Balixafortide (POL6326)

Catalog No.S9725

For research use only.

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.

Balixafortide (POL6326) Chemical Structure

CAS No. 1051366-32-5

Purity & Quality Control

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Biological Activity

Description

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.

Targets
CXCR4 [1]
()
In vivo

POL6326 enhances systolic function in a porcine closed-chest model of reperfused acute MI. POL6326 mobilizes Treg cells, enhances Treg cell recruitment to the infarct, attenuates tumor necrosis factor expression in monocytes and macrophages in the infarcted region, enhances infarct border-zone capillarization, reduces infarct scar size, and attenuates LV remodeling and systolic dysfunction in mice.[2]

Protocol (from reference)

Animal Research:

[2]

  • Animal Models: C57BL/6NCrl wild-type (WT) mice, domestic (DanBred hybrid) female pigs
  • Dosages: 8 mg/kg, 3 mg/kg
  • Administration: IV
  • (Only for Reference)

Solubility (25°C)

In vitro

Water 100 mg/mL
(53.64 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1864.11
Formula

C84H118N24O21S2

CAS No. 1051366-32-5
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04826016 Not yet recruiting Drug: POL6326|Drug: Eribulin|Drug: Nab paclitaxel Advanced Breast Cancer MedSIR July 2021 Phase 1|Phase 2
NCT01905475 Completed Drug: POL6326|Drug: Placebo Large Reperfused ST-Elevation Myocardial Infarction Polyphor Ltd. July 2013 Phase 2
NCT01837095 Completed Drug: POL6326 Metastatic Breast Cancer Polyphor Ltd. June 2013 Phase 1
NCT01841476 Completed Drug: POL6326 Healthy Polyphor Ltd. February 2012 Phase 1
NCT01105403 Completed Drug: POL6326 Multiple Myeloma Polyphor Ltd. April 2009 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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