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Bisantrene (CS1) FTO inhibitor

Name: Bisantrene (CS1)
Brand: Selleck Chemicals
SKU: S9946
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S9946

Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity and a potent and selective FTO inhibitor.

Chemical Structure

Molecular Weight: 398.46

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Quality Control

Batch: S994601 0.1MHCl]15 mg/mL]true]DMSO]3 mg/mL]true]Water]Insoluble]false Purity: 99.4%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.4

Related Targets	PRMT EZH2 MAT2A DNA Methyltransferase LSD1 JMJD G9a/GLP MLL NSD SETD
Other FTO Inhibitors	FB23-2 Dac51 Rheic Acid FB23

Solubility

In vitro
Batch:

0.1MHCl : 15 mg/mL

DMSO : 3 mg/mL (7.52 mM) Warmed with 50°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	398.46	Formula	C₂₂H₂₂N₈	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	78186-34-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	FTO
References	[1] https://pubmed.ncbi.nlm.nih.gov/34727689/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06084533	Enrolling by invitation	Parkinson Disease	Washington University School of Medicine	January 10 2024	--
NCT06129838	Recruiting	Alzheimer Disease	Washington University School of Medicine	May 5 2023	--
NCT04517552	Active not recruiting	Alzheimer Disease	Tammie L. S. Benzinger MD PhD\|Washington University School of Medicine	November 2 2020	--
NCT04142619	Terminated	Relapsed/Refractory Multiple Myeloma	Cellectis S.A.	November 21 2019	Phase 1

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Handling Instructions

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