Benzyl benzoate

Catalog No.S4599 Synonyms: Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester

For research use only.

Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.

Benzyl benzoate Chemical Structure

CAS No. 120-51-4

Purity & Quality Control

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Biological Activity

Description Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei.
In vitro

Benzyl benzoate possess oestrogenic activity in MCF7 human breast cancer cells in vitro. It is able to increase the growth of oestrogen-dependent MCF7 human breast cancer cells[1].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: Oestrogen-responsive MCF7 human breast cancer cell line
  • Concentrations: 0-100 μM
  • Incubation Time: 7 days
  • Method:

    Cells are added to the required volume of phenol red-free RPMI 1640 medium containing 5% DCFCS at a concentration of about 0.2 × 105 cells ml−1 and plated in monolayer in 0.5 ml aliquots into 24-well plastic tissue culture dishes (Nunc). After 24 h, the medium is changed to the same medium but containing the required concentration of test compound. Culture medium is changed routinely every 3–4 days. Cell counts are performed by counting released nuclei on a model ZBI Coulter Counter.

Chemical Information

Molecular Weight 212.24
Formula

C14H12O2

Density 1.118 g/mL at 20 °C
CAS No. 120-51-4
Storage 2 years -20°C(in the dark) liquid
Smiles C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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