Home Neuronal Signaling COX inhibitor - IFN inhibitor Bufexamac

Bufexamac

Catalog No.S3023

For research use only.

Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.

Bufexamac Chemical Structure

CAS No. 2438-72-4

Selleck's Bufexamac has been cited by 5 Publications

2 Customer Reviews

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Biological Activity

Description Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
Features A specific inhibitor of class IIB histone deacetylases.
Targets
IFN-α [1]
8.9 μM
In vitro

Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. [1] Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

 DMSO 45 mg/mL
(201.54 mM)
Water Insoluble
Ethanol '3 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 223.27
Formula

C12H17NO3
CAS No. 2438-72-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCOC1=CC=C(C=C1)CC(=O)NO

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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