For research use only.

Catalog No.S7607

1 publication

BQU57 Chemical Structure

CAS No. 1637739-82-2

BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.

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Selleck's BQU57 has been cited by 1 publication

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Biological Activity

Description BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA.
GTPase Ral [1]
In vitro

In both the H2122 and H358 cell lines, BQU57 inhibits both RalA and RalB activation, and thus causes cell growth inhibition. [1]

Methods Test Index PMID
Western blot

PubMed: 30995277     

HeLa cells were treated with 50 μM BQU57 for 2 hours and an Immunoblot was performed for the indicated proteins.

In vivo In mice bearing human lung H2122 tumors, BQU57 (50 mg/kg, i.p.) significantly inhibits activation of both RalA and RalB, and causes dose-dependent tumor growth inhibition. [1]


Cell Research:[1]
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  • Cell lines: Human lung cancer lines, H2122, H358, H460 and Calu6
  • Concentrations: ~10 μM
  • Incubation Time: 48 hours
  • Method: Growth inhibition on human lung cancer cells by the compounds are measured under anchorage-independent conditions in soft agar. Cells are seeded into 6-well plates (coated with a base layer made of 2.0 mL of 1% low-melting-point agarose) at 15,000 cells per well in 3.0 mL of 0.4% low-melting-point agarose containing various concentration of drug. Two to four weeks (depending on cell line) after incubation, cells are stained with 1.0 mg/mL Nitro Blue Tetrazolium and colonies are counted under a microscope. The IC50 values are defined as the concentration of drug that resulted in 50% reduction in colony number compared to DMSO treated control. After 48 hr, cells are subjected to the soft agar colony formation assay.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mice bearing human lung H2122 tumors
  • Dosages: 50 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 66 mg/mL warmed (197.54 mM)
Ethanol 20 mg/mL warmed (59.86 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 334.1


CAS No. 1637739-82-2
Storage powder
in solvent
Synonyms N/A
Smiles CC1=NN(C2=C1C(C(=C(O2)N)C#N)C3=CC=C(C=C3)C(F)(F)F)C

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Ras Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID