BX430

For research use only.

Catalog No.S0758

BX430 Chemical Structure

CAS No. 688309-70-8

BX430 is a potent and selective noncompetitive allosteric antagonist of human P2X4 receptor channels with IC50 of 0.54 μM. BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs. BX430 is used for chronic pain and cardiovascular disease.

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Biological Activity

Description BX430 is a potent and selective noncompetitive allosteric antagonist of human P2X4 receptor channels with IC50 of 0.54 μM. BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs. BX430 is used for chronic pain and cardiovascular disease.
Targets
hP2X4 [1]
(Cell-free assay)
0.54 μM

Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.91 mM)
Ethanol 83 mg/mL (200.91 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.11
Formula

C15H15Br2N3O

CAS No. 688309-70-8
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C1=CC(=C(C(=C1)Br)NC(=O)NC2=CN=CC=C2)Br

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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