BMS202 (PD-1/PD-L1 inhibitor 2)

Catalog No.S7912

For research use only.

BMS202 (PD-1/PD-L1 inhibitor 2) is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.

BMS202 (PD-1/PD-L1 inhibitor 2) Chemical Structure

CAS No. 1675203-84-5

Selleck's BMS202 (PD-1/PD-L1 inhibitor 2) has been cited by 12 Publications

Purity & Quality Control

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Biological Activity

Description BMS202 (PD-1/PD-L1 inhibitor 2) is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.
PD-1/PD-L1 interaction [2]
(Cell-free assay)
0.018 μM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) MmHzSpVv[3Srb36gZZN{[Xl? NHLSPIpDcW6maX7nJIFn\mmwaYT5JJRwKFtzNV6tWJlzZS2uYXLlcIVlKGi3bXHuJHBFNUxzIDixPEB1dyBzM{SgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGoSGU{MSCkeTCxTE0yPU5iMlSgTG1SSyCQTWKgd5Bm[3S{b4Pjc5Bq[yCjbnHsfZNqey5? NX7NcFFTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NVM5PjJpPkK4OlE{QDZ{PD;hQi=>
BL21(DE3) NVPrN5BGTnWwY4Tpc44h[XO|YYm= NUXFcI45SmmwZHnu[{Bi\m[rbnn0fUB1dyCdMUXOMXZidF1vbHHi[Yxm\CCqdX3hckBRTC2OMTCoNVghfG9iMUO0JJJme2mmdXXzLUBmgHC{ZYPz[YQhcW5iRYPjbIVzcWOqaXGgZ49tcSCETEKxLGRGOyliYomgNWguOTWQIELEJGhOWUNiTl3SJJNx\WO2cn;zZ49xcWNiYX7hcJl{cXNw MkDBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh4MUO4OlIoRjJ6NkGzPFYzRC:jPh?=

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 419.52


CAS No. 1675203-84-5
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
I would like to know the difference of S8158, S7912, S7911, and the reason of why the IC50 is different.

These three compounds are three different PD-l/PD-L1 inhibitors. They have different structures, characteristics, and probably function through different mechanisms. And this is why the IC50s are different. Inhibitor 1 and 2 are small-molecule inhibitors while inhibitor 3 is Macrocyclic inhibitor.

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