Batimastat (BB-94)

For research use only.

Catalog No.S7155

21 publications

Batimastat (BB-94) Chemical Structure

CAS No. 130370-60-4

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.

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Selleck's Batimastat (BB-94) has been cited by 21 publications

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Biological Activity

Description Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Also inhibits the activitity of other metalloproteases, such as ADAM17.
Targets
MMP-1 [1]
()
MMP-2 [1]
()
MMP-9 [1]
()
MMP-7 [1]
()
MMP-3 [1]
()
3 nM 4 nM 4 nM 6 nM 20 nM
In vitro

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. [1]Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 insect cells NWXYOINMTnWwY4Tpc44h[XO|YYm= MVXJcohq[mm2aX;uJI9nKGi3bXHuJI1ifHKreDDt[ZRidGyxcILveIVie2VvMjDlfJBz\XO|ZXSgbY4hW2Z7IHnud4VkfCClZXzsd{whUUN3ME2wMlAyOyEQvF2= MkK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV3OEK0N|YoRjF3NUiyOFM3RC:jPh?=
Sf9 insect cells M3zifmZ2dmO2aX;uJIF{e2G7 NEn3emNKdmirYnn0bY9vKG:oIHj1cYFvKG2jdILpfEBu\XSjbHzvdJJwfGWjc3WtPUBmgHC{ZYPz[YQhcW5iU3[5JIlve2WldDDj[YxteyxiSVO1NF0xNjB{NTFOwG0> NXTW[pVvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUW1PFI1OzZpPkG1OVgzPDN4PD;hQi=>
HT1080 M3rCVWZ2dmO2aX;uJIF{e2G7 M{LPTmlvKH[rdILvJIlvcGmkaYTvdpkh[WO2aY\peJkh[WejaX7zeEBu[XS{aYigcYV1[Wyub4Dyc5Rm[XOnIEKgbZNwdGG2ZXSg[pJwdSCqdX3hckBJXDFyOECg[oljem:|YYLjc41iKGOnbHzzJIlv\HWlZXSge4l1cCCWTl[sJGlEPTB;MD6wNFIy|ryP MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDd|N{GyK|46QDd|N{GyQE9iRg>?
white blood cells NHG1S2xCdnSrZnnido91cWNiYYPzZZk> M134d|I2KHSxIEG1NEBu\y:tZx?= NH25SJcyOyCmYYnz NYK4PHhRSW62aX\pZpJwfGmlIHHjeIl3cXS7IHnuJIJt\W:veXPpck1qdmS3Y3XkJGM2P0JzL{[gcY92e2VibX;k[Ywh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB4cGm2ZTDicI9w\CClZXzsd{BqdiCkcn;uZ4hw[Wy4ZX;sZZIhdGG4YXflJIF1KDJ3IITvJFE2OCCvZz;r[{wheG9iYnnkJIFldWmwaYP0[ZJm\CB{IHjyd{BxemmxcjDicIVwdXmlaX6gbY5lfWO2aX;uJIZweiBzMzDkZZl{ MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPTV6MkSzOkc,OTV3OEK0N|Y9N2F-
RPM18866 NVTuSZlmTnWwY4Tpc44h[XO|YYm= M2S5e3Rme3SnZDDmc5IhcW6qaXLpeIlwdiCjZ3HpcpN1KEOGMkOgLGloTSC{ZXPldJRweilicILveIVwdHm|aYOgbY4hdWWvYoLhcoV{KGSncnn2[YQh\nKxbTDSVG0yQDh4NjDj[YxteyBqIHGgbJVu[W5iQj3j[YxtKGyrbnWpMEBKSzVyPUCuNe69VQ>? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDdzNkKyK|46QDdzNkKyQE9iRg>?
RPM18866 NWHjXHRnTnWwY4Tpc44h[XO|YYm= NIrTSoRKdmirYnn0bY9vKGGpYXnud5QhS0R{MzCoTYdGKHKnY3XweI9zMSCycn;0[Y9tgXOrczDpckBu\W2kcnHu[ZMh\GW{aY\l[EBnem:vIGLQUVE5QDZ4IHPlcIx{NCCLQ{WwQVAvOc7:TR?= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDdzNkKzK|46QDdzNkKzQE9iRg>?

... Click to View More Cell Line Experimental Data

In vivo Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. [1] In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).[3]Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures. [4]

Protocol

Animal Research:[3]
- Collapse
  • Animal Models: Nude mouse
  • Dosages: 30mg/ml
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 96 mg/mL (200.98 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
2mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 477.64
Formula

C23H31N3O4S2

CAS No. 130370-60-4
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)CC(C(CSC1=CC=CS1)C(=O)NO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC

In vivo Formulation Calculator (Clear solution)

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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MMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID