Molecular Weight(MW): 463.61
Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.
Purity & Quality Control
Choose Selective Histamine Receptor Inhibitors
|Description||Bilastine is a new, well-tolerated, nonsedating H1 receptor antihistamine and has a rapid onset and prolonged duration of action.|
Bilastine has a high specific affinity for the H1-receptor but it has no or very low affinity for 30 other tested receptors. It is lack of significant antagonism against serotonin, bradykinin, leukotriene D4, calcium, muscarinic M3-receptors, α1-adrenoceptors, β2-adrenoceptors, and H2- and H3- receptors.
|In vivo||Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms in patients with allergic rhinoconjunctivitis. Bilastine is well tolerated. In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice. In vivo studies in rats have demonstrated reduction in histamine-stimulated smooth muscular contraction, bronchospasms, endothelial permeability, and microvascular extravasation.|
|In vitro||DMSO||1 mg/mL (2.15 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03633760||Recruiting||Pharmacokinetics||A.Menarini Asia-Pacific Holdings Pte Ltd||August 28 2018||Phase 1|
|NCT03479307||Completed||Allergic Conjunctivitis||Faes Farma S.A.|ORA Inc.||February 26 2018||Phase 3|
|NCT03231969||Completed||Allergic Conjunctivitis||Faes Farma S.A.|ORA Inc.||July 20 2017||Phase 2|
|NCT02761252||Completed||Seasonal Allergic Rhinoconjunctivitis|Asthma||Menarini International Operations Luxembourg SA||April 2016||Phase 4|
|NCT02576041||Completed||Allergic Rhinitis|Urticaria||Menarini International Operations Luxembourg SA||October 2015||Phase 4|
|NCT02557269||Unknown status||Seasonal Allergic Rhinitis||Association Asthma Bulgaria|Nasaleze||May 2015||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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