Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

Amino-acid Sequence

CAS No. 1607799-13-2

Purity & Quality Control

Batch: P110801 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.97%

99.97

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (92.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Bremelanotide Acetate (PT-141 Acetate) is a melanocortin receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

In Vivo
In vivo	Bremelanotide, an analogue of the naturally occurring peptide a-MSH, activates the medial preoptic area (mPOA) and other hypothalamic and limbic regions of the brain involved in sexual behavior, and may work by activating dopamine terminals in the mPOA.^[2]
Animal Research	Animal Models	rat model of sexual desire
	Dosages	5, 100, 200, 800 μg/kg
	Administration	s.c.

References
[1] Dhillon S, et al. Drugs. 2019 Sep;79(14):1599-1606. [2] Pfaus J, et al. J Sex Med. 2007 Nov;4 Suppl 4:269-79.

References

Product Information

Molecular Formula:	C₅₀H₆₈N₁₄O₁₀.C₂H₄O₂
Molecular Weight:	1085.22
CAS No.:	1607799-13-2
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)