Buspirone HCl

For research use only.

Catalog No.S4256

1 publication

Buspirone HCl Chemical Structure

CAS No. 33386-08-2

Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.

Size Price Stock Quantity  
EUR 95 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Selleck's Buspirone HCl has been cited by 1 publication

Purity & Quality Control

Choose Selective 5-HT Receptor Inhibitors

Biological Activity

Description Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect, used for anxiety disorders.
5-HT1A [1]
In vitro

Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. [1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. [2]

In vivo Buspirone (3 mg/rat, i.p.) dose dependently and completely inhibits shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus of rats, a brain region rich in somatodendritic 5-HT1A receptors. [3] Buspirone (20 mg/kg) decreases immobility in the rat forced swim test. [4] Buspirone is a serotonergic (5HT(1A) receptor agonist) anxiolytic drug with some D(2) dopaminergic effect in a zebrafish model of anxiety. [5] Buspirone dose-dependently reduces LID and improved l-DOPA-related motor performance due to action at the 5-HT(1A) receptor in l-DOPA-primed rats. Buspirone delayes LID development while improving l-DOPA's anti-parkinsonian efficacy indicating the potential long-term benefits of 5-HT(1A) agonists for reduction of l-DOPA-related side effects in l-DOPA-naive rats. [6]


Solubility (25°C)

In vitro DMSO 84 mg/mL (199.07 mM)
Water 84 mg/mL (199.07 mM)
Ethanol 36 mg/mL (85.31 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 421.96


CAS No. 33386-08-2
Storage powder
in solvent
Synonyms N/A
Smiles C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03444831 Completed Drug: Buspirone|Drug: Placebo Oral Tablet Dyspepsia Isfahan University of Medical Sciences March 1 2016 Phase 4
NCT02483598 Terminated Drug: Buspirone|Drug: Buspirone and Grapefruit Juice Gastric Bypass North Dakota State University|Neuropsychiatric Research Institute Fargo North Dakota June 2015 Phase 4
NCT01699828 Completed Drug: Buspirone|Drug: Placebo Smoking Cessation|Tobacco Use Cessation Centre for Addiction and Mental Health October 2012 Phase 1|Phase 2
NCT01496612 Terminated Drug: Buspirone Anxiety Disorder|Seizures|Epilepsy|Partial Epilepsy|Depression National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) November 22 2011 Phase 2
NCT00873509 Completed Drug: Buspirone|Drug: Placebo Autistic Disorder Chugani Diane C.|National Institute of Neurological Disorders and Stroke (NINDS) May 2009 Phase 2|Phase 3
NCT00174226 Completed Drug: Atomoxetine|Drug: Buspirone Attention Deficit Disorder With Hyperactivity Pfizer November 2004 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

5-HT Receptor Signaling Pathway Map

Related 5-HT Receptor Products

Tags: buy Buspirone HCl | Buspirone HCl ic50 | Buspirone HCl price | Buspirone HCl cost | Buspirone HCl solubility dmso | Buspirone HCl purchase | Buspirone HCl manufacturer | Buspirone HCl research buy | Buspirone HCl order | Buspirone HCl mouse | Buspirone HCl chemical structure | Buspirone HCl mw | Buspirone HCl molecular weight | Buspirone HCl datasheet | Buspirone HCl supplier | Buspirone HCl in vitro | Buspirone HCl cell line | Buspirone HCl concentration | Buspirone HCl nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID