Berberine chloride hydrate
For research use only.
Catalog No.S5967 Synonyms: Natural Yellow 18 chloride hydrate
CAS No. 68030-18-2
Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
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|Description||Berberine (Natural Yellow 18) chloride hydrate is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.|
|In vitro||DMSO||78 mg/mL (200.08 mM)|
|Water||39 mg/mL (100.04 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Natural Yellow 18 chloride hydrate|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03281096||Unknown status||Drug: Berberine hydrochloride|Drug: Placebo||Colorectal Adenomas||xiaohua li|Xijing Hospital of Digestive Diseases||August 29 2017||Phase 2|Phase 3|
|NCT02806999||Unknown status||Drug: Berberine; Insulin|Drug: Insulin||Hyperglycemia||Guangdong Provincial People''s Hospital||July 2016||Phase 4|
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