Buclizine HCl

Catalog No.S4140 Synonyms: UCB-4445

For research use only.

Buclizine HCl (UCB-4445) is an antihistamine and anticholinergic of the piperazine derivative family.

Buclizine HCl Chemical Structure

CAS No. 129-74-8

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Biological Activity

Description Buclizine HCl (UCB-4445) is an antihistamine and anticholinergic of the piperazine derivative family.
Targets
Histamine receptor [1] Cholinergic [1]
In vitro

Buclizine hydrochloride, a piperazine derivative, is a sedating antihistamine with antimuscarinic and moderate sedative action. Buclizine is used in the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness. Additionally, it has been used in the management of vertigo in diseases affecting the vestibular apparatus. Although the mechanism by which buclizine exerts its antiemetic and antivertigo effects has not been fully elucidated, its central anticholinergic properties are partially responsible. The drug depresses labyrinth excitability and vestibular stimulation, and it may affect the medullary chemoreceptor trigger zone. It also possesses anticholinergic, antihistaminic, central nervous system depressant, and local anesthetic effects. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 0.2 mg/mL
(0.39 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 505.95
Formula

C28H33ClN2.2HCl

CAS No. 129-74-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C)C1=CC=C(C=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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