research use only

Bleximenib oxalate MLL inhibitor

Name: Bleximenib oxalate
Brand: Selleck Chemicals
SKU: E4679
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E4679

Bleximenib oxalate(Menin-MLL inhibitor 24 oxalate) is an inhibitor of menin-mixed-lineage leukemia 1 (menin-MLL) . It can be used for the research of cancer.

Bleximenib oxalate MLL inhibitor Chemical Structure

Quality Control

Batch: Purity: 99.40%

99.40

Related Targets	HDAC JAK BET Histone Methyltransferase PKC PARP HIF PRMT EZH2 AMPK
Other MLL Inhibitors	Ziftomenib (KO-539) SNDX-5613 (Revumenib) VTP50469 DSP5336

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (144.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	689.83	Formula	C₃₂H₅₀FN₇O₃.C₂H₂O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2866179-95-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	Menin-MLL
References	[1] https://patents.google.com/patent/WO2022237720A1/en

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-09-03)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03013998	RECRUITING	Previously Untreated Relapsed Refractory Acute Myeloid Leukemia	Beat AML, LLC	2016-11	PHASE2; PHASE3
NCT07223814	RECRUITING	Acute Myeloid Leukemia	Stichting Hemato-Oncologie voor Volwassenen Nederland	2026-03-01	PHASE3
NCT06852222	RECRUITING	Leukemia, Myeloid, Acute	Janssen Research & Development, LLC	2025-06-04	PHASE3
NCT04811560	RECRUITING	Acute Leukemia	Janssen Research & Development, LLC	2021-05-19	PHASE1; PHASE2
NCT05453903	ACTIVE_NOT_RECRUITING	Leukemia, Myeloid, Acute	Janssen Research & Development, LLC	2022-10-04	PHASE1
NCT07295951	RECRUITING	Acute Lymphoblastic Leukemia; Acute Leukemias; Acute Myeloid Leukemia	Janssen Research & Development, LLC	2025-11-18	PHASE1

Tech Support

Handling Instructions

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