Batimastat (BB-94)

Catalog No.S7155

For research use only.

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.

Batimastat (BB-94) Chemical Structure

CAS No. 130370-60-4

Selleck's Batimastat (BB-94) has been cited by 23 publications

Purity & Quality Control

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Biological Activity

Description Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.
Targets
MMP-1 [1]
()
MMP-2 [1]
()
MMP-9 [1]
()
MMP-7 [1]
()
MMP-3 [1]
()
3 nM 4 nM 4 nM 6 nM 20 nM
In vitro

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. [1]Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 insect cells MYXGeY5kfGmxbjDhd5NigQ>? M37nUGlvcGmkaYTpc44hd2ZiaIXtZY4hdWG2cnn4JI1mfGGubH;wdo91\WG|ZT2yJIV5eHKnc4Pl[EBqdiCVZkmgbY5{\WO2IHPlcIx{NCCLQ{WwQVAvODF|IN88US=> M4TRTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3NUiyOFM3Lz5zNUW4NlQ{PjxxYU6=
Sf9 insect cells NIHReW5HfW6ldHnvckBie3OjeR?= NXjaPFZKUW6qaXLpeIlwdiCxZjDoeY1idiCvYYTybZghdWW2YXzsc5Bzd3SnYYPlMVkh\XiycnXzd4VlKGmwIGPmPUBqdnOnY4SgZ4VtdHNuIFnDOVA:OC5yMkWg{txO Mm\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3OEK0N|YoRjF3NUiyOFM3RC:jPh?=
HT1080 M2fPVmZ2dmO2aX;uJIF{e2G7 NGLxNWlKdiC4aYTyc{BqdmirYnn0c5J6KGGldHn2bZR6KGGpYXnud5QhdWG2cnn4JI1mfGGubH;wdo91\WG|ZTCyJIl{d2yjdHXkJIZzd21iaIXtZY4hUFRzMEiwJIZq[nKxc3HyZ49u[SClZXzsd{BqdmS3Y3XkJJdqfGhiVF7GMEBKSzVyPUCuNFAzOc7:TR?= NX;SNZVpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3N|cyOid-OUi3N|cyOjxxYU6=
white blood cells NY\acol6SW62aX\pZpJwfGmlIHHzd4F6 NVPROldjOjVidH:gNVUxKG2pL3vn MkDVNVMh\GG7cx?= NGKzTFZCdnSrZnnido91cWNiYXP0bZZqfHliaX6gZoxmd227Y3nuMYlv\HWlZXSgR|U4SjFxNjDtc5V{\SCvb3TlcEBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJdpcXSnIHLsc49lKGOnbHzzJIlvKGK{b37jbI9idH[nb3zhdkBt[X[jZ3WgZZQhOjVidH:gNVUxKG2pL3vnMEBxdyCkaXSgZYRucW6rc4TldoVlKDJiaILzJJBzcW:{IHLs[Y9ugWOrbjDpcoR2[3Srb36g[o9zKDF|IHThfZM> NYL1[pZDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1PFI1OzZpPkG1OVgzPDN4PD;hQi=>
RPM18866 NYDLTmEzTnWwY4Tpc44h[XO|YYm= NXXD[W9XXGW|dHXkJIZweiCrbnjpZol1cW:wIHHnZYlve3RiQ1SyN{ApUWeHIILlZ4VxfG:{KTDwdo91\W:ueYPpd{BqdiCvZX3idoFv\XNiZHXybZZm\CCocn;tJHJRVTF6OE[2JINmdGy|IDigZUBpfW2jbjDCMYNmdGxibHnu[UktKEmFNUC9NE4y|ryP M3G4WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl6N{G2NlIoRjl6N{G2NlI9N2F-
RPM18866 MXHGeY5kfGmxbjDhd5NigQ>? Mlf1TY5pcWKrdHnvckBi\2GrboP0JGNFOjNiKFnnSUBz\WOncITvdkkheHKxdHXvcJl{cXNiaX6gcYVu[nKjbnXzJIRmemm4ZXSg[pJwdSCUUF2xPFg3PiClZXzsd{whUUN3ME2wMlHPxE1? NW\3fZlVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3NVYzOyd-OUi3NVYzOzxxYU6=
In vivo Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. [1] In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).[3]Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures. [4]

Protocol (from reference)

Animal Research:[3]
  • Animal Models: Nude mouse
  • Dosages: 30mg/ml
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 96 mg/mL
(200.98 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 477.64
Formula

C23H31N3O4S2

CAS No. 130370-60-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)CC(C(CSC1=CC=CS1)C(=O)NO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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