Bobcat339 hydrochloride

Catalog No.S6682 Synonyms: Bobcat339 HCl

For research use only.

Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.

Bobcat339 hydrochloride Chemical Structure

CAS No. 2436747-44-1

Selleck's Bobcat339 hydrochloride has been cited by 2 Publications

Purity & Quality Control

Choose Selective DNA Methyltransferase Inhibitors

Biological Activity

Description Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.
Targets
TET1 [1]
(Cell-free assay)
TET2 [1]
(Cell-free assay)
33 μM 73 μM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 334.2
Formula

C16H13Cl2N3O

CAS No. 2436747-44-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=NC3=O)N)Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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