Bohemine

Catalog No.S6531

Bohemine Chemical Structure

Molecular Weight(MW): 340.42

Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.

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Biological Activity

Description Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively.
Targets
Cdk9/cyclin T1 [1]
()
Cdk2/cyclin E [1]
()
Cdk2/cyclin A [1]
()
2.7 μM 4.6 μM 83 μM
In vitro

Treatment of HCT116 cells bohemine results in a 11% to 15% loss of cells from the S phase of the cell cycle with a 6% to 17% increase in the proportion of cells in the G2-M phase after 24 hours of treatment, as determined by propidium iodide staining and analysis by flow cytometry.Bohemine reduces RB phosphorylation at pharmacologically relevant concentrations that inhibit cell growth in cell culture[1].

In vivo

Given i.v., the single dose maximum tolerated dose for bohemine is 100 mg/kg. Following administration of 50 mg/kg i.v. bohemine to BALB/c− mice, Cmax is 72,308 nM, observed clearance is 0.23 L/h and T1/2 is 1.39 h[1].

Protocol

Animal Research:

[1]

- Collapse
  • Animal Models: BALB/c-mice bearing the s.c. colon 26 murine tumor
  • Formulation: HCl/saline
  • Dosages: 50 mg/kg
  • Administration: IV
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 68 mg/mL (199.75 mM)
Ethanol 68 mg/mL (199.75 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 340.42
Formula

C18H24N6O

CAS No. 189232-42-6
Storage powder
in solvent
Synonyms N/A

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Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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CDK Signaling Pathway Map

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