Molecular Weight(MW): 361.39
Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.
Purity & Quality Control
|Description||Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.|
Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells. 
|In vivo||Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats.  Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL.  Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods.  Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content.  Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats. |
-  Ikarashi N, et al. Am J Physiol Gastrointest Liver Physiol, 2011, 301(5), G887-895.
-  Saunders DR, et al. Gastroenterology, 1977, 72(5 Pt 1), 849-856.
-  Karmeli F, et al. Scand J Gastroenterol, 1997, 32(8), 791-796.
|In vitro||DMSO||72 mg/mL (199.23 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03279341||Completed||Drug: polyethylene glycol|Drug: Bisacodyl|Drug: Prucalopride||Chronic Constipation||University Hospital Gasthuisberg||December 3 2012||Phase 4|
|NCT01424228||Completed||Drug: placebo|Drug: prucalopride||Constipation||Shire||June 2011||Phase 4|
|NCT01147926||Completed||Drug: Placebo|Drug: Prucalopride||Male Subjects With Chronic Constipation||Shire||September 2010||Phase 3|
|NCT01116206||Completed||Drug: Prucalopride|Drug: Placebo||Constipation||Johnson & Johnson Pharmaceutical Research & Development L.L.C.||May 2010||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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