Berberine chloride hydrate

Catalog No.S5967 Synonyms: Natural Yellow 18 chloride hydrate

For research use only.

Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.

Berberine chloride hydrate Chemical Structure

CAS No. 68030-18-2

Selleck's Berberine chloride hydrate has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Targets
Caspase 3 [1]
()
Caspase 8 [1]
()
PARP [1]
()
cytochrome c [1]
()
c-IAP1 [1]
()
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Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 78 mg/mL
(200.08 mM)
Water 39 mg/mL
(100.04 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 389.83
Formula

C20H20ClNO5

CAS No. 68030-18-2
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03281096 Unknown status Drug: Berberine hydrochloride|Drug: Placebo Colorectal Adenomas xiaohua li|Xijing Hospital of Digestive Diseases August 29 2017 Phase 2|Phase 3
NCT02806999 Unknown status Drug: Berberine; Insulin|Drug: Insulin Hyperglycemia Guangdong Provincial People''s Hospital July 2016 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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