Name: Brequinar Sodium
Brand: Selleck Chemicals
SKU: S3565
Rating: 5 (2 reviews)

Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.

Brequinar Sodium Chemical Structure

CAS: 96201-88-6

Selleck's Brequinar Sodium has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.78%

99.78

Brequinar Sodium Related Products

Related Targets	ALDH1A	Click to Expand
Related Products	Disulfiram Glycyrrhizin (NSC 167409) Devimistat (CPI-613) Teriflunomide Gossypol Acetate Enasidenib (AG-221) Emodin Ivosidenib (AG-120) AGI-5198 AGI-6780 DCA (Sodium dichloroacetate) Mycophenolate mofetil Trilostane 6AN (6-Aminonicotinamide) NCT-503 Brequinar SW033291 RRx-001 Gossypol Farudodstat Orludodstat (BAY 2402234) Enasidenib(AG-221) Mesylate Vidofludimus Fomepizole Vorasidenib (AG-881) Ammonium Glycyrrhizinate (R)-GNE-140 Merimepodib BVT 2733 AG-120 (racemic) ML390 Alda 1 Gimeracil NCT-501 G6PDi-1 Enoxolone Alpha-Mangostin GSK 2837808A BAY 1436032	Click to Expand
Related Compound Libraries	Metabolism Compound Library Anti-cancer Metabolism Compound Library Glutamine Metabolism Compound Library Carbohydrate Metabolism Compound Library Lipid Metabolism Compound Library	Click to Expand

Signaling Pathway

Dehydrogenase Signaling Pathway

Choose Selective Dehydrogenase Inhibitors

Biological Activity

Description

Brequinar Sodium (Bipenquinate, BRQ, DUP-785, NSC 368390) is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of ~20 nM and triggers differentiation in the ER-HoxA9, U937, and THP1 cells with ED50 of ~1 μM.

Targets

DHODH ^[1]
(Cell-free assay)

20 nM

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05945251	Not yet recruiting	Functional Abdominal Pain Syndrome	Karolinska Institutet\|Child and Adolescent Psychiatry Stockholm	September 2023	--
NCT04294420	Completed	Functional Gastrointestinal Disorders	Karolinska Institutet	May 1 2020	Not Applicable
NCT03252743	Completed	Functional Gastrointestinal Disorders\|Irritable Bowel Syndrome\|Dyspepsia\|Functional Abdominal Pain	Karolinska Institutet	September 1 2017	Not Applicable
NCT02873078	Completed	Functional Abdominal Pain Disorders	Karolinska Institutet	August 2016	Not Applicable
NCT02475096	Completed	Functional Gastrointestinal Disorders	Karolinska Institutet	July 2015	Not Applicable

References

[1] David B Sykes, et al. Cell. 2016 Sep 22;167(1):171-186.e15.

Chemical Information & Solubility

Molecular Weight	397.35	Formula	C₂₃H₁₄F₂NNaO₂
CAS No.	96201-88-6	SDF	--
Smiles	CC1=C(C(=O)O[Na])C2=CC(=CC=C2N=C1C3=CC=C(C=C3)C4=C(F)C=CC=C4)F
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 79 mg/mL ( (198.81 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):