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BUSPIRONE 5-HT Receptor agonist

Name: BUSPIRONE
Brand: Selleck Chemicals
SKU: E6060
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E6060

BUSPIRONE (Ansial) is a potent agonist of serotonin 5-HT1A receptor as well as an antagonist of dopamine D2 autoreceptor. It exhibits anxiolytic and antidepressant activity, alleviates anxiety, depression, and colitis, suppresses neuroinflammation, modulates gut microbiota, and can be used in research for treating anxiety and depression.

Chemical Structure

Molecular Weight: 385.50

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Quality Control

Batch: E606001 DMSO]77 mg/mL]false]Ethanol]20 mg/mL]false]Water]Insoluble]false Purity: 99.85%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.85

Related Targets	Adrenergic Receptor AChR COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other 5-HT Receptor Inhibitors	Serotonin Hydrochloride (5-HT HCl) WAY-100635 Maleate Puerarin SB269970 HCl Ketanserin BRL-15572 Dihydrochloride Nuciferine RS-127445 Flopropione Azacyclonol

Solubility

In vitro
Batch:

DMSO : 77 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	385.50	Formula	C₂₁H₃₁N₅O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	36505-84-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/33731795/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-09-04)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07439042	NOT_YET_RECRUITING	Anxiety; Autism Spectrum Disorder	Massachusetts General Hospital	2026-09	PHASE4
NCT04400266	RECRUITING	Depression; Brain Injuries, Traumatic	Massachusetts General Hospital	2020-08-01	PHASE4
NCT05511909	RECRUITING	Opioid Use Disorder; Opioid Withdrawal; Opioid Craving; Anxiety	University of Maryland, Baltimore	2022-12-15	PHASE2
NCT04118387	RECRUITING	Sleep Disordered Breathing; Able Bodied	VA Office of Research and Development	2021-01-07	PHASE4
NCT03954483	RECRUITING	Anxiety	University of Manitoba	2023-10-16
NCT04458324	ACTIVE_NOT_RECRUITING	Spinal Cord Injuries	Spaulding Rehabilitation Hospital	2020-12-22	PHASE2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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