Home Metabolism phosphatase inhibitor BCI For research use only.

BCI

Synonyms: (E)-BCI

BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.

BCI Chemical Structure

BCI Chemical Structure

CAS: 1245792-51-1

Purity & Quality Control

Batch: S283701 DMSO] 63 mg/mL] false] Ethanol] 20 mg/mL] false] Water] Insoluble] false Purity: 99.88%
99.88

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Biological Activity

Description BCI ((E)-BCI, compound 1) is an allosteric dual specificity phosphatase (DUSP) inhibitor with EC50 of 13.3 μM and 8.0 μM in cells for DUSP6 and DUSP1, respectively.
Targets
DUSP1 [1]
(Cell-free assay)		 DUSP6 [1]
(Cell-free assay)
8.0 μM(EC50) 13.3 μM(EC50)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05470478 Not yet recruiting
Spinal Cord Injury|Amyotrophic Lateral Sclerosis|Brain Stem Infarctions|Locked-in Syndrome|Muscular Dystrophy
VA Office of Research and Development
 December 29 2023 Not Applicable
NCT05827900 Not yet recruiting
Ultra-high Risk for Psychosis|Clinical High Risk for Psychosis|At-risk Mental State
Medical University of Vienna
 October 21 2023 Not Applicable

Chemical Information & Solubility

Molecular Weight 317.42 Formula

C22H23NO
CAS No. 1245792-51-1 SDF --
Smiles O=C1\C(=C\C2=CC=CC=C2)C(NC3CCCCC3)C4=C1C=CC=C4
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 63 mg/mL ( (198.47 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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