B-Raf inhibitor 1 (Compound 13) dihydrochloride

Catalog No.S6660

For research use only.

B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.

B-Raf inhibitor 1 (Compound 13) dihydrochloride Chemical Structure

CAS No. 1191385-19-9

Selleck's B-Raf inhibitor 1 (Compound 13) dihydrochloride has been cited by 1 Publication

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Biological Activity

Description B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively.
Targets
C-Raf [1]
(Cell-free assay)
B-Raf(WT) [1]
(Cell-free assay)
B-Raf(V600E) [1]
(Cell-free assay)
0.3 nM(Ki) 1 nM(Ki) 1 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(181.2 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 551.86
Formula

C26H21Cl3N8

CAS No. 1191385-19-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6.Cl.Cl

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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