Home Methylation FTO inhibitor Bisantrene (CS1)

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Bisantrene (CS1) FTO inhibitor

Cat.No.S9946

Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity and a potent and selective FTO inhibitor.

Bisantrene (CS1) FTO inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 398.46

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S994601 0.1MHCl]15 mg/mL]true]DMSO]3 mg/mL]true]Water]Insoluble]false Purity: 99.4%
99.4

Chemical Information, Storage & Stability

Molecular Weight 398.46 Formula

C22H22N8

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 78186-34-2 -- Storage of Stock Solutions

Solubility

In vitro
Batch:

0.1MHCl : 15 mg/mL

DMSO : 3 mg/mL (7.52 mM) Warmed with 50°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
FTO [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06084533 Enrolling by invitation
Parkinson Disease
Washington University School of Medicine
 January 10 2024 --
NCT06129838 Recruiting
Alzheimer Disease
Washington University School of Medicine
 May 5 2023 --
NCT04517552 Active not recruiting
Alzheimer Disease
Tammie L. S. Benzinger MD PhD|Washington University School of Medicine
 November 2 2020 --
NCT04142619 Terminated
Relapsed/Refractory Multiple Myeloma
Cellectis S.A.
 November 21 2019 Phase 1

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