Home PI3K/Akt/mTOR AMPK inhibitor BAY-3827

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BAY-3827 AMPK inhibitor

Cat.No.S9833

BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration.
BAY-3827 AMPK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 468.53

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Quality Control

Batch: S983301 DMSO]12 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.05%
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99.05

Solubility

In vitro
Batch:

DMSO : 12 mg/mL (25.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight 468.53 Formula

C27H25FN6O

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2377576-35-5 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
AMPK
(in AMPK activity inhibition assay and at a low, 10 μM ATP concentration)
1.4 nM
AMPK
(in AMPK activity inhibition assay and at a high, 2 mM ATP concentration)
15 nM
References

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