2,3-Butanedione-2-monoxime

Catalog No.S3699 Synonyms: Diacetyl monoxime, Diacetylmonoxime

2,3-Butanedione-2-monoxime Chemical Structure

Molecular Weight(MW): 101.10

2,3-Butanedione monoxime (BDM) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.

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Description 2,3-Butanedione monoxime (BDM) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II and inhibits skeletal and cardiac muscle contraction.
Targets
skeletal muscle myosin-II [1]
()
In vitro

BDM inhibits skeletal muscle myosin-II, but it does not inhibit the ATPase activity of the other myosins. BDM has a broad effect on many non-myosin proteins (many uncharacterized), and thus should not be used in whole-cell experiments as a myosin inhibitor[1]. BDM inhibits the L-type Ca2+-channel and reduces the opening probability, thereby increasing the closed time of this particular channel. BDM drives nonspecific protein dephosphorylation of many cellular proteins, including ion channels[2].

In vivo BDM significant lowers the blood pressure in normo- and hypertensive rats. BDM has been shown to improve right atrial function in a porcine model of allogenic heart transplantation[2].

Protocol

Animal Research:[2]
- Collapse
  • Animal Models: Male SD rats
  • Formulation: freshly autoclaved water
  • Dosages: 250 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 20 mg/mL (197.82 mM)
Water 20 mg/mL (197.82 mM)
Ethanol 20 mg/mL (197.82 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 101.10
Formula

C4H7NO2

CAS No. 57-71-6
Storage powder
in solvent
Synonyms Diacetyl monoxime, Diacetylmonoxime

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID