BMS202 (PD-1/PD-L1 inhibitor 2)

Catalog No.S7912

For research use only.

BMS202 (PD-1/PD-L1 inhibitor 2) is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.

BMS202 (PD-1/PD-L1 inhibitor 2) Chemical Structure

CAS No. 1675203-84-5

Selleck's BMS202 (PD-1/PD-L1 inhibitor 2) has been cited by 11 Publications

Purity & Quality Control

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Biological Activity

Description BMS202 (PD-1/PD-L1 inhibitor 2) is a small-molecule PD-1/PD-L1 interaction inhibitor with IC50 of 18 nM.
Targets
PD-1/PD-L1 interaction [2]
(Cell-free assay)
0.018 μM
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BL21(DE3) NF\QZoRHfW6ldHnvckBie3OjeR?= MWjCbY5lcW6pIHHm[olvcXS7IITvJHsyPU5vVInyYU1t[WKnbHXkJIh2dWGwIGDEMWwyKChzODD0c{AyOzRicnXzbYR2\XNrIHX4dJJme3OnZDDpckBGe2OqZYLpZ4hq[SClb3zpJGJNOjFqRFWzLUBjgSBzSD2xOW4hOkRiSF3RR{BPVVJic4DlZ5Rzd3Olb4DpZ{BidmGueYPpd{4> M4jTPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NkGzPFYzLz5{OE[xN|g3OjxxYU6=
BL21(DE3) NFzufXVHfW6ldHnvckBie3OjeR?= NGP0NYtDcW6maX7nJIFn\mmwaYT5JJRwKFtzNV6tWoFtZS2uYXLlcIVlKGi3bXHuJHBFNUxzIDixPEB1dyBzM{SgdoV{cWS3ZYOpJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKEKOMkGoSGU{MSCkeTCxTE0yPU5iMlSgTG1SSyCQTWKgd5Bm[3S{b4Pjc5Bq[yCjbnHsfZNqey5? NYHsbXNvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2NVM5PjJpPkK4OlE{QDZ{PD;hQi=>

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 83 mg/mL
(197.84 mM)
Ethanol 83 mg/mL
(197.84 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 419.52
Formula

C25H29N3O3

CAS No. 1675203-84-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C=CC=C1C2=CC=CC=C2)COC3=NC(=C(C=C3)CNCCNC(=O)C)OC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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Frequently Asked Questions

Question 1:
I would like to know the difference of S8158, S7912, S7911, and the reason of why the IC50 is different.

Answer:
These three compounds are three different PD-l/PD-L1 inhibitors. They have different structures, characteristics, and probably function through different mechanisms. And this is why the IC50s are different. Inhibitor 1 and 2 are small-molecule inhibitors while inhibitor 3 is Macrocyclic inhibitor.

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