Catalog No.S7857 Synonyms: 8-Br-Camp

For research use only.

8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.

8-Bromo-cAMP Chemical Structure

CAS No. 76939-46-3

Selleck's 8-Bromo-cAMP has been cited by 19 publications

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Biological Activity

Description 8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.
PKA [1]
0.05 μM(Ka)
In vitro

8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. [1] In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
RAW 264.7 MWLGeY5kfGmxbjDhd5NigQ>? NWDEV5k{PTEkgJpOwG0> NYX1SmNkOjBibXnu MWP0bIUhSUSSLXXubIFv[2WmIFXST{B{cWewYXzpcochf2G|IIPp[45q\mmlYX70cJkh\GWlcnXhd4VlNg>? Ml;xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd6NkexPVYoRjJ5OE[3NVk3RC:jPh?=
HUVECs MUjGeY5kfGmxbjDhd5NigQ>? MU\lcohidmOnczDjZZBqdGyjcomgcoV1f2:{azDmc5Ju[XSrb36= MmjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2OUOyPFkoRjJ2NEmzNlg6RC:jPh?=
MC3T3-E1 NG\CeXpHfW6ldHnvckBie3OjeR?= MXmxJIRigQ>? NWPobHh[e2mpbnnmbYNidnRiaX7jdoVie2W|IHnuJGFNWCCjY4Tpeol1cWW| M1zKOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEmzNlg6Lz5{NES5N|I5QTxxYU6=
CHO  MnzySpVv[3Srb36gZZN{[Xl? M4iyW|AtKDFyLDDhcoQhOTByIN88cY9tN0x? NILZb3M5NUK{LXPBUXAhcW6lcnXhd4VlKFuFYUKrYYkhcW5iTlPYNUB1emGwc3\lZ5RidnS|IHH0JJJmfmW{c3WgcY9l\Q>? NIfGTI89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2OFA5Oyd-MkO1OlQxQDN:L3G+
N2a cells MoK2SpVv[3Srb36gZZN{[Xl? NXvlO45OOS1zLECwNEDPxE1? MkfVNlQhcA>? NXvD[HNqSc7{NECsJGHPujR{IHHu[EB{SVCSzsGge4Vz\SC|aXfubYZq[2GwdHz5JIlv[3KnYYPl[C=> NVPGfHpYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyPVcxPjNpPkKzNlk4ODZ|PD;hQi=>

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 430.08


CAS No. 76939-46-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-].[Na+]

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