Home Biosimilar Antibodies Stem Cells & Wnt Notch Brontictuzumab (Anti-NOTCH1)
For research use only. Not for use in humans.

Brontictuzumab (Anti-NOTCH1)

Synonyms: OMP 52M51

Brontictuzumab (Anti-NOTCH1) is a monoclonal antibody that targets Notch1 signal. It inhibits tumor cell proliferation and can be used in the research of leukemia and lymphoma. MW :150 KD.

Brontictuzumab (Anti-NOTCH1)

Quality Control

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  • SDS
  • Datasheet

Specificity

Name Citation Notch Others
RO4929097 (RG-4733) 124 γ secretase,Aβ40
Semagacestat (LY450139) 22 Aβ42,Aβ38,Aβ40
Dibenzazepine (YO-01027) 40 γ secretase
LY411575 45 γ secretase
IMR-1A 0
IMR-1 7
FLI-06 13
Crenigacestat (LY3039478) 25
DAPT 398 Aβ
Limantrafin (CB-103) 4
Compound E 0 γ-secretase
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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Brontictuzumab (Anti-NOTCH1) is a monoclonal antibody that targets Notch1 signal. It inhibits tumor cell proliferation and can be used in the research of leukemia and lymphoma. MW :150 KD.
References

Product Details

CAS No. 1447814-75-6
Molecular Weight 150
Isotype Human IgG2SA
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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