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Butylparaben Fungal inhibitor

Cat.No.S4584

Butylparaben (Butyl parahydroxybenzoate, Butyl 4-hydroxybenzoate) is a chemical compound commonly used as an antifungal preservative in cosmetic products.
Butylparaben Fungal inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 194.23

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Quality Control

Batch: S458401 DMSO]38 mg/mL]false]Water]38 mg/mL]false]Ethanol]38 mg/mL]false Purity: 99.08%
99.08

Solubility

In vitro
Batch:

DMSO : 38 mg/mL (195.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 38 mg/mL

Ethanol : 38 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 194.23 Formula

C11H14O3

 Storage (From the date of receipt)
CAS No. 94-26-8 Download SDF Storage of Stock Solutions

Synonyms Butyl parahydroxybenzoate, Butyl paraben, Butyl 4-hydroxybenzoate Smiles CCCCOC(=O)C1=CC=C(C=C1)O

Mechanism of Action

In vitro
After butylparaben treatment, vimentin filaments in Sertolicells are disrupted. Sertoli cell cytoskeleton responds to butylparaben by exhibiting a marked collapse in vimentin filaments distribution.
In vivo
Butylparaben induces collapse of Sertoli cell vimentin filaments in vivo. Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system.
References

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