Bexagliflozin (EGT1442) | SGLT inhibitor | Highly Cited | In Stock

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Batch: E014101 DMSO]93 mg/mL]false]Water]93 mg/mL]false]Ethanol]23 mg/mL]false Purity: 99.73%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
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Datasheet

99.73

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other SGLT Inhibitors	Sotagliflozin (LX4211) Phlorizin Phloretin (RJC 02792) Tofogliflozin(CSG 452) Ipragliflozin L-Proline Ipragliflozin (ASP1941) Swertisin KGA-2727 Mizagliflozin (KWA 0711, DSP-3235 free base)

Solubility

In vitro
Batch:

DMSO : 93 mg/mL (200.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 93 mg/mL

Ethanol : 23 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

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%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	464.94	Formula	C₂₄H₂₉ClO₇	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1118567-05-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	EGT-0001442, THR-1442			SMILES	OCC1OC(C(O)C(O)C1O)C2=CC(=C(Cl)C=C2)CC3=CC=C(OCCOC4CC4)C=C3

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	SGLT2 2 nM
References	[1] https://pubmed.ncbi.nlm.nih.gov/21215314/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-27)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05612594	RECRUITING	Sleep Apnea	Yale University	2024-03-27	PHASE4
NCT02769481	COMPLETED	Type 2 Diabetes Mellitus	Theracos	2016-08-15	PHASE3
NCT03259789	COMPLETED	Type2 Diabetes Mellitus	Theracos	2017-11-28	PHASE3
NCT03557658	COMPLETED	Type2 Diabetes Mellitus	Theracos	2018-07-26	PHASE1
NCT03514641	COMPLETED	Essential Hypertension	Theracos	2017-10-18	PHASE2; PHASE3
NCT03115112	COMPLETED	Type 2 Diabetes Mellitus	Theracos	2017-10-12	PHASE3

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Bexagliflozin (EGT1442) SGLT inhibitor

Chemical Structure

Molecular Weight: 464.94