BAPTA-AM

For research use only.

Catalog No.S7534

26 publications

BAPTA-AM Chemical Structure

Molecular Weight(MW): 764.68

BAPTA-AM is a selective, membrane-permeable calcium chelator.

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Selleck's BAPTA-AM has been cited by 26 publications

Purity & Quality Control

Biological Activity

Description BAPTA-AM is a selective, membrane-permeable calcium chelator.
In vitro

BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. [1] BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SKOV3 MmPYSpVv[3Srb36gZZN{[Xl? NVr0UplpOTJiaB?= NX\1cWFwfHKnYYTt[Y51KHerdHigRmFRXEFvQV2gdoVlfWOnZDD0bIUhdGW4ZXzzJI9nKFuFYUKrYYk> M3fqblMxQDF7MkOw
OVCAR3 M{DvWWZ2dmO2aX;uJIF{e2G7 NF;4bFkyOiCq NUT5TW1lfHKnYYTt[Y51KHerdHigRmFRXEFvQV2gdoVlfWOnZDD0bIUhdGW4ZXzzJI9nKFuFYUKrYYk> Ml\VN|A5OTl{M{C=
MC3T3-E1 cells NULkTZR4TnWwY4Tpc44h[XO|YYm= Ml6zNuKh|ryP NHfBNm8zPCCq MV;CRXBVSS:DTTDheJRmdnWjdHXkJHRoMHSqYYDzbYdiemerbjmtbY5lfWOnZDDORWRRUCCxeHnkZZNmKGGldHn2bZR6 NIfF[YszPzR3N{C3OS=>
HUVECs NYnhOm1DTnWwY4Tpc44h[XO|YYm= M1fH[FUh|ryvb3yvUC=> MUWzJIg> Mn2xcYFzc2WmbImgd5VxeHKnc4Pl[EBE[TJtIHnuZ5Jm[XOn Mn\5NlU3PDNzNEe=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-ERK / ERK ; 

PubMed: 23185493     


Effects of BAPTA-AM (20 µM, 30 min) on SKF83959 (30 µM, 10 min)-induced ERK1/2 phosphorylation. 

23185493
In vivo BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca2+ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats. [3]

Protocol

Animal Research:[3]
- Collapse
  • Animal Models: BDL rats
  • Dosages: ~6 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 20 mg/mL (26.15 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 764.68
Formula

C34H40N2O18

CAS No. 126150-97-8
Storage powder
in solvent
Synonyms N/A
Smiles CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=C(OCCOC2=C(C=CC=C2)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C=CC=C1

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID