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Bufexamac

Name: Bufexamac
Brand: Selleck Chemicals
SKU: S3023
Rating: 5 (5 reviews)

Catalog No.S3023

For research use only.

Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

CAS No. 2438-72-4

Selleck's Bufexamac has been cited by 5 Publications

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COX Signaling Pathway Map

Biological Activity

Description

Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

Features

A specific inhibitor of class IIB histone deacetylases.

Targets

IFN-α ^[1]

8.9 μM

In vitro

Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. ^[1] Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. ^[2]

Protocol (from reference)

References

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	223.27
Formula	C₁₂H₁₇NO₃
CAS No.	2438-72-4
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CCCCOC1=CC=C(C=C1)CC(=O)NO

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In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

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