For research use only.

Catalog No.S1370 Synonyms: L-627, LJC10627

Biapenem Chemical Structure

CAS No. 120410-24-4

Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.

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Biological Activity

Description Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.
In vitro

Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. [1] Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. [2] Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. [3]

In vivo Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa. [4]


Solubility (25°C)

In vitro Water 16 mg/mL (45.66 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 350.39


CAS No. 120410-24-4
Storage powder
in solvent
Synonyms L-627, LJC10627
Smiles CC1C2C(C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)[O-])C(C)O

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Molarity Calculator

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Dilution Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01772836 Completed Drug: RPX7009|Drug: Biapenem|Drug: Normal saline Healthy Volunteers|Bacterial Infections Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company) March 2013 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID