bpV (HOpic)
Synonyms: Bisperoxovanadium (HOpic)
bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively.
bpV (HOpic) Chemical Structure
CAS No. 722494-26-0
Purity & Quality Control
bpV (HOpic) Related Products
| Related Products | SF1670 VO-Ohpic trihydrate | Click to Expand |
|---|---|---|
| Related Compound Libraries | Kinase Inhibitor Library PI3K/Akt Inhibitor Library Apoptosis Compound Library Cell Cycle compound library NF-κB Signaling Compound Library | Click to Expand |
Biological Activity
| Description | bpV (HOpic) (Bisperoxovanadium (HOpic)) is a potent inhibitor of PTEN with an IC50 of 14 nM. The IC50s for PTP-β and PTP-1B are about 350- and 1800-fold higher than the IC50 for PTEN, respectively. | ||
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| Targets |
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| In vitro | ||||
| In vitro | 1 μM BpV(Hopic) treatment is capable of increasing the in vitro migration of C2C12 myoblasts, without significantly reducing their ability to differentiate and fuse into multinucleated myotubes. The effects on myoblast migration is in conjuction with enhanced AKT and ERK1/2 signaling[2]. | |||
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| Cell Research | Cell lines | C2C12 myoblasts | ||
| Concentrations | 1 μM or 10 μM | |||
| Incubation Time | 72 h | |||
| Method | C2C12 myoblasts are grown to high confluency and triggered to differentiate in the presence of DM, supplemented with 1 μM or 10 μM BpV(Hopic). |
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| In Vivo | ||
| In vivo | Pharmacological inhibition of PTEN with bpV(HOpic) exacerbates renal dysfunction and promotes tubular damage in mice with IRI(renal ischemia/reperfusion injury) compared with vehicle-treated mice with IRI. PTEN inhibition enhances tubular cell apoptosis in kidneys with IRI, which is associated with excessive caspase-3 activation. Furthermore, PTEN inhibition expands the infiltration of neutrophils and macrophages into kidneys with IRI, which is accompanied by increased expression of the proinflammatory molecules[3]. | |
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| Animal Research | Animal Models | mouse model of ischemia-reperfusion injury (C57BL/6 mice, 8-12 weeks old) |
| Dosages | 200 μg/kg | |
| Administration | i.p. | |
Chemical Information & Solubility
| Molecular Weight | 347.24 | Formula | C6H4NO8V.2K |
| CAS No. | 722494-26-0 | SDF | -- |
| Smiles | [K+].[K+].OC1=CC=C2N(=C1)|[V+3]|3|4(|[O-][O-]|3)(|[O-][O-]|4)(|[O-]C2=O)=O | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
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In vitro |
Water : 69 mg/mL DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) Ethanol : Insoluble |
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In vivo Add solvents to the product individually and in order. |
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