Catalog No.S2854 Synonyms: IMMA

For research use only.

BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor.

BML-190 Chemical Structure

CAS No. 2854-32-2

Selleck's BML-190 has been cited by 2 Publications

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Biological Activity

Description BML-190 (IMMA) is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor.
CB2 [1]
435 nM(Ki)
In vitro

BML-190 has 50-fold selectivity for CB2 receptors over CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, BML-190 potentiates the forskolin-stimulated accumulation of cAMP. BML-190 reduces the basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 μM of BML-190 decreases inositol phosphates accumulation by 38%. [1] BML-190 is an aminoalkylindole. BML-190 is found to yield at least 15 metabolic products. [2] BML-190 diminishes LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibits LPS-induced PGE2 production and COX-2 induction. [3]

Protocol (from reference)

Cell Research:[1]
  • Cell lines: 293/CB2 cells with [3H]adenine (1 μCi/mL)
  • Concentrations: 0 μM -100 μM
  • Incubation Time: 20 hours–24 hours
  • Method: 293/CB2 cells are labeled with [3H]adenine (1 μCi/mL) in MEM with 1% FBS for 20 hours-24 hours. Labelled cells are challenged with 50 μM forskolin and appropriate BML-190 for 30 minutes at 37°C and assayed for cAMP accumulation. For IP assays, 2 × 105 293/CB2 cells are transiently transfected with 16z44 and/or pcDNA3 using transfection reagents. Cells are labelled, challenged with BML-190 and assayed for IP production. Triplicates are performed for each data point and at least three separate trials are done for each ligand.

Solubility (25°C)

In vitro

DMSO 22 mg/mL
(51.53 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 426.89


CAS No. 2854-32-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)N4CCOCC4

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01123655 Completed Drug: APLA12|Drug: Placebo Rheumatoid Arthritis VA Office of Research and Development October 2009 Phase 1

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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