Belotecan (CKD-602) hydrochloride

Catalog No.S6631

For research use only.

Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.

Belotecan (CKD-602) hydrochloride Chemical Structure

CAS No. 213819-48-8

Purity & Quality Control

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Biological Activity

Description Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.
Targets
DNA topoisomerase I [1]
In vitro

CKD-602 promotes pro-apoptotic activity, induces cell-cycle arrest in the G2/M phase and inhibits cancer invasion in cervical cancer[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: CaSki, HeLa and SiHa cells
  • Concentrations: 0-150 nM
  • Incubation Time: 48 h
  • Method:

    --

Animal Research:

[1]

  • Animal Models: BALB/c-nude mice subcutaneously injected with CaSki cells
  • Dosages: 25 m/kg
  • Administration: IV

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 469.96
Formula

C25H28ClN3O4

CAS No. 213819-48-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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