Bismuth Subcitrate Potassium

For research use only.

Catalog No.S4093

1 publication

Bismuth Subcitrate Potassium Chemical Structure

CAS No. 880149-29-1

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

Selleck's Bismuth Subcitrate Potassium has been cited by 1 publication

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Biological Activity

Description Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
In vitro

Colloidal Bismuth Subcitrate is crystallized in dilute HCl at pH 3, and unique assembly of three basic bismuth citrate dimeric units ([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D polymer, the solubility of Colloidal Bismuth Subcitrate in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3. [1] Bismuth Subcitrate is effective against the 12 C. pyloridis strains with MIC50 of 8 μg/mL. Bismuth Subcitrate combined with oxolinic acid exhibits synergistic activity against the 12 C. pyloridis strains. [2] Colloidal bismuth subcitrate (5 mg/mL) significantly increases the frequencies of sister-chromatid exchange (SCE) and micronucleus rate in peripheral lymphocytes compared with controls in human whole blood cultures. [3] Bismuth Subcitrate (100μM) inhibits Helicobacter pyloriF1-ATPase activity, and inhibition is prevented and reversed by the mercaptan glutathione, indicating that Bismuth Subcitrate interfere with sulfhydryl groups of the enzyme. [4] Colloidal Bismuth Subcitrate (150 mg/mL) inhibits the lipolytic activity of C. pylori filtrate, causing a 21% reduction in lipase activity and a 60% reduction in the activity of phospholipase A. [5]

Protocol

Solubility (25°C)

In vitro Water 100 mg/mL (127.76 mM)
DMSO Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 782.67
Formula

C12H8BiK5O14

CAS No. 880149-29-1
Storage powder
in solvent
Synonyms N/A
Smiles C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+].[K+].[K+].[Bi+3]

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID