Bumetanide

For research use only.

Catalog No.S1287

1 publication

Bumetanide Chemical Structure

CAS No. 28395-03-1

Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Selleck's Bumetanide has been cited by 1 publication

Purity & Quality Control

Choose Selective NKCC Inhibitors

Biological Activity

Description Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.

Protocol

References

Solubility (25°C)

In vitro DMSO 73 mg/mL (200.31 mM)
Water Insoluble
Ethanol '36 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 364.42
Formula

C17H20N2O5S

CAS No. 28395-03-1
Storage powder
in solvent
Synonyms N/A
Smiles CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02582476 Terminated Drug: Bumetanide|Drug: Placebo Hypokalemic Periodic Paralysis University College London January 2015 Phase 2
NCT00830531 Completed Drug: Bumetanide|Drug: Normal Saline as Placebo Seizures Soul Janet M.D.|Citizens United for Research in Epilepsy|Harvard Catalyst- Harvard Clinical and Translational Science Center|Translational Research Program Boston Children''s Hospital|Charles H. Hood Foundation|National Institute of Neurological Disorders and Stroke (NINDS)|Mooney Family Initiative for Translational Studies in Rare Diseases Boston Children''s Hospital January 2010 Phase 1
NCT00930865 Completed Drug: Bumetanide|Drug: Dapagliflozin Type 2 Diabetes Mellitus AstraZeneca|Bristol-Myers Squibb July 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Bumetanide | Bumetanide ic50 | Bumetanide price | Bumetanide cost | Bumetanide solubility dmso | Bumetanide purchase | Bumetanide manufacturer | Bumetanide research buy | Bumetanide order | Bumetanide mouse | Bumetanide chemical structure | Bumetanide mw | Bumetanide molecular weight | Bumetanide datasheet | Bumetanide supplier | Bumetanide in vitro | Bumetanide cell line | Bumetanide concentration | Bumetanide nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID