For research use only.
Catalog No.S1500 Synonyms: NSC-39470, SCH-4831
CAS No. 378-44-9
Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Purity & Quality Control
Choose Selective Glucocorticoid Receptor Inhibitors
|Description||Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.|
Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. 
|In vivo||Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep.  Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats.  Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain.  Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%.  Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. |
-  Schwab M, et al. J Physiol,?000, 528(Pt 3), 619-632.
-  Xie W, et al. Ann Clin Lab Sci,?006, 36(1), 39-46.
-  Antonow-Schlorke I, et al. Neurosci Lett,?001, 297(3), 147-150.
|In vitro||DMSO||79 mg/mL (201.29 mM)|
|Ethanol||10 mg/mL (25.48 mM)|
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In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
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|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04645979||Not yet recruiting||Other: Online survey||Rhinitis Allergic||Bayer||November 20 2020||--|
|NCT04492072||Recruiting||Drug: Oxytocin|Drug: Misoprostol||Cesarean Section|Misoprostol|Oxytocin|High Risk Pregnancy||Thomas Jefferson University||August 17 2020||Not Applicable|
|NCT04212312||Not yet recruiting||--||Twin; Complicating Pregnancy||Rambam Health Care Campus||February 1 2020||--|
|NCT03979196||Recruiting||Other: Inpatient Management|Other: Outpatient Management||Preterm Birth|Pregnancy High Risk||Sunnybrook Health Sciences Centre|North York General Hospital||June 6 2019||Not Applicable|
|NCT03476746||Completed||Drug: LEO 90100 foam|Drug: Dovobet® ointment||Healthy||LEO Pharma||March 20 2018||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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