloride and AR-A014418, CHIR-99021 treatment does not reduce the viability of INS-1E cells even at high concentrations. Instead, CHIR-99021 robustly increases the rate of proliferation of INS-1E cells in a dose-dependent manner, and significantly inhibits INS-E cell death induced by high glucose and high palmitate in a concentration-dependent manner. CHIR-99021 promotes primary beta cell replication in isolated rat islets at concentrations as low as 1 μM, with 2-3 fold increase of cell replication at 5 μM of CHIR-99021 treatment. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
NCI-H1581	MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHjYUFdKSzVyPUmwNE4zOzFizszN	Ml;KQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H1155	M3Xl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3;abmlEPTB;OEG4MlA2QSEQvF2=	NX3YS3Y5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
BC-3	NEW5PIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3rwV2lEPTB;OEC1MlIxOyEQvF2=	NHqxRnE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
KARPAS-422	MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUfN[JIxUUN3ME23PFkvOzF3IN88US=>	NXn1SGZHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
DEL	NGXtcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M3PNWmlEPTB;N{CwMlg{QCEQvF2=	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KM-H2	MkDyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVzmUoRQUUN3ME22PVkvODV7IN88US=>	NH3abo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
U-87-MG	NHfaUG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mn3nTWM2OD14OUSuOVg2KM7:TR?=	M{P2[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-SNU-1	M2DZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUL4TnNCUUN3ME22PVAvOTd{IN88US=>	NWWyOHhuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-SNU-16	MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MWfJR\|UxRTZ6MD60OlIh\|ryP	NEjyUZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
TUR	NX;SbJRMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NWTTZpRVUUN3ME22O\|EvOzJ{IN88US=>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
IM-9	M1nQfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NGfJdIpKSzVyPU[1NU42PDFizszN	MlL2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
L-363	M1rHdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{fZPWlEPTB;NkS4MlA3PCEQvF2=	NEi1UHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H226	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MVnJR\|UxRTZ{OD6zOVMh\|ryP	MlXPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HT	M{fXZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIDteGhKSzVyPU[yNk44QDVizszN	NHHzdJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
KARPAS-45	NYXKR5JVT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Ml7JTWM2OD14MUiuNlIyKM7:TR?=	M2DMUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
ML-2	M2KydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NWXJXnZ2UUN3ME22NFYvPTd7IN88US=>	NWTN[nJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LP-1	NHzRSHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmrWTWM2OD14MEOuOVg4KM7:TR?=	MkXxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
L-428	MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYrJR\|UxRTZyMD62O\|Eh\|ryP	M1va[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
K052	M2rwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M{jobGlEPTB;NUe5MlIyOyEQvF2=	MmfuQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
CAL-148	M4foRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M37xOmlEPTB;NU[1MlA5QSEQvF2=	MoD0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
UACC-812	NFvScJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWfJR\|UxRTV3OT6zPVEh\|ryP	M2nNO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
EW-11	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NGL1XWxKSzVyPUW1Nk4{QTlizszN	NFvxVYI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
COLO-320-HSR	NXfCPFhWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVHmd\|dmUUN3ME21OVEvOzVizszN	NHK3OIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H889	NWK1XFk4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYDJR\|UxRTV2Nz6yN{DPxE1?	MlnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
EVSA-T	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmLpTWM2OD13NEOuOlg1KM7:TR?=	M2H6XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
RL	MoPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MW\JR\|UxRTV2Mj60OFIh\|ryP	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
HSC-4	MoDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NFzqb\|dKSzVyPUWzPU4zQTNizszN	M3HEWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H2227	NEW4XmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUTJR\|UxRTV\|MD6yOVQh\|ryP	NUXPVVlTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NB5	NIXVcIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV\JR\|UxRTV{Nj60N{DPxE1?	M{ixb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H2081	NGDyWGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Ml\hTWM2OD13MkWuOVE{KM7:TR?=	MnrxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H510A	Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NYSwNVlFUUN3ME21NlQvPjl4IN88US=>	NWXZUWJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H1436	M4DRR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M1LVVGlEPTB;NUKzMlA3PCEQvF2=	NHjDOZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HL-60	NHGxV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTV{Mj65NlQh\|ryP	NHXzbVA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
Mo-T	NYntR2NsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWHJR\|UxRTVzNT6xNVYh\|ryP	M4n6XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H2171	Ml;0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYDJR\|UxRTVzMj63NFUh\|ryP	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H1694	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M1PLdmlEPTB;NUGyMlQ{QSEQvF2=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
P12-ICHIKAWA	NEXu[\|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2e2e2lEPTB;NUGxMlQyPiEQvF2=	NEXmZ489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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RPMI-8402	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmjOTWM2OD13MUCuNFIyKM7:TR?=	NFTEW5Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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CPC-N	MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NUXvUXE5UUN3ME21NFIvODZ\|IN88US=>	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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HDLM-2	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MkX0TWM2OD12OECuPFY6KM7:TR?=	NEC1T\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
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COR-L279	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnzwTWM2OD12NkSuPFQ4KM7:TR?=	NXzBeZZmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H1092	NYP6c\|VlT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1;qcGlEPTB;NE[zMlk1OyEQvF2=	Ml73QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
A3-KAW	NELzPXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NGHHfnpKSzVyPUS2NE45PDFizszN	NGPJNZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
TE-441-T	M3;vZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUfkSZNNUUN3ME20OVcvOTh4IN88US=>	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
KMS-12-PE	NUnDdYVyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MYfJR\|UxRTR3Nj64NlIh\|ryP	NF;S[3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SCLC-21H	M3v4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUnJR\|UxRTR3NT62PVkh\|ryP	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
TALL-1	M4Tvbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M2LrSWlEPTB;NEW1MlI6PyEQvF2=	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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DMS-79	NIrZXWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYfJR\|UxRTR2OT62PEDPxE1?	MoHtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
COLO-684	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MX7JR\|UxRTR2OD64PFgh\|ryP	M{PxdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
BL-70	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYDJR\|UxRTR\|OT60Nlkh\|ryP	MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
AM-38	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlvwTWM2OD12M{iuOVQh\|ryP	MlvZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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NCI-H2141	M1[4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NF7zOndKSzVyPUSyOE4{QDhizszN	MoHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
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NCI-H716	NFP3fW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NFfOXm1KSzVyPUSxNE4xPzVizszN	Mor5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MES-SA	M2nJTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3PMPGlEPTB;NEC5Mlk5KM7:TR?=	M2P2NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
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IST-SL1	NF3WSlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MYTJR\|UxRTN7ND60NFYh\|ryP	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MN-60	M3LjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				Ml\wTWM2OD1\|OUOuPVQ5KM7:TR?=	M2jVRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H719	M4O4cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3nyNWlEPTB;M{mxMlg6OyEQvF2=	NWfqU3BERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
GOTO	NGDqV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2nhcGlEPTB;M{mwMlY1OSEQvF2=	M1rxO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H596	NIjNUlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NELwNXVKSzVyPUO4OU4{PCEQvF2=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
COR-L88	M3:3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MoTYTWM2OD1\|OEOuOlc4KM7:TR?=	MkPWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HCC2157	NHPDUnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXnJR\|UxRTN5OD6xOlEh\|ryP	MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
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NCI-H82	MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MkX3TWM2OD1zMz6yPVA6KM7:TR?=	MlL3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
C8166	M2ThRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYTJR\|UxRTF\|LkKzNVgh\|ryP	NHXSSYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
PC-14	NFW2dIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmHMTWM2OD1zMj6zNlQh\|ryP	MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
PA-1	MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NFv1Z29KSzVyPUGxMlk{KM7:TR?=	M1HnNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
HEL	NXe4SmdTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NYntUpd[UUN3ME2xNU43PTd7IN88US=>	NEnTWFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
NCI-H526	Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MoO4TWM2OD1zMT6xN\|Y2KM7:TR?=	NHXvb3Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SNU-387	MmnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHfLfFJKSzVyPUGwMlczOzVizszN	NF;wNo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HT-3	MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUnJR\|UxRTFyLk[xO\|kh\|ryP	NITLcY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
M059J	M1\nOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVi5XI56UUN3ME2xNE43OTB{IN88US=>	MoXkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MZ2-MEL	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml32TWM2OD1zMD60Olc4KM7:TR?=	M1;SN\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
NCI-H28	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MnnOTWM2OD1zMD60OFE{KM7:TR?=	Mke5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
LB1047-RCC	MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmPrTWM2OD17Lkm5O\|k5KM7:TR?=	MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
U-118-MG	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MYHJR\|UxRTlwOUS0OFQh\|ryP	NGXBc2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
DBTRG-05MG	M{KxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MUnJR\|UxRTlwN{e3O{DPxE1?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
EFM-19	NF\wUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mkf3TWM2OD17Lke1OVY3KM7:TR?=	MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
SK-N-DZ	M{PM[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M4fkZmlEPTB;OT62OVc1OiEQvF2=	NV7lcWFJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LB996-RCC	NUPZW3N2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				Mn[zTWM2OD17LkWyN\|k4KM7:TR?=	NXflenl2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
U-2-OS	NGe4OnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MUDJR\|UxRTlwNEWwNFYh\|ryP	NH3VU3Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
CTV-1	M4PVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NVzSVIh{UUN3ME25MlQ{QDl2IN88US=>	NH:yRnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
COLO-205	NIrHeoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXrJR\|UxRTlwNEO4NlEh\|ryP	MkjiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H64	MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYPJR\|UxRTlwNEKyOVUh\|ryP	MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
NCI-H1755	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlK0TWM2OD17LkO5PVg3KM7:TR?=	M4P2S\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
ACHN	MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				Mlr1TWM2OD17LkOwOVQ3KM7:TR?=	NXrHW3BXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
MEG-01	NIrscYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				Mo\jTWM2OD16Lkm5NFQ{KM7:TR?=	MkHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MKN28	MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnTvTWM2OD16Lki4OVE3KM7:TR?=	M3vV[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
CAL-72	MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MmXuTWM2OD16Lke2NVE{KM7:TR?=	MkPIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
MV-4-11	M17H[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NEPJcYRKSzVyPUiuOVQ{ODRizszN	MnLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
SW1417	NUH4W2lTT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NH\UWlVKSzVyPUeuOlQ2QDRizszN	MnvLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
G-361	NH:2TYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MmrUTWM2OD15LkS2OVYyKM7:TR?=	NIDpRXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
MC116	NXfFRo1OT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWPJR\|UxRTdwMki2PVEh\|ryP	NUT1Z\|FHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
RT-112	NXXWbYRJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NXLs[FVEUUN3ME23MlE3PDV4IN88US=>	NIS3eHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
CAL-85-1	M1XreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				M3WwcGlEPTB;Nj62NFk{PiEQvF2=	M2noZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
BB65-RCC	NEHwNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MW\JR\|UxRTZwNUOxPVUh\|ryP	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
CGTH-W-1	MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MlnPTWM2OD14LkSxO{DPxE1?	NIPSV4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
WM-115	NHX2RmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M4[4cGlEPTB;NT64NVUxQSEQvF2=	M3ryS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
SK-MEL-2	NFrTV4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MWDJR\|UxRTZwM{izOFQh\|ryP	NXzIVXc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
BL-41	M13vNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYXJR\|UxRTVwOEGyOlYh\|ryP	NVH5V5A6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
LB2518-MEL	NXKzdG9xT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M4jITmlEPTB;NT63NlYzPyEQvF2=	NGTidmo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
D-392MG	NELZTYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MVrJR\|UxRTVwNEmxOFUh\|ryP	NYLK[JN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NCI-H2452	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MY\JR\|UxRTVwNEW2Nlgh\|ryP	NEPScXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SW1710	NH7iWJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{e4[GlEPTB;NT60NlQ2PiEQvF2=	NVrrc4JPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
SK-OV-3	MlvNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NVTCPIsyUUN3ME20Mlk6OzRizszN	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
ALL-PO	NV63RVN2T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NUfVN4lSUUN3ME20Mlg{QDV6IN88US=>	NG\pfWI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
BxPC-3	NULhU\|lzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NVSzXZMzUUN3ME20MlcxOzlzIN88US=>	NUDTOIhVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
RCC10RGB	Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGnie3dKSzVyPUSuNlk1PzlizszN	NV;temhnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
NKM-1	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MlrVTWM2OD12LkGzPVcyKM7:TR?=	M1O1dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
MHH-ES-1	MnvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NInobXRKSzVyPUSuNFQ2PDVizszN	M17iclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
OE19	NYmzc2FZT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MmC5TWM2OD1\|Lkm2OFUyKM7:TR?=	MknUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
TE-15	MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MmHMTWM2OD1\|Lkm1N\|Q{KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
MOLT-16	M3\4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NIHjXlZKSzVyPUOuPFg2PTZizszN	NEPs[Xo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
A172	MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MV;JR\|UxRTNwN{W0PVgh\|ryP	NGXxcpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HCC1569	NF7nSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				NY\ld2xCUUN3ME2zMlQ5OzB3IN88US=>	Ml;oQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
HOP-62	MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M3Ls[GlEPTB;Mz6zOlA2PCEQvF2=	MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
A704	M375WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NILESVlKSzVyPUOuNFgyOiEQvF2=	NETrO2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SCC-9	Mme4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MljvTWM2OD1{Lkm1OFg2KM7:TR?=	M1:yOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
COLO-829	MojqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MomwTWM2OD1{Lke2OVQh\|ryP	MoL4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
RPMI-7951	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				MoTJTWM2OD1{LkewNVk{KM7:TR?=	NH7rdGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SK-LMS-1	MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MWjJR\|UxRTJwNkSxNlgh\|ryP	NEH3e5o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SNU-423	MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				M1LFVmlEPTB;Mj60PVc5PyEQvF2=	Mmm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
NCI-H2122	NVLHTllMT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NV3PR4FKUUN3ME2yMlI4Pjh2IN88US=>	NFXyVFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
RS4-11	MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NULmRmpLUUN3ME2xMlk2PDF3IN88US=>	NIP1bXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
HCC1395	MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Ml[0TWM2OD1zLke4Nlc{KM7:TR?=	NHz3V4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
MIA-PaCa-2	M2DmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MY\JR\|UxRTFwN{W5O\|ch\|ryP	M17RTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
KYSE-180	NXexdm96T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWjJR\|UxRTFwN{K3PFgh\|ryP	M13MbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFQyOjF2Mj:nQnNCVkeHUkyvZV4>
BCPAP	MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4jJeGlEPTB;MT62Olg6QCEQvF2=	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
A498	NHjjboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MXvJR\|UxRTFwM{C0Olkh\|ryP	MmHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOFEzOTR{Lze+V2FPT0WUPD;hQi=>
TYK-nu	M{\2NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MYXJR\|UxRTFwMEe5NVIh\|ryP	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
D-247MG	NWq2fpZJT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				NHPVfoZKSzVyPUCuPVQ5PTJizszN	NF3PfIk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
S-117	M3qwdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MXLJR\|UxRTBwOUKxN\|Eh\|ryP	NEnVfIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
D-336MG	MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				Mn7NTWM2OD1yLki0OlIh\|ryP	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly0NVIyPDJxJ{7TRW5ITVJ:L3G+
LOXIMVI	Mo\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MYHJR\|UxRTBwNUi4N\|Ih\|ryP	NEHEZVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
769-P	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				NX7WeFhzUUN3ME2wMlU5PDl7IN88US=>	NXvDXndQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
GCT	NIHKb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MV7JR\|UxRTBwM{C2O\|Ih\|ryP	NGK2Zmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw1OTJzNEKvK\|5USU6JRWK8M4E,
SW982	M1HhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				NUm0NIx6UUN3ME2wMlIyPDF4IN88US=>	NX3ZWJJZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPDF{MUSyM{c,W0GQR1XSQE9iRg>?
ES-CCE	NU\RbVdLTnWwY4Tpc44hSXO\|YYm=	MXi1xsDPxE1?	Ml7LN{Bl	MXrEUXNQ	NXzxSmxiW3S{b37ncJkhcW6mdXPld{B1cGViYXP0bZZqfHlib3[gW451N2KndHGtZ4F1\W6rbjDwZZRpf2G7	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd5OUO2OUc,OjR5N{mzOlU9N2F-
ES-D3	MorhSpVv[3Srb36gRZN{[Xl?	MnTJOeKh\|ryP	MnTWN{Bl	M{e1VWROW09?	NGjjenRUfHKxbnfsfUBqdmS3Y3XzJJRp\SCjY4Tpeol1gSCxZjDXcpQw[mW2YT3jZZRmdmmwIIDheIh4[Xl?	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd5OUO2OUc,OjR5N{mzOlU9N2F-
ES-CCE	M1jHZ2N6fG:2b4jpZ{BCe3OjeR?=	NGDKU4EyOMLizszN	M2LoWVMh\A>?	MkX2SG1UVw>?	NYDORY5ZUW6mdXPld{Bud2SncnH0[UBkgXSxdH;4bYNqfHl?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDd5OUO2OUc,OjR5N{mzOlU9N2F-
ES-D3	M{PWOWN6fG:2b4jpZ{BCe3OjeR?=	MkjvNVDDqM7:TR?=	MkPFN{Bl	MULEUXNQ	MXrJcoR2[2W\|IH3v[IVz[XSnIHP5eI91d3irY3n0fUB4cXSqIFnDOVAhd2ZiND65JO69VQ>?	M2W1d\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{e5N\|Y2Lz5{NEe3PVM3PTxxYU6=
Neural progenitor cells	NH\tOXhHfW6ldHnvckBCe3OjeR?=	NXP3Wo1EOyEQvF2=	MV2xNEBl	MX\EUXNQ	M324c2lv\HWlZYOg[4Vv\XKjdHnvckBw\iCwZYXyZYwheHKxZ3XubZRweiClZXzsdy=>	NV\lfYF7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2N\|gxOzRpPkK0OlM5ODN2PD;hQi=>
A549	NYi5OZZUSXCxcITvd4l{KEG\|c3H5	NYnyeFJRPSEEtV2=	NVPXNWJJOjRiaB?=	M{nPSGROW09?	MYrJcoNz\WG\|ZYOgZ4VtdCCjcH;weI9{cXN?	MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN4N{[4PEc,OjR\|Nke2PFg9N2F-
H157	NHrP[WRCeG:ydH;zbZMhSXO\|YYm=	NGfDRpo2KML3TR?=	NYnjV\|dyOjRiaB?=	MVfEUXNQ	NGnMN5hFd2W\|IH7veEB{cWewaX\pZ4FvfGy7IHHm[oVkfCCjcH;weI9{cXN?	NYLtfGtIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlc3QDhpPkK0N\|Y4Pjh6PD;hQi=>
H460	NUO0cVZJSXCxcITvd4l{KEG\|c3H5	MnHGOUDDvU1?	NGDYOFMzPCCq	MX;EUXNQ	MnzMRZR1\W63YYTld{Bk\WyuIHHwc5B1d3Orcx?=	NXPaeG8{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlc3QDhpPkK0N\|Y4Pjh6PD;hQi=>
H157	MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NHniW5g2KML3TR?=	NUf2fHRzOjRiaB?=	MlfXSG1UVw>?	MlqyVJJwdW:2ZYOgZ4VtdCCycn;sbYZmemG2aX;u	NVfLSotCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOlc3QDhpPkK0N\|Y4Pjh6PD;hQi=>
H460	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MmnNOUDDvU1?	MnjhNlQhcA>?	MnS1SG1UVw>?	M4DGPHBzd22xdHXzJINmdGxicILvcIln\XKjdHnvci=>	Mof1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR\|Nke2PFgoRjJ2M{[3Olg5RC:jPh?=
embryonic stem cells (ESC)	MYjGeY5kfGmxbjDBd5NigQ>?	M2fEdFMhyrWP	NXmyVpNmOTFiZB?=	MkfaSG1UVw>?	NF;1TYxRem:vb4Tld{B{\WyoLYLlcoV4[Wxib3[gcoHEt3[nLYT5dIUhdW:3c3Wg[Y1jenmxbnnjJJN1\W1iY3XscJMhMEWVQzm=	MnPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NEOzNVIoRjJ\|OESzN\|EzRC:jPh?=
DN3	MoHzSpVv[3Srb36gRZN{[Xl?	MYKxNEDPxE1?	NEHhcok6PiCq	MlrRSG1UVw>?	NXOxU3pOUW6lcnXhd4V{KGOnbHyg[IV3\WyxcH3lcpQh[W6mIIDyc4xq\mW{YYTpc44>	M4PrbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NUK2PVg6Lz5{M{WyOlk5QTxxYU6=
platelets	MWDGeY5kfGmxbjDBd5NigQ>?	Mn[yNVAh\|ryP	NHvOUJcyPSCvaX6=	NHziW2JFVVOR	NX3hcJRqUW6lcnXhd4V{KHSqcn;tZolvNW2nZHnheIVlKHCuYYTlcIV1KGGpZ4Ll[4F1cW:wIHHu[EBCXFBic3XjdoV1cW:w	M3rrdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MkO5PFc4Lz5{M{KzPVg4PzxxYU6=
hiPSC-NPs	NYnONI1RT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M4\kW\|PjiIoQvF2=	NWjmT3JlPzJiaB?=	MlvZSG1UVw>?	M4nQT2lv[3KnYYPld{Bk\WyuIIDyc4xq\mW{YYTpc47DqA>?	MmSxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4NEK2PFcoRjJ{NkSyOlg4RC:jPh?=
INS-1E	MWDGeY5kfGmxbjDBd5NigQ>?	Mn7wNk42KM7:TR?=	NEHqN3czPCCq	MX3EUXNQ	NIT5RWNKdmS3Y3XzJIEhemWmdXP0bY9vKG:oIF7QNUBwfmW{ZYjwdoV{e2mxbh?=	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR{N{ewOEc,OjJ2Mke3NFQ9N2F-
PANC1	MYDBdI9xfG:\|aYOgRZN{[Xl?	NVLXWpdPyqB3IN88US=>	M4PuZVczKGh?	NYqzRmVPTE2VTx?=	NIXpTFdVemmpZ3Xyd{BidiCjcH;weI91cWNicnXzdI9ve2V?	NFS3XpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKwNVE5Pid-MkKyNFEyQDZ:L3G+
Endothelial cell(EC)	MUjGeY5kfGmxbjDBd5NigQ>?	MYGzJO69VQ>?		MUDEUXNQ	MWjQdo9ud3SnczDlcoRwfGinbHnhcEBk\WyuIDjFR{kh\GmoZnXy[Y51cWG2aX;u	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB3MkCwOkc,OjJyNUKwNFY9N2F-
HMC1.2	MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	MmfLN\|Ah\|ryP	MU[3NkBp	NH\GPW5FVVOR	MoDNVoVlfWOnczDj[YxtKHO3co\peoFt	M1fjWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEO5N\|AyLz5{MkCzPVMxOTxxYU6=
Sca-1+ HPC	MlLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NWrhTJozOiEQvF2=	M33FdlYh\A>?	M4m1UGROW09?	M1;YdHN6dmW{Z3nzeIlk[WyueTDwdo9ud3SnczDTZ4EuOSwEoFjQR{Bxem:uaX\ldoF1cW:wIHHu[EBkd2yxbomg[o9zdWG2aX;uJJRw\2W2aHXyJJdqfGhiRVfG	NUjuXIp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2NlQ{PDhpPkKxOlI1OzR6PD;hQi=>
Oct4/Sox2/Klf4-infected MEFs	MVTGeY5kfGmxbjDBd5NigQ>?	MUCxNEDPxE1?	M3\FTFI5KGR?	NVjSXWg6TE2VTx?=	MWPQdo9ud3SnczDNSWZ{KHKncILv[5JidW2rbnegWJJidnOmdXPl[EBjgSCRY4S0MEBUd3h{LDDhcoQhU2yoNB?=	M4nIcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEO5NFU2Lz5zOUizPVA2PTxxYU6=
H4IIE	MoXGSpVv[3Srb36gRZN{[Xl?	M3HEd\|ExKM7:TR?=	MXOyOEBp	MYjEUXNQ	NIjsTItT\We3bHH0[ZMh\|rJvY3H0[Y5qdiCjY4Tpeol1gSCjbnSgWGlTTSClb370ZYlvcW6pIIDyc41wfGW{IHHjeIl3cXS7	M1;rNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3M{WwNVk2Lz5zNUO1NFE6PTxxYU6=
insulin receptor–expressing CHO-IR	NGPVcnVHfW6ldHnvckBCe3OjeR?=	MoG3OVAxKG6P	M4HXc\|MxKG2rbh?=	MkPBSG1UVw>?	MXPBZ5RqfmG2ZYOgS4x6[2:pZX6gV5lvfGijc3WgLGdUMQ>?	NGTyV4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMk[wOlQ6Pyd-MUK2NFY1QTd:L3G+
3T3-L1	NXHCSHhTTnWwY4Tpc44hSXO\|YYm=	MUezJO69VQ>?	MVu0JIg>	NXLRb5U4TE2VTx?=	NYHzVYJUUW6qaXLpeJMheHKnYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdg>?	NG\jfWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMkC1OVIxOCd-MUKwOVUzODB:L3G+
CHO-IR	NXjye\|VTTnWwY4Tpc44hSXO\|YYm=		NUL0cVBHOzBibXnu		NXf2V4J6TUN3ME2wMlc4KM7:TR?=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTBzNkGyNUc,OjlyMU[xNlE9N2F-
HepG2	NY\QSFBvTnWwY4Tpc44hSXO\|YYm=		M4e2b\|MhcA>?		NXX2VpE1TUN3ME2xMlUh\|ryP	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJ4MUCyN{c,OjJ{NkGwNlM9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cleaved PARP / CD31 / VE-Cadherin / α-SMA / vimentin; PubMed: 30709379 J Exp Clin Cancer Res NCI-H460 cells were co-cultured with HUVECs in a 3D culture system, and then treated with 1 μM CHIR-99021, 10 μM or 20 μM Cisplatin, or a combination of both, for 24 h. Cells were harvested and immunoblotted with anti-cleaved PARP, anti-CD31, anti-VE-cadherin, anti-α-SMA, anti-vimentin, and anti-β-actin antibodies. CTNNB1; PubMed: 23993102 Cell Treatment with the GSK3β inhibitor CHIR-99021 led to increased levels of β-catenin in RKO and HT29 (non-mutant) cells. β-catenin; PubMed: 24165128 J Biol Chem HeLa cells were treated with 5 μm CHIR-99021 for the indicated times. The samples were analyzed by Western blot.	30709379 23993102 24165128
Growth inhibition assay	Cell viability; PubMed: 22039301 J Immunol HMC-1.2 cells were cultured in the absence or presence of GSK3β inhibitor (CHIR 99021, 3–30 µM) and viability cell count was assessed by trypan blue dye exclusion after 24 h, 48 h or 72 h. All data are presented as the mean ± SEM of three independent experiments conducted in triplicate. p < 0.05, p < 0.001* p < 0.0001*** vs vehicle treated control cells.	22039301
Immunofluorescence	SOX10 / EdU; PubMed: 28174705 Cell Mol Gastroenterol Hepatol Incorporation of EdU (white arrowheads) into SOX10+ ENS (enteric nervous system) cells with and without CHIR-99021. Oct3/4; PubMed: 24779365 BMC Res Notes Fluorescence micrographs showing the protein expression of Brachyury/Oct3/4 after a three day differentiation of ES-D3 cells with BIO (0.5 μM), SB-216763 (5 μM), CHIR-99021 (5 μM), or CHIR-98014 (1 μM). Nuclei were counterstained with DAPI (blue). The merge is shown in yellow. Original magnification 400x. Scale bar = 50 μm.	28174705 24779365

In vivo

Oral administration of CHIR-99021 at 30 mg/kg enhances glucose metabolism in a rodent model of type 2 diabetes, with a maximal plasma glucose reduction of nearly 150 mg/dl 3-4 hours after administration, while plasma insulin remains at or below control levels. Oral administration of CHIR-99021 at 16 or 48 mg/kg 1 hour before oral glucose challenges in ZDF rats significantly improves glucose tolerance with 14% and 33% reduction in plasma glucose at 16 mg/kg and 48 mg/kg, respectively, and the higher dose of CHIR-99021 also reduces hyperglycemia before the oral glucose challenge. ^[1] Administration of CHIR-99021 significantly augments hematopoietic repopulation in recipient mice transplanted with mouse or human hematopoietic stem cells (HSCs), suggesting that GSK-3 is a specific modulator of HSC activity. ^[4]

Protocol

Kinase Assay: ^[1]	- Collapse Cell-free kinase assays: Polypropylene 96-well plates are filled with 300 μL/well buffer (50 mM tris HCl, 10 mM MgCl₂, 1 mM EGTA, 1 mM dithiothreitol, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) containing 27 nM GSK-3α or 29 nM GSK-3β, and 0.5 μM biotin-CREB peptide substrate. Various concentrations of CHIR-99021 are added in 3.5 μL of DMSO, followed by 50 μL of ATP stock to yield a final concentration of 1 μM ATP in all cell-free assays. After incubation, triplicate 100-μL aliquots are transferred to Combiplate eight plates containing 100 μL/well 50 μM ATP and 20 mM EDTA. After 1 hour, the wells are rinsed five times with PBS, filled with 200 μL of scintillation fluid, sealed, left 30 minutes, and counted in a scintillation counter. All steps are performed at room temperature.
Cell Research: ^[3]	- Collapse Cell lines: INS-1E Concentrations: Dissolved in DMSO, final concentrations ~ 20 μM Incubation Time: 1, or 4 days Method: Cells are maintained for 24 hours in starvation medium (culture medium with only 5 mM glucose, 1% fetal calf serum). Then cells are exposed to various concentrations of CHIR-99021 for 1, or 4 days. Cell number is measured by staining of cellular DNA with CyQuant dye, which becomes fluorescent when bound to DNA. Fluorescence is measured after 30 minutes of incubation using the FLUOstar Optima reader. Cell replication is determined by BrdUrd incorporation. BrdUrd labeling solution is added to the medium for the last 4 hours before the cells are fixed using FixDenat solution and incubated with monoclonal anti-BrdUrd-POD antibodies. After substrate solution is added to each well, the light emission is measured in a microplate luminometer using the Analyst HT detection system. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: Female db/db mice or male ZDF rats with type 2 diabetes Dosages: ~48 mg/kg Administration: Orally (Only for Reference)

References

Solubility (25°C)

In vitro	DMSO	93 mg/mL (185.33 mM)
	Ethanol	2 mg/mL (3.98 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+ddH2O For best results, use promptly after mixing.	24mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download CHIR-99021 (CT99021) HCl SDF

Molecular Weight	501.8
Formula	C₂₂H₁₈Cl₂N_8.HCl
CAS No.	1797989-42-4
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl

In vivo Formulation Calculator (Clear solution)

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Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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The Serial Dilution Calculator Equation

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Computed Result

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?
Answer:
The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.
Question 2:
How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?
Answer:
Please change the culture medium each day to add the new comound in it if the duration is more than 72h.
Question 3:
What is the difference between S2924 and S1263? Which one is better for differentiation?
Answer:
S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

Selective GSK-3 Inhibitor

TWS119 : GSK-3β-selective, IC50 of 30 nM.
Most Potent GSK-3 Inhibitor

CHIR-98014 : GSK-3α, IC50=0.65 nM; GSK-3β, IC50=0.58 nM.
GSK-3 Inhibitor in Clinical Trial

Tideglusib : Phase II for Alzheimer's disease.
Newest GSK-3 Inhibitor

AZD1080 : Orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with K_i of 6.9 nM and 31 nM, respectively.

Related GSK-3 Products

CHIR-99021 (CT99021) ^New

CHIR-99021 (CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
LY2090314 ^New

LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.
TDZD-8 ^New

TDZD-8 (NP 01139) is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
TWS119

TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.
SB216763

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β. SB216763 activates autophagy.
Tideglusib

Tideglusib (NP031112, NP-12) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.
CHIR-98014

CHIR-98014 (CT98014) is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
BIO

BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.

Features:The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.
AR-A014418

AR-A014418 (GSK-3β Inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor with IC50 and K_i of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.
IM-12

IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.

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CHIR-99021 (CT99021) HCl