BEC HCl

Catalog No.S7929

For research use only.

BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.

BEC HCl Chemical Structure

CAS No. 222638-67-7

Purity & Quality Control

Choose Selective Arginase Inhibitors

Biological Activity

Description BEC HCl is a slow-binding, and competitive arginase inhibitor with Ki of 0.31 μM (pH7.5) and 0.4-0.6 μM for Arginase II and rat Arginase I, respectively.
Targets
Arginase II [1] rat Arginase I [2]
0.31 μM(Ki) <0.6 μM(Ki)
In vitro

BEC causes significant enhancement of NO-dependent smooth muscle relaxation. [2] In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. [3] BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK. [5]

In vivo In mice with allergic inflammation (OVA/OVA), BEC enhances peribronchiolar and perivascular inflammation, leads to enhanced NF-κB DNA binding and NF-κB-dependent inflammatory gene expression, and causes an increase in the content of NOx. [4] In rats with pulmonary arterial hypertension, BEC reduces the right ventricle systolic pressure. [5]

Protocol (from reference)

Animal Research:[4]
  • Animal Models: Mice with allergic inflammation (OVA/OVA)
  • Dosages: 0.30 mM, 40 μl
  • Administration: oropharyngeal aspiration

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 229.49
Formula

C5H12BNO4S.HCl

CAS No. 222638-67-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles B(CCSCC(C(=O)O)N)(O)O.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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