Catalog No.S4248 Synonyms: AHR 10282R
Molecular Weight(MW): 356.15
Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
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Choose Selective COX Inhibitors
|Description||Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.|
|In vivo||Bromfenac (bromfenac sodium) by the oral route at pretreatment times of 10 min, 20 min and 300 min is respectively 3.7, 6.5 and 2.9 times more potent than zomepirac and 3.4, 6.6, and 44.2 times more potent than suprofen in the acetylcholine abdominal constriction assay in mice. Bromfenac when given orally is 5.8 times more potent than zomepirac in blocking the nociceptive response to bradykinin in dogs. Bromfenac is 6.1 to 32.8 times more potent than indometacin in inhibiting the formation of prostaglandin E2 and F2 alpha from microsomes of bovine seminal vesicles, rabbit uteri, and rabbit renal medullae. Bromfenac, given orally, is more potent than indometacin in suppressing acute (7.5-20 times) and chronic (3.8 times) inflammation in mice.  Bromfenac (1 mg/kg, i.v.) is metabolited into an unusual conjugate, bromfenac N-glucoside, in rats bile.  Bromfenac shows a rapid onset of activity (20 min) that persisted for at least 4 hours in a mouse model of pain (acetylcholine abdominal constriction). Bromfenac (0.316 mg/kg) produces significant anti-inflammatory activity up to 24 hours after dosing in a rat model of inflammation (carrageenan foot edema). Bromfenac is readily absorbed after oral administration, peak plasma levels being achieved at the earliest time tested: 20 min in the mouse and 30 min in the rat. |
|In vitro||DMSO||71 mg/mL (199.35 mM)|
|Water||71 mg/mL (199.35 mM)|
|Ethanol||2 mg/mL (5.61 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02681679||Completed||Cataract||Sun Yat-sen University|Ministry of Health China||October 2014||Not Applicable|
|NCT02137161||Completed||Cataract|Pseudoexfoliation Syndrome||Arcispedale Santa Maria Nuova-IRCCS||November 2013||Phase 4|
|NCT01847638||Unknown status||Cataract|Retinal Edema|Inflammation||Melissa Toyos MD|Bausch & Lomb Incorporated|Discover Vision Centers||April 2013||Not Applicable|
|NCT01387464||Completed||Cataract||InSite Vision||July 2011||Phase 2|
|NCT01367249||Completed||Pain|Inflammation|Cataract||Bausch & Lomb Incorporated||May 2011||Phase 3|
|NCT01310127||Completed||Inflammation|Pseudophakia||Toyos Clinic|Bausch & Lomb Incorporated||November 2010||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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