Bedaquiline fumarate

Catalog No.S4854 Synonyms: TMC-207

For research use only.

Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.

Bedaquiline fumarate Chemical Structure

CAS No. 845533-86-0

Selleck's Bedaquiline fumarate has been cited by 1 Publication

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(148.9 mM)
Water Insoluble
Ethanol '4 mg/mL

Chemical Information

Molecular Weight 671.58
Formula

C32H31BrN2O2.C4H4O4

CAS No. 845533-86-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCC(C1=CC=CC2=CC=CC=C21)(C(C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O.C(=CC(=O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01341184 Completed Drug: Rifabutin|Drug: Rifampin|Drug: TMC207 Tuberculosis National Institute of Allergy and Infectious Diseases (NIAID) October 21 2011 Phase 1
NCT01215110 Completed Drug: TMC207|Drug: Rifafour e-275 mg Pulmonary Tuberculosis Global Alliance for TB Drug Development April 2010 Phase 2
NCT02216331 Completed Drug: TMC207|Drug: rifapentine|Drug: rifampicin Tuberculosis Global Alliance for TB Drug Development March 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Bedaquiline fumarate | Bedaquiline fumarate supplier | purchase Bedaquiline fumarate | Bedaquiline fumarate cost | Bedaquiline fumarate manufacturer | order Bedaquiline fumarate | Bedaquiline fumarate distributor