Home Immunology & Inflammation CXCR antagonist Balixafortide (POL6326)

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Balixafortide (POL6326) CXCR antagonist

Cat.No.S9725

An orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist, Balixafortide (POL6326) is a compound of interest in this context.

Balixafortide (POL6326) CXCR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 1864.11

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Quality Control

Batch: S972501 Water]100 mg/mL]false]]]false]]]false Purity: 98.69%
98.69

Solubility

In vitro
Batch:

Water : 100 mg/mL

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Chemical Information, Storage & Stability

Molecular Weight 1864.11 Formula

C84H118N24O21S2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1051366-32-5 -- Storage of Stock Solutions

Synonyms N/A SMILES CC1NNC(CC2=CN=C[NH]2)C(=O)NC(CC3=CC=C(O)C=C3)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC7CSSCC(NC1=O)C(=O)NC(CO)C(=O)NC(C)C(=O)N8CCCC8C(=O)NC(CCN)C(=O)NC(CCCNC(N)=N)C(=O)C(=O)C(CC9=CC=C(O)C=C9)NC7=O

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Mechanism of Action

Targets/IC50/Ki
CXCR4
In vivo

In a porcine closed-chest model of reperfused acute MI, Balixafortide (POL6326) enhances systolic function. It mobilizes Treg cells, enhances Treg cell recruitment to the infarct, attenuates tumor necrosis factor expression in monocytes and macrophages in the infarcted region, enhances infarct border-zone capillarization, reduces infarct scar size, and attenuates LV remodeling and systolic dysfunction in mice.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04826016 Withdrawn
Advanced Breast Cancer
MedSIR
 2022-03-16 Phase 1|Phase 2
NCT01905475 Completed
Large Reperfused ST-Elevation Myocardial Infarction
Polyphor Ltd.
 2013-07 Phase 2
NCT01837095 Completed
Metastatic Breast Cancer
Polyphor Ltd.
 2013-06 Phase 1
NCT01841476 Completed
Healthy
Polyphor Ltd.
 2012-02 Phase 1
NCT01105403 Completed
Multiple Myeloma
Polyphor Ltd.
 2009-04 Phase 2

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