BMS-986020

For research use only.

Catalog No.S3572 Synonyms: AM152, AP-3152 free acid

BMS-986020 Chemical Structure

CAS No. 1257213-50-5

BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).

Purity & Quality Control

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Biological Activity

Description BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).
Targets
LPA1 [1]
()
BSEP [1]
(Cell-free assay)
MRP4 [1]
(Cell-free assay)
MDR3 [1]
(Cell-free assay)
4.8 μM 6.2 μM 7.5 μM

Protocol

Solubility (25°C)

In vitro DMSO 97 mg/mL (201.02 mM)
Water Insoluble
Ethanol '''97 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 482.53
Formula

C29H26N2O5

CAS No. 1257213-50-5
Storage powder
in solvent
Synonyms AM152, AP-3152 free acid

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02101125 Completed Drug: BMS-986020|Drug: Rosuvastatin Immunosuppression For Disease Bristol-Myers Squibb March 2014 Phase 1
NCT02068053 Completed Drug: [14C] BMS-986020 Immunosuppression For Disease Bristol-Myers Squibb March 2014 Phase 1
NCT02017730 Completed Drug: BMS-986020|Drug: [11C]BMT-136088 Immunology Bristol-Myers Squibb January 2014 Phase 1
NCT01766817 Completed Drug: BMS-986020|Drug: Placebo matching with BMS-986020 Idiopathic Pulmonary Fibrosis Bristol-Myers Squibb January 31 2013 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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LPA Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID