Bisacodyl

Catalog No.S4047

For research use only.

Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.

Bisacodyl Chemical Structure

CAS No. 603-50-9

Purity & Quality Control

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Biological Activity

Description Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
In vitro

Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells. [1]

In vivo Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats. [1] Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL. [2] Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods. [3] Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content. [4] Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 72 mg/mL
(199.23 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 361.39
Formula

C22H19NO4

CAS No. 603-50-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03279341 Completed Drug: polyethylene glycol|Drug: Bisacodyl|Drug: Prucalopride Chronic Constipation University Hospital Gasthuisberg December 3 2012 Phase 4
NCT01424228 Completed Drug: placebo|Drug: prucalopride Constipation Shire|Takeda April 6 2011 Phase 4
NCT01147926 Completed Drug: Placebo|Drug: Prucalopride Male Subjects With Chronic Constipation Shire|Takeda September 23 2010 Phase 3
NCT01116206 Completed Drug: Prucalopride|Drug: Placebo Constipation Johnson & Johnson Pharmaceutical Research & Development L.L.C. May 2010 Phase 3

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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