For research use only.

Catalog No.S2837 Synonyms: (E)-BCI

BCI Chemical Structure

CAS No. 1245792-51-1

BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.

Purity & Quality Control

Choose Selective phosphatase Inhibitors

Biological Activity

Description BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.
DUSP1 [1]
(Cell-free assay)
DUSP6 [1]
(Cell-free assay)
8.0 μM(EC50) 13.3 μM(EC50)


Solubility (25°C)

In vitro DMSO 63 mg/mL (198.47 mM)
Water Insoluble
Ethanol '''20 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 317.42


CAS No. 1245792-51-1
Storage powder
in solvent
Synonyms (E)-BCI

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05003817 Not yet recruiting Device: Percutaneous left ventricular unloading Ischemic Heart Disease|Coronary Artery Disease Guy''s and St Thomas'' NHS Foundation Trust|London School of Hygiene and Tropical Medicine|Queen Elizabeth Hospital Birmingham|Royal Bournemouth Hospital Bournemouth|St. George''s Hospital London|Belfast Health and Social Care Trust Belfast|King''s College Hospital London|King''s College London August 2021 Phase 3
NCT04874974 Recruiting Behavioral: Metacognitive and Defusion Training Schizophrenia|Schizotypal Disorder|Delusional Disorder|Brief Psychotic Disorder|Shared Psychotic Disorder|Schizoaffective Disorder|Other Psychotic Disorder Not Due to A Substance or Known Physiological Condition|Unspecified Psychosis Not Due to a Substance or Known Physiological Condition|Manic Episode Severe With Psychotic Symptoms|Bipolar Disorder Current Episode Manic Severe With Psychotic Features|Bipolar Disorder Current Episode Depressed Severe With Psychotic Features|Major Depressive Disorder Single Episode Severe With Psychotic Features|Major Depressive Disorder Recurrent Severe With Psychotic Symptoms Max-Planck-Institute of Psychiatry May 10 2021 Not Applicable
NCT03827187 Not yet recruiting Other: Motor imagery based EEG-BCI Disorder of Consciousness|Paralysis|Motor Neuron Disease|Stroke|Physical Disability University of Ulster|National Rehabilitation Hospital Ireland|St Conal''s Campus Rehabilitation Unit Letterkenny Ireland|Belfast Health and Social Care Trust|Western Health and Social Care Trust|South Eastern Health and Social Care Trust|Southern Health and Social Care Trust|Northern Health and Social Care Trust|Barnsley Hospital NHS Foundation Trust|NHS Lothian|Walton Centre NHS Foundation Trust|Hull University Teaching Hospitals NHS Trust|Northern Lincolnshire and Goole Hospitals NHS Foundation Trust|Imperial College Healthcare NHS Trust|Woodland Neuro rehab Center York (Christchurch Group)|Glenside care Salisbury|Frenchay Brain Injury Rehabilitation Centre Bristol|Royal Hospital for Neuro-disability January 15 2021 Not Applicable
NCT04740463 Recruiting -- Major Depressive Episode University Hospital Montpellier January 1 2021 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID