Home Microbiology Fungal inhibitor Butylparaben For research use only.

Butylparaben

Synonyms: Butyl parahydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate

Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products.

Butylparaben Chemical Structure

Butylparaben Chemical Structure

CAS: 94-26-8

Selleck's Butylparaben has been cited by 1 publication

Purity & Quality Control

Batch: S458401 DMSO] 38 mg/mL] false] Water] 38 mg/mL] false] Ethanol] 38 mg/mL] false Purity: 99.08%
99.08

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Biological Activity

Description Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products.
In vitro
In vitro After butylparaben treatment, vimentin filaments in Sertolicells are disrupted. Sertoli cell cytoskeleton responds to butylparaben by exhibiting a marked collapse in vimentin filaments distribution[1].
Cell Research Cell lines Primary Sertoli cell
Concentrations 0, 1, 100 and 1000 nmol/ml
Incubation Time 6, 24h
Method

Mixed cultures of Sertoli and spermatogenic cells are prepared from three-week-old SD rats. Single cells are obtained by gravity sedimentation and use of 50% trypsin-EDTA. Cells are finally suspended at a concentration of 1 × 108cell/ml and maintained for 24 h in Dulbecco’s modified Eagle medium supplemented with 100 U/ml penicillin, 100 μg/ml streptomycin, and 10% fetal bovineserum. Thereafter, cells are maintained in serum-freemedium, which is changed every 24 h. At 72 h, spermatogenic cells are removed by treatment with hypotonic Tris buffer (20 mMTris–HCl, pH 7.4) for 5 min. The Sertoli cell-enriched cultures obtained are then maintained in serum-free medium for 24 h before being reseeded onto chamber slides. The samples are cultured for a further 5 days. Subsequently, they are exposed to 0, 1, 100 and 1000 nmol/ml butylparaben for 6 and 24 h. Some slides are stained with 0.5% toluidine blue for light microscopic observations, whereas the rest are used for vimentin immuno-histochemical analysis.
In Vivo
In vivo Butylparaben induces collapse of Sertoli cell vimentin filaments in vivo[1]. Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system[2].
Animal Research Animal Models Male Sprague–Dawley rats
Dosages 1000 mg/kg
Administration oral administration

Chemical Information & Solubility

Molecular Weight 194.23 Formula

C11H14O3
CAS No. 94-26-8 SDF Download Butylparaben SDF
Smiles CCCCOC(=O)C1=CC=C(C=C1)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 38 mg/mL ( (195.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 38 mg/mL

Ethanol : 38 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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