Catalog No.S1500 Synonyms: NSC-39470, SCH-4831

Betamethasone  Chemical Structure

Molecular Weight(MW): 392.46

Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Betamethasone is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Glucocorticoid receptor [1]
In vitro

Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. [1]

In vivo Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. [1] Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. [2] Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. [3] Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. [4] Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. [5]


Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 10 mg/mL (25.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46


CAS No. 378-44-9
Storage powder
in solvent
Synonyms NSC-39470, SCH-4831

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03979196 Recruiting Other: Inpatient Management|Other: Outpatient Management Preterm Birth|Pregnancy High Risk Sunnybrook Health Sciences Centre|North York General Hospital June 6 2019 Not Applicable
NCT03476746 Completed Drug: LEO 90100 foam|Drug: Dovobet® ointment Healthy LEO Pharma March 20 2018 Phase 1
NCT02897076 Recruiting Drug: betamethasone 24 mg|Drug: 12mg betamethasone +placebo Neonatal Complications Assistance Publique - Hôpitaux de Paris January 2017 Phase 3
NCT03119454 Completed Drug: Diprospan Pharmacological Action Federal State Budgetary Scientific Institution Scientific Research Institute of Rheumatology|Institute of Biomedical Chemistry Russia|The League of Clinical Research Russia October 2016 --
NCT02948309 Recruiting Drug: Mistletoe extract (Iscador Qu)|Drug: Placebo Pancreatic Cancer Karolinska University Hospital|University of Witten/Herdecke|Karolinska Institutet|Regional Cancer Centre Stockholm Gotland|Stiftelsen Konung Gustaf V:s Jubileumsfond för cancerforskning|Signe & Ane Gyllenbergs Stiftelse|Ekhagastiftelsen|Dagmar Ferbs Minnesfond|Cancerforskningsfonden i Norrland|Immunpathologisches Labor University Tübingen Prof. Dr. med. R. Klein June 2016 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID