BMS-833923

For research use only.

Catalog No.S7138 Synonyms: XL139

6 publications

BMS-833923 Chemical Structure

CAS No. 1059734-66-5

BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.

Selleck's BMS-833923 has been cited by 6 publications

2 Customer Reviews

  • Cell viability assays performed on H1650 and H1975 cells with various concentrations of BMS-833923 (B).

    Neoplasia, 2015, 17(7):538-51.. BMS-833923 purchased from Selleck.

    Proliferation assay indicating that GDC or BMS and various dose of SBE cooperatively repress NSCLC cell proliferation.

    Sci Rep, 2017, 7(1):1899. BMS-833923 purchased from Selleck.

Purity & Quality Control

Choose Selective Hedgehog/Smoothened Inhibitors

Biological Activity

Description BMS-833923 (XL139) is an orally bioavailable Smoothened antagonist. Phase 2.
Targets
Smoothened [1]
In vitro

BMS-833923 reduces hedgehog pathway activity, decreases cell proliferation and induces apoptosis via the intrinsic pathway in esophageal adenocarcinoma (EAC) cell lines. [2] BMS-833923 dose-dependently affects canonical and prostate hedgehog signature gene transcription in vitro. [3]

Protocol

Solubility (25°C)

In vitro DMSO 95 mg/mL (200.6 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 473.57
Formula

C30H27N5O

CAS No. 1059734-66-5
Storage powder
in solvent
Synonyms XL139
Smiles CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Step 2: Enter the in vivo formulation ()
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
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    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01413906 Completed Drug: BMS-833923 (XL139) Cancer Bristol-Myers Squibb November 2011 Phase 1
NCT01218477 Completed Drug: Dasatinib|Drug: BMS-833923 Leukemia Bristol-Myers Squibb January 2011 Phase 1|Phase 2
NCT00927875 Completed Drug: BMS-833923|Drug: Carboplatin|Drug: Etoposide Small Cell Lung Carcinoma Bristol-Myers Squibb|Exelixis February 2010 Phase 1
NCT00909402 Completed Drug: BMS-833923|Drug: Cisplatin|Drug: Capecitabine Stomach Neoplasms|Esophageal Neoplasms Bristol-Myers Squibb|Exelixis November 2009 Phase 1
NCT00670189 Completed Drug: BMS-833923 (XL139) Hedgehog Pathway|Smoothened|Basal Cell Carcinoma (BCC)|Basal Cell Nevoid Syndrome (BCNS) Bristol-Myers Squibb|Exelixis July 2008 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Hedgehog/Smoothened Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID