Balixafortide (POL6326)

Catalog No.S9725

For research use only.

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.

Balixafortide (POL6326) Chemical Structure

CAS No. 1051366-32-5

Purity & Quality Control

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Biological Activity


Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.

CXCR4 [1]
In vivo

POL6326 enhances systolic function in a porcine closed-chest model of reperfused acute MI. POL6326 mobilizes Treg cells, enhances Treg cell recruitment to the infarct, attenuates tumor necrosis factor expression in monocytes and macrophages in the infarcted region, enhances infarct border-zone capillarization, reduces infarct scar size, and attenuates LV remodeling and systolic dysfunction in mice.[2]

Protocol (from reference)

Animal Research:


  • Animal Models: C57BL/6NCrl wild-type (WT) mice, domestic (DanBred hybrid) female pigs
  • Dosages: 8 mg/kg, 3 mg/kg
  • Administration: IV
  • (Only for Reference)

Solubility (25°C)

In vitro

Water 100 mg/mL
(53.64 mM)
Ethanol '-1 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1864.11


CAS No. 1051366-32-5
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04826016 Not yet recruiting Drug: POL6326|Drug: Eribulin|Drug: Nab paclitaxel Advanced Breast Cancer MedSIR July 2021 Phase 1|Phase 2
NCT01905475 Completed Drug: POL6326|Drug: Placebo Large Reperfused ST-Elevation Myocardial Infarction Polyphor Ltd. July 2013 Phase 2
NCT01837095 Completed Drug: POL6326 Metastatic Breast Cancer Polyphor Ltd. June 2013 Phase 1
NCT01841476 Completed Drug: POL6326 Healthy Polyphor Ltd. February 2012 Phase 1
NCT01105403 Completed Drug: POL6326 Multiple Myeloma Polyphor Ltd. April 2009 Phase 2

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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