Bavdegalutamide (ARV-110)

Catalog No.S6965

For research use only.

Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.

Bavdegalutamide (ARV-110) Chemical Structure

CAS No. 2222112-77-6

Purity & Quality Control

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Biological Activity

Description Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
Targets
AR [1]
(Cell-free assay)
1 nM(DC50)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 812.29
Formula

C41H43ClFN9O6

CAS No. 2222112-77-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05177042 Recruiting Drug: ARV-110 in Combination with Abiraterone Prostate Cancer Metastatic Arvinas Androgen Receptor Inc.|Arvinas Inc. February 1 2022 Phase 1
NCT03888612 Recruiting Drug: ARV-110 Prostate Cancer Metastatic Arvinas Androgen Receptor Inc.|Arvinas Inc. March 1 2019 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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