Home Immunology & Inflammation CXCR antagonist Balixafortide (POL6326) For research use only.

Balixafortide (POL6326)

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.

Balixafortide (POL6326) Chemical Structure

Balixafortide (POL6326) Chemical Structure

CAS: 1051366-32-5

Purity & Quality Control

Batch: S972501 Water] 100 mg/mL] false] ] ] false] ] ] false Purity: 98.69%
98.69

Balixafortide (POL6326) Related Products

Signaling Pathway

CXCR Signaling Pathways

CXCR Signaling Pathway

Choose Selective CXCR Inhibitors

Biological Activity

Description

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.
Targets
CXCR4 [1]
In Vivo
In vivo

POL6326 enhances systolic function in a porcine closed-chest model of reperfused acute MI. POL6326 mobilizes Treg cells, enhances Treg cell recruitment to the infarct, attenuates tumor necrosis factor expression in monocytes and macrophages in the infarcted region, enhances infarct border-zone capillarization, reduces infarct scar size, and attenuates LV remodeling and systolic dysfunction in mice.[2]
Animal Research Animal Models C57BL/6NCrl wild-type (WT) mice, domestic (DanBred hybrid) female pigs
Dosages 8 mg/kg, 3 mg/kg
Administration IV
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04826016 Withdrawn
Advanced Breast Cancer
MedSIR
 March 16 2022 Phase 1|Phase 2
NCT01905475 Completed
Large Reperfused ST-Elevation Myocardial Infarction
Polyphor Ltd.
 July 2013 Phase 2
NCT01837095 Completed
Metastatic Breast Cancer
Polyphor Ltd.
 June 2013 Phase 1
NCT01841476 Completed
Healthy
Polyphor Ltd.
 February 2012 Phase 1
NCT01105403 Completed
Multiple Myeloma
Polyphor Ltd.
 April 2009 Phase 2

Chemical Information & Solubility

Molecular Weight 1864.11 Formula

C84H118N24O21S2
CAS No. 1051366-32-5 SDF --
Smiles CC1NNC(CC2=CN=C[NH]2)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC7CSSCC(NC1=O)C(=O)NC(CO)C(=O)NC(C)C(=O)N8CCCC8C(=O)NC(CCN)C(=O)NC(CCCNC(N)=N)C(=O)C(=O)C(CC9=CC=C(O)C=C9)NC7=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

Water : 100 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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