Home GPCR & G Protein Opioid Receptor modulator BMS-986122 For research use only.

BMS-986122

BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.

BMS-986122 Chemical Structure

BMS-986122 Chemical Structure

CAS: 313669-88-4

Purity & Quality Control

Batch: E047201 DMSO] 90 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 98.87%
98.87

BMS-986122 Related Products

Signaling Pathway

Opioid Receptor Signaling Pathways

Opioid Receptor Signaling Pathway

Choose Selective Opioid Receptor Inhibitors

Biological Activity

Description BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (µ-OR), shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation, and potentiates DAMGO-mediated [35S]GTPγS binding in mouse brain membranes.
Targets
µ-OR [1]

Chemical Information & Solubility

Molecular Weight 448.78 Formula

C16H15BrClNO3S2
CAS No. 313669-88-4 SDF --
Smiles COC1=CC=C(C=C1Br)C2SCCN2[S](=O)(=O)C3=CC=C(Cl)C=C3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 90 mg/mL ( (200.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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