Bithionol

For research use only.

Catalog No.S4552 Synonyms: Actamer

2 publications

Bithionol Chemical Structure

CAS No. 97-18-7

Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.

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Biological Activity

Description Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
Targets
sAC [2]
(Cell-free assay)
4.0 μM

Protocol

Cell Research:

[1]

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  • Cell lines: ovarian cancer cell lines
  • Concentrations: 0.178 μM-400μM
  • Incubation Time: 48h, 72h
  • Method:

    Ovarian cancer cell lines (5 × 103 cells/well) were plated into 96-well flat bottom plates and incubated for overnight. Cells were treated with different concentrations of BT ranging from 0.178 μM to 400 μM and further incubated for 48 hrs or 72 hrs.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 71 mg/mL (199.41 mM)
Ethanol 22 mg/mL (61.78 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.05
Formula

C12H6Cl4O2S

CAS No. 97-18-7
Storage powder
in solvent
Synonyms Actamer
Smiles C1=C(C=C(C(=C1SC2=C(C(=CC(=C2)Cl)Cl)O)O)Cl)Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID