BMS-754807

For research use only.

Catalog No.S1124

37 publications

BMS-754807 Chemical Structure

CAS No. 1001350-96-4

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.

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Selleck's BMS-754807 has been cited by 37 publications

Purity & Quality Control

Choose Selective IGF-1R Inhibitors

Biological Activity

Description BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM in cell-free assays, less potent to Met (c-Met), Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc. Phase 2.
Features Muti-inhibitor of the IGR-1R/IR family.
Targets
Insulin Receptor [1]
(Cell-free assay)
IGF-1R [1]
(Cell-free assay)
TrkB [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
TrkA [1]
(Cell-free assay)
1.7 nM 1.8 nM 4.1 nM 5.6 nM 7.4 nM
In vitro

BMS-754807 effectively inhibits the growth of a broad range of human tumor cell lines of different histologic origins including mesenchymal (Ewing's, rhabdomyosarcoma, neuroblastoma, and liposarcoma), epithelial (breast, lung, pancreatic, colon, and gastric), and hematopoietic (multiple myeloma and leukemia), the IC50 values range from 5 nM to 365 nM for the most sensitive cell lines. BMS-754807 inhibits proliferation of IGF-1R-Sal cells and RH41 cells with IC50 of 7 nM and 5 nM. BMS-754807 inhibits phosphorylation of IGF-1R in IGF-1R-Sal cells, Rh41 and Geo with IC50 of 13 nM, 6 nM and 21 nM. BMS-754807 inhibits phosphorylation of Akt in IGF-1R-Sal cells, Rh41 and Geo with IC50 of 22 nM, 13 nM and 16 nM. BMS-754807 induces greater apoptosis in Rh41 cells by 24 hours as indicated by an increased sub-G1 peak (23.1%), compared with control (2.4%). [1] BMS-754807 inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK (IC50 = 13nM) in the IGF-Sal cell line with IC50 consistent with the antiproliferative IC50 (7 nM) in this cell line. The crystal structure of BMS-754807 cocrystallized with the kinase domain of IGF-1R shows that the donor/acceptor/donor hydrogen bond triad with Met1052 and Glu1050 within the hinge region of the kinase. [2] BMS-754807 shows a median EC50 value of 0.62 μM against 23 cell lines in the pediatric preclinical testing program (PPTP). [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
IGF-Sal MUHLbY5ie2ViYYPzZZk> NFzMOm9qdmirYnn0d{B1cGVicHjvd5Bpd3K7bHH0bY9vKG:oIFnHSk0yWiBqSVO1NEA:KDF|bl2pJIFv\CC2aHWg[I94dnO2cnXhcUB1[XKpZYTzJGFsfCBqSVO1NEA:KDJ{bl2pJIFv\CCPQWDLJEhKSzVyIE2gNVNvVSl? MlKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5N{iwNlQoRjF7N{e4NFI1RC:jPh?=
IGF-Sal MlP0S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NVHvNIxxUUN3ME23JI5O MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl5N{iwNlQoRjF7N{e4NFI1RC:jPh?=
CCRF-CEM (ALL) NXHqb29jT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M3zJSJ42KM7:TR?= MUnEUXNQ MW\JR|UxRTFwMkO5JO69VQ>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
PC3 NEXkNWZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= MV7+OUDPxE1? M2ntcGROW09? M2nMW2lEPTB;MD65OlUh|ryP Mle4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
JD MojpS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MYP+OUDPxE1? MlfwSG1UVw>? NWDiTod2UUN3ME2wMlM6OSEQvF2= NHzCRXo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
DU145 M2ixTWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MVT+OUDPxE1? NG[5enVFVVOR MnnSTWM2OD1zLkS2OUDPxE1? NYPXcnlURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
KAG M331fGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NUDWeVlDhjVizszN NWflbGR6TE2VTx?= MkfnTWM2OD1zLk[2OUDPxE1? M2XwV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
K-562 (CML) M3zQXmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NIXGc3N,PSEQvF2= M4DQcGROW09? NX3oPYxYUUN3ME2yMlMxOiEQvF2= M1fCO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
B6-P210 (Murine ALL) M{D6c2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NUfzbXQ2hjVizszN MVLEUXNQ M1XjOGlEPTB;MT6yPVMh|ryP NFLVdmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
LN CAP-FGC MYrHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MkLSglUh|ryP NW\tVJB[TE2VTx?= NFTKdphKSzVyPUGuOFM1KM7:TR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
VW NH75S4RIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NEDwNVh,PSEQvF2= NE\JUmtFVVOR Mn[2TWM2OD1yLkCxPUDPxE1? MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
MV411 (B Myelomonocytic) NYrk[lZGT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUD+OUDPxE1? NH3jTZFFVVOR NYnFR2FtUUN3ME2wMlM{KM7:TR?= NWLQSmNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
MDA-PCa-2b NVzkdVRQT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NXPtN2JxhjVizszN M2G5ZmROW09? Mlu5TWM2OD1yLkC5PEDPxE1? MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
LG MnixS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MnnvglUh|ryP NW\NfoJoTE2VTx?= M2LFU2lEPTB;MD6wN|gh|ryP M3\JcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
RS411 (B cell precursor-ALL) M4DQeGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MlvGglUh|ryP M4PmZWROW09? MlfLTWM2OD1yLkGwNkDPxE1? M3vYOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
22-r-1 MV;Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M2L5[542KM7:TR?= M2jXZ2ROW09? NHnxNodKSzVyPUCuNVc2KM7:TR?= Mk\5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
5838 MnHwS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NFi2emV,PSEQvF2= MXnEUXNQ NUfIWVBLUUN3ME2wMlA{PCEQvF2= M3[ybFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
P388 (Murine) MXzHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M3XWWZ42KM7:TR?= Ml72SG1UVw>? NXS5R3NCUUN3ME20MlI4KM7:TR?= NYO1fVlMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
A2780/S NICzT|NIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M3ywOJ42KM7:TR?= NYPqTZhLTE2VTx?= M4TKeWlEPTB;MD6xNlIh|ryP NGDBSWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
RDES M2Pqbmdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXe5e4duhjVizszN MWXEUXNQ NED4SohKSzVyPUCuNFEzKM7:TR?= MmjUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
B6-T315I (Murine B-ALL) NXWzTINFT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NXrNPFBQhjVizszN MoTQSG1UVw>? NVfZTZprUUN3ME2yMlg{KM7:TR?= MofvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
TOV 112D NWHGZpJyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M2XRTp42KM7:TR?= NXXuUYJtTE2VTx?= NF;6fIRKSzVyPUKuNVQ3KM7:TR?= MmXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
TC32 NIq2[5ZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NFzIT5V,PSEQvF2= M3;TNWROW09? NIX2XYdKSzVyPUCuNFA5KM7:TR?= MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
HL60 (acute myelocytic) MYHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NWTjNXZ5hjVizszN NXTtUlNNTE2VTx?= MYDJR|UxRTBwMUKg{txO NIHCWYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
TOV 21G NG\zZXdIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWnhVm5MhjVizszN NHnaeYdFVVOR NUXHXXpjUUN3ME20MlI4QSEQvF2= MmHvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
TC71 NXv0SGtYT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M4Dx[J42KM7:TR?= NHy3dY5FVVOR NG\q[GNKSzVyPUCuNFE1KM7:TR?= NWL1b|FCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HPN-ALL (T-cell) MlTZS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M{jpfp42KM7:TR?= M4\FOWROW09? MmC3TWM2OD1yLkWyJO69VQ>? MoXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
A2780R M{jLS2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MoK5glUh|ryP MkPsSG1UVw>? NUn4elJ{UUN3ME2xMlU3PCEQvF2= NVr0c21ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
Rh1 MWjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MUT+OUDPxE1? M{\oRWROW09? M37NeWlEPTB;MD6wNlch|ryP NE\xfVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Kasumi-1 (acute myeloid) NX;hfnRpT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUD+OUDPxE1? NU[wOG84TE2VTx?= NVrYfnpFUUN3ME2wMlE3KM7:TR?= NGm1XIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
sk-ov-3 NYLKTnhNT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MUn+OUDPxE1? NFy3WXNFVVOR M2LIb2lEPTB;NT6xJO69VQ>? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
ME MWfHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M4nl[542KM7:TR?= NHXBdJJFVVOR MnLvTWM2OD1yLkCxOUDPxE1? NVTNXJAxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
L1210 (Murine lymphocytic) MonES5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NXntVIFrhjVizszN NX\JT256TE2VTx?= NYnuTpc4UUN3ME2yMlM6KM7:TR?= MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
sw-626 MXrHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M{C0fp42KM7:TR?= MljvSG1UVw>? NVywe|NqUUN3ME2yMlMxPiEQvF2= MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
CTR NWLJVYFTT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MXH+OUDPxE1? MXHEUXNQ M17D[mlEPTB;MD6yOVMh|ryP NF7sfVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
ML2 (Myelomonocytic) MWPHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M12yZ542KM7:TR?= NHznUnZFVVOR MkPmTWM2OD1yLkC5JO69VQ>? M3PM[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
ovcar-3 NH\iSJpIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NGOw[FV,PSEQvF2= MYXEUXNQ NW\3dZliUUN3ME21JO69VQ>? Mn\NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Rh36 MYTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MX\+OUDPxE1? NYO4T2t3TE2VTx?= NHWyXFdKSzVyPUGuOFMzKM7:TR?= NUTwWG42RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
MOLM-13 (acute myeloid) MW\Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NUP1T5I6hjVizszN Mn3MSG1UVw>? MWHJR|UxRTBwNEKg{txO MkCxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
ovcar-4 MlGzS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MlvmglUh|ryP M3\ETWROW09? MoLSTWM2OD1zIN88US=> NH;MUIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Rh41 MkXsS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NVP1fWNOhjVizszN MWHEUXNQ NF\lUm5KSzVyPUCuNFA2KM7:TR?= NFjMWpE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Mutz 2 (acute myeloid) NWTOO293T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NYjOepBphjVizszN Mk\sSG1UVw>? NXW0SZJEUUN3ME2xMlE2KM7:TR?= MlPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
ovcar-5 MVjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NWPTeo1EhjVizszN NYH6fop7TE2VTx?= Mlu2TWM2OD1yLkC1JO69VQ>? MnWxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
RD1 MY\Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NVfGdHdQhjVizszN NFHCRWVFVVOR NGfSc2VKSzVyPUCuNFY5KM7:TR?= MnrJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
OCI-AML 2 (acute myeloid) NGPBSpFIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWi5THVrhjVizszN NInsUpVFVVOR M1rhZWlEPTB;Mz6zN{DPxE1? MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
786-O NXz6SHlnT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M{XpTJ42KM7:TR?= M3PtWGROW09? NHPnbldKSzVyPUGuOlQ4KM7:TR?= M1jNZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
A673 M1XZOWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MYj+OUDPxE1? NHTjZ5ZFVVOR MWfJR|UxRTBwNEC4JO69VQ>? M4q1blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
TALL-1 (T-cell) NHrqS3pIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NELNWFN,PSEQvF2= M1nJbGROW09? NEjWOGZKSzVyPUGuNlgh|ryP NHX3Z5k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
151-B Ml3BS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MkTjglUh|ryP Mmi2SG1UVw>? MYrJR|UxRTJwNkeg{txO M{jNfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
PFSK-1 MVXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? M1Tsbp42KM7:TR?= NFq4Wo9FVVOR MorCTWM2OD1yLkGzNkDPxE1? NFPab5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
THP-1 MXTHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MlvaglUh|ryP NYjIeVlXTE2VTx?= M3S2PGlEPTB;Nj61PEDPxE1? MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
HEK293 M4jabWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M3vyTp42KM7:TR?= NYDMOlNFTE2VTx?= NID4OmRKSzVyPUCuPVE2KM7:TR?= NH7nfIU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
DAOY MkCyS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MlzxglUh|ryP MXnEUXNQ NHPpco9KSzVyPUGuPVc6KM7:TR?= MmDhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SET2 M4XC[Gdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NVfVc41FhjVizszN MV\EUXNQ Mln5TWM2OD1yLkK5PEDPxE1? NFnhZYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
HTB-46 Mn\vS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NYLBOYh1hjVizszN NXXIfVd{TE2VTx?= MnLUTWM2OD13LkK1JO69VQ>? NFT2[pE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
SK-NAS MX7Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NWTBXGRUhjVizszN MYHEUXNQ NUGzV4tJUUN3ME2wMlQ6PyEQvF2= M4nBTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
CTLL2 NUP2ZodyT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NEDUZ4x,PSEQvF2= M1HoW2ROW09? MoDHTWM2OD5zLkCwJO69VQ>? NXvzZ5RxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HTB-47 M1vCV2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 M3;4Wp42KM7:TR?= Mn\tSG1UVw>? MUfJR|UxRTJwMEW2JO69VQ>? NHPIcng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
LAN-1 NYOxXnFbT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M4HiTJ42KM7:TR?= Mmi1SG1UVw>? NGD0VFJKSzVyPUCuNFQh|ryP MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
ST486 MXnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NFvqXox,PSEQvF2= NWWwVnY6TE2VTx?= M1S2WGlEPTB;MT6xPUDPxE1? NXH4[mVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
HS766T NVjpZolZT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MWP+OUDPxE1? M{H4d2ROW09? Mnn3TWM2OD1{LkCwNUDPxE1? M3WzeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
IMR-32 NWrp[JNCT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MWH+OUDPxE1? MWjEUXNQ MmS1TWM2OD1yLkK2NUDPxE1? M3zKbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Daudi (Burkitt's) M3j5NGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NXq3PFc{hjVizszN MWHEUXNQ M3jzVmlEPTB;Mj62N|ch|ryP M2GzeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Aspc-1 MWjHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MlLyglUh|ryP NGnVOWFFVVOR NUO5eIVuUUN3ME2wMlM4QSEQvF2= NGWybIw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
SK-NSH MUnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MWX+OUDPxE1? M{jrdWROW09? NVnPfII{UUN3ME2wMlE{QSEQvF2= MljZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
MEC-1 (Chronic B cell) MmqwS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? M2XwR542KM7:TR?= M4K3S2ROW09? MVzJR|UxRTJwNkO3JO69VQ>? MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
Capan-2 M4LrUWdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MXP+OUDPxE1? MljqSG1UVw>? MnHwTWM2OD1zLke3OEDPxE1? NUXDU|YxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
SHSY5Y MVnHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MmHrglUh|ryP NIizelhFVVOR NHzK[nBKSzVyPUCuNVA3KM7:TR?= NWDGbVV4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
U937 (Histioocytic) NHvUZXFIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWjOWZhihjVizszN NGnGRldFVVOR MkXpTWM2OD53LkCwJO69VQ>? M2fPfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
Bxpc-1 MWDHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NYfoUJNXhjVizszN NYnnflI4TE2VTx?= MkP6TWM2OD1zLkmyOEDPxE1? NGT4dmY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
Bxpc-3 M{Ts[2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MXL+OUDPxE1? NVGyeFF6TE2VTx?= MUHJR|UxRjVwMECg{txO MmDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
HTB-92 NHrZeYVIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M{LVZZ42KM7:TR?= NGPGRlRFVVOR MUDJR|UxRTFwMEKg{txO NUTRTnFWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
OCI-LY10 (B-cell) MXHHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NGDiXoh,PSEQvF2= NF:3RllFVVOR Mm[wTWM2OD1yLkS1JO69VQ>? NVLKSoJ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
PANC-1 M4\sV2dzd3e2aDDpcohq[mm2b4L5JIF{e2G7 NWD0dnVyhjVizszN M{m4XGROW09? NV\icFhMUUN3ME61MlAxKM7:TR?= MmTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
To184.T Mn:xS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MYn+OUDPxE1? MU\EUXNQ MlfZTWM2OD1yLkS2PUDPxE1? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
OCI-LY19 (B-cell) NIX6T4ZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M1zq[J42KM7:TR?= NGLjN4xFVVOR NF;WNoVKSzVyPUCuOEDPxE1? M3PBWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
PANC-1 BM MkKyS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NF7odlh,PSEQvF2= NVjEV486TE2VTx?= M4XpNWlEPTB-NT6wNEDPxE1? NWL0TWoxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm5PVYzPzJpPkG5PVk3Ojd{PD;hQi=>
SA-4 NY\CdW9lT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= MYL+OUDPxE1? Ml;kSG1UVw>? MVLJR|UxRTFwM{CxJO69VQ>? M4DmSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
RPMI 8226 Ml;yS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? MWX+OUDPxE1? NU\QW25bTE2VTx?= MUfJR|UxRTFwMkmzJO69VQ>? MojQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
HPAF-II Mli1S5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NWDr[JFPhjVizszN M4ntZWROW09? M{S0SmlEPTB;MD62OFQh|ryP M2H2UVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
SHP-77 NWPpcGxoT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M{H5fZ42KM7:TR?= NV:y[oxlTE2VTx?= MYrJR|UxRTFwOEi4JO69VQ>? MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
U266 B1 NHzwNVlIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M{fuXJ42KM7:TR?= MU\EUXNQ MV;JR|UxRTFwNk[5JO69VQ>? Ml\lQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
Hs700t NUPjblNET3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NYjVZ3BVhjVizszN M1TvPWROW09? M3nmXmlEPTB;MD6yN|Eh|ryP Mn\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
NCI-446 MY\Hdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? MVz+OUDPxE1? M3zSNmROW09? MYnJR|UxRTFwMUW0JO69VQ>? MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
H929 NIniUHhIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= NWnzdpYxhjVizszN M{TTWWROW09? M1P5W2lEPTB;MD6wNVQh|ryP M1zEeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
PL45 NWLjOpJRT3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= M4jhS542KM7:TR?= MXvEUXNQ MojETWM2OD1{LkK1OUDPxE1? NGfFe2g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUm5OlI4Oid-MUm5PVYzPzJ:L3G+
NCI-H383 NH3rT5lIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= M2HNVZ42KM7:TR?= MnPNSG1UVw>? NFvzWI1KSzVyPkWuNFAh|ryP Moq1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
JJN3 NYW1PWl3T3Kxd4ToJIlvcGmkaYTvdpkh[XO|YYm= NITzR4F,PSEQvF2= Mnm3SG1UVw>? M{jZVGlEPTB;Mj60N|Mh|ryP M2fwO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
SU.86.86 MonwS5Jwf3SqIHnubIljcXSxcomgZZN{[Xl? NGjkXoF,PSEQvF2= NHe1UYNFVVOR MXvJR|UxRTJwNkeyJO69VQ>? M2TKVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OUm2NlczLz5zOUm5OlI4OjxxYU6=
H1299 NIfESnZIem:5dHigbY5pcWKrdH;yfUBie3OjeR?= Mn3CglUh|ryP M4q0WGROW09? MWLJR|UxRjVwMECg{txO MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTl7NkK3Nkc,OTl7OU[yO|I9N2F-
MDA-MB-468 MYXHdo94fGhiaX7obYJqfG:{eTDhd5NigQ>? NEW5RYV,PSEQvF2= MoH4SG1UVw>? M1vNT2lEPTB;MD61NFQh|ryP MmnkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
SW1990 M2nWOGdzd3e2aDDpcohq[mm2b4L5JIF{e2G7 MY\+OUDPxE1? M17FO2ROW09? NHPjTXdKSzVyPUCuPFI3KM7:TR?= MmC2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl7OU[yO|IoRjF7OUm2NlczRC:jPh?=
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647-V MlTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTuZXNKdmirYnn0bY9vKG:oIHj1cYFvKDZ2Nz3WJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1OS56OEOyJO69VS5? M2r6ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
PF-382 Mn;WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rMXGlvcGmkaYTpc44hd2ZiaIXtZY4hWEZvM{iyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oi5yMkSyJO69VS5? MkjzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
IST-SL1 M{jmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITwNoZKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NEA:KDR{LkOyOFch|ryPLh?= M{fEPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
MKN7 NFXndYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnqTZpnUW6qaXLpeIlwdiCxZjDoeY1idiCPS163JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oi52OUe3JO69VS5? MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
CP50-MEL-B NWPyXIJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXxUYhsUW6qaXLpeIlwdiCxZjDoeY1idiCFUEWwMW1GVC2EIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0Nk43QTBzIN88UU4> M2HKPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
K052 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK3TY5pcWKrdHnvckBw\iCqdX3hckBMODV{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0N{4xPjl6IN88UU4> NWDvcFVbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
23132-87 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJFI{OTN{LUi3JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUCgQUA1Oy53Mki2JO69VS5? MoPtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>
GAK NWrQZ|JvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3L2bGlvcGmkaYTpc44hd2ZiaIXtZY4hT0GNIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0OE4yOjdizszNMi=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQly1O|U1PDhxJ{7TRW5ITVJ:L3G+
Mewo M3HVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG1mf29iY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OCB;IES1MlU5PzhizszNMi=> NVz2UY9YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:ve5d4NmWkaT7hZ{52cy:laHXtZoww[2:vcH;1coRgemWyb4L0Y4NiemRxQ1jFUWJNPTd3NES4M{c,W0GQR1XSQE9iRg>?
RMG-I M{LKWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXqwOFZEUW6qaXLpeIlwdiCxZjDoeY1idiCUTVetTUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwJF0hPDVwN{O3NkDPxE1w M2H3fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4f3e{5m[mlwYXOueYsw[2inbXLsM4NwdXCxdX7kY5JmeG:{dG;jZZJlN0OKRV3CUFU4PTR2OD:nQnNCVkeHUkyvZV4>
BE-13 MnzhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L5NGlvcGmkaYTpc44hd2ZiaIXtZY4hSkVvMUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3MDC9JFQ2Njl|OUKg{txONg>? NFrScos9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;3e5cv\WKrLnHjMpVsN2OqZX3icE9kd22yb4Xu[H9z\XCxcoTfZ4Fz\C:FSFXNRmw2PzV2NEivK|5USU6JRWK8M4E,
SW684 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJHNYPjh2IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTBiPTC0O{41QTZ7IN88UU4> MnPOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xd4f3MoVjcS6jYz71b{9kcGWvYnyvZ49ueG:3bnTfdoVxd3K2X3PhdoQwS0iHTVLMOVc2PDR6Lze+V2FPT0WUPD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-IGFIRRβ/InsRβ / IGFIRβ / p-AKT / AKT / p-ERK / ERK ; 

PubMed: 26136493     


(C) T4105 cells were treated with OSI-906 or BMS-754807 at indicated concentrations for 24 hours, lysed, and subjected to immunoblotting.

26136493
Growth inhibition assay
Cell viability; 

PubMed: 30754629     


Response of SK-CO-1 to various drugs and drug combinations.

30754629
In vivo BMS-754807 (12.5mg/kg, orally) inhibits IGF-1R phosphorylation in tumor and serum in IGF-1R-Sal tumor–bearing nude mice. BMS-754807 inhibits tumor growth in a selected group of epithelial (IGF-1R-Sal, GEO, and Colo205), hematopoietic (JJN3), and mesenchymal (RD1 and Rh41) xenograft tumor models with TGI ranging from 53% to 115%. [1] BMS-754807 (6.25 mg/kg) achieves complete tumor growth inhibition in the transgenic-derived IGF-Sal tumor mouse model with correlated inhibition of pIGF-1R and pAKT. The protein binding for BMS-754807 ranges from of 98.5% in mouse plasma to 95.9% in human plasma. BMS-754807 results in clearance of 113 (mL/min)/kg, 20 (mL/min)/kg, 3.5 (mL/min)/kg and 41 (mL/min)/kg. [2] BMS-754807 (25 mg/kg) significantly inhibits tumor in KT-5 (Wilms), KT-14 (rhabdoid), Rh28 (rhabdomyosarcoma), and OS-1 xenografts mice model. [3]

Protocol

Kinase Assay:[1]
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Kinase inhibition assays:

The primary screen for BMS-754807 is an in vitro kinase assay using recombinant human IGF-1 receptor enzyme in biochemical assays using synthetic peptide KKSRGDYMTMQIG as a phosphoacceptor substrate. The selectivity profile is evaluated against multiple recombinant enzymes that are generated at BMS or purchased externally. The enzymatic assays are performed in Ubottom 384-well plates using a 30 μL reaction volume in assay buffer (100 mM Hepes pH 7.4, 10 mM MgCl2, 0.015% Brij35 and 4 mM DTT). The 60 minute reactions are initiated by combining ATP (concentration equivalent to Km ATP), 1.5 μM fluoresceinlabeled peptide substrate, enzyme and BMS-754807. The reactions are terminated with EDTA. The reaction mixtures are analyzed on the Caliper LabChip 3000 by electrophoretic separation of the fluorescent substrate and phosphorylated product. Inhibition data are calculated by comparison to enzyme-free control reactions for 100% inhibition and vehicle-only reactions for 0% inhibition. Compounds are dissolved in dimethylsulfoxide (DMSO, 10mM stock) and evaluated at eleven concentrations. IC50 values are derived by non-linear regression analysis of the dose response curves.
Cell Research:[1]
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  • Cell lines: IGF-1R-Sal, RH41 and Geo cell lines
  • Concentrations: 365 nM
  • Incubation Time: 72 hours
  • Method: Cells are grown at their optimal density in RPMI +GlutaMax supplemented with 10% heat-inactivated fetal bovine serum (FBS), 10 mM Hepes, penicillin, and streptomycin. Cell proliferation is evaluated by incorporation of 3H-thymidine into DNA after exposure of cells to BMS-754807 for 72 hours. Results are expressed as an IC50, which is the drug concentration required to inhibit cell proliferation by 50% compared with untreated control cells.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: IGF-1R-Sal, GEO, Colo205, JJN3, RD1 or Rh41 tumor–bearing nude mice
  • Dosages: 150 mg/kg
  • Administration: Orally
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 92 mg/mL (199.35 mM)
Water Insoluble
Ethanol '''92 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+30% PEG 300+ddH2O
For best results, use promptly after mixing.
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.49
Formula

C23H24FN9O

CAS No. 1001350-96-4
Storage powder
in solvent
Synonyms N/A
Smiles CC1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01525823 Completed Drug: BMS-754807 (IGR-IR/IR Inhibitor)|Drug: Metformin Healthy Volunteers Bristol-Myers Squibb February 2012 Phase 1
NCT00908024 Terminated Drug: BMS-754807|Drug: cetuximab (Erbitux®) Colorectal Cancer|Head and Neck Cancer|Neoplasm Metastasis Bristol-Myers Squibb October 2009 Phase 1|Phase 2
NCT00898716 Completed Drug: BMS-754807 Neoplasms Bristol-Myers Squibb September 2009 Phase 1
NCT00788333 Completed Drug: BMS-754807|Drug: trastuzumab (Herceptin®) Breast Cancer Bristol-Myers Squibb July 2009 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID