Home Immunology & Inflammation Anti-infection inhibitor - Caspase activator - PARP modulator - P450 (e.g. CYP17) activator - IAP inhibitor - Bcl-2 inhibitor - p38 MAPK activator Berberine chloride hydrate

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Berberine chloride hydrate Anti-infection inhibitor

Cat.No.S5967

Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
Berberine chloride hydrate Anti-infection inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 389.83

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S596701 Water]39 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 389.83 Formula

C20H20ClNO5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 68030-18-2 -- Storage of Stock Solutions

Synonyms Natural Yellow 18 chloride hydrate Smiles O.[Cl-].COC1=C(OC)C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(OCO5)C=C4CC3

Solubility

In vitro
Batch:

Water : 39 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
Caspase 3 [1]
Caspase 8 [1]
PARP [1]
cytochrome c [1]
c-IAP1 [1]
Bcl-2 [1]
Bcl-XL [1]
TopI [2]
TopII [2]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06273241 Not yet recruiting
Pharmacokinetic Study in Healthy Volunteers
University Medicine Greifswald
 March 4 2024 Not Applicable
NCT05845931 Recruiting
Pharmacokinetic Study in Healthy Volunteers
University Medicine Greifswald
 May 5 2023 Not Applicable
NCT05480670 Completed
Polycystic Ovary Syndrome
Ayub Teaching Hospital
 November 1 2022 Not Applicable
NCT05463003 Completed
Pharmacokinetic Study in Healthy Volunteers
University Medicine Greifswald
 July 19 2022 Not Applicable

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