8-Bromo-cAMP

Catalog No.S7857 Synonyms: 8-Br-Camp

For research use only.

8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.

8-Bromo-cAMP Chemical Structure

CAS No. 76939-46-3

Selleck's 8-Bromo-cAMP has been cited by 17 publications

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Biological Activity

Description 8-bromo-cAMP (8-Br-Camp) is a cell permeable analog of cAMP that activates cyclic-AMP-dependent protein kinase with a Ka value of 0.05 μM; and a PKA activator.
Targets
PKA [1]
()
0.05 μM(Ka)
In vitro

8-Bromo-cAMP improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. [1] In bronchial epithelial cells, 8-Bromo-cAMP decreases HDE-stimulated tumor necrosis factor (TNF)-α-converting enzyme (TACE; ADAM-17) activity and subsequent TNF-α release. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
RAW 264.7 MlLOSpVv[3Srb36gZZN{[Xl? NUDnS|VjPTEkgJpOwG0> MVWyNEBucW5? NVvaVpE5fGinIFHEVE1mdmijbnPl[EBGWktic3nncoFtcW6pIIfhd{B{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnZD6= NHLDdII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{i2O|E6Pid-Mke4OlcyQTZ:L3G+
HUVECs NH3Ze3NHfW6ldHnvckBie3OjeR?= NHX4fGJmdmijbnPld{Bk[XCrbHzhdpkhdmW2d3;yb{Bnd3KvYYTpc44> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR7M{K4PUc,OjR2OUOyPFk9N2F-
MC3T3-E1 MnnZSpVv[3Srb36gZZN{[Xl? MmqzNUBl[Xl? NY\1eoRse2mpbnnmbYNidnRiaX7jdoVie2W|IHnuJGFNWCCjY4Tpeol1cWW| M4W5fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEmzNlg6Lz5{NES5N|I5QTxxYU6=
CHO  MoTLSpVv[3Srb36gZZN{[Xl? NXTLdFJ1OCxiMUCsJIFv\CBzMECg{txud2xxTB?= MYO4MWJzNWODTWCgbY5kemWjc3XkJHtE[TJtXXmgbY4hVkO[MTD0doFve2[nY4ThcpR{KGG2IILleoVze2VibX;k[S=> M4PDZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NU[0NFg{Lz5{M{W2OFA5OzxxYU6=
N2a cells MXTGeY5kfGmxbjDhd5NigQ>? MVexMVEtODByIN88US=> MYmyOEBp MmWyRe6zPDBuIFJOtlQzKGGwZDDzRXBR|rFid3Xy[UB{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnZB?= M2DxVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mkm3NFY{Lz5{M{K5O|A3OzxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

Water 80 mg/mL warmed
(186.01 mM)
DMSO 5 mg/mL warmed
(11.62 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 430.08
Formula

C10H10BrN5NaO6P

CAS No. 76939-46-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1C2C(C(C(O2)N3C4=NC=NC(=C4N=C3Br)N)O)OP(=O)(O1)[O-].[Na+]

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