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BI 01383298 Sodium Channel inhibitor

Cat.No.S0073

BI 01383298 is an irreversible and non-competitive inhibitor of human sodium-coupled citrate transporter (hNaCT), in which the inhibition is evident for the constitutively expressed transporter in HepG2 cells and for the ectopically expressed human NaCT in HEK293 cells, with IC50 of ~100 nM.
BI 01383298 Sodium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 445.34

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Quality Control

Batch: S007301 DMSO]45 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.91%
99.91

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (101.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 445.34 Formula

C19H19Cl2FN2O3S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2227549-00-8 -- Storage of Stock Solutions

Synonyms N/A Smiles C1CN(CCC1C(=O)NCC2=CC=C(C=C2)F)S(=O)(=O)C3=CC(=CC(=C3)Cl)Cl

Mechanism of Action

References

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