Home GPCR & G Protein Cannabinoid Receptor agonist Bay 59-3074

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Bay 59-3074 Cannabinoid Receptor agonist

Cat.No.S0412

Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 55.4 nM, 48.3 nM and 45.5 nM at rat and human CB1 and human CB2 receptors, respectively. This compound displays analgesic properties.
Bay 59-3074 Cannabinoid Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 453.36

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S041201 DMSO]91 mg/mL]false]Ethanol]91 mg/mL]false]Water]Insoluble]false Purity: 99.51%
99.51

Chemical Information, Storage & Stability

Molecular Weight 453.36 Formula

C18H13F6NO4S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 406205-74-1 -- Storage of Stock Solutions

Synonyms N/A Smiles C1=CC(=CC(=C1)OS(=O)(=O)CCCC(F)(F)F)OC2=CC=CC(=C2C#N)C(F)(F)F

Solubility

In vitro
Batch:

DMSO : 91 mg/mL ( (200.72 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 91 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
human CB2 receptor [1]
(Cell-free assay)
45.5 nM(Ki)
human CB1 receptor [1]
(Cell-free assay)
48.3 nM(Ki)
rat CB1 receptor [1]
(Cell-free assay)
55.4 nM(Ki)
References

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