Budesonide

For research use only.

Catalog No.S1286

1 publication

Budesonide Chemical Structure

CAS No. 51333-22-3

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.

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Selleck's Budesonide has been cited by 1 publication

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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.
Targets
Glucocorticoid receptor [1]
()
In vitro

Budesonide effectively inhibits production of eotaxin and RANTES protein although Budesonide inhibits the expression of chemokine mRNA to a variable extent in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide inhibits both RANTES- and eotaxin promoter-driven reporter gene activity in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. Budesonide also selectively accelerates the decay of eotaxin and MCP-4 mRNA in the human bronchial epithelial cell line BEAS-2B and in primary human bronchial epithelial cells. [1] Budesonide time- and protein synthesis-dependently reduces VEGF secretion and VEGF mRNA expression in both cell types and these effects are inhibited by mifepristone (RU 486), a glucocorticoid receptor antagonist, suggesting that Budesonide reduces VEGF secretion and expression through its glucocorticoid receptor-mediated action. [2] Budesonide causes a dose-dependent, almost total, inhibition of swine dust-induced IL-6 and IL-8 release from epithelial cells and LPS-induced IL-6 and TNF-alpha from alveolar macrophages. [3]

In vivo Budesonide totally prevents the increased production of TNF-alpha, interleukin (IL)-1beta, IL-6, and monocyte chemoattractive protein (MCP)-1 after LPS challenge at both low (2.5 mg/mL/kg) and high (50 mg/mL/kg) concentrations in rats. [4] Budesonide exerts its effects of chemoprevention through growth arrest via Mad2/3 and through apoptosis via Bim/Blk and, by inference, caspase-8/9 in A/J mice. [5]

Protocol

Solubility (25°C)

In vitro DMSO 86 mg/mL (199.75 mM)
Ethanol 19 mg/mL (44.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 430.53
Formula

C25H34O6

CAS No. 51333-22-3
Storage powder
in solvent
Synonyms N/A
Smiles CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04342039 Not yet recruiting Drug: Budesonide Nasal|Other: Placebo Epigenetic Effects of Intranasal Steroids|Environmental Exposure University of British Columbia|Genome British Columbia|Johnson & Johnson Consumer Inc. (J&JCI) September 1 2020 Phase 4
NCT02853578 Suspended Drug: Busonid (budesonide 200mcg and 400mcg) Asthma Ache Laboratorios Farmaceuticos S.A. December 2019 Phase 3
NCT04019106 Not yet recruiting Drug: Budesonide in bovine lipid extract surfactant (BLES) Bronchopulmonary Dysplasia|Respiratory Distress Syndrome in Premature Infant University of Manitoba|Health Sciences Centre Winnipeg Manitoba|St. Boniface General Hospital Research Centre|Manitoba Institute of Child Health|University of Utah|Winnipeg Rh Institute Foundation Inc.|BLES Biochemicals Inc. October 15 2019 Phase 1|Phase 2
NCT04163978 Recruiting Drug: Nitric Oxide|Drug: Budesonide Chronic Sinusitis Sanotize Research and Development corp. October 27 2019 Phase 2
NCT03934333 Completed Drug: BDA MDI 160/180 mcg|Drug: Pulmicort Flexhaler 180 mcg Relative Bioavailability AstraZeneca May 16 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID