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Brincidofovir Anti-infection chemical

Name: Brincidofovir
Brand: Selleck Chemicals
SKU: E0938
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0938

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir with long-acting antiviral effect, shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections.

Chemical Structure

Molecular Weight: 561.69

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Quality Control

Batch: Purity: 99.72%

99.72

Related Targets	Integrase Bacterial Antibiotics Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Anti-infection Inhibitors	Berberine chloride Clorsulon Sodium Tauroursodeoxycholate (TUDC) Ascomycin (FK520) LL37 (Human cathelicidin) Ethacridine lactate Cetylpyridinium Chloride Cystamine dihydrochloride p-Coumaric Acid Cinchonidine

Solubility

In vitro
Batch:

0.1mNAOH : 10 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	5%0.1MNAOH 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.500mg/ml (0.89mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified 0.1MNAOH stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5%0.1mNaOH 1 40%PEG300 2 5%Tween80 3 50%DDH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.000mg/ml (1.78mM)	Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clarified 0.1mNaOH stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	561.69	Formula	C₂₇H₅₂N₃O₇P	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	444805-28-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/29846280/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07511049	RECRUITING	Progressive Multifocal Leukoencephalopathy	National Institute of Neurological Disorders and Stroke (NINDS)	2026-06-05	PHASE2
NCT07387367	RECRUITING	Adenovirus Infections	SymBio Pharmaceuticals	2026-03-17	PHASE3
NCT06761677	SUSPENDED	Relapsed or Refractory Lymphoma Including ENKL	SymBio Pharmaceuticals	2025-06-09	PHASE1; PHASE2
NCT04706923	COMPLETED	Adenovirus Infections; Cytomegalovirus Infection	SymBio Pharmaceuticals	2021-08-16	PHASE2
NCT05935917	COMPLETED	Smallpox	Emergent BioSolutions	2023-05-30	PHASE1
NCT05511779	TERMINATED	BK Virus Infection; Nephropathy; Kidney Transplantation	SymBio Pharmaceuticals	2022-10-14	PHASE2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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