Catalog No.S7534

For research use only.

BAPTA-AM is a selective, membrane-permeable calcium chelator.

BAPTA-AM Chemical Structure

CAS No. 126150-97-8

Selleck's BAPTA-AM has been cited by 57 publications

Purity & Quality Control

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Biological Activity

Description BAPTA-AM is a selective, membrane-permeable calcium chelator.
In vitro

BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. [1] BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SKOV3 MY\GeY5kfGmxbjDhd5NigQ>? M1HHflEzKGh? NHvmVFV1emWjdH3lcpQhf2m2aDDCRXBVSS2DTTDy[YR2[2WmIITo[UBt\X[nbIOgc4YhY0OjMjvdbS=> MkfUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB6MUmyN|AoRjNyOEG5NlMxRC:jPh?=
OVCAR3 NEL1U|dHfW6ldHnvckBie3OjeR?= MXSxNkBp NYW4WXNJfHKnYYTt[Y51KHerdHigRmFRXEFvQV2gdoVlfWOnZDD0bIUhdGW4ZXzzJI9nKFuFYUKrYYk> MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODhzOUKzNEc,OzB6MUmyN|A9N2F-
MC3T3-E1 cells NGKzS|VHfW6ldHnvckBie3OjeR?= NYXzT5VwOsLizszN MnTqNlQhcA>? NX3XPWR[SkGSVFGvRW0h[XS2ZX71ZZRm\CCWZzj0bIFxe2mpYYLnbY4qNWmwZIXj[YQhVkGGUFigc5hq\GG|ZTDhZ5Rqfmm2eR?= M3f0bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5NEW3NFc2Lz5{N{S1O|A4PTxxYU6=
HUVECs NWrYbJhoTnWwY4Tpc44h[XO|YYm= MYO1JO69dW:uL1y= NFzXdXA{KGh? NVHqelZ1dWG{a3XkcJkhe3WycILld5Nm\CCFYUKrJIlv[3KnYYPl M4PBdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkSzNVQ4Lz5{NU[0N|E1PzxxYU6=
Methods Test Index PMID
Western blot p-ERK / ERK 23185493
In vivo BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca2+ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats. [3]

Protocol (from reference)

Animal Research:[3]
  • Animal Models: BDL rats
  • Dosages: ~6 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 764.68


CAS No. 126150-97-8
Storage 3 years -20°C powder
2 years -80°C in solvent

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Tech Support

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