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Biapenem Bacterial chemical

Cat.No.S1370

Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.
Biapenem Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 350.39

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Chemical Information, Storage & Stability

Molecular Weight 350.39 Formula

C15H18N4O4S

 Storage (From the date of receipt)
CAS No. 120410-24-4 Download SDF Storage of Stock Solutions

Synonyms L-627, LJC10627 Smiles CC1C2C(C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-])C(C)O

Solubility

In vitro
Batch:

Water : 5 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

In vitro
Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. This compound is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. It is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. [1] This agent shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. [2] It is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. [3]
In vivo
Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. This compound prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. It significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa. [4]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01772836 Completed
Healthy Volunteers|Bacterial Infections
Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
 March 2013 Phase 1

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