BMS-754807

For research use only.

Catalog No.S1124

40 publications

BMS-754807 Chemical Structure

CAS No. 1001350-96-4

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.

Selleck's BMS-754807 has been cited by 40 publications

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Choose Selective IGF-1R Inhibitors

Biological Activity

Description BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
Features Muti-inhibitor of the IGR-1R/IR family.
Targets
Insulin Receptor [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
TrkB [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
TrkA [1]
(Cell-free assay)
1.7 nM 1.8 nM 4.1 nM 5.6 nM 7.4 nM
In vitro

BMS-754807 effectively inhibits the growth of a broad range of human tumor cell lines of different histologic origins including mesenchymal (Ewing's, rhabdomyosarcoma, neuroblastoma, and liposarcoma), epithelial (breast, lung, pancreatic, colon, and gastric), and hematopoietic (multiple myeloma and leukemia), the IC50 values range from 5 nM to 365 nM for the most sensitive cell lines. BMS-754807 inhibits proliferation of IGF-1R-Sal cells and RH41 cells with IC50 of 7 nM and 5 nM. BMS-754807 inhibits phosphorylation of IGF-1R in IGF-1R-Sal cells, Rh41 and Geo with IC50 of 13 nM, 6 nM and 21 nM. BMS-754807 inhibits phosphorylation of Akt in IGF-1R-Sal cells, Rh41 and Geo with IC50 of 22 nM, 13 nM and 16 nM. BMS-754807 induces greater apoptosis in Rh41 cells by 24 hours as indicated by an increased sub-G1 peak (23.1%), compared with control (2.4%). [1] BMS-754807 inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK (IC50 = 13nM) in the IGF-Sal cell line with IC50 consistent with the antiproliferative IC50 (7 nM) in this cell line. The crystal structure of BMS-754807 cocrystallized with the kinase domain of IGF-1R shows that the donor/acceptor/donor hydrogen bond triad with Met1052 and Glu1050 within the hinge region of the kinase. [2] BMS-754807 shows a median EC50 value of 0.62 μM against 23 cell lines in the pediatric preclinical testing program (PPTP). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
IGF-Sal MULLbY5ie2ViYYPzZZk> M1rHXYlvcGmkaYTzJJRp\SCyaH;zdIhwenmuYYTpc44hd2ZiSVfGMVFTKCiLQ{WwJF0hOTOwTTmgZY5lKHSqZTDkc5dve3S{ZXHtJJRiemendIOgRYt1KCiLQ{WwJF0hOjKwTTmgZY5lKE2DUFugLGlEPTBiPTCxN45OMQ>? NIjqT5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUe3PFAzPCd-MUm3O|gxOjR:L3G+
IGF-Sal NEDWU21Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1uyfWlEPTB;NzDuUS=> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTd5OECyOEc,OTl5N{iwNlQ9N2F-
CCRF-CEM (ALL) NXvxUJVkT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= Mn7HglUh|ryP M3\BbGROW09? MoTPTWM2OD1zLkKzPUDPxE1? NXzt[JA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
PC3 NFjKWJJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MU\+OUDPxE1? Mkj4SG1UVw>? MWjJR|UxRTBwOU[1JO69VQ>? NGHLU2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
JD M2HPbWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGT4flJ,PSEQvF2= NWHLfGxwTE2VTx?= MXfJR|UxRTBwM{mxJO69VQ>? NXXTOG9xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
DU145 NHHPTVRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M{HmfZ42KM7:TR?= MVjEUXNQ MnzqTWM2OD1zLkS2OUDPxE1? NFXIcYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
KAG MmnBS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFjzcHR,PSEQvF2= NHjaUWNFVVOR MUfJR|UxRTFwNk[1JO69VQ>? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
K-562 (CML) M330dGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXywfGRXhjVizszN Mlq1SG1UVw>? NF3hWlNKSzVyPUKuN|AzKM7:TR?= MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
B6-P210 (Murine ALL) M2\NOWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MX7+OUDPxE1? MofjSG1UVw>? NXPOTHRyUUN3ME2xMlI6OyEQvF2= M1vxe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
LN CAP-FGC Mkn2S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NHT3WYN,PSEQvF2= MXjEUXNQ NF\6TndKSzVyPUGuOFM1KM7:TR?= NVvmPZd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
VW NFjhXYRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MUD+OUDPxE1? MWnEUXNQ M2ruNGlEPTB;MD6wNVkh|ryP NGSzVYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
MV411 (B Myelomonocytic) NXjQRYdyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MXz+OUDPxE1? MUXEUXNQ MoTITWM2OD1yLkOzJO69VQ>? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
MDA-PCa-2b M1vaTmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NG\OfWF,PSEQvF2= NFnSZlVFVVOR MlXUTWM2OD1yLkC5PEDPxE1? NFLI[FY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
LG Mlj0S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFyy[Wx,PSEQvF2= NGLnc2hFVVOR MkDsTWM2OD1yLkCzPEDPxE1? NH\pZZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
RS411 (B cell precursor-ALL) NULLVG1[T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUK2d2xMhjVizszN MX\EUXNQ MnXNTWM2OD1yLkGwNkDPxE1? MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
22-r-1 MnPtS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MkfqglUh|ryP NUjSVm94TE2VTx?= MX7JR|UxRTBwMUe1JO69VQ>? NH3EbG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
5838 NF;h[INIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MknQglUh|ryP Mn7ySG1UVw>? MkW0TWM2OD1yLkCzOEDPxE1? MkP2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
P388 (Murine) NGGxeZpIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVr+OUDPxE1? MUHEUXNQ M1ThWWlEPTB;ND6yO{DPxE1? NULQPINLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
A2780/S MWHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MU\+OUDPxE1? NWX2WGJjTE2VTx?= NEXjNJlKSzVyPUCuNVIzKM7:TR?= NH33OmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
RDES M2i5dmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGPPT3J,PSEQvF2= MX;EUXNQ MkXkTWM2OD1yLkCxNkDPxE1? NWTPPXh4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
B6-T315I (Murine B-ALL) M2jhNmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MX\+OUDPxE1? NX25eVU{TE2VTx?= M3XJSGlEPTB;Mj64N{DPxE1? M2TjOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
TOV 112D M1;2Smdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MoPSglUh|ryP M{jEbGROW09? NETlWZhKSzVyPUKuNVQ3KM7:TR?= NH3nbng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
TC32 M4LuS2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXThe|VihjVizszN MWTEUXNQ NVrrS2ZtUUN3ME2wMlAxQCEQvF2= NIr1TJc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
HL60 (acute myelocytic) MXnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NVX0WYt3hjVizszN M2nx[2ROW09? NIjRc41KSzVyPUCuNVIh|ryP NWS2bIV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
TOV 21G MXXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? Mor6glUh|ryP M3zyOGROW09? M1fEeGlEPTB;ND6yO|kh|ryP NInRW3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
TC71 NHjEe4lIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M{XI[Z42KM7:TR?= NWXpcHZRTE2VTx?= M{nEc2lEPTB;MD6wNVQh|ryP M1HrUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
HPN-ALL (T-cell) MnrPS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MUn+OUDPxE1? NELIW|RFVVOR M4nKNmlEPTB;MD61NkDPxE1? M2TYV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
A2780R M3[zWWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MVT+OUDPxE1? NGC1bVhFVVOR MkLCTWM2OD1zLkW2OEDPxE1? NEP0d5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Rh1 NFPKenJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MWL+OUDPxE1? M{f1cmROW09? NX7jSGIzUUN3ME2wMlAzPyEQvF2= NVK2cYRZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Kasumi-1 (acute myeloid) MVTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MWj+OUDPxE1? NVnyVGtyTE2VTx?= NXHRdpJlUUN3ME2wMlE3KM7:TR?= M37nWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
sk-ov-3 M4qz[Gdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MoLQglUh|ryP MlziSG1UVw>? NGDRT|lKSzVyPUWuNUDPxE1? M4HvRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
ME Mk\hS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NIP2Z4d,PSEQvF2= MmjQSG1UVw>? M{W5NmlEPTB;MD6wNVUh|ryP NEm2T5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
L1210 (Murine lymphocytic) M3LyTmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MYf+OUDPxE1? MYjEUXNQ NVP6SlJZUUN3ME2yMlM6KM7:TR?= Mo\GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
sw-626 Mn3BS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M1ewSJ42KM7:TR?= MXfEUXNQ NFi3cFBKSzVyPUKuN|A3KM7:TR?= NIjqfII9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
CTR NEmwbWNIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MXL+OUDPxE1? NEPQPFlFVVOR MnHLTWM2OD1yLkK1N{DPxE1? NFTFR|Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
ML2 (Myelomonocytic) Mmf2S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MnHxglUh|ryP MoW5SG1UVw>? NUHncYQzUUN3ME2wMlA6KM7:TR?= NIryZpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
ovcar-3 NXrhcohMT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M1n2XZ42KM7:TR?= NXHmTmpiTE2VTx?= NIrnPItKSzVyPUWg{txO NET5Xo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Rh36 NIixNY9Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NEXjXoZ,PSEQvF2= M{TMPWROW09? NUf2[Gh7UUN3ME2xMlQ{OiEQvF2= NV2wdW82RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
MOLM-13 (acute myeloid) MXPHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MlHvglUh|ryP NHy4dlhFVVOR NIfnWlNKSzVyPUCuOFIh|ryP M2TiPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
ovcar-4 MljvS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFnHOFN,PSEQvF2= MVPEUXNQ NYrRcXdxUUN3ME2xJO69VQ>? M1TBSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Rh41 NVe5Um91T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M2LZcp42KM7:TR?= NYnEZYdwTE2VTx?= NWfVeYplUUN3ME2wMlAxPSEQvF2= M3\XSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Mutz 2 (acute myeloid) MXLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFLTVZd,PSEQvF2= NGjEU2JFVVOR Ml\kTWM2OD1zLkG1JO69VQ>? MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
ovcar-5 M1PVdmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXfNcItbhjVizszN NXToXJc3TE2VTx?= MUDJR|UxRTBwMEWg{txO Mm\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
RD1 NFrmPHBIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MnT0glUh|ryP NIHsXHdFVVOR NE\1XphKSzVyPUCuNFY5KM7:TR?= M{PvOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
OCI-AML 2 (acute myeloid) NXHBW5d[T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NFXKb2d,PSEQvF2= NW\je2pyTE2VTx?= NFvjZ|VKSzVyPUOuN|Mh|ryP M1nkV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
786-O MYLHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFHuco1,PSEQvF2= MlrzSG1UVw>? MkXtTWM2OD1zLk[0O{DPxE1? NWDaT4JmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
A673 M2L0fWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NHfSUlF,PSEQvF2= MX3EUXNQ MUTJR|UxRTBwNEC4JO69VQ>? M1LJS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
TALL-1 (T-cell) MUDHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NIfWUIx,PSEQvF2= M3rhNmROW09? NVeyb4R5UUN3ME2xMlI5KM7:TR?= NIXzcW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
151-B NHm5W29Iem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MlS4glUh|ryP NEK0Xm9FVVOR NHzWb4tKSzVyPUKuOlch|ryP MlvJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
PFSK-1 M4i2XGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NITEe2N,PSEQvF2= NW\uTGN[TE2VTx?= NFfrUIVKSzVyPUCuNVMzKM7:TR?= Ml;xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
THP-1 NFrscllIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVT+OUDPxE1? NXXyOYdLTE2VTx?= NY\YVnFiUUN3ME22MlU5KM7:TR?= M{\YcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
HEK293 M4HFSWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXzXcmpFhjVizszN NEX4[lFFVVOR NILld5RKSzVyPUCuPVE2KM7:TR?= MnPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
DAOY NYPVemJ2T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NHPQbGF,PSEQvF2= M4\SOGROW09? MnLQTWM2OD1zLkm3PUDPxE1? NVvUclRXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
SET2 Mm\5S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MWH+OUDPxE1? NGT0O|BFVVOR MYDJR|UxRTBwMkm4JO69VQ>? MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
HTB-46 M4W0eWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NEPhSZB,PSEQvF2= MUTEUXNQ MW\JR|UxRTVwMkWg{txO NIrXUY49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
SK-NAS NVHOc|N1T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NUe5XIprhjVizszN Mo\6SG1UVw>? NF7zU2ZKSzVyPUCuOFk4KM7:TR?= M1LJSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
CTLL2 M4jsZ2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MWD+OUDPxE1? NHH6UnpFVVOR NYXUTWpPUUN3ME6xMlAxKM7:TR?= NInxeo89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
HTB-47 MnvOS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MWX+OUDPxE1? MkDTSG1UVw>? NVLucYY1UUN3ME2yMlA2PiEQvF2= NWH6[WszRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
LAN-1 MnjvS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MWH+OUDPxE1? M4HSdWROW09? NXO1S5pSUUN3ME2wMlA1KM7:TR?= NXWwZ49sRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
ST486 M2\meWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NFmybId,PSEQvF2= NFW3PFlFVVOR MYPJR|UxRTFwMUmg{txO NWXy[5lJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HS766T NGXodGRIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NY[wTGpqhjVizszN MV7EUXNQ NVLOVXo2UUN3ME2yMlAxOSEQvF2= MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
IMR-32 MnezS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M1nUUJ42KM7:TR?= M4PkPWROW09? MnniTWM2OD1yLkK2NUDPxE1? NX;oR2pXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Daudi (Burkitt's) M{f3VWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NGnRVVN,PSEQvF2= M2r3fmROW09? MnzHTWM2OD1{Lk[zO{DPxE1? M1;KT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Aspc-1 MXzHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NVq5O41rhjVizszN NYfTRmJtTE2VTx?= NXTiOFRWUUN3ME2wMlM4QSEQvF2= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
SK-NSH MmXPS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NUjQXY8yhjVizszN MUXEUXNQ NX7Lco9GUUN3ME2wMlE{QSEQvF2= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
MEC-1 (Chronic B cell) NFLnVFJIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MX;+OUDPxE1? NWHqZ3RyTE2VTx?= MXzJR|UxRTJwNkO3JO69VQ>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
Capan-2 MYjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MYn+OUDPxE1? NVjXb5JZTE2VTx?= NV63T4V{UUN3ME2xMlc4PCEQvF2= MnW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SHSY5Y MYPHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NHew[mp,PSEQvF2= M1jGdmROW09? NXjjT2xUUUN3ME2wMlExPiEQvF2= NFLmZXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
U937 (Histioocytic) Ml\ZS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFLU[ZV,PSEQvF2= MXzEUXNQ MlzuTWM2OD53LkCwJO69VQ>? M{XLUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Bxpc-1 NYDpbVZZT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MmTLglUh|ryP MmnmSG1UVw>? NGfsWo5KSzVyPUGuPVI1KM7:TR?= NWLoXW5SRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Bxpc-3 MUnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? Mm\KglUh|ryP M3rHd2ROW09? NFS2PHFKSzVyPkWuNFAh|ryP M1ixTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
HTB-92 M33icWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MWr+OUDPxE1? NGnW[|FFVVOR M1rXW2lEPTB;MT6wNkDPxE1? M4DWOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
OCI-LY10 (B-cell) M3\nb2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MVT+OUDPxE1? MnTnSG1UVw>? M{P1SGlEPTB;MD60OUDPxE1? NIXkV3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
PANC-1 NGXNbGxIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1OzRp42KM7:TR?= NX\CXJl6TE2VTx?= MUTJR|UxRjVwMECg{txO NIj6fVY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
To184.T MUTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M2XM[542KM7:TR?= M{\kbmROW09? M1vlT2lEPTB;MD60Olkh|ryP M1TTS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
OCI-LY19 (B-cell) MYXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NV:2SHRIhjVizszN M3XpSmROW09? NVLrU5V{UUN3ME2wMlQh|ryP MnHHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
PANC-1 BM NUL1fmg5T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MWP+OUDPxE1? NX3QdnlwTE2VTx?= MmLETWM2OD53LkCwJO69VQ>? M1fG[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
SA-4 NHLJOnBIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NInoRXl,PSEQvF2= NFXWW|ZFVVOR NFnReIlKSzVyPUGuN|AyKM7:TR?= M3nKfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
RPMI 8226 MofZS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NGiybmh,PSEQvF2= NYT5[YRoTE2VTx?= NF31cI1KSzVyPUGuNlk{KM7:TR?= M4\sPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
HPAF-II NHT2[IxIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NUP0c5BZhjVizszN MXPEUXNQ Ml3qTWM2OD1yLk[0OEDPxE1? MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
SHP-77 MlTYS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NF3tSZF,PSEQvF2= NVfJPGtCTE2VTx?= MYrJR|UxRTFwOEi4JO69VQ>? M1TRe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
U266 B1 MknrS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NEfHTHJ,PSEQvF2= NXOzU4x3TE2VTx?= MofHTWM2OD1zLk[2PUDPxE1? NXrudoEzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Hs700t MV;Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NILaO|R,PSEQvF2= Ml\LSG1UVw>? M1z3ZWlEPTB;MD6yN|Eh|ryP NX:5ZpgyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
NCI-446 M{nwNmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M2XwWJ42KM7:TR?= NX;wS3QzTE2VTx?= MXrJR|UxRTFwMUW0JO69VQ>? MmTXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
H929 MYfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M{PmbZ42KM7:TR?= M2\4NGROW09? MV7JR|UxRTBwMEG0JO69VQ>? MkHBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
PL45 NUPJO4JIT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MoHzglUh|ryP Mlu0SG1UVw>? Mn\pTWM2OD1{LkK1OUDPxE1? NX;t[G9NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
NCI-H383 M163SWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MkSxglUh|ryP NWG3V5ozTE2VTx?= NYfk[|FsUUN3ME61MlAxKM7:TR?= NFrNNpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
JJN3 M1\Cbmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M2\Z[542KM7:TR?= MUnEUXNQ MnXqTWM2OD1{LkSzN{DPxE1? NFrUUmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
SU.86.86 MYfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NH\JNYJ,PSEQvF2= MUTEUXNQ MkXLTWM2OD1{Lk[3NkDPxE1? NV\OUpZiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
H1299 M2eyTWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MofqglUh|ryP NVPud29nTE2VTx?= NFvOSG9KSzVyPkWuNFAh|ryP M{C0eFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
MDA-MB-468 MUfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MXn+OUDPxE1? NWDa[2FpTE2VTx?= M4fSOmlEPTB;MD61NFQh|ryP MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
SW1990 M2X3[2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M17lZp42KM7:TR?= M1\tOmROW09? M2HkWmlEPTB;MD64NlYh|ryP Mm[1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Calu-6 NEjDcoxIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MVL+OUDPxE1? MneySG1UVw>? M3jpV2lEPTB-NT6wNEDPxE1? M2\IXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
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NCI-H358 MmrSS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M4PiTJ4yOOLCit88US=> Ml7HSG1UVw>? MkLqTWM2OD1zLkC5JO69VQ>? NUmwSmJ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[5Nlg2PzhpPkK2PVI5PTd6PD;hQi=>
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A549 NWHlb4JnTnWwY4Tpc44h[XO|YYm= NVfuc4p1OC534pEK{txO MlXCSG1UVw>? MXzy[YR2[2W|IIfveY5lKGOub4P1doU> M3mw[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4OUK4OVc5Lz5{NkmyPFU4QDxxYU6=
NCI-H358 NGOwepJHfW6ldHnvckBie3OjeR?= NULzcYxNOC534pEK{txO NVr2ZnB2TE2VTx?= MWny[YR2[2W|IIfveY5lKGOub4P1doU> MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjl{OEW3PEc,OjZ7Mki1O|g9N2F-
IGF1R-SAL NXHWVHNPTnWwY4Tpc44h[XO|YYm= NUPHV4NtUW6qaXLpeIlwdiCxZjDJS2YyWiCrbjDJS2YyWi2VQVygZ4VtdHNuIFnDOVAhRSByLkCwNlEh|ryPLh?= NX33eoxlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC2O|UyOzdpPkKwOlc2OTN5PD;hQi=>
TC32 MoW5dWhVWyCjc4PhfS=> MUnxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBRemmvYYL5JJNkemWnbjDmc5IhXEN|MjDj[Yxtew>? MluzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
SJ-GBM2 MX;xTHRUKGG|c3H5 NFviR4dyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1qtS2JOOiClZXzsdy=> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
A673 MlXLdWhVWyCjc4PhfS=> NYL2UWxkeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IFG2O|Mh[2WubIO= M3zlXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
SK-N-MC M{XoO5FJXFNiYYPzZZk> M4iyfZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KFC{aX3hdpkhe2O{ZXXuJIZweiCVSz3OMW1EKGOnbHzz NECxU209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
NB-EBc1 M4rXVpFJXFNiYYPzZZk> NEizVVByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTlKtSWJkOSClZXzsdy=> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
Saos-2 NWHKT5pXeUiWUzDhd5NigQ>? NYDFZWJIeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IGPhc5MuOiClZXzsdy=> NHe4PHQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
SK-N-SH M1[3c5FJXFNiYYPzZZk> NF7qb2VyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiU1utUk1UUCClZXzsdy=> NXrDfnBCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
NB1643 MmfHdWhVWyCjc4PhfS=> NWDUWHhDeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF7CNVY1OyClZXzsdy=> NFfWU4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
LAN-5 MmWxdWhVWyCjc4PhfS=> NILOcoxyUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCScnntZZJ6KHOlcnXlckBnd3JiTFHOMVUh[2WubIO= NFXpSpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
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OHS-50 MlLrdWhVWyCjc4PhfS=> NWjIe25qeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF;IV{02OCClZXzsdy=> M3\4WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
MG 63 (6-TG R) M{HOepFJXFNiYYPzZZk> NWLxUpJQeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IF3HJFY{KCh4LWTHJHIqKGOnbHzz MlHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
wild type fibroblast cells MmrVdWhVWyCjc4PhfS=> NUfoUXVEeUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiUILpcYFzgSC|Y4Ll[Y4h\m:{IHPvcpRzd2xiSHige4lt\CC2eYDlJIZq[nKxYnzhd5Qh[2WubIO= NF7ZfFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
Rh41 M1W0d5FJXFNiYYPzZZk> MlrjdWhVWyCxZjDw[YRq[XS{aXOgZ4Fv[2W{IHPlcIwhdGmwZYOgeI8hcWSnboTp[pkhdXWudHnwcIUhd3Cyb4L0eY5qfGmnczDmc5Ih\HK3ZzDy[ZB2enCxc3nu[|ohWHKrbXHyfUB{[3KnZX6g[o9zKFKqNEGgZ4VtdHN? MnTGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB1643 MUXxTHRUKGG|c3H5 NF7NPHByUFSVIH;mJJBm\GmjdILpZ{Bk[W6lZYKgZ4VtdCCuaX7ld{B1dyCrZHXueIlngSCvdXz0bZBt\SCxcIDvdpR2dmm2aXXzJIZweiCmcoXnJJJmeHW{cH;zbY5oQiCFb37mbZJu[XSxcomgd4Nz\WWwIH\vdkBPSjF4NEOgZ4VtdHN? NWrNcXJvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm0N|UyOzlpPkK5OFM2OTN7PD;hQi=>
A673 M2mxfZFJXFNiYYPzZZk> M1zDPZFJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGE3PzNiY3XscJMq MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR|NUGzPUc,Ojl2M{WxN|k9N2F-
LAN-5 MUXxTHRUKGG|c3H5 MVPxTHRUKG:oIIDl[IlifHKrYzDjZY5k\XJiY3XscEBtcW6nczD0c{Bq\GWwdHnmfUBufWy2aYDs[UBweHCxcoT1col1cWW|IH\vdkBlenWpIILldJVzeG:|aX7nPkBEd26oaYLtZZRwenlic3Py[YVvKG[xcjDMRW4uPSClZXzsdy=> MnO5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl2M{WxN|koRjJ7NEO1NVM6RC:jPh?=
NB-EBc1 NE\w[HNyUFSVIHHzd4F6 NXXLU5J3eUiWUzDv[kBx\WSrYYTybYMh[2GwY3XyJINmdGxibHnu[ZMhfG9iaXTlcpRq\nlibYXseIlxdGVib4Dwc5J1fW6rdHnld{Bnd3JiZIL1[{Bz\XC3coDvd4lv\zpiQ3;u[olzdWG2b4L5JJNkemWnbjDmc5IhVkJvRVLjNUBk\Wyucx?= NFL6cnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUSzOVE{QSd-Mkm0N|UyOzl:L3G+
BT-37 MYnxTHRUKGG|c3H5 M{TZZ5FJXFNib3[gdIVlcWG2cnnjJINidmOncjDj[YxtKGyrbnXzJJRwKGmmZX70bYZ6KG23bITpdIxmKG:ycH;yeJVvcXSrZYOg[o9zKGS{dXegdoVxfXKyb4Ppcoc7KEOxbn\pdo1ifG:{eTDzZ5Jm\W5iZn;yJGJVNTN5IHPlcIx{ M1;PN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEO1NVM6Lz5{OUSzOVE{QTxxYU6=
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647-V NYe2N|NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LsXGlvcGmkaYTpc44hd2ZiaIXtZY4hPjR5LW[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQyNjh6M{Kg{txONg>? NInrUlk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
PF-382 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37KTGlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oi5yMkSyJO69VS5? MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
IST-SL1 NHi4So9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjPeWc3UW6qaXLpeIlwdiCxZjDoeY1idiCLU2StV2wyKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVAhRSB2Mj6zNlQ4KM7:TT6= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
MKN7 NVXqOJpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mke3TY5pcWKrdHnvckBw\iCqdX3hckBOU055IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0Nk41QTd5IN88UU4> MmrVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
CP50-MEL-B NXLpb|h[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHqSnFKdmirYnn0bY9vKG:oIHj1cYFvKEOSNUCtUWVNNUJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IESyMlY6ODFizszNMi=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
K052 NEnB[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XaNmlvcGmkaYTpc44hd2ZiaIXtZY4hUzB3MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyIE2gOFMvODZ7ODFOwG0v M2[3O|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
23132-87 MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvwbJNyUW6qaXLpeIlwdiCxZjDoeY1idiB{M{GzNk05PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxKD1iNEOuOVI5PiEQvF2u MnjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
GAK MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrqTJBQUW6qaXLpeIlwdiCxZjDoeY1idiCJQVugZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ1NjF{NzFOwG0v NVL4e2lzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
Mewo M1zKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3Jcohq[mm2aX;uJI9nKGi3bXHuJG1mf29iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES1MlU5PzhizszNMi=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
RMG-I M{XO[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnBXohKdmirYnn0bY9vKG:oIHj1cYFvKFKPRz3JJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1PS55M{eyJO69VS5? NVTB[5B2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
BE-13 M2ju[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0OU46Ozl{IN88UU4> NWfONoFIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
SW684 NHPpc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvGSohKdmirYnn0bY9vKG:oIHj1cYFvKFOZNki0JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Py52OU[5JO69VS5? M4O0OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-IGFIRRβ/InsRβ / IGFIRβ / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 26136493     


(C) T4105 cells were treated with OSI-906 or BMS-754807 at indicated concentrations for 24 hours, lysed, and subjected to immunoblotting.

26136493
Growth inhibition assay
Cell viability; 

PubMed: 30754629     


Response of SK-CO-1 to various drugs and drug combinations.

30754629
In vivo BMS-754807 (12.5mg/kg, orally) inhibits IGF-1R phosphorylation in tumor and serum in IGF-1R-Sal tumor–bearing nude mice. BMS-754807 inhibits tumor growth in a selected group of epithelial (IGF-1R-Sal, GEO, and Colo205), hematopoietic (JJN3), and mesenchymal (RD1 and Rh41) xenograft tumor models with TGI ranging from 53% to 115%. [1] BMS-754807 (6.25 mg/kg) achieves complete tumor growth inhibition in the transgenic-derived IGF-Sal tumor mouse model with correlated inhibition of pIGF-1R and pAKT. The protein binding for BMS-754807 ranges from of 98.5% in mouse plasma to 95.9% in human plasma. BMS-754807 results in clearance of 113 (mL/min)/kg, 20 (mL/min)/kg, 3.5 (mL/min)/kg and 41 (mL/min)/kg. [2] BMS-754807 (25 mg/kg) significantly inhibits tumor in KT-5 (Wilms), KT-14 (rhabdoid), Rh28 (rhabdomyosarcoma), and OS-1 xenografts mice model. [3]

Protocol

Kinase Assay:[1]
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Kinase inhibition assays:

The primary screen for BMS-754807 is an in vitro kinase assay using recombinant human IGF-1 receptor enzyme in biochemical assays using synthetic peptide KKSRGDYMTMQIG as a phosphoacceptor substrate. The selectivity profile is evaluated against multiple recombinant enzymes that are generated at BMS or purchased externally. The enzymatic assays are performed in Ubottom 384-well plates using a 30 μL reaction volume in assay buffer (100 mM Hepes pH 7.4, 10 mM MgCl2, 0.015% Brij35 and 4 mM DTT). The 60 minute reactions are initiated by combining ATP (concentration equivalent to Km ATP), 1.5 μM fluoresceinlabeled peptide substrate, enzyme and BMS-754807. The reactions are terminated with EDTA. The reaction mixtures are analyzed on the Caliper LabChip 3000 by electrophoretic separation of the fluorescent substrate and phosphorylated product. Inhibition data are calculated by comparison to enzyme-free control reactions for 100% inhibition and vehicle-only reactions for 0% inhibition. Compounds are dissolved in dimethylsulfoxide (DMSO, 10mM stock) and evaluated at eleven concentrations. IC50 values are derived by non-linear regression analysis of the dose response curves.
Cell Research:[1]
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  • Cell lines: IGF-1R-Sal, RH41 and Geo cell lines
  • Concentrations: 365 nM
  • Incubation Time: 72 hours
  • Method: Cells are grown at their optimal density in RPMI +GlutaMax supplemented with 10% heat-inactivated fetal bovine serum (FBS), 10 mM Hepes, penicillin, and streptomycin. Cell proliferation is evaluated by incorporation of 3H-thymidine into DNA after exposure of cells to BMS-754807 for 72 hours. Results are expressed as an IC50, which is the drug concentration required to inhibit cell proliferation by 50% compared with untreated control cells.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: IGF-1R-Sal, GEO, Colo205, JJN3, RD1 or Rh41 tumor–bearing nude mice
  • Dosages: 150 mg/kg
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 92 mg/mL (199.35 mM)
Water Insoluble
Ethanol '''92 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.49
Formula

C23H24FN9O

CAS No. 1001350-96-4
Storage powder
in solvent
Synonyms N/A
Smiles CC1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01525823 Completed Drug: BMS-754807 (IGR-IR/IR Inhibitor)|Drug: Metformin Healthy Volunteers Bristol-Myers Squibb February 2012 Phase 1
NCT00908024 Terminated Drug: BMS-754807|Drug: cetuximab (Erbitux®) Colorectal Cancer|Head and Neck Cancer|Neoplasm Metastasis Bristol-Myers Squibb October 2009 Phase 1|Phase 2
NCT00898716 Completed Drug: BMS-754807 Neoplasms Bristol-Myers Squibb September 2009 Phase 1
NCT00788333 Completed Drug: BMS-754807|Drug: trastuzumab (Herceptin®) Breast Cancer Bristol-Myers Squibb July 2009 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID